Incidental Mutation 'IGL03347:Igsf10'
ID 419511
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igsf10
Ensembl Gene ENSMUSG00000036334
Gene Name immunoglobulin superfamily, member 10
Synonyms 6530405F15Rik, CMF608, Adlican2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.193) question?
Stock # IGL03347
Quality Score
Status
Chromosome 3
Chromosomal Location 59224156-59251815 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 59239321 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 287 (S287T)
Ref Sequence ENSEMBL: ENSMUSP00000141391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039419] [ENSMUST00000193455] [ENSMUST00000194546]
AlphaFold Q3V1M1
Predicted Effect possibly damaging
Transcript: ENSMUST00000039419
AA Change: S287T

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000037246
Gene: ENSMUSG00000036334
AA Change: S287T

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 3.24e-4 SMART
LRR 57 79 9.24e1 SMART
LRR 80 103 2.02e-1 SMART
LRR 104 127 7.16e0 SMART
LRR_TYP 128 151 1.2e-3 SMART
LRR 152 175 1.25e-1 SMART
LRR 188 207 2.33e2 SMART
LRRCT 219 280 4.19e-4 SMART
IGc2 488 558 2.34e-4 SMART
IGc2 586 652 7.88e-11 SMART
low complexity region 917 930 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
low complexity region 1245 1263 N/A INTRINSIC
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1449 1465 N/A INTRINSIC
IGc2 1632 1701 7.69e-14 SMART
IGc2 1729 1798 5.07e-14 SMART
IGc2 1826 1895 2.19e-9 SMART
IGc2 1925 1994 4.59e-12 SMART
IGc2 2022 2097 1.33e-8 SMART
IGc2 2125 2191 2.96e-15 SMART
IGc2 2223 2291 2.03e-4 SMART
IGc2 2321 2389 9.99e-13 SMART
IGc2 2416 2484 3.03e-12 SMART
IGc2 2512 2583 7.76e-10 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000193455
AA Change: S287T

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000141971
Gene: ENSMUSG00000036334
AA Change: S287T

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 3.24e-4 SMART
LRR 57 79 9.24e1 SMART
LRR 80 103 2.02e-1 SMART
LRR 104 127 7.16e0 SMART
LRR_TYP 128 151 1.2e-3 SMART
LRR 152 175 1.25e-1 SMART
LRR 188 207 2.33e2 SMART
LRRCT 219 280 4.19e-4 SMART
IGc2 488 558 2.34e-4 SMART
IGc2 586 652 7.88e-11 SMART
low complexity region 917 930 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
low complexity region 1245 1263 N/A INTRINSIC
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1449 1465 N/A INTRINSIC
IGc2 1632 1701 7.69e-14 SMART
IGc2 1729 1798 5.07e-14 SMART
IGc2 1826 1895 2.19e-9 SMART
IGc2 1925 1994 4.59e-12 SMART
IGc2 2022 2097 1.33e-8 SMART
IGc2 2125 2191 2.96e-15 SMART
IGc2 2223 2291 2.03e-4 SMART
IGc2 2321 2389 9.99e-13 SMART
IGc2 2416 2484 3.03e-12 SMART
IGc2 2512 2583 7.76e-10 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000194546
AA Change: S287T

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000141391
Gene: ENSMUSG00000036334
AA Change: S287T

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 3.24e-4 SMART
LRR 57 79 9.24e1 SMART
LRR 80 103 2.02e-1 SMART
LRR 104 127 7.16e0 SMART
LRR_TYP 128 151 1.2e-3 SMART
LRR 152 175 1.25e-1 SMART
LRR 188 207 2.33e2 SMART
LRRCT 219 280 4.19e-4 SMART
IGc2 488 558 2.34e-4 SMART
IGc2 586 652 7.88e-11 SMART
low complexity region 917 930 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
low complexity region 1245 1263 N/A INTRINSIC
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1449 1465 N/A INTRINSIC
