Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03349:Cyp2c67'

419592

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c67

Ensembl Gene

ENSMUSG00000062624

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 67

Synonyms

C730004C24Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.100) question?

Stock #

IGL03349

Quality Score

Status

Chromosome

Chromosomal Location

39608842-39649051 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 39643684 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 80 (Y80C)

Ref Sequence

ENSEMBL: ENSMUSP00000065796 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067328]

AlphaFold

Q569X9

Predicted Effect

probably damaging
Transcript: ENSMUST00000067328
AA Change: Y80C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000065796
Gene: ENSMUSG00000062624
AA Change: Y80C

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	8.5e-150	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	G	13: 81,481,336	Y3648H	probably benign	Het
Akr1c20	T	A	13: 4,508,250	R172*	probably null	Het
Apba1	A	T	19: 23,917,575	E458D	probably benign	Het
Atg2a	T	A	19: 6,258,024	V1590D	possibly damaging	Het
Atp13a4	A	G	16: 29,456,671	S332P	probably benign	Het
Atp8b2	A	T	3: 89,957,817	F163I	probably damaging	Het
Azin2	A	T	4: 128,946,114	Y228*	probably null	Het
Cd109	C	T	9: 78,636,485	H104Y	probably benign	Het
Ces2a	G	T	8: 104,734,080	L3F	probably damaging	Het
Crebbp	A	G	16: 4,117,358	V889A	possibly damaging	Het
Crim1	A	T	17: 78,355,150	K801*	probably null	Het
Cxcr1	T	C	1: 74,192,528	T112A	possibly damaging	Het
Cyp1a2	A	G	9: 57,679,875	S378P	possibly damaging	Het
Dennd4a	T	C	9: 64,888,974	W761R	probably damaging	Het
Dgki	C	T	6: 37,097,627		probably null	Het
Dnase1l3	T	C	14: 7,984,146	T89A	probably benign	Het
Dock4	C	A	12: 40,733,310	Q748K	probably benign	Het
Elmo3	A	G	8: 105,306,388	E68G	possibly damaging	Het
Fer1l4	C	A	2: 156,044,734	E692*	probably null	Het
Fkbp9	T	A	6: 56,849,718	M101K	probably damaging	Het
Gm4763	T	A	7: 24,722,836	S163C	probably damaging	Het
Grin1	C	A	2: 25,310,436	V225L	probably benign	Het
Gucy2d	T	C	7: 98,449,841	V288A	possibly damaging	Het
Heatr5b	C	A	17: 78,755,320	K1933N	probably benign	Het
Hsdl1	A	T	8: 119,565,697	S260T	probably benign	Het
Hspg2	T	C	4: 137,560,522		probably benign	Het
Ift172	A	T	5: 31,284,130	V220E	probably benign	Het
Igkv12-47	C	T	6: 69,750,866		noncoding transcript	Het
Ism1	C	T	2: 139,731,975	R82*	probably null	Het
Lrch3	A	G	16: 32,955,324	T187A	probably damaging	Het
Ltbr	T	A	6: 125,312,366	D160V	probably damaging	Het
Mark3	A	T	12: 111,628,250	K353I	probably benign	Het
Mrm3	A	T	11: 76,249,946	H260L	probably damaging	Het
Nckap1	T	C	2: 80,525,560	Q627R	probably benign	Het
Neb	T	A	2: 52,278,952	Y1857F	possibly damaging	Het
Ntsr1	A	G	2: 180,500,502	T29A	probably benign	Het
Ofcc1	C	T	13: 40,072,752	G768D	probably benign	Het
Olfr181	T	C	16: 58,925,960	M204V	probably benign	Het
Pde8b	T	C	13: 95,043,043		probably benign	Het
Pld4	A	T	12: 112,767,879	Q393L	probably benign	Het
Prss23	T	C	7: 89,509,857	I335V	probably benign	Het
Prune2	A	G	19: 17,123,346	I2071M	probably damaging	Het
Ptprz1	T	A	6: 23,000,332	V807E	probably damaging	Het
Rnf20	G	A	4: 49,655,936	A961T	probably damaging	Het
Slc25a24	A	G	3: 109,149,549	Q126R	possibly damaging	Het
Slc35e1	A	T	8: 72,483,852	Y382N	probably damaging	Het
Snrpn	C	T	7: 59,985,865	G129D	probably damaging	Het
Spag9	A	T	11: 94,093,509	N386I	possibly damaging	Het
Ssna1	T	C	2: 25,271,530	N102D	possibly damaging	Het
Tcrg-C2	T	A	13: 19,305,176	T129S	probably benign	Het
Tex21	A	T	12: 76,221,591	I139N	probably benign	Het
Trim21	T	C	7: 102,563,277	T161A	probably benign	Het
Vmn2r82	T	A	10: 79,377,869	H96Q	probably benign	Het

