Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03115:Srpk2'

419404

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Srpk2

Ensembl Gene

ENSMUSG00000062604

Gene Name

serine/arginine-rich protein specific kinase 2

Synonyms

WBP6, mSRPK2

Accession Numbers

NCBI RefSeq: NM_009274.2; MGI:1201408

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03115

Quality Score

Status

Chromosome

Chromosomal Location

23503264-23684617 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 23524618 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000085734 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088392] [ENSMUST00000196388] [ENSMUST00000196929]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000088392

SMART Domains

Protein: ENSMUSP00000085734
Gene: ENSMUSG00000062604

Domain	Start	End	E-Value	Type
low complexity region	5	46	N/A	INTRINSIC
Pfam:Pkinase	79	228	1.3e-22	PFAM
Pfam:Pkinase_Tyr	79	228	1e-9	PFAM
coiled coil region	263	314	N/A	INTRINSIC
coiled coil region	339	373	N/A	INTRINSIC
low complexity region	393	406	N/A	INTRINSIC
Pfam:Pkinase	506	680	1.9e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000196388

SMART Domains

Protein: ENSMUSP00000143453
Gene: ENSMUSG00000062604

Domain	Start	End	E-Value	Type
S_TKc	3	129	7.2e-6	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000196929

SMART Domains

Protein: ENSMUSP00000143216
Gene: ENSMUSG00000062604

Domain	Start	End	E-Value	Type
Pfam:Pkinase_Tyr	1	131	2.6e-8	PFAM
Pfam:Pkinase	2	130	2.3e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200173

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a targeted allele exhibit normal phenotype. [provided by MGI curators]

Allele List at MGI

All alleles(39) : Targeted(3) Gene trapped(36)

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamdec1	T	A	14: 68,571,353	H302L	probably damaging	Het
Adamts12	T	A	15: 11,263,336	C595S	probably damaging	Het
Arid2	G	A	15: 96,370,273	V756I	probably damaging	Het
Asah1	A	T	8: 41,360,299	W26R	possibly damaging	Het
Brinp1	C	T	4: 68,904,736		probably null	Het
Cers2	A	G	3: 95,321,352	D162G	probably damaging	Het
Clasp1	G	T	1: 118,501,323	E106*	probably null	Het
Col12a1	T	C	9: 79,681,437	E1132G	probably damaging	Het
Dhdds	G	T	4: 133,982,871	H196N	probably benign	Het
Eps8	T	C	6: 137,527,381	D118G	probably damaging	Het
Fmo9	A	G	1: 166,677,651	S7P	probably damaging	Het
Gamt	A	G	10: 80,258,438	L197P	probably damaging	Het
Grb7	A	G	11: 98,451,119	I82V	probably damaging	Het
Hectd2	T	C	19: 36,599,721		probably null	Het
Ilk	T	C	7: 105,740,335	V83A	probably damaging	Het
Kif21a	T	A	15: 90,985,395	I418F	probably damaging	Het
Kndc1	A	G	7: 139,921,509	I905V	probably benign	Het
Lyl1	C	T	8: 84,702,671	P3L	possibly damaging	Het
Morc3	T	C	16: 93,871,083	I710T	probably damaging	Het
Nefm	T	C	14: 68,120,279		probably benign	Het
Olfr452	A	G	6: 42,790,665	T209A	probably benign	Het
Olfr937	C	A	9: 39,059,963	R234S	probably damaging	Het
Olfr975	T	C	9: 39,950,744	E9G	probably damaging	Het
Pard6g	T	G	18: 80,079,853	L34W	probably damaging	Het
Patj	C	T	4: 98,443,803	S562L	probably damaging	Het
Pcsk4	A	G	10: 80,329,049	I61T	probably damaging	Het
Pcsk7	T	A	9: 45,914,372	H300Q	probably damaging	Het
Pip5kl1	A	G	2: 32,580,021	D288G	probably damaging	Het
Plxnb2	T	A	15: 89,162,438		probably benign	Het
Poldip2	T	C	11: 78,521,144		probably benign	Het
Ralgapa2	T	C	2: 146,424,814	Y614C	probably damaging	Het
Rarres1	C	A	3: 67,495,812		probably null	Het
Samd3	C	T	10: 26,271,708	T427M	probably damaging	Het
Skap1	A	G	11: 96,702,620	I98V	probably benign	Het
Skint11	T	C	4: 114,244,623	S87P	probably damaging	Het
Slc22a22	T	G	15: 57,263,274	E133A	probably damaging	Het
Slc23a2	T	C	2: 132,091,265	Y91C	probably damaging	Het
Slc6a20b	T	A	9: 123,597,338	E494V	possibly damaging	Het
Slco1a4	A	C	6: 141,817,859	M377R	probably damaging	Het
Slco1a4	A	T	6: 141,819,603	D304E	probably benign	Het
Supt3	T	G	17: 45,041,227	C271W	probably damaging	Het
Taar7d	C	A	10: 24,027,641	F140L	probably benign	Het
Tmbim7	T	C	5: 3,679,158	*225Q	probably null	Het
Tpst1	T	C	5: 130,101,911	I74T	probably damaging	Het
Utp3	T	C	5: 88,555,320	V236A	possibly damaging	Het
Vmn2r55	A	T	7: 12,670,631	F282I	probably damaging	Het
Vwa5b1	A	T	4: 138,600,149	I372N	possibly damaging	Het
Wtip	C	T	7: 34,125,533	A209T	probably damaging	Het
Zbbx	T	C	3: 75,078,560	D395G	probably benign	Het
Zfp273	A	T	13: 67,825,650	H299L	probably damaging	Het
Zfp459	G	A	13: 67,408,677	R96*	probably null	Het