IGc2 1632 1701 7.69e-14 SMART
IGc2 1729 1798 5.07e-14 SMART
IGc2 1826 1895 2.19e-9 SMART
IGc2 1925 1994 4.59e-12 SMART
IGc2 2022 2097 1.33e-8 SMART
IGc2 2125 2191 2.96e-15 SMART
IGc2 2223 2291 2.03e-4 SMART
IGc2 2321 2389 9.99e-13 SMART
IGc2 2416 2484 3.03e-12 SMART
IGc2 2512 2583 7.76e-10 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts8 T A 9: 30,870,534 (GRCm39) S670T possibly damaging Het
Adamts9 G T 6: 92,864,413 (GRCm39) Y185* probably null Het
Ahcyl A G 16: 45,974,852 (GRCm39) V175A probably benign Het
Arid3a T A 10: 79,787,113 (GRCm39) S512R possibly damaging Het
Atf6b T C 17: 34,872,214 (GRCm39) V524A probably damaging Het
Camk2d A G 3: 126,590,550 (GRCm39) T254A probably damaging Het
Camsap2 G T 1: 136,208,724 (GRCm39) Q923K possibly damaging Het
Car10 G A 11: 92,991,122 (GRCm39) probably benign Het
Ccdc39 A G 3: 33,891,992 (GRCm39) L160P probably damaging Het
Cdh20 A T 1: 110,065,973 (GRCm39) D749V possibly damaging Het
Cox6a2 A T 7: 127,804,900 (GRCm39) probably benign Het
Cpne1 A T 2: 155,921,096 (GRCm39) Y65N probably damaging Het
Dnm1 T C 2: 32,243,199 (GRCm39) D8G probably benign Het
Emsy A G 7: 98,259,892 (GRCm39) S140P probably damaging Het
Fam13b G A 18: 34,595,104 (GRCm39) probably benign Het
Fbn2 T C 18: 58,146,737 (GRCm39) R2720G probably damaging Het
Fkbpl A G 17: 34,865,287 (GRCm39) probably benign Het
Gpr179 A G 11: 97,242,664 (GRCm39) L60P probably damaging Het
Iftap A G 2: 101,413,864 (GRCm39) probably null Het
Kat2b G A 17: 53,931,379 (GRCm39) probably null Het
Kazald1 A G 19: 45,066,855 (GRCm39) D218G possibly damaging Het
Mbtd1 A G 11: 93,814,005 (GRCm39) E216G probably benign Het
Mtmr9 C A 14: 63,781,016 (GRCm39) V25L probably benign Het
Myo16 A G 8: 10,426,120 (GRCm39) probably null Het
Nfkbil1 A T 17: 35,439,559 (GRCm39) V318E probably damaging Het
Or2ag15 A T 7: 106,340,177 (GRCm39) probably benign Het
Or5g9 T C 2: 85,552,151 (GRCm39) V134A probably benign Het
Pidd1 A G 7: 141,019,081 (GRCm39) V800A probably damaging Het
Ptprs G A 17: 56,742,972 (GRCm39) S390L probably benign Het
Ralgapb G A 2: 158,307,880 (GRCm39) V729I possibly damaging Het
Sfrp5 T A 19: 42,187,207 (GRCm39) M288L probably benign Het
Slc26a1 C A 5: 108,821,676 (GRCm39) G71V probably damaging Het
Srcin1 A T 11: 97,416,170 (GRCm39) S1021T probably damaging Het
Supt6 A T 11: 78,123,011 (GRCm39) M124K possibly damaging Het
Thada A G 17: 84,705,633 (GRCm39) F1157S probably damaging Het
Tmcc2 A G 1: 132,285,390 (GRCm39) S424P probably damaging Het
Trim37 G A 11: 87,092,447 (GRCm39) R752Q possibly damaging Het
Unc80 A T 1: 66,734,625 (GRCm39) Q238L probably damaging Het
Vmn2r23 C A 6: 123,681,333 (GRCm39) H80Q probably benign Het
Wnt9a A T 11: 59,221,740 (GRCm39) T213S probably damaging Het
Zfp953 T A 13: 67,491,490 (GRCm39) Q154L probably benign Het
Other mutations in Igsf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00773:Igsf10 APN 3 59,238,960 (GRCm39) missense probably benign 0.03
IGL00790:Igsf10 APN 3 59,226,938 (GRCm39) missense probably damaging 1.00
IGL00916:Igsf10 APN 3 59,238,548 (GRCm39) missense probably damaging 0.97
IGL00928:Igsf10 APN 3 59,238,018 (GRCm39) missense probably benign 0.00
IGL01066:Igsf10 APN 3 59,235,203 (GRCm39) critical splice donor site probably null
IGL01107:Igsf10 APN 3 59,238,945 (GRCm39) missense probably damaging 1.00
