Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03351:Zfp369'

419714

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp369

Ensembl Gene

ENSMUSG00000021514

Gene Name

zinc finger protein 369

Synonyms

B930030B22Rik, NRIF2, D230020H11Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL03351

Quality Score

Status

Chromosome

Chromosomal Location

65278814-65304221 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 65296153 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Arginine at position 370 (L370R)

Ref Sequence

ENSEMBL: ENSMUSP00000119114 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000126879] [ENSMUST00000130799]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000126879
AA Change: L370R

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000119114
Gene: ENSMUSG00000021514
AA Change: L370R

Domain	Start	End	E-Value	Type
KRAB	35	95	7.13e-20	SMART
SCAN	178	289	2.57e-39	SMART
KRAB	300	367	1.63e-14	SMART
low complexity region	440	452	N/A	INTRINSIC
ZnF_C2H2	701	723	5.42e-2	SMART
ZnF_C2H2	729	751	4.79e-3	SMART
ZnF_C2H2	757	779	1.47e-3	SMART
ZnF_C2H2	785	807	2.43e-4	SMART
ZnF_C2H2	813	835	6.88e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000130799

SMART Domains

Protein: ENSMUSP00000116221
Gene: ENSMUSG00000021514

Domain	Start	End	E-Value	Type
KRAB	35	95	7.13e-20	SMART
SCAN	178	289	2.57e-39	SMART
KRAB	300	354	3.54e-15	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930550L24Rik	G	A	X: 58,918,937	V19I	probably benign	Het
4932414N04Rik	T	A	2: 68,731,083	D251E	probably benign	Het
4932415D10Rik	T	C	10: 82,283,567		probably benign	Het
5730460C07Rik	C	T	3: 153,789,958		noncoding transcript	Het
Coch	G	A	12: 51,603,206	R326Q	probably benign	Het
Cpa3	A	G	3: 20,215,962	V366A	probably benign	Het
Csf1r	C	T	18: 61,117,108	Q382*	probably null	Het
Csta1	C	A	16: 36,131,041	G4*	probably null	Het
Cts7	T	C	13: 61,356,603	R49G	probably damaging	Het
Dlg5	A	G	14: 24,170,454	V575A	probably benign	Het
Ero1l	G	T	14: 45,294,533	N227K	probably benign	Het
Faap24	G	T	7: 35,395,309	C58*	probably null	Het
Gm13089	G	A	4: 143,697,088	T377I	possibly damaging	Het
Hfm1	G	A	5: 106,911,575	Q194*	probably null	Het
Hs3st5	T	A	10: 36,833,323	Y285N	probably damaging	Het
Hyal6	G	A	6: 24,743,429	G375R	probably damaging	Het
Itgb5	T	C	16: 33,910,552	S93P	probably benign	Het
Kcnj6	A	T	16: 94,832,583	M205K	probably damaging	Het
Kdm6a	C	T	X: 18,247,104	Q92*	probably null	Het
Klhl38	A	G	15: 58,323,330	M1T	probably null	Het
Krtap7-1	T	C	16: 89,507,996		probably benign	Het
L1cam	T	C	X: 73,863,028	T270A	probably damaging	Het
Lmod2	A	G	6: 24,598,016	N45S	probably benign	Het
Mmp2	A	G	8: 92,839,342	I424V	probably benign	Het
Myh8	A	G	11: 67,303,913	Q1650R	possibly damaging	Het
Naalad2	T	A	9: 18,364,187	E313V	possibly damaging	Het
Nipsnap3a	A	G	4: 52,994,134	T74A	probably benign	Het
Npr2	G	T	4: 43,640,652	M368I	probably benign	Het
Nupl1	T	C	14: 60,228,775	T445A	probably benign	Het
Olfr294	A	G	7: 86,615,677	Y323H	possibly damaging	Het
Olfr582	A	G	7: 103,042,130	D212G	probably damaging	Het
Pkp3	A	G	7: 141,082,693	T73A	probably benign	Het
Pole	A	G	5: 110,301,998		probably benign	Het
Ppp2r3a	C	T	9: 101,211,192	G644D	probably benign	Het
Ptprb	T	C	10: 116,339,582	Y1161H	probably benign	Het
Ptprs	T	A	17: 56,437,943	K264N	probably damaging	Het
Rasal2	T	C	1: 157,192,741		probably benign	Het
Serpina6	A	T	12: 103,646,913	I376N	probably damaging	Het
Setx	T	G	2: 29,161,799	I2062M	probably benign	Het
Slc9c1	A	G	16: 45,543,168	D99G	probably benign	Het
Taok1	A	G	11: 77,560,328	Y309H	probably damaging	Het
Trappc10	T	C	10: 78,188,761	D1178G	probably damaging	Het
Trav5-1	G	A	14: 52,622,845	E36K	probably damaging	Het
Vmn1r237	T	C	17: 21,314,837	V274A	probably benign	Het
Vmn1r29	A	T	6: 58,307,750	S152C	probably damaging	Het
Washc5	C	A	15: 59,363,350		probably benign	Het
Zfp750	T	C	11: 121,513,347	Y234C	probably damaging	Het