Other mutations in Cyp2c67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Cyp2c67	APN	19	39643385	missense	possibly damaging	0.95
IGL01025:Cyp2c67	APN	19	39639932	nonsense	probably null
IGL01363:Cyp2c67	APN	19	39639967	missense	probably damaging	0.99
IGL01819:Cyp2c67	APN	19	39615721	missense	probably damaging	0.98
IGL01902:Cyp2c67	APN	19	39649026	missense	probably damaging	1.00
IGL02172:Cyp2c67	APN	19	39649002	missense	possibly damaging	0.76
IGL02351:Cyp2c67	APN	19	39617417	missense	probably damaging	1.00
IGL02355:Cyp2c67	APN	19	39643405	missense	probably benign	0.34
IGL02355:Cyp2c67	APN	19	39617382	nonsense	probably null
IGL02358:Cyp2c67	APN	19	39617417	missense	probably damaging	1.00
IGL02362:Cyp2c67	APN	19	39643405	missense	probably benign	0.34
IGL02362:Cyp2c67	APN	19	39617382	nonsense	probably null
IGL02388:Cyp2c67	APN	19	39643355	missense	probably benign	0.20
IGL03106:Cyp2c67	APN	19	39643675	missense	probably benign	0.27
IGL03219:Cyp2c67	APN	19	39643294	missense	possibly damaging	0.54
IGL03326:Cyp2c67	APN	19	39643269	critical splice donor site	probably null
IGL03356:Cyp2c67	APN	19	39639961	missense	probably damaging	1.00
IGL03052:Cyp2c67	UTSW	19	39648885	missense	possibly damaging	0.88
R0585:Cyp2c67	UTSW	19	39638694	missense	possibly damaging	0.59
R0975:Cyp2c67	UTSW	19	39609178	missense	possibly damaging	0.49
R0976:Cyp2c67	UTSW	19	39643374	missense	probably damaging	1.00
R1252:Cyp2c67	UTSW	19	39626141	missense	possibly damaging	0.93
R1398:Cyp2c67	UTSW	19	39638625	missense	probably damaging	0.96
R1411:Cyp2c67	UTSW	19	39638591	missense	probably damaging	1.00
R1505:Cyp2c67	UTSW	19	39648964	missense	probably benign	0.00
R1543:Cyp2c67	UTSW	19	39643264	splice site	probably benign
R1613:Cyp2c67	UTSW	19	39626199	missense	probably benign	0.00
R1618:Cyp2c67	UTSW	19	39643264	splice site	probably benign
R1667:Cyp2c67	UTSW	19	39643590	critical splice donor site	probably null
R1852:Cyp2c67	UTSW	19	39617367	missense	probably benign	0.01
R2005:Cyp2c67	UTSW	19	39643345	missense	probably damaging	1.00
R2105:Cyp2c67	UTSW	19	39626237	missense	probably benign	0.24
R2181:Cyp2c67	UTSW	19	39609097	missense	possibly damaging	0.94
R3817:Cyp2c67	UTSW	19	39638683	missense	probably benign	0.00
R4669:Cyp2c67	UTSW	19	39643654	missense	probably benign	0.00
R4689:Cyp2c67	UTSW	19	39638588	missense	probably benign	0.00
R4756:Cyp2c67	UTSW	19	39643744	missense	probably benign	0.03
R4823:Cyp2c67	UTSW	19	39615724	missense	probably benign	0.13
R5152:Cyp2c67	UTSW	19	39638688	missense	probably benign	0.00
R5345:Cyp2c67	UTSW	19	39626232	missense	probably benign	0.01
R5580:Cyp2c67	UTSW	19	39615650	missense	probably damaging	0.99
R5644:Cyp2c67	UTSW	19	39615694	missense	possibly damaging	0.84
R6116:Cyp2c67	UTSW	19	39617435	missense	probably damaging	1.00
R6516:Cyp2c67	UTSW	19	39617429	missense	probably damaging	1.00
R6550:Cyp2c67	UTSW	19	39617410	nonsense	probably null
R6939:Cyp2c67	UTSW	19	39643334	missense	possibly damaging	0.68
R6995:Cyp2c67	UTSW	19	39615679	missense	probably damaging	0.96
R7028:Cyp2c67	UTSW	19	39639897	missense	possibly damaging	0.68
R7144:Cyp2c67	UTSW	19	39615694	missense	probably benign	0.00
R7242:Cyp2c67	UTSW	19	39617339	missense	probably benign	0.30
R7335:Cyp2c67	UTSW	19	39640007	nonsense	probably null
R7337:Cyp2c67	UTSW	19	39609264	splice site	probably null
R7474:Cyp2c67	UTSW	19	39617432	missense	probably null	0.05
R7642:Cyp2c67	UTSW	19	39615640	missense	probably damaging	0.97
R7870:Cyp2c67	UTSW	19	39609225	missense	probably damaging	1.00
R8152:Cyp2c67	UTSW	19	39640008	missense	probably benign	0.21
R8367:Cyp2c67	UTSW	19	39638674	missense	probably benign	0.01
R8717:Cyp2c67	UTSW	19	39638711	missense	probably benign	0.05
R8728:Cyp2c67	UTSW	19	39626161	missense	probably damaging	1.00
R9275:Cyp2c67	UTSW	19	39609255	missense	probably damaging	1.00
R9278:Cyp2c67	UTSW	19	39609255	missense	probably damaging	1.00
R9376:Cyp2c67	UTSW	19	39638734	missense	probably damaging	1.00
Z1177:Cyp2c67	UTSW	19	39643679	missense	possibly damaging	0.89

Posted On

2016-08-02