Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03348:Eif4b'

419586

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Eif4b

Ensembl Gene

ENSMUSG00000058655

Gene Name

eukaryotic translation initiation factor 4B

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.958) question?

Stock #

IGL03348

Quality Score

Status

Chromosome

Chromosomal Location

102073773-102097173 bp(+) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 102093031 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000155206 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169681] [ENSMUST00000229400]

AlphaFold

Q8BGD9

Predicted Effect

unknown
Transcript: ENSMUST00000169681
AA Change: L451P

SMART Domains

Protein: ENSMUSP00000127774
Gene: ENSMUSG00000058655
AA Change: L451P

Domain	Start	End	E-Value	Type
low complexity region	6	13	N/A	INTRINSIC
RRM	97	169	1.54e-15	SMART
low complexity region	221	273	N/A	INTRINSIC
low complexity region	282	327	N/A	INTRINSIC
low complexity region	347	359	N/A	INTRINSIC
low complexity region	372	391	N/A	INTRINSIC
low complexity region	408	428	N/A	INTRINSIC
low complexity region	574	581	N/A	INTRINSIC
low complexity region	584	597	N/A	INTRINSIC
low complexity region	599	608	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229122

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229254

Predicted Effect

probably benign
Transcript: ENSMUST00000229400

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A330008L17Rik	A	C	8: 99,421,692 (GRCm38)		noncoding transcript	Het
Adgrv1	T	C	13: 81,499,058 (GRCm38)	N3121S	possibly damaging	Het
Aldh16a1	C	T	7: 45,141,975 (GRCm38)	R102Q	possibly damaging	Het
Atp9b	A	T	18: 80,836,422 (GRCm38)	I346K	possibly damaging	Het
Baiap2l1	T	C	5: 144,278,531 (GRCm38)	K388R	probably benign	Het
BC024978	T	G	7: 27,197,120 (GRCm38)		probably null	Het
Cfap65	A	C	1: 74,927,619 (GRCm38)	I303S	probably damaging	Het
Chd5	C	T	4: 152,376,685 (GRCm38)	P1244L	probably damaging	Het
Col12a1	A	G	9: 79,693,430 (GRCm38)	S791P	possibly damaging	Het
Ctsz	T	A	2: 174,428,697 (GRCm38)	I231F	probably damaging	Het
Dnah8	A	G	17: 30,746,986 (GRCm38)	T2431A	probably damaging	Het
Epha4	T	C	1: 77,507,172 (GRCm38)	I67V	possibly damaging	Het
Exoc1	T	A	5: 76,535,593 (GRCm38)	V55D	probably damaging	Het
Exosc8	A	T	3: 54,732,722 (GRCm38)	D72E	possibly damaging	Het
F5	C	T	1: 164,194,152 (GRCm38)	P1399S	possibly damaging	Het
Fmo1	T	A	1: 162,850,151 (GRCm38)	N132I	possibly damaging	Het
Fndc1	T	A	17: 7,772,647 (GRCm38)	H739L	unknown	Het
Glb1l2	T	C	9: 26,765,680 (GRCm38)	D415G	probably benign	Het
Gphn	T	A	12: 78,627,119 (GRCm38)	H498Q	probably damaging	Het
Lrrc56	A	G	7: 141,207,240 (GRCm38)	N342S	probably benign	Het
Mbnl3	G	A	X: 51,164,548 (GRCm38)	T16I	probably damaging	Het
Mrps5	T	G	2: 127,601,385 (GRCm38)	H294Q	probably damaging	Het
Neu4	A	G	1: 94,024,974 (GRCm38)	Y355C	possibly damaging	Het
Obscn	A	T	11: 59,050,362 (GRCm38)	D5105E	probably damaging	Het
Olfr1187-ps1	T	C	2: 88,540,141 (GRCm38)		noncoding transcript	Het
Olfr1305	C	A	2: 111,873,148 (GRCm38)	A236S	probably damaging	Het
Olfr498	A	G	7: 108,465,408 (GRCm38)	D28G	probably benign	Het
Olfr725	A	G	14: 50,034,755 (GRCm38)	I216T	probably benign	Het
Parp1	T	A	1: 180,577,707 (GRCm38)		probably benign	Het
Plac1	A	T	X: 53,070,640 (GRCm38)	N64K	probably damaging	Het
Plcd1	C	A	9: 119,072,490 (GRCm38)	K655N	possibly damaging	Het
Psme4	T	C	11: 30,876,796 (GRCm38)	S1772P	probably damaging	Het
Shcbp1	C	T	8: 4,765,089 (GRCm38)	V130I	probably benign	Het
Slc25a11	T	C	11: 70,645,344 (GRCm38)		probably benign	Het
Svep1	C	T	4: 58,113,635 (GRCm38)	G1004E	probably damaging	Het
Tars2	T	C	3: 95,740,268 (GRCm38)		probably null	Het
Tbc1d12	C	T	19: 38,916,620 (GRCm38)	T593I	probably damaging	Het
Tcerg1l	T	A	7: 138,213,371 (GRCm38)	E526D	probably damaging	Het
Tmcc3	G	A	10: 94,579,080 (GRCm38)	V215M	possibly damaging	Het
Trappc8	T	C	18: 20,852,781 (GRCm38)	D601G	probably damaging	Het
Trp53bp2	T	A	1: 182,453,748 (GRCm38)	N971K	probably damaging	Het
Ube2g2	A	T	10: 77,630,877 (GRCm38)	E36D	probably benign	Het
Uggt2	T	A	14: 119,070,888 (GRCm38)	R360S	probably benign	Het
Utp20	A	G	10: 88,758,317 (GRCm38)	V2182A	probably benign	Het