Other mutations in Zfp369

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00969:Zfp369	APN	13	65297260	missense	probably benign	0.41
IGL01393:Zfp369	APN	13	65294474	missense	possibly damaging	0.85
IGL02277:Zfp369	APN	13	65284932	missense	probably damaging	1.00
IGL02986:Zfp369	APN	13	65280281	missense	probably damaging	1.00
IGL02992:Zfp369	APN	13	65294451	missense	possibly damaging	0.50
IGL03170:Zfp369	APN	13	65294410	missense	probably damaging	0.99
R0136:Zfp369	UTSW	13	65297202	missense	probably benign	0.08
R0600:Zfp369	UTSW	13	65296434	missense	probably damaging	0.97
R0646:Zfp369	UTSW	13	65297548	missense	probably damaging	1.00
R1190:Zfp369	UTSW	13	65292293	missense	probably damaging	0.99
R1191:Zfp369	UTSW	13	65291962	nonsense	probably null
R1528:Zfp369	UTSW	13	65292165	missense	probably damaging	1.00
R1934:Zfp369	UTSW	13	65297151	missense	probably damaging	1.00
R2168:Zfp369	UTSW	13	65296948	missense	probably benign	0.01
R4386:Zfp369	UTSW	13	65296992	missense	probably benign	0.00
R4928:Zfp369	UTSW	13	65296800	missense	possibly damaging	0.91
R5127:Zfp369	UTSW	13	65279033	start gained	probably benign
R5549:Zfp369	UTSW	13	65297380	missense	probably damaging	1.00
R5740:Zfp369	UTSW	13	65296767	missense	probably benign
R5743:Zfp369	UTSW	13	65295680	missense	probably benign	0.02
R5840:Zfp369	UTSW	13	65297278	missense	possibly damaging	0.46
R6351:Zfp369	UTSW	13	65296230	missense	possibly damaging	0.83
R7248:Zfp369	UTSW	13	65296117	missense	probably damaging	0.98
R7288:Zfp369	UTSW	13	65285018	critical splice donor site	probably null
R7314:Zfp369	UTSW	13	65292104	missense	probably damaging	0.97
R7470:Zfp369	UTSW	13	65292146	missense	probably benign	0.12
R7508:Zfp369	UTSW	13	65279273	missense	unknown
R7796:Zfp369	UTSW	13	65296215	missense	probably benign
R7886:Zfp369	UTSW	13	65292054	missense	possibly damaging	0.95
R8425:Zfp369	UTSW	13	65296675	missense	possibly damaging	0.96
R8671:Zfp369	UTSW	13	65296281	missense	possibly damaging	0.92
R8868:Zfp369	UTSW	13	65297268	missense	possibly damaging	0.60
R8918:Zfp369	UTSW	13	65295715	nonsense	probably null
R8921:Zfp369	UTSW	13	65296230	missense	possibly damaging	0.92
R9201:Zfp369	UTSW	13	65296582	missense	probably benign	0.07
R9236:Zfp369	UTSW	13	65297196	missense	probably benign	0.08
Z1177:Zfp369	UTSW	13	65292160	missense	probably benign	0.00

Posted On

2016-08-02