Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03352:Eif3l'

419791

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Eif3l

Ensembl Gene

ENSMUSG00000033047

Gene Name

eukaryotic translation initiation factor 3, subunit L

Synonyms

Eif3s6ip, HSP-66Y, 0610011H21Rik, Eif3eip, PAF67, D15N1e

Accession Numbers

Essential gene?

Probably essential (E-score: 0.964) question?

Stock #

IGL03352

Quality Score

Status

Chromosome

Chromosomal Location

78959423-78978600 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 78961251 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000154872 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040518] [ENSMUST00000229310]

AlphaFold

Q8QZY1

Predicted Effect

probably benign
Transcript: ENSMUST00000040518

SMART Domains

Protein: ENSMUSP00000038839
Gene: ENSMUSG00000033047

Domain	Start	End	E-Value	Type
low complexity region	12	24	N/A	INTRINSIC
Pfam:Paf67	152	550	7e-179	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000229310

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000229338

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aoah	A	G	13: 21,184,213 (GRCm39)	S426G	probably benign	Het
Arap3	T	C	18: 38,114,355 (GRCm39)		probably benign	Het
Arhgap45	T	A	10: 79,866,585 (GRCm39)	N1029K	probably damaging	Het
Arhgef10l	A	T	4: 140,311,242 (GRCm39)	M1K	probably null	Het
Bloc1s6	T	C	2: 122,584,638 (GRCm39)	L71P	probably damaging	Het
Ccer1	G	T	10: 97,529,439 (GRCm39)	R34M	unknown	Het
Cd44	T	C	2: 102,675,759 (GRCm39)		probably benign	Het
Col17a1	T	C	19: 47,669,814 (GRCm39)		probably null	Het
Cspp1	A	G	1: 10,117,662 (GRCm39)	E38G	possibly damaging	Het
Dock10	A	T	1: 80,584,013 (GRCm39)		probably benign	Het
Dsg3	A	T	18: 20,660,689 (GRCm39)	M343L	probably benign	Het
Fcrl1	T	C	3: 87,292,398 (GRCm39)	L150P	probably benign	Het
Flg2	T	G	3: 93,109,801 (GRCm39)	S610A	unknown	Het
Grin3b	C	T	10: 79,809,615 (GRCm39)	R374C	probably damaging	Het
H2-Oa	A	T	17: 34,313,377 (GRCm39)	I143F	probably damaging	Het
Itgae	C	T	11: 73,022,556 (GRCm39)	P924S	probably damaging	Het
Itpr2	T	A	6: 146,058,602 (GRCm39)	D2521V	probably damaging	Het
Itprid2	T	A	2: 79,475,445 (GRCm39)	M468K	probably damaging	Het
Laptm4a	G	A	12: 8,981,719 (GRCm39)	G143D	probably benign	Het
Lrp6	T	C	6: 134,456,726 (GRCm39)	Y846C	probably damaging	Het
Mcm10	A	T	2: 4,999,407 (GRCm39)	S749T	probably damaging	Het
Nemf	T	C	12: 69,378,679 (GRCm39)	N548D	probably damaging	Het
Nlrp4e	T	A	7: 23,020,251 (GRCm39)	L246Q	probably damaging	Het
Nsun6	A	T	2: 15,001,157 (GRCm39)	C466*	probably null	Het
Olfm2	T	C	9: 20,580,019 (GRCm39)	D252G	probably damaging	Het
Or10j5	A	C	1: 172,784,850 (GRCm39)	M163L	probably benign	Het
Or14j9	T	A	17: 37,874,681 (GRCm39)	I174F	probably damaging	Het
Or2h1	G	A	17: 37,404,311 (GRCm39)	L152F	probably benign	Het
Or9i14	T	C	19: 13,792,292 (GRCm39)	I221V	probably damaging	Het
Pcdhb14	C	T	18: 37,582,057 (GRCm39)	R388C	possibly damaging	Het
Piwil1	C	T	5: 128,828,136 (GRCm39)	T712I	probably benign	Het
Piwil4	G	T	9: 14,637,183 (GRCm39)	T377K	probably damaging	Het
Prg3	T	C	2: 84,823,370 (GRCm39)	F182L	probably damaging	Het
Ptgds	T	C	2: 25,359,622 (GRCm39)	T22A	probably benign	Het
Retsat	T	C	6: 72,575,666 (GRCm39)	V19A	probably damaging	Het
Rpl21-ps4	A	T	14: 11,227,760 (GRCm38)		noncoding transcript	Het
Sh3glb2	A	G	2: 30,235,363 (GRCm39)	V370A	probably damaging	Het
Skint4	G	T	4: 112,022,883 (GRCm39)	W459C	possibly damaging	Het
Slco1a1	T	A	6: 141,857,611 (GRCm39)	R573S	probably benign	Het
Smgc	T	C	15: 91,744,876 (GRCm39)	S694P	probably damaging	Het
Spaca6	A	G	17: 18,058,401 (GRCm39)	Y7C	probably damaging	Het
Spn	T	C	7: 126,736,178 (GRCm39)	T110A	probably benign	Het
Tepsin	C	T	11: 119,982,703 (GRCm39)	V456I	probably benign	Het
Tex261	C	T	6: 83,748,249 (GRCm39)	R171Q	possibly damaging	Het
Tmem184a	A	T	5: 139,798,755 (GRCm39)	F65I	probably damaging	Het
Tpm3	G	A	3: 89,995,052 (GRCm39)		probably null	Het
Tubgcp2	T	A	7: 139,580,940 (GRCm39)	H671L	probably benign	Het
Unc13b	T	G	4: 43,237,110 (GRCm39)	D3393E	possibly damaging	Het
Vcan	T	A	13: 89,853,125 (GRCm39)	M612L	probably benign	Het
Vmn1r180	C	A	7: 23,652,077 (GRCm39)	S80*	probably null	Het
Vmn1r64	C	T	7: 5,887,070 (GRCm39)	V158I	probably benign	Het
Vps13d	C	T	4: 144,894,072 (GRCm39)	V496I	possibly damaging	Het
Wee2	T	G	6: 40,429,589 (GRCm39)		probably null	Het
Zfp804b	T	C	5: 6,820,039 (GRCm39)	N972S	probably benign	Het

