Incidental Mutation 'IGL03116:Ninl'
ID419441
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ninl
Ensembl Gene ENSMUSG00000068115
Gene Nameninein-like
SynonymsLOC381387, LOC381388, 4930519N13Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03116
Quality Score
Status
Chromosome2
Chromosomal Location150934519-151039382 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 150964219 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 361 (A361T)
Ref Sequence ENSEMBL: ENSMUSP00000105522 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109896] [ENSMUST00000150595]
Predicted Effect probably damaging
Transcript: ENSMUST00000109896
AA Change: A361T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105522
Gene: ENSMUSG00000068115
AA Change: A361T

DomainStartEndE-ValueType
EFh 12 40 6.56e0 SMART
low complexity region 76 93 N/A INTRINSIC
EFh 201 229 4.45e1 SMART
EFh 238 266 8.98e-4 SMART
low complexity region 295 306 N/A INTRINSIC
coiled coil region 381 423 N/A INTRINSIC
coiled coil region 461 517 N/A INTRINSIC
coiled coil region 541 584 N/A INTRINSIC
coiled coil region 620 699 N/A INTRINSIC
coiled coil region 728 751 N/A INTRINSIC
coiled coil region 835 863 N/A INTRINSIC
coiled coil region 1058 1334 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128564
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149268
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149979
Predicted Effect probably benign
Transcript: ENSMUST00000150595
SMART Domains Protein: ENSMUSP00000117001
Gene: ENSMUSG00000068115

DomainStartEndE-ValueType
low complexity region 33 45 N/A INTRINSIC
coiled coil region 85 122 N/A INTRINSIC
coiled coil region 160 216 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit bone-marrow myeloid hyperplasia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810030O07Rik T C X: 12,669,653 probably benign Het
9530068E07Rik A G 11: 52,403,504 I199V probably benign Het
Aasdh A T 5: 76,902,089 probably null Het
Aatk T C 11: 120,016,751 I84V probably benign Het
Adcy1 A G 11: 7,150,071 H727R probably benign Het
Aff2 T C X: 69,834,486 V626A probably benign Het
Ano2 C A 6: 125,980,171 Y634* probably null Het
Apob C A 12: 8,016,350 Q4407K probably damaging Het
Asz1 T C 6: 18,076,643 probably benign Het
Atp2b4 T G 1: 133,728,768 T715P possibly damaging Het
Brip1 G T 11: 86,064,909 S926* probably null Het
Cpd A T 11: 76,811,713 Y610N probably damaging Het
Dennd4c T C 4: 86,788,820 probably benign Het
Dido1 G A 2: 180,670,979 T1041I probably damaging Het
Dpp8 A T 9: 65,066,467 T658S probably damaging Het
Fcer1a G A 1: 173,221,561 Q172* probably null Het
Frem3 A G 8: 80,612,806 E576G possibly damaging Het
Gcsam T C 16: 45,620,068 F136S possibly damaging Het
Glmn T G 5: 107,551,083 T430P probably damaging Het
Gm11639 T A 11: 104,721,533 S661T probably benign Het
Gm5934 T C X: 24,474,692 N194S probably benign Het
Gpatch11 T A 17: 78,843,853 L231* probably null Het
Hibadh A T 6: 52,548,932 N244K probably damaging Het
Kank2 A G 9: 21,772,764 V723A probably damaging Het
Kcnn2 A T 18: 45,655,206 D192V probably damaging Het
Ksr2 G A 5: 117,707,957 E630K probably benign Het
Lmod3 T C 6: 97,247,195 H555R possibly damaging Het
Mycs A G X: 5,468,868 F53L probably damaging Het
