Incidental Mutation 'IGL03348:Eif4b'
ID 419586
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Eif4b
Ensembl Gene ENSMUSG00000058655
Gene Name eukaryotic translation initiation factor 4B
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.963) question?
Stock # IGL03348
Quality Score
Status
Chromosome 15
Chromosomal Location 102073773-102097173 bp(+) (GRCm38)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 102093031 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169681] [ENSMUST00000229400]
AlphaFold Q8BGD9
Predicted Effect unknown
Transcript: ENSMUST00000169681
AA Change: L451P
SMART Domains Protein: ENSMUSP00000127774
Gene: ENSMUSG00000058655
AA Change: L451P

DomainStartEndE-ValueType
low complexity region 6 13 N/A INTRINSIC
RRM 97 169 1.54e-15 SMART
low complexity region 221 273 N/A INTRINSIC
low complexity region 282 327 N/A INTRINSIC
low complexity region 347 359 N/A INTRINSIC
low complexity region 372 391 N/A INTRINSIC
low complexity region 408 428 N/A INTRINSIC
low complexity region 574 581 N/A INTRINSIC
low complexity region 584 597 N/A INTRINSIC
low complexity region 599 608 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229122
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229254
Predicted Effect probably benign
Transcript: ENSMUST00000229400
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A330008L17Rik A C 8: 99,421,692 noncoding transcript Het
Adgrv1 T C 13: 81,499,058 N3121S possibly damaging Het
Aldh16a1 C T 7: 45,141,975 R102Q possibly damaging Het
Atp9b A T 18: 80,836,422 I346K possibly damaging Het
Baiap2l1 T C 5: 144,278,531 K388R probably benign Het
BC024978 T G 7: 27,197,120 probably null Het
Cfap65 A C 1: 74,927,619 I303S probably damaging Het
Chd5 C T 4: 152,376,685 P1244L probably damaging Het
Col12a1 A G 9: 79,693,430 S791P possibly damaging Het
Ctsz T A 2: 174,428,697 I231F probably damaging Het
Dnah8 A G 17: 30,746,986 T2431A probably damaging Het
Epha4 T C 1: 77,507,172 I67V possibly damaging Het
Exoc1 T A 5: 76,535,593 V55D probably damaging Het
Exosc8 A T 3: 54,732,722 D72E possibly damaging Het
F5 C T 1: 164,194,152 P1399S possibly damaging Het
Fmo1 T A 1: 162,850,151 N132I possibly damaging Het
Fndc1 T A 17: 7,772,647 H739L unknown Het
Glb1l2 T C 9: 26,765,680 D415G probably benign Het
Gphn T A 12: 78,627,119 H498Q probably damaging Het
Lrrc56 A G 7: 141,207,240 N342S probably benign Het
Mbnl3 G A X: 51,164,548 T16I probably damaging Het
Mrps5 T G 2: 127,601,385 H294Q probably damaging Het
Neu4 A G 1: 94,024,974 Y355C possibly damaging Het
Obscn A T 11: 59,050,362 D5105E probably damaging Het
Olfr1187-ps1 T C 2: 88,540,141 noncoding transcript Het
Olfr1305 C A 2: 111,873,148 A236S probably damaging Het
Olfr498 A G 7: 108,465,408 D28G probably benign Het
Olfr725 A G 14: 50,034,755 I216T probably benign Het
Parp1 T A 1: 180,577,707 probably benign Het
Plac1 A T X: 53,070,640 N64K probably damaging Het
Plcd1 C A 9: 119,072,490 K655N possibly damaging Het
Psme4 T C 11: 30,876,796 S1772P probably damaging Het
Shcbp1 C T 8: 4,765,089 V130I probably benign Het
Slc25a11 T C 11: 70,645,344 probably benign Het
Svep1 C T 4: 58,113,635 G1004E probably damaging Het
Tars2 T C 3: 95,740,268 probably null Het
Tbc1d12 C T 19: 38,916,620 T593I probably damaging Het
Tcerg1l T A 7: 138,213,371 E526D probably damaging Het
Tmcc3 G A 10: 94,579,080 V215M possibly damaging Het
Trappc8 T C 18: 20,852,781 D601G probably damaging Het
Trp53bp2 T A 1: 182,453,748 N971K probably damaging Het
Ube2g2 A T 10: 77,630,877 E36D probably benign Het
Uggt2 T A 14: 119,070,888 R360S probably benign Het
Utp20 A G 10: 88,758,317 V2182A probably benign Het
Other mutations in Eif4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01349:Eif4b APN 15 102091423 missense probably benign 0.23
IGL01896:Eif4b APN 15 102095286 missense probably benign 0.23
R1577:Eif4b UTSW 15 102089901 nonsense probably null
R1727:Eif4b UTSW 15 102090062 missense possibly damaging 0.71
R1931:Eif4b UTSW 15 102088976 missense unknown
R3927:Eif4b UTSW 15 102084310 missense probably damaging 1.00
R4051:Eif4b UTSW 15 102086604 missense probably benign 0.31
R4392:Eif4b UTSW 15 102086641 critical splice donor site probably null
R5105:Eif4b UTSW 15 102084196 missense probably benign 0.42
R5716:Eif4b UTSW 15 102082059 missense probably benign 0.36
R6488:Eif4b UTSW 15 102092987 unclassified probably benign
R7048:Eif4b UTSW 15 102093136 unclassified probably benign
R7647:Eif4b UTSW 15 102088694 missense unknown
R7648:Eif4b UTSW 15 102089000 missense unknown
R8145:Eif4b UTSW 15 102092988 missense unknown
R8709:Eif4b UTSW 15 102093681 missense unknown
R9079:Eif4b UTSW 15 102094742 missense unknown
R9298:Eif4b UTSW 15 102082014 missense possibly damaging 0.72
R9716:Eif4b UTSW 15 102082008 missense probably benign 0.31
Posted On 2016-08-02