IGL01420:Igsf10 APN 3 59,227,071 (GRCm39) missense probably benign 0.02
IGL01533:Igsf10 APN 3 59,226,651 (GRCm39) missense probably damaging 0.98
IGL01537:Igsf10 APN 3 59,237,452 (GRCm39) missense probably benign 0.00
IGL01676:Igsf10 APN 3 59,236,756 (GRCm39) missense probably benign 0.17
IGL01676:Igsf10 APN 3 59,233,432 (GRCm39) missense probably benign 0.06
IGL01960:Igsf10 APN 3 59,226,158 (GRCm39) missense probably benign 0.00
IGL02123:Igsf10 APN 3 59,226,081 (GRCm39) missense probably damaging 0.97
IGL02198:Igsf10 APN 3 59,233,399 (GRCm39) missense possibly damaging 0.95
IGL02268:Igsf10 APN 3 59,238,573 (GRCm39) nonsense probably null
IGL02313:Igsf10 APN 3 59,238,111 (GRCm39) missense probably benign 0.01
IGL02368:Igsf10 APN 3 59,235,652 (GRCm39) missense probably benign
IGL02494:Igsf10 APN 3 59,235,427 (GRCm39) missense probably damaging 0.98
IGL02549:Igsf10 APN 3 59,236,662 (GRCm39) missense probably benign 0.03
IGL02616:Igsf10 APN 3 59,226,027 (GRCm39) missense probably benign 0.06
IGL02957:Igsf10 APN 3 59,238,285 (GRCm39) missense probably damaging 1.00
IGL03067:Igsf10 APN 3 59,226,339 (GRCm39) missense probably benign 0.25
IGL03104:Igsf10 APN 3 59,226,905 (GRCm39) missense probably damaging 1.00
IGL03124:Igsf10 APN 3 59,227,086 (GRCm39) missense probably benign 0.01
IGL03212:Igsf10 APN 3 59,235,586 (GRCm39) missense probably benign 0.09
IGL03357:Igsf10 APN 3 59,243,632 (GRCm39) missense probably benign 0.35
F6893:Igsf10 UTSW 3 59,238,481 (GRCm39) missense probably damaging 1.00
FR4449:Igsf10 UTSW 3 59,226,531 (GRCm39) missense probably damaging 1.00
PIT1430001:Igsf10 UTSW 3 59,235,579 (GRCm39) missense probably benign 0.06
PIT4402001:Igsf10 UTSW 3 59,233,000 (GRCm39) missense probably benign 0.00
PIT4810001:Igsf10 UTSW 3 59,225,903 (GRCm39) missense probably damaging 1.00
R0068:Igsf10 UTSW 3 59,238,045 (GRCm39) missense probably damaging 0.98
R0095:Igsf10 UTSW 3 59,238,617 (GRCm39) nonsense probably null
R0095:Igsf10 UTSW 3 59,238,617 (GRCm39) nonsense probably null
R0112:Igsf10 UTSW 3 59,233,429 (GRCm39) missense probably benign 0.00
R0141:Igsf10 UTSW 3 59,238,253 (GRCm39) missense probably damaging 1.00
R0538:Igsf10 UTSW 3 59,227,527 (GRCm39) missense probably damaging 0.99
R0551:Igsf10 UTSW 3 59,236,089 (GRCm39) missense probably benign 0.01
R0556:Igsf10 UTSW 3 59,236,296 (GRCm39) missense probably benign 0.02
R0582:Igsf10 UTSW 3 59,227,188 (GRCm39) missense probably benign 0.00
R0630:Igsf10 UTSW 3 59,233,483 (GRCm39) missense probably damaging 1.00
R0675:Igsf10 UTSW 3 59,236,015 (GRCm39) missense probably benign 0.14
R0948:Igsf10 UTSW 3 59,238,525 (GRCm39) missense probably damaging 1.00
R1252:Igsf10 UTSW 3 59,239,269 (GRCm39) missense probably benign 0.03
R1412:Igsf10 UTSW 3 59,235,196 (GRCm39) splice site probably benign
R1473:Igsf10 UTSW 3 59,226,188 (GRCm39) missense probably damaging 1.00
R1585:Igsf10 UTSW 3 59,237,838 (GRCm39) missense probably damaging 1.00
R1650:Igsf10 UTSW 3 59,233,583 (GRCm39) missense probably damaging 1.00
R1660:Igsf10 UTSW 3 59,238,706 (GRCm39) missense probably damaging 1.00
R1671:Igsf10 UTSW 3 59,235,921 (GRCm39) nonsense probably null
R1748:Igsf10 UTSW 3 59,226,514 (GRCm39) missense probably damaging 1.00
R1758:Igsf10 UTSW 3 59,236,617 (GRCm39) missense probably benign 0.09
R1856:Igsf10 UTSW 3 59,238,693 (GRCm39) missense possibly damaging 0.63
