Incidental Mutation 'IGL03115:Fmo9'
ID419366
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fmo9
Ensembl Gene ENSMUSG00000026560
Gene Nameflavin containing monooxygenase 9
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #IGL03115
Quality Score
Status
Chromosome1
Chromosomal Location166662055-166681845 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 166677651 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 7 (S7P)
Ref Sequence ENSEMBL: ENSMUSP00000114750 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027843] [ENSMUST00000148677]
Predicted Effect probably damaging
Transcript: ENSMUST00000027843
AA Change: S58P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027843
Gene: ENSMUSG00000026560
AA Change: S58P

DomainStartEndE-ValueType
Pfam:FMO-like 3 535 1.2e-252 PFAM
Pfam:Pyr_redox_2 4 262 2.9e-12 PFAM
Pfam:Pyr_redox_3 7 221 2.3e-14 PFAM
Pfam:NAD_binding_8 8 83 1.2e-6 PFAM
Pfam:K_oxygenase 77 334 8.9e-11 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000148677
AA Change: S7P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114750
Gene: ENSMUSG00000026560
AA Change: S7P

DomainStartEndE-ValueType
Pfam:FMO-like 1 484 1.6e-222 PFAM
Pfam:Pyr_redox_3 3 170 1.2e-12 PFAM
Pfam:K_oxygenase 28 283 6.2e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 T A 14: 68,571,353 H302L probably damaging Het
Adamts12 T A 15: 11,263,336 C595S probably damaging Het
Arid2 G A 15: 96,370,273 V756I probably damaging Het
Asah1 A T 8: 41,360,299 W26R possibly damaging Het
Brinp1 C T 4: 68,904,736 probably null Het
Cers2 A G 3: 95,321,352 D162G probably damaging Het
Clasp1 G T 1: 118,501,323 E106* probably null Het
Col12a1 T C 9: 79,681,437 E1132G probably damaging Het
Dhdds G T 4: 133,982,871 H196N probably benign Het
Eps8 T C 6: 137,527,381 D118G probably damaging Het
Gamt A G 10: 80,258,438 L197P probably damaging Het
Grb7 A G 11: 98,451,119 I82V probably damaging Het
Hectd2 T C 19: 36,599,721 probably null Het
Ilk T C 7: 105,740,335 V83A probably damaging Het
Kif21a T A 15: 90,985,395 I418F probably damaging Het
Kndc1 A G 7: 139,921,509 I905V probably benign Het
Lyl1 C T 8: 84,702,671 P3L possibly damaging Het
Morc3 T C 16: 93,871,083 I710T probably damaging Het
Nefm T C 14: 68,120,279 probably benign Het
Olfr452 A G 6: 42,790,665 T209A probably benign Het
Olfr937 C A 9: 39,059,963 R234S probably damaging Het
Olfr975 T C 9: 39,950,744 E9G probably damaging Het
Pard6g T G 18: 80,079,853 L34W probably damaging Het
Patj C T 4: 98,443,803 S562L probably damaging Het
Pcsk4 A G 10: 80,329,049 I61T probably damaging Het
Pcsk7 T A 9: 45,914,372 H300Q probably damaging Het
Pip5kl1 A G 2: 32,580,021 D288G probably damaging Het
Plxnb2 T A 15: 89,162,438 probably benign Het
Poldip2 T C 11: 78,521,144 probably benign Het
Ralgapa2 T C 2: 146,424,814 Y614C probably damaging Het
Rarres1 C A 3: 67,495,812 probably null Het
Samd3 C T 10: 26,271,708 T427M probably damaging Het
Skap1 A G 11: 96,702,620 I98V probably benign Het
Skint11 T C 4: 114,244,623 S87P probably damaging Het
Slc22a22 T G 15: 57,263,274 E133A probably damaging Het
Slc23a2 T C 2: 132,091,265 Y91C probably damaging Het
Slc6a20b T A 9: 123,597,338 E494V possibly damaging Het
Slco1a4 A C 6: 141,817,859 M377R probably damaging Het
Slco1a4 A T 6: 141,819,603 D304E probably benign Het
Srpk2 T C 5: 23,524,618 probably null Het
Supt3 T G 17: 45,041,227 C271W probably damaging Het
Taar7d C A 10: 24,027,641 F140L probably benign Het
Tmbim7 T C 5: 3,679,158 *225Q probably null Het
Tpst1 T C 5: 130,101,911 I74T probably damaging Het
Utp3 T C 5: 88,555,320 V236A possibly damaging Het
Vmn2r55 A T 7: 12,670,631 F282I probably damaging Het
Vwa5b1 A T 4: 138,600,149 I372N possibly damaging Het
Wtip C T 7: 34,125,533 A209T probably damaging Het
Zbbx T C 3: 75,078,560 D395G probably benign Het
Zfp273 A T 13: 67,825,650 H299L probably damaging Het
Zfp459 G A 13: 67,408,677 R96* probably null Het
Other mutations in Fmo9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Fmo9 APN 1 166680145 intron probably null
IGL01796:Fmo9 APN 1 166663335 missense probably benign 0.31
IGL03005:Fmo9 APN 1 166674519 missense probably benign 0.02
IGL03163:Fmo9 APN 1 166674450 missense possibly damaging 0.77
R0089:Fmo9 UTSW 1 166667309 missense probably benign 0.05
R0570:Fmo9 UTSW 1 166674462 missense probably null 0.00
R1520:Fmo9 UTSW 1 166667455 missense probably benign 0.19
R1779:Fmo9 UTSW 1 166663299 missense probably benign 0.18
R1783:Fmo9 UTSW 1 166673648 missense probably benign 0.01
R2858:Fmo9 UTSW 1 166673667 missense probably damaging 1.00
R2859:Fmo9 UTSW 1 166673667 missense probably damaging 1.00
R3851:Fmo9 UTSW 1 166663367 missense probably benign 0.00
R3924:Fmo9 UTSW 1 166664652 missense probably benign 0.03
R4470:Fmo9 UTSW 1 166680230 missense probably damaging 1.00
R4728:Fmo9 UTSW 1 166663311 missense possibly damaging 0.82
R5538:Fmo9 UTSW 1 166673629 missense probably benign 0.01
R5650:Fmo9 UTSW 1 166663446 missense probably damaging 1.00
R5820:Fmo9 UTSW 1 166664601 missense possibly damaging 0.67
R6163:Fmo9 UTSW 1 166667393 missense probably benign
R6229:Fmo9 UTSW 1 166677557 missense possibly damaging 0.64
R6243:Fmo9 UTSW 1 166667369 missense probably benign 0.45
R6375:Fmo9 UTSW 1 166664595 critical splice donor site probably null
R7144:Fmo9 UTSW 1 166677620 missense probably benign 0.40
R7236:Fmo9 UTSW 1 166676571 missense probably damaging 1.00
R7316:Fmo9 UTSW 1 166663646 missense probably benign 0.21
R7341:Fmo9 UTSW 1 166676546 missense probably damaging 1.00
R7382:Fmo9 UTSW 1 166663660 splice site probably null
R7589:Fmo9 UTSW 1 166674428 missense possibly damaging 0.61
R7679:Fmo9 UTSW 1 166667489 missense probably benign 0.01
Z1088:Fmo9 UTSW 1 166673545 critical splice donor site probably null
Posted On2016-08-02