Incidental Mutation 'IGL03348:Eif4b'
ID 419586
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Eif4b
Ensembl Gene ENSMUSG00000058655
Gene Name eukaryotic translation initiation factor 4B
Accession Numbers
Essential gene? Probably essential (E-score: 0.958) question?
Stock # IGL03348
Quality Score
Chromosome 15
Chromosomal Location 102073773-102097173 bp(+) (GRCm38)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 102093031 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169681] [ENSMUST00000229400]
AlphaFold Q8BGD9
Predicted Effect unknown
Transcript: ENSMUST00000169681
AA Change: L451P
SMART Domains Protein: ENSMUSP00000127774
Gene: ENSMUSG00000058655
AA Change: L451P

low complexity region 6 13 N/A INTRINSIC
RRM 97 169 1.54e-15 SMART
low complexity region 221 273 N/A INTRINSIC
low complexity region 282 327 N/A INTRINSIC
low complexity region 347 359 N/A INTRINSIC
low complexity region 372 391 N/A INTRINSIC
low complexity region 408 428 N/A INTRINSIC
low complexity region 574 581 N/A INTRINSIC
low complexity region 584 597 N/A INTRINSIC
low complexity region 599 608 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229122
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229254
Predicted Effect probably benign
Transcript: ENSMUST00000229400
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A330008L17Rik A C 8: 99,421,692 (GRCm38) noncoding transcript Het
Adgrv1 T C 13: 81,499,058 (GRCm38) N3121S possibly damaging Het
Aldh16a1 C T 7: 45,141,975 (GRCm38) R102Q possibly damaging Het
Atp9b A T 18: 80,836,422 (GRCm38) I346K possibly damaging Het
Baiap2l1 T C 5: 144,278,531 (GRCm38) K388R probably benign Het
BC024978 T G 7: 27,197,120 (GRCm38) probably null Het
Cfap65 A C 1: 74,927,619 (GRCm38) I303S probably damaging Het
Chd5 C T 4: 152,376,685 (GRCm38) P1244L probably damaging Het
Col12a1 A G 9: 79,693,430 (GRCm38) S791P possibly damaging Het
Ctsz T A 2: 174,428,697 (GRCm38) I231F probably damaging Het
Dnah8 A G 17: 30,746,986 (GRCm38) T2431A probably damaging Het
Epha4 T C 1: 77,507,172 (GRCm38) I67V possibly damaging Het
Exoc1 T A 5: 76,535,593 (GRCm38) V55D probably damaging Het
Exosc8 A T 3: 54,732,722 (GRCm38) D72E possibly damaging Het
F5 C T 1: 164,194,152 (GRCm38) P1399S possibly damaging Het
Fmo1 T A 1: 162,850,151 (GRCm38) N132I possibly damaging Het
Fndc1 T A 17: 7,772,647 (GRCm38) H739L unknown Het
Glb1l2 T C 9: 26,765,680 (GRCm38) D415G probably benign Het
Gphn T A 12: 78,627,119 (GRCm38) H498Q probably damaging Het
Lrrc56 A G 7: 141,207,240 (GRCm38) N342S probably benign Het
Mbnl3 G A X: 51,164,548 (GRCm38) T16I probably damaging Het
Mrps5 T G 2: 127,601,385 (GRCm38) H294Q probably damaging Het
Neu4 A G 1: 94,024,974 (GRCm38) Y355C possibly damaging Het
Obscn A T 11: 59,050,362 (GRCm38) D5105E probably damaging Het
Olfr1187-ps1 T C 2: 88,540,141 (GRCm38) noncoding transcript Het
Olfr1305 C A 2: 111,873,148 (GRCm38) A236S probably damaging Het
Olfr498 A G 7: 108,465,408 (GRCm38) D28G probably benign Het
Olfr725 A G 14: 50,034,755 (GRCm38) I216T probably benign Het
Parp1 T A 1: 180,577,707 (GRCm38) probably benign Het
Plac1 A T X: 53,070,640 (GRCm38) N64K probably damaging Het
Plcd1 C A 9: 119,072,490 (GRCm38) K655N possibly damaging Het
Psme4 T C 11: 30,876,796 (GRCm38) S1772P probably damaging Het
Shcbp1 C T 8: 4,765,089 (GRCm38) V130I probably benign Het
Slc25a11 T C 11: 70,645,344 (GRCm38) probably benign Het
Svep1 C T 4: 58,113,635 (GRCm38) G1004E probably damaging Het
Tars2 T C 3: 95,740,268 (GRCm38) probably null Het
Tbc1d12 C T 19: 38,916,620 (GRCm38) T593I probably damaging Het
Tcerg1l T A 7: 138,213,371 (GRCm38) E526D probably damaging Het
Tmcc3 G A 10: 94,579,080 (GRCm38) V215M possibly damaging Het
Trappc8 T C 18: 20,852,781 (GRCm38) D601G probably damaging Het
Trp53bp2 T A 1: 182,453,748 (GRCm38) N971K probably damaging Het
Ube2g2 A T 10: 77,630,877 (GRCm38) E36D probably benign Het
Uggt2 T A 14: 119,070,888 (GRCm38) R360S probably benign Het
Utp20 A G 10: 88,758,317 (GRCm38) V2182A probably benign Het
Other mutations in Eif4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01349:Eif4b APN 15 102,091,423 (GRCm38) missense probably benign 0.23
IGL01896:Eif4b APN 15 102,095,286 (GRCm38) missense probably benign 0.23
R1577:Eif4b UTSW 15 102,089,901 (GRCm38) nonsense probably null
R1727:Eif4b UTSW 15 102,090,062 (GRCm38) missense possibly damaging 0.71
R1931:Eif4b UTSW 15 102,088,976 (GRCm38) missense unknown
R3927:Eif4b UTSW 15 102,084,310 (GRCm38) missense probably damaging 1.00
R4051:Eif4b UTSW 15 102,086,604 (GRCm38) missense probably benign 0.31
R4392:Eif4b UTSW 15 102,086,641 (GRCm38) critical splice donor site probably null
R5105:Eif4b UTSW 15 102,084,196 (GRCm38) missense probably benign 0.42
R5716:Eif4b UTSW 15 102,082,059 (GRCm38) missense probably benign 0.36
R6488:Eif4b UTSW 15 102,092,987 (GRCm38) unclassified probably benign
R7048:Eif4b UTSW 15 102,093,136 (GRCm38) unclassified probably benign
R7647:Eif4b UTSW 15 102,088,694 (GRCm38) missense unknown
R7648:Eif4b UTSW 15 102,089,000 (GRCm38) missense unknown
R8145:Eif4b UTSW 15 102,092,988 (GRCm38) missense unknown
R8709:Eif4b UTSW 15 102,093,681 (GRCm38) missense unknown
R9079:Eif4b UTSW 15 102,094,742 (GRCm38) missense unknown
R9298:Eif4b UTSW 15 102,082,014 (GRCm38) missense possibly damaging 0.72
R9716:Eif4b UTSW 15 102,082,008 (GRCm38) missense probably benign 0.31
Posted On 2016-08-02