Other mutations in Eif3l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01133:Eif3l	APN	15	78,961,120 (GRCm39)	missense	possibly damaging	0.82
IGL02457:Eif3l	APN	15	78,962,296 (GRCm39)	missense	probably benign	0.01
IGL02658:Eif3l	APN	15	78,961,142 (GRCm39)	missense	probably damaging	1.00
IGL02689:Eif3l	APN	15	78,970,719 (GRCm39)	missense	possibly damaging	0.77
IGL02797:Eif3l	APN	15	78,959,477 (GRCm39)	missense	probably benign	0.00
IGL02824:Eif3l	APN	15	78,960,023 (GRCm39)	splice site	probably null
IGL02957:Eif3l	APN	15	78,974,028 (GRCm39)	missense	probably benign	0.00
R0528:Eif3l	UTSW	15	78,973,809 (GRCm39)	missense	probably benign	0.00
R0550:Eif3l	UTSW	15	78,961,067 (GRCm39)	missense	probably damaging	1.00
R0751:Eif3l	UTSW	15	78,959,966 (GRCm39)	splice site	probably null
R1101:Eif3l	UTSW	15	78,959,467 (GRCm39)	missense	probably damaging	1.00
R1184:Eif3l	UTSW	15	78,959,966 (GRCm39)	splice site	probably null
R1585:Eif3l	UTSW	15	78,968,381 (GRCm39)	missense	possibly damaging	0.63
R1895:Eif3l	UTSW	15	78,973,677 (GRCm39)	missense	possibly damaging	0.55
R2442:Eif3l	UTSW	15	78,969,807 (GRCm39)	missense	probably damaging	1.00
R4865:Eif3l	UTSW	15	78,965,849 (GRCm39)	nonsense	probably null
R5092:Eif3l	UTSW	15	78,968,354 (GRCm39)	missense	probably benign	0.01
R5239:Eif3l	UTSW	15	78,973,995 (GRCm39)	missense	possibly damaging	0.95
R5328:Eif3l	UTSW	15	78,977,561 (GRCm39)	nonsense	probably null
R6575:Eif3l	UTSW	15	78,970,778 (GRCm39)	missense	possibly damaging	0.67
R6624:Eif3l	UTSW	15	78,974,129 (GRCm39)	missense	probably damaging	1.00
R6875:Eif3l	UTSW	15	78,969,760 (GRCm39)	missense	probably damaging	0.99
R7484:Eif3l	UTSW	15	78,968,336 (GRCm39)	missense	probably benign	0.00
R7838:Eif3l	UTSW	15	78,973,799 (GRCm39)	missense	possibly damaging	0.91
R7841:Eif3l	UTSW	15	78,973,779 (GRCm39)	missense	probably benign	0.05
R8085:Eif3l	UTSW	15	78,961,066 (GRCm39)	missense	probably damaging	0.99
R8296:Eif3l	UTSW	15	78,963,220 (GRCm39)	missense	possibly damaging	0.82
R8440:Eif3l	UTSW	15	78,961,120 (GRCm39)	missense	possibly damaging	0.82
R8932:Eif3l	UTSW	15	78,960,006 (GRCm39)	nonsense	probably null
R9011:Eif3l	UTSW	15	78,973,725 (GRCm39)	missense	possibly damaging	0.85
R9029:Eif3l	UTSW	15	78,968,412 (GRCm39)	missense	probably damaging	1.00
R9324:Eif3l	UTSW	15	78,978,423 (GRCm39)	missense	probably benign	0.11
R9473:Eif3l	UTSW	15	78,970,704 (GRCm39)	missense	probably damaging	0.97
R9614:Eif3l	UTSW	15	78,978,423 (GRCm39)	missense	probably benign	0.11

Posted On

2016-08-02