R1912:Igsf10 UTSW 3 59,236,993 (GRCm39) missense probably benign 0.40
R2148:Igsf10 UTSW 3 59,243,998 (GRCm39) missense possibly damaging 0.77
R2155:Igsf10 UTSW 3 59,239,101 (GRCm39) missense probably damaging 1.00
R2509:Igsf10 UTSW 3 59,239,287 (GRCm39) missense probably damaging 1.00
R2511:Igsf10 UTSW 3 59,239,287 (GRCm39) missense probably damaging 1.00
R2680:Igsf10 UTSW 3 59,232,875 (GRCm39) missense probably benign 0.14
R2913:Igsf10 UTSW 3 59,239,157 (GRCm39) missense possibly damaging 0.70
R2927:Igsf10 UTSW 3 59,236,848 (GRCm39) missense probably benign
R3547:Igsf10 UTSW 3 59,243,935 (GRCm39) missense probably damaging 1.00
R3547:Igsf10 UTSW 3 59,237,962 (GRCm39) missense probably benign 0.02
R3548:Igsf10 UTSW 3 59,243,935 (GRCm39) missense probably damaging 1.00
R3620:Igsf10 UTSW 3 59,243,752 (GRCm39) missense probably damaging 1.00
R3732:Igsf10 UTSW 3 59,233,135 (GRCm39) missense probably benign 0.29
R3743:Igsf10 UTSW 3 59,233,546 (GRCm39) missense possibly damaging 0.69
R3973:Igsf10 UTSW 3 59,239,345 (GRCm39) missense probably damaging 1.00
R4005:Igsf10 UTSW 3 59,235,981 (GRCm39) missense probably benign 0.00
R4184:Igsf10 UTSW 3 59,227,152 (GRCm39) missense probably damaging 1.00
R4302:Igsf10 UTSW 3 59,226,171 (GRCm39) missense probably damaging 1.00
R4404:Igsf10 UTSW 3 59,236,972 (GRCm39) missense probably benign 0.04
R4575:Igsf10 UTSW 3 59,237,521 (GRCm39) missense probably benign
R4676:Igsf10 UTSW 3 59,233,370 (GRCm39) missense probably benign 0.23
R4700:Igsf10 UTSW 3 59,227,751 (GRCm39) missense probably damaging 0.99
R4765:Igsf10 UTSW 3 59,237,126 (GRCm39) missense probably benign 0.01
R4986:Igsf10 UTSW 3 59,236,027 (GRCm39) missense probably benign 0.24
R5012:Igsf10 UTSW 3 59,226,143 (GRCm39) missense probably damaging 1.00
R5070:Igsf10 UTSW 3 59,235,714 (GRCm39) missense probably benign 0.02
R5083:Igsf10 UTSW 3 59,233,694 (GRCm39) missense probably damaging 1.00
R5336:Igsf10 UTSW 3 59,227,553 (GRCm39) missense probably damaging 1.00
R5462:Igsf10 UTSW 3 59,233,175 (GRCm39) missense probably damaging 1.00
R5648:Igsf10 UTSW 3 59,235,574 (GRCm39) missense probably benign 0.01
R5810:Igsf10 UTSW 3 59,226,492 (GRCm39) missense probably damaging 1.00
R5871:Igsf10 UTSW 3 59,237,832 (GRCm39) missense possibly damaging 0.83
R5880:Igsf10 UTSW 3 59,238,252 (GRCm39) missense probably damaging 1.00
R5935:Igsf10 UTSW 3 59,235,578 (GRCm39) missense probably benign 0.12
R5979:Igsf10 UTSW 3 59,243,894 (GRCm39) missense probably damaging 1.00
R6145:Igsf10 UTSW 3 59,239,077 (GRCm39) missense possibly damaging 0.83
R6222:Igsf10 UTSW 3 59,226,336 (GRCm39) missense possibly damaging 0.90
R6224:Igsf10 UTSW 3 59,232,931 (GRCm39) missense probably damaging 1.00
R6264:Igsf10 UTSW 3 59,235,928 (GRCm39) missense possibly damaging 0.88
R6283:Igsf10 UTSW 3 59,226,870 (GRCm39) missense probably damaging 1.00
R6336:Igsf10 UTSW 3 59,237,760 (GRCm39) missense probably benign 0.00
R6490:Igsf10 UTSW 3 59,236,992 (GRCm39) missense probably benign 0.06
R6785:Igsf10 UTSW 3 59,226,665 (GRCm39) missense probably damaging 1.00
R6873:Igsf10 UTSW 3 59,235,865 (GRCm39) missense probably benign
R6889:Igsf10 UTSW 3 59,239,354 (GRCm39) missense probably benign
R7024:Igsf10 UTSW 3 59,239,122 (GRCm39) missense probably benign 0.00
R7056:Igsf10 UTSW 3 59,238,501 (GRCm39) missense probably damaging 1.00
