Incidental Mutation 'IGL03353:Zfp60'
| ID |
419814 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp60
|
| Ensembl Gene |
ENSMUSG00000037640 |
| Gene Name |
zinc finger protein 60 |
| Synonyms |
Mfg-3, Mfg3, 6330516O17Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03353
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
27430834-27451114 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 27447759 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 142
(Y142*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132607
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042641]
[ENSMUST00000108336]
[ENSMUST00000130997]
[ENSMUST00000136373]
[ENSMUST00000167955]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000042641
AA Change: Y142*
|
| SMART Domains |
Protein: ENSMUSP00000036627
Gene: ENSMUSG00000037640
AA Change: Y142*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
75 |
8.48e-36 |
SMART |
|
ZnF_C2H2
|
173 |
195 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
201 |
223 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
229 |
251 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
257 |
279 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
285 |
307 |
2.65e-5 |
SMART |
|
ZnF_C2H2
|
313 |
335 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
341 |
363 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
369 |
391 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
397 |
419 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
425 |
447 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
453 |
475 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
481 |
503 |
4.4e-2 |
SMART |
|
ZnF_C2H2
|
509 |
531 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
537 |
559 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
565 |
587 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
593 |
615 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
621 |
643 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
649 |
671 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
677 |
699 |
8.34e-3 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000108336
AA Change: Y142*
|
| SMART Domains |
Protein: ENSMUSP00000103973
Gene: ENSMUSG00000037640
AA Change: Y142*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
75 |
8.48e-36 |
SMART |
|
ZnF_C2H2
|
173 |
195 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
201 |
223 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
229 |
251 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
257 |
279 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
285 |
307 |
2.65e-5 |
SMART |
|
ZnF_C2H2
|
313 |
335 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
341 |
363 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
369 |
391 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
397 |
419 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
425 |
447 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
453 |
475 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
481 |
503 |
4.4e-2 |
SMART |
|
ZnF_C2H2
|
509 |
531 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
537 |
559 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
565 |
587 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
593 |
615 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
621 |
643 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
649 |
671 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
677 |
699 |
8.34e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000130997
|
| SMART Domains |
Protein: ENSMUSP00000118469
Gene: ENSMUSG00000037640
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
75 |
8.48e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136373
|
| SMART Domains |
Protein: ENSMUSP00000117049
Gene: ENSMUSG00000037640
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
55 |
3.2e-13 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000167955
AA Change: Y142*
|
| SMART Domains |
Protein: ENSMUSP00000132607
Gene: ENSMUSG00000037640
AA Change: Y142*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
75 |
8.48e-36 |
SMART |
|
ZnF_C2H2
|
173 |
195 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
201 |
223 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
229 |
251 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
257 |
279 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
285 |
307 |
2.65e-5 |
SMART |
|
ZnF_C2H2
|
313 |
335 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
341 |
363 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
369 |
391 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
397 |
419 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
425 |
447 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
453 |
475 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
481 |
503 |
4.4e-2 |
SMART |
|
ZnF_C2H2
|
509 |
531 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
537 |
559 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
565 |
587 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
593 |