Ndufa10 G A 1: 92,464,387 Q215* probably null Het
Pbsn A G X: 77,848,018 C58R probably damaging Het
Pcsk1 T A 13: 75,132,216 L720Q probably damaging Het
Prss12 T C 3: 123,506,276 F679L probably benign Het
Sohlh1 C T 2: 25,845,648 probably null Het
Sspo T C 6: 48,494,101 F701L probably benign Het
Tdp1 T C 12: 99,955,031 S609P probably benign Het
Tmtc4 T A 14: 122,927,632 N605I probably benign Het
Tnc G A 4: 64,014,033 P715S probably damaging Het
Ubn2 T C 6: 38,491,899 S1181P probably damaging Het
Ubr4 T C 4: 139,479,581 probably benign Het
Vmn1r46 T C 6: 89,976,916 F249S probably benign Het
Zfp382 T C 7: 30,134,189 S422P probably damaging Het
Other mutations in Ninl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00230:Ninl APN 2 150966241 missense probably damaging 0.98
IGL01697:Ninl APN 2 150939947 missense probably damaging 1.00
IGL01756:Ninl APN 2 150979516 missense probably damaging 1.00
IGL01925:Ninl APN 2 150971059 missense probably damaging 1.00
IGL02341:Ninl APN 2 150944605 nonsense probably null
IGL02838:Ninl APN 2 150955711 splice site probably null
IGL02868:Ninl APN 2 150937054 missense probably benign
IGL03396:Ninl APN 2 150966212 missense possibly damaging 0.88
R0117:Ninl UTSW 2 150937673 missense probably damaging 0.98
R0685:Ninl UTSW 2 150939855 missense possibly damaging 0.73
R0928:Ninl UTSW 2 150963475 missense probably damaging 0.99
R1051:Ninl UTSW 2 150970126 missense probably damaging 1.00
R1441:Ninl UTSW 2 150971124 missense probably benign 0.10
R1493:Ninl UTSW 2 150980095 missense probably damaging 1.00
R1499:Ninl UTSW 2 150980176 missense possibly damaging 0.70
R1539:Ninl UTSW 2 150975947 missense probably damaging 1.00
R1658:Ninl UTSW 2 150964159 missense probably damaging 1.00
R2038:Ninl UTSW 2 150975843 nonsense probably null
R2156:Ninl UTSW 2 150944583 missense probably damaging 1.00
R2232:Ninl UTSW 2 150950050 missense probably benign 0.00
R2373:Ninl UTSW 2 150980117 missense probably damaging 1.00
R3743:Ninl UTSW 2 150950248 missense probably benign 0.01
R3906:Ninl UTSW 2 150980119 missense probably damaging 1.00
R3950:Ninl UTSW 2 150952488 missense possibly damaging 0.90
R4283:Ninl UTSW 2 150953416 unclassified probably benign
R4798:Ninl UTSW 2 150959881 nonsense probably null
R4963:Ninl UTSW 2 150939909 missense probably benign 0.04
R4998:Ninl UTSW 2 150953364 missense probably damaging 1.00
R5343:Ninl UTSW 2 150971190 missense probably benign 0.01
R5810:Ninl UTSW 2 150950168 missense probably benign 0.31
R5825:Ninl UTSW 2 150940724 missense probably damaging 1.00
R6436:Ninl UTSW 2 150966178 missense probably damaging 1.00
R6728:Ninl UTSW 2 150975857 nonsense probably null
R6734:Ninl UTSW 2 150945083 critical splice donor site probably null
R6997:Ninl UTSW 2 150966225 missense probably benign 0.08
R7135:Ninl UTSW 2 150955604 missense probably benign 0.00
R7157:Ninl UTSW 2 150949343 missense possibly damaging 0.63
R7315:Ninl UTSW 2 150950050 missense probably benign 0.00
R7840:Ninl UTSW 2 150966096 missense probably benign 0.00
R7923:Ninl UTSW 2 150966096 missense probably benign 0.00
X0062:Ninl UTSW 2 150970046 missense probably damaging 1.00
Z1177:Ninl UTSW 2 150953398 missense probably damaging 1.00
Posted On2016-08-02