Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03350:Cyp2a22'

419663

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2a22

Ensembl Gene

ENSMUSG00000091867

Gene Name

cytochrome P450, family 2, subfamily a, polypeptide 22

Synonyms

EG233005

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.090) question?

Stock #

IGL03350

Quality Score

Status

Chromosome

Chromosomal Location

26931631-26939384 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 26934854 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 292 (T292A)

Ref Sequence

ENSEMBL: ENSMUSP00000128030 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170227]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170227
AA Change: T292A

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000128030
Gene: ENSMUSG00000091867
AA Change: T292A

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
Pfam:p450	33	489	7.4e-148	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206638

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206957

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4922502D21Rik	C	A	6: 129,331,023	V28L	probably benign	Het
Adam26a	A	T	8: 43,569,552	Y300*	probably null	Het
Adgre1	T	A	17: 57,401,908	V33E	probably benign	Het
AI987944	A	G	7: 41,393,237		probably benign	Het
Atp4a	T	C	7: 30,720,867	L813P	probably damaging	Het
Blmh	A	G	11: 76,971,948	N396D	probably damaging	Het
Brat1	T	C	5: 140,705,995	L9P	probably damaging	Het
Ccdc171	T	C	4: 83,681,378	I810T	possibly damaging	Het
Ecm2	C	T	13: 49,520,944	T280I	probably benign	Het
Fa2h	C	T	8: 111,349,296	V232I	probably benign	Het
Fbxw24	T	C	9: 109,607,013	D317G	probably damaging	Het
Flt4	C	A	11: 49,634,793	S722*	probably null	Het
Fryl	T	C	5: 73,133,306	Q85R	probably damaging	Het
Gm3239	A	G	14: 4,667,115	R188G	possibly damaging	Het
Hspa13	A	T	16: 75,757,829	S456R	probably damaging	Het
Htr1b	T	C	9: 81,632,122	Y144C	probably damaging	Het
Hydin	A	G	8: 110,312,224	H198R	possibly damaging	Het
Krt78	A	T	15: 101,946,517	M953K	probably benign	Het
Lgr5	G	T	10: 115,471,988	T255K	probably damaging	Het
Lrp2	T	A	2: 69,438,453	D4162V	probably damaging	Het
Map3k2	A	G	18: 32,212,148	D342G	probably damaging	Het
Miip	A	G	4: 147,862,522	V258A	probably benign	Het
Muc6	T	C	7: 141,652,059	H52R	probably damaging	Het
Nfs1	T	C	2: 156,127,740	E329G	probably benign	Het
Npsr1	T	C	9: 24,098,309	V37A	probably benign	Het
Olfr1107	A	C	2: 87,071,560	D191E	probably damaging	Het
Olfr23	A	T	11: 73,940,838	L197F	probably damaging	Het
Olfr356	T	C	2: 36,937,583	Y155H	probably damaging	Het
Pex16	T	A	2: 92,377,497	M98K	probably damaging	Het
Pla2r1	C	T	2: 60,455,173	C699Y	probably damaging	Het
Plcd4	A	T	1: 74,549,301	D103V	probably damaging	Het
Pnpla1	A	G	17: 28,876,992	D129G	probably damaging	Het
Rad23a	T	C	8: 84,837,479	E265G	possibly damaging	Het
Rbm11	C	T	16: 75,600,808	P209S	probably benign	Het
Ribc2	T	A	15: 85,135,502	W162R	probably damaging	Het
Rnf4	A	G	5: 34,346,860	E32G	possibly damaging	Het
Rpe65	A	T	3: 159,614,517	S269C	possibly damaging	Het
Slc7a14	T	A	3: 31,237,409	Y240F	probably benign	Het
Sorbs2	C	T	8: 45,805,807	P1047L	probably damaging	Het
Ttn	T	C	2: 76,749,822	I23576V	probably damaging	Het
Usp24	T	G	4: 106,371,079	Y780*	probably null	Het
Wee2	T	C	6: 40,449,731	S145P	probably damaging	Het
Zcchc7	A	G	4: 44,931,188	T126A	probably benign	Het
Zpld1	A	G	16: 55,241,329		probably benign	Het
Zufsp	G	A	10: 33,928,111	R456C	probably benign	Het

Other mutations in Cyp2a22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00156:Cyp2a22	APN	7	26937738	missense	probably benign	0.09
IGL01111:Cyp2a22	APN	7	26936458	missense	probably damaging	1.00
IGL01388:Cyp2a22	APN	7	26937792	missense	probably benign	0.02
IGL01449:Cyp2a22	APN	7	26933553	missense	probably benign	0.01
IGL01642:Cyp2a22	APN	7	26938759	missense	possibly damaging	0.81
IGL02253:Cyp2a22	APN	7	26938237	splice site	probably benign
IGL02327:Cyp2a22	APN	7	26934781	missense	probably damaging	0.99
IGL02673:Cyp2a22	APN	7	26938100	missense	probably benign	0.00
IGL02813:Cyp2a22	APN	7	26936434	missense	probably benign	0.19
IGL02896:Cyp2a22	APN	7	26936461	missense	probably damaging	0.98
IGL03193:Cyp2a22	APN	7	26936421	missense	probably benign	0.00
R1648:Cyp2a22	UTSW	7	26932368	missense	probably damaging	0.98
R1679:Cyp2a22	UTSW	7	26936311	nonsense	probably null
R1733:Cyp2a22	UTSW	7	26934762	missense	possibly damaging	0.78
R2001:Cyp2a22	UTSW	7	26934772	missense	probably damaging	1.00
R2858:Cyp2a22	UTSW	7	26934262	missense	probably damaging	0.99
R3054:Cyp2a22	UTSW	7	26938829	missense	probably damaging	1.00
R4528:Cyp2a22	UTSW	7	26934769	missense	possibly damaging	0.95
R4623:Cyp2a22	UTSW	7	26933491	missense	probably damaging	1.00
R4669:Cyp2a22	UTSW	7	26937855	missense	possibly damaging	0.88
R4690:Cyp2a22	UTSW	7	26939209	nonsense	probably null
R4840:Cyp2a22	UTSW	7	26932524	missense	probably benign	0.13
R4915:Cyp2a22	UTSW	7	26937770	missense	probably benign	0.33
R5071:Cyp2a22	UTSW	7	26932481	missense	probably benign	0.01
R5072:Cyp2a22	UTSW	7	26932481	missense	probably benign	0.01
R5074:Cyp2a22	UTSW	7	26932481	missense	probably benign	0.01
R5147:Cyp2a22	UTSW	7	26936325	missense	probably damaging	1.00
R5363:Cyp2a22	UTSW	7	26936433	missense	probably damaging	0.99
R5705:Cyp2a22	UTSW	7	26939215	missense	probably benign	0.05
R6014:Cyp2a22	UTSW	7	26939180	splice site	probably null
R6042:Cyp2a22	UTSW	7	26934239	missense	probably damaging	1.00
R6253:Cyp2a22	UTSW	7	26934232	missense	probably benign	0.18
R6757:Cyp2a22	UTSW	7	26939204	missense	probably benign	0.00
R6994:Cyp2a22	UTSW	7	26939181	critical splice donor site	probably null
R7581:Cyp2a22	UTSW	7	26938148	missense	possibly damaging	0.87
R8212:Cyp2a22	UTSW	7	26937780	missense	possibly damaging	0.89

Posted On

2016-08-02