Other mutations in Eif4b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01349:Eif4b	APN	15	102,091,423 (GRCm38)	missense	probably benign	0.23
IGL01896:Eif4b	APN	15	102,095,286 (GRCm38)	missense	probably benign	0.23
R1577:Eif4b	UTSW	15	102,089,901 (GRCm38)	nonsense	probably null
R1727:Eif4b	UTSW	15	102,090,062 (GRCm38)	missense	possibly damaging	0.71
R1931:Eif4b	UTSW	15	102,088,976 (GRCm38)	missense	unknown
R3927:Eif4b	UTSW	15	102,084,310 (GRCm38)	missense	probably damaging	1.00
R4051:Eif4b	UTSW	15	102,086,604 (GRCm38)	missense	probably benign	0.31
R4392:Eif4b	UTSW	15	102,086,641 (GRCm38)	critical splice donor site	probably null
R5105:Eif4b	UTSW	15	102,084,196 (GRCm38)	missense	probably benign	0.42
R5716:Eif4b	UTSW	15	102,082,059 (GRCm38)	missense	probably benign	0.36
R6488:Eif4b	UTSW	15	102,092,987 (GRCm38)	unclassified	probably benign
R7048:Eif4b	UTSW	15	102,093,136 (GRCm38)	unclassified	probably benign
R7647:Eif4b	UTSW	15	102,088,694 (GRCm38)	missense	unknown
R7648:Eif4b	UTSW	15	102,089,000 (GRCm38)	missense	unknown
R8145:Eif4b	UTSW	15	102,092,988 (GRCm38)	missense	unknown
R8709:Eif4b	UTSW	15	102,093,681 (GRCm38)	missense	unknown
R9079:Eif4b	UTSW	15	102,094,742 (GRCm38)	missense	unknown
R9298:Eif4b	UTSW	15	102,082,014 (GRCm38)	missense	possibly damaging	0.72
R9716:Eif4b	UTSW	15	102,082,008 (GRCm38)	missense	probably benign	0.31

Posted On

2016-08-02