Other mutations in Srpk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00697:Srpk2	APN	5	23540379	missense	probably benign	0.10
IGL02057:Srpk2	APN	5	23518707	missense	probably damaging	0.99
IGL02217:Srpk2	APN	5	23545570	missense	probably damaging	1.00
FR4737:Srpk2	UTSW	5	23545196	splice site	probably null
P0008:Srpk2	UTSW	5	23513978	missense	probably damaging	1.00
R0142:Srpk2	UTSW	5	23527930	missense	probably damaging	0.97
R0462:Srpk2	UTSW	5	23518426	missense	probably damaging	1.00
R0992:Srpk2	UTSW	5	23545543	missense	probably damaging	0.99
R1569:Srpk2	UTSW	5	23514026	missense	probably damaging	1.00
R1677:Srpk2	UTSW	5	23525750	splice site	probably null
R1696:Srpk2	UTSW	5	23548494	nonsense	probably null
R1752:Srpk2	UTSW	5	23528019	missense	probably damaging	1.00
R1862:Srpk2	UTSW	5	23524150	missense	probably benign	0.32
R1989:Srpk2	UTSW	5	23518423	missense	probably damaging	1.00
R2173:Srpk2	UTSW	5	23518615	splice site	probably null
R4096:Srpk2	UTSW	5	23540502	intron	probably benign
R4271:Srpk2	UTSW	5	23548515	missense	possibly damaging	0.95
R4894:Srpk2	UTSW	5	23545529	missense	probably damaging	1.00
R5043:Srpk2	UTSW	5	23524517	missense	probably benign
R5044:Srpk2	UTSW	5	23524392	missense	possibly damaging	0.91
R5309:Srpk2	UTSW	5	23525718	missense	probably damaging	0.97
R5478:Srpk2	UTSW	5	23524183	missense	possibly damaging	0.71
R5568:Srpk2	UTSW	5	23525699	missense	possibly damaging	0.73
R5665:Srpk2	UTSW	5	23518477	missense	probably damaging	0.99
R5678:Srpk2	UTSW	5	23524606	frame shift	probably null
R6364:Srpk2	UTSW	5	23540467	missense	probably damaging	1.00
R7201:Srpk2	UTSW	5	23507628	missense	possibly damaging	0.64
R7597:Srpk2	UTSW	5	23548519	missense	possibly damaging	0.96
R8251:Srpk2	UTSW	5	23524268	missense	probably benign
R8477:Srpk2	UTSW	5	23513988	missense	probably benign	0.03
R9348:Srpk2	UTSW	5	23514673	missense	probably damaging	0.98
RF035:Srpk2	UTSW	5	23525575	utr 3 prime	probably benign
RF042:Srpk2	UTSW	5	23525575	utr 3 prime	probably benign

Posted On

2016-08-02