R7128:Igsf10 UTSW 3 59,236,326 (GRCm39) missense probably benign
R7251:Igsf10 UTSW 3 59,226,875 (GRCm39) missense probably damaging 1.00
R7313:Igsf10 UTSW 3 59,236,837 (GRCm39) missense probably benign 0.05
R7340:Igsf10 UTSW 3 59,233,189 (GRCm39) missense probably damaging 1.00
R7447:Igsf10 UTSW 3 59,239,222 (GRCm39) missense probably benign 0.39
R7506:Igsf10 UTSW 3 59,226,775 (GRCm39) missense probably damaging 1.00
R7678:Igsf10 UTSW 3 59,226,761 (GRCm39) missense possibly damaging 0.81
R7695:Igsf10 UTSW 3 59,233,612 (GRCm39) missense probably damaging 1.00
R7709:Igsf10 UTSW 3 59,238,964 (GRCm39) missense probably damaging 0.96
R7749:Igsf10 UTSW 3 59,236,549 (GRCm39) missense possibly damaging 0.88
R7808:Igsf10 UTSW 3 59,235,489 (GRCm39) missense probably benign 0.00
R7850:Igsf10 UTSW 3 59,227,053 (GRCm39) missense probably benign 0.33
R7879:Igsf10 UTSW 3 59,238,145 (GRCm39) missense probably damaging 1.00
R7886:Igsf10 UTSW 3 59,235,748 (GRCm39) missense probably benign 0.01
R7891:Igsf10 UTSW 3 59,235,832 (GRCm39) nonsense probably null
R7946:Igsf10 UTSW 3 59,227,125 (GRCm39) missense possibly damaging 0.69
R7948:Igsf10 UTSW 3 59,239,279 (GRCm39) missense probably benign 0.02
R8004:Igsf10 UTSW 3 59,237,130 (GRCm39) missense probably benign 0.01
R8096:Igsf10 UTSW 3 59,236,380 (GRCm39) missense probably damaging 0.98
R8141:Igsf10 UTSW 3 59,237,949 (GRCm39) missense probably damaging 0.96
R8183:Igsf10 UTSW 3 59,238,036 (GRCm39) missense probably benign 0.04
R8203:Igsf10 UTSW 3 59,236,254 (GRCm39) missense probably benign 0.11
R8325:Igsf10 UTSW 3 59,225,954 (GRCm39) missense probably damaging 0.96
R8350:Igsf10 UTSW 3 59,238,949 (GRCm39) missense probably damaging 1.00
R8387:Igsf10 UTSW 3 59,236,564 (GRCm39) missense probably damaging 1.00
R8488:Igsf10 UTSW 3 59,227,431 (GRCm39) missense probably damaging 1.00
R8697:Igsf10 UTSW 3 59,226,308 (GRCm39) missense probably benign 0.02
R8786:Igsf10 UTSW 3 59,238,063 (GRCm39) missense probably benign 0.25
R8804:Igsf10 UTSW 3 59,243,876 (GRCm39) missense probably damaging 1.00
R8886:Igsf10 UTSW 3 59,237,410 (GRCm39) missense probably benign 0.00
R8902:Igsf10 UTSW 3 59,243,633 (GRCm39) missense probably benign 0.00
R8906:Igsf10 UTSW 3 59,233,739 (GRCm39) missense probably benign 0.01
R8917:Igsf10 UTSW 3 59,226,888 (GRCm39) missense possibly damaging 0.69
R9051:Igsf10 UTSW 3 59,236,668 (GRCm39) missense probably benign 0.00
R9178:Igsf10 UTSW 3 59,233,480 (GRCm39) missense possibly damaging 0.69
R9228:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9230:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9231:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9232:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9417:Igsf10 UTSW 3 59,236,526 (GRCm39) missense possibly damaging 0.94
R9609:Igsf10 UTSW 3 59,226,869 (GRCm39) missense probably damaging 1.00
R9631:Igsf10 UTSW 3 59,237,904 (GRCm39) missense probably damaging 1.00
R9689:Igsf10 UTSW 3 59,233,624 (GRCm39) missense probably damaging 1.00
R9762:Igsf10 UTSW 3 59,237,106 (GRCm39) missense probably damaging 1.00
R9770:Igsf10 UTSW 3 59,227,199 (GRCm39) missense probably benign 0.07
R9798:Igsf10 UTSW 3 59,239,126 (GRCm39) missense probably damaging 1.00
Z1088:Igsf10 UTSW 3 59,237,359 (GRCm39) missense possibly damaging 0.59
Z1177:Igsf10 UTSW 3 59,237,026 (GRCm39) nonsense probably null
Posted On 2016-08-02