615 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
621 |
643 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
649 |
671 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
677 |
699 |
8.34e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aco1 |
A |
G |
4: 40,175,893 (GRCm39) |
I176V |
probably damaging |
Het |
| Aldh1l2 |
T |
C |
10: 83,358,777 (GRCm39) |
T73A |
probably benign |
Het |
| Btaf1 |
G |
T |
19: 36,969,900 (GRCm39) |
L1191F |
probably damaging |
Het |
| Caskin1 |
G |
A |
17: 24,718,331 (GRCm39) |
|
probably benign |
Het |
| Clcn3 |
T |
C |
8: 61,376,022 (GRCm39) |
T624A |
probably benign |
Het |
| Dicer1 |
A |
G |
12: 104,679,366 (GRCm39) |
V537A |
probably damaging |
Het |
| Dock4 |
A |
G |
12: 40,867,757 (GRCm39) |
|
probably null |
Het |
| Dsp |
A |
T |
13: 38,370,671 (GRCm39) |
Y858F |
probably damaging |
Het |
| Eya1 |
A |
G |
1: 14,249,751 (GRCm39) |
Y550H |
probably damaging |
Het |
| Frmpd1 |
A |
G |
4: 45,261,926 (GRCm39) |
K204E |
probably damaging |
Het |
| Frrs1l |
G |
A |
4: 56,968,121 (GRCm39) |
T217M |
probably damaging |
Het |
| Fsip2 |
G |
A |
2: 82,807,737 (GRCm39) |
S1352N |
possibly damaging |
Het |
| Hfm1 |
T |
C |
5: 107,004,795 (GRCm39) |
D1177G |
probably damaging |
Het |
| Itih4 |
G |
A |
14: 30,609,801 (GRCm39) |
V44I |
probably damaging |
Het |
| Kif2c |
A |
G |
4: 117,023,533 (GRCm39) |
M393T |
probably benign |
Het |
| Klhdc10 |
T |
A |
6: 30,447,991 (GRCm39) |
|
probably benign |
Het |
| Lrch1 |
G |
T |
14: 75,095,482 (GRCm39) |
H119Q |
probably damaging |
Het |
| Ncam2 |
A |
T |
16: 81,231,788 (GRCm39) |
N84I |
probably benign |
Het |
| Nlrx1 |
A |
G |
9: 44,167,890 (GRCm39) |
V669A |
probably benign |
Het |
| Pdcl3 |
A |
G |
1: 39,034,917 (GRCm39) |
N158S |
probably benign |
Het |
| Polk |
C |
T |
13: 96,625,719 (GRCm39) |
A362T |
probably damaging |
Het |
| Rnf40 |
T |
A |
7: 127,192,063 (GRCm39) |
L403* |
probably null |
Het |
| Skint5 |
T |
C |
4: 113,599,379 (GRCm39) |
D720G |
unknown |
Het |
| Snx6 |
A |
G |
12: 54,812,469 (GRCm39) |
|
probably benign |
Het |
| St6galnac2 |
A |
T |
11: 116,581,128 (GRCm39) |
|
probably benign |
Het |
| Stk26 |
A |
T |
X: 49,959,275 (GRCm39) |
D62V |
probably damaging |
Het |
| Tgds |
G |
A |
14: 118,364,919 (GRCm39) |
Q101* |
probably null |
Het |
| Tmem135 |
C |
A |
7: 88,791,161 (GRCm39) |
R421L |
probably damaging |
Het |
| Tspyl4 |
T |
A |
10: 34,174,135 (GRCm39) |
V209E |
probably damaging |
Het |
| Tulp2 |
C |
A |
7: 45,165,696 (GRCm39) |
P98Q |
probably damaging |
Het |
| Txk |
C |
T |
5: 72,893,745 (GRCm39) |
V12I |
probably benign |
Het |
| Usp30 |
A |
G |
5: 114,259,119 (GRCm39) |
T398A |
probably benign |
Het |
| Vmn1r8 |
A |
G |
6: 57,013,776 (GRCm39) |
T276A |
probably benign |
Het |
| Xdh |
G |
A |
17: 74,202,781 (GRCm39) |
A1123V |
possibly damaging |
Het |
|
| Other mutations in Zfp60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
PIT4494001:Zfp60
|
UTSW |
7 |
27,448,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1281:Zfp60
|
UTSW |
7 |
27,437,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1643:Zfp60
|
UTSW |
7 |
27,436,400 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1883:Zfp60
|
UTSW |
7 |
27,449,435 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1930:Zfp60
|
UTSW |
7 |
27,436,382 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R3623:Zfp60
|
UTSW |
7 |
27,448,753 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3624:Zfp60
|
UTSW |
7 |
27,448,753 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3875:Zfp60
|
UTSW |
7 |
27,449,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Zfp60
|
UTSW |
7 |
27,437,955 (GRCm39) |
intron |
probably benign |
|
|
R5491:Zfp60
|
UTSW |
7 |
27,447,940 (GRCm39) |
splice site |
probably null |
|
|
R5724:Zfp60
|
UTSW |
7 |
27,447,758 (GRCm39) |
missense |
probably benign |
|
|
R6134:Zfp60
|
UTSW |
7 |
27,449,323 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6312:Zfp60
|
UTSW |
7 |
27,448,201 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6477:Zfp60
|
UTSW |
7 |
27,449,228 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6649:Zfp60
|
UTSW |
7 |
27,448,151 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6653:Zfp60
|
UTSW |
7 |
27,448,151 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7041:Zfp60
|
UTSW |
7 |
27,448,451 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7166:Zfp60
|
UTSW |
7 |
27,448,937 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7185:Zfp60
|
UTSW |
7 |
27,437,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7334:Zfp60
|
UTSW |
7 |
27,448,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7560:Zfp60
|
UTSW |
7 |
27,448,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7560:Zfp60
|
UTSW |
7 |
27,448,561 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7561:Zfp60
|
UTSW |
7 |
27,447,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7673:Zfp60
|
UTSW |
7 |
27,447,740 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7961:Zfp60
|
UTSW |
7 |
27,447,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2016-08-02 |
Incidental Mutation