Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03114:Prdx3'

419350

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prdx3

Ensembl Gene

ENSMUSG00000024997

Gene Name

peroxiredoxin 3

Synonyms

SP22, D0Tohi1, Ef2l, TDXM, Mer5, Prx III, Aop1

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.339) question?

Stock #

IGL03114

Quality Score

Status

Chromosome

Chromosomal Location

60852504-60862976 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 60861556 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000025961 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025961]

AlphaFold

P20108

Predicted Effect

probably benign
Transcript: ENSMUST00000025961

SMART Domains

Protein: ENSMUSP00000025961
Gene: ENSMUSG00000024997

Domain	Start	End	E-Value	Type
low complexity region	11	27	N/A	INTRINSIC
Pfam:Redoxin	59	215	8.5e-19	PFAM
Pfam:AhpC-TSA	66	199	3.6e-39	PFAM
Pfam:1-cysPrx_C	219	254	1.2e-15	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
PHENOTYPE: Homozygotes for a null allele show increased fat mass, adipocyte hypertrophy, mitochondrial dysfunction, oxidative stress, adipokine dysregulation and altered lipid and glucose metabolism. Homozygotes for a gene-trap allele show reduced weight and high susceptibility to LPS-induced oxidative stress. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2fm2	A	T	3: 59,651,144 (GRCm39)	I89F	possibly damaging	Het
Abca13	T	A	11: 9,478,999 (GRCm39)	H4282Q	probably benign	Het
Acta2	A	G	19: 34,222,310 (GRCm39)		probably null	Het
Arl10	A	G	13: 54,723,579 (GRCm39)		probably benign	Het
Avpr1a	A	G	10: 122,285,623 (GRCm39)	Y305C	probably damaging	Het
Bmpr2	T	A	1: 59,906,603 (GRCm39)	N565K	probably damaging	Het
Boc	A	T	16: 44,307,115 (GRCm39)	S1035R	probably benign	Het
Brd10	A	T	19: 29,694,532 (GRCm39)	S1654T	probably benign	Het
Ccdc7a	T	C	8: 129,753,170 (GRCm39)	N187S	possibly damaging	Het
Cntn5	C	T	9: 9,748,457 (GRCm39)	E680K	probably damaging	Het
Copa	T	A	1: 171,946,835 (GRCm39)	Y1014*	probably null	Het
Csmd3	A	G	15: 47,683,847 (GRCm39)	S1662P	probably damaging	Het
Cyp2e1	T	C	7: 140,353,042 (GRCm39)	F360L	possibly damaging	Het
Efnb3	A	T	11: 69,447,628 (GRCm39)		probably benign	Het
Egf	A	T	3: 129,530,529 (GRCm39)	L211Q	probably damaging	Het
Eno1	G	A	4: 150,325,583 (GRCm39)	R56H	probably benign	Het
Fyb2	A	G	4: 104,852,975 (GRCm39)	T552A	probably damaging	Het
Git2	G	A	5: 114,871,918 (GRCm39)		probably benign	Het
Gtf2ird2	A	G	5: 134,245,752 (GRCm39)		probably null	Het
Hyal4	A	T	6: 24,755,964 (GRCm39)	I61L	probably benign	Het
Kat14	T	C	2: 144,217,885 (GRCm39)		probably null	Het
Kif13b	T	C	14: 65,025,897 (GRCm39)	V1418A	probably benign	Het
Lcn12	T	C	2: 25,383,274 (GRCm39)	K35E	probably benign	Het
Lyrm7	G	T	11: 54,741,198 (GRCm39)	N45K	possibly damaging	Het
Mical2	G	T	7: 111,996,764 (GRCm39)	G559V	probably damaging	Het
Mtrr	A	T	13: 68,712,441 (GRCm39)	C648*	probably null	Het
Muc5b	C	A	7: 141,412,556 (GRCm39)	S1834*	probably null	Het
Mup16	G	A	4: 61,436,250 (GRCm39)	T101M	probably benign	Het
Myof	A	T	19: 37,892,309 (GRCm39)	L1148Q	probably damaging	Het
Nags	A	T	11: 102,039,814 (GRCm39)	I501F	probably damaging	Het
Nbeal1	A	T	1: 60,317,886 (GRCm39)	Y672F	probably damaging	Het
Ncapg2	A	G	12: 116,415,993 (GRCm39)		probably benign	Het
Obscn	A	G	11: 58,891,365 (GRCm39)	S7056P	unknown	Het
Or52s1	T	C	7: 102,861,928 (GRCm39)	I287T	probably damaging	Het
Pde2a	C	A	7: 101,157,890 (GRCm39)		probably benign	Het
Piezo2	T	C	18: 63,163,343 (GRCm39)		probably null	Het
Pkhd1	C	A	1: 20,268,395 (GRCm39)	D3328Y	probably damaging	Het
Plxdc2	T	C	2: 16,654,935 (GRCm39)	V178A	probably damaging	Het
Prkce	T	A	17: 86,961,983 (GRCm39)	D694E	probably damaging	Het
Prss1l	T	A	6: 41,374,012 (GRCm39)	C205S	probably damaging	Het
Ptdss1	T	A	13: 67,142,058 (GRCm39)	Y405*	probably null	Het
Rad54l	A	T	4: 115,955,729 (GRCm39)	W608R	probably damaging	Het
Rassf6	G	T	5: 90,756,649 (GRCm39)		probably benign	Het
Sema5a	A	T	15: 32,673,573 (GRCm39)	I804F	probably damaging	Het
Slc15a2	A	T	16: 36,572,267 (GRCm39)	I668N	probably damaging	Het
Thsd7b	A	G	1: 130,116,288 (GRCm39)	E1347G	probably benign	Het
Tmco3	T	C	8: 13,348,205 (GRCm39)		probably benign	Het
Ttn	T	C	2: 76,551,996 (GRCm39)	M31214V	probably null	Het
Uck1	G	A	2: 32,148,334 (GRCm39)	R161C	probably benign	Het
Ugt2b5	T	C	5: 87,276,209 (GRCm39)	Y355C	probably damaging	Het
Usp48	C	A	4: 137,383,436 (GRCm39)	T1031K	probably damaging	Het
Vmn1r202	G	A	13: 22,685,640 (GRCm39)	T259I	probably benign	Het
Vmn1r202	T	A	13: 22,685,500 (GRCm39)		probably benign	Het
Vmn2r90	T	C	17: 17,953,771 (GRCm39)	I645T	probably damaging	Het
Vps18	T	C	2: 119,124,132 (GRCm39)	V353A	possibly damaging	Het
Vwf	C	T	6: 125,576,326 (GRCm39)	Q469*	probably null	Het

Other mutations in Prdx3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02444:Prdx3	APN	19	60,859,899 (GRCm39)	missense	possibly damaging	0.76
IGL03410:Prdx3	APN	19	60,859,848 (GRCm39)	splice site	probably benign
R0058:Prdx3	UTSW	19	60,862,950 (GRCm39)	start gained	probably benign
R1612:Prdx3	UTSW	19	60,862,872 (GRCm39)	missense	possibly damaging	0.94
R3899:Prdx3	UTSW	19	60,853,621 (GRCm39)	missense	probably benign	0.44
R4654:Prdx3	UTSW	19	60,853,674 (GRCm39)	missense	possibly damaging	0.92
R4720:Prdx3	UTSW	19	60,858,551 (GRCm39)	missense	possibly damaging	0.90
R4760:Prdx3	UTSW	19	60,861,621 (GRCm39)	missense	possibly damaging	0.63
R5643:Prdx3	UTSW	19	60,859,963 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02