Incidental Mutation 'IGL03354:Olfr140'
ID419834
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr140
Ensembl Gene ENSMUSG00000075068
Gene Nameolfactory receptor 140
SynonymsMOR235-1, GA_x6K02T2Q125-51484508-51483600, A16
Accession Numbers

Genbank: NM_020515; MGI: 2177523

Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #IGL03354
Quality Score
Status
Chromosome2
Chromosomal Location90049380-90063594 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 90051567 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Tryptophan at position 252 (C252W)
Ref Sequence ENSEMBL: ENSMUSP00000150438 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099757] [ENSMUST00000111506] [ENSMUST00000216475]
Predicted Effect probably damaging
Transcript: ENSMUST00000099757
AA Change: C252W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097346
Gene: ENSMUSG00000075068
AA Change: C252W

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 1.3e-30 PFAM
Pfam:7tm_4 137 278 7e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111506
AA Change: C252W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107131
Gene: ENSMUSG00000075068
AA Change: C252W

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 2.9e-48 PFAM
Pfam:7tm_1 39 285 9.9e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216475
AA Change: C252W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik G A 5: 138,646,779 A309T possibly damaging Het
Abca15 C A 7: 120,394,488 Y1310* probably null Het
Adad1 G T 3: 37,106,173 C552F probably damaging Het
Adam22 A G 5: 8,158,890 S180P possibly damaging Het
Anxa10 A T 8: 62,096,744 D22E probably damaging Het
Astn1 T C 1: 158,688,604 S1255P probably damaging Het
Bhlhe41 T C 6: 145,864,203 T92A probably damaging Het
Bicc1 G A 10: 70,946,602 P603S probably benign Het
Camk2d T C 3: 126,796,966 probably null Het
Ccdc136 T A 6: 29,419,103 I808N probably damaging Het
Cd200r3 C T 16: 44,953,597 A124V possibly damaging Het
Cfap70 T C 14: 20,431,982 E310G probably damaging Het
Cyp2d12 A T 15: 82,558,961 D357V probably damaging Het
Dnah7b G A 1: 46,085,689 V173I probably damaging Het
Dnajb4 T A 3: 152,186,478 E239D probably benign Het
Dzip1 G A 14: 118,912,569 probably benign Het
Emp2 A G 16: 10,285,565 I74T probably damaging Het
Ermn T G 2: 58,052,622 E32A probably benign Het
F10 C A 8: 13,045,089 T82N probably benign Het
Fam227a T C 15: 79,636,750 D295G possibly damaging Het
Gm527 T A 12: 64,922,380 F194I probably damaging Het
Gmcl1 G A 6: 86,726,158 T98M probably damaging Het
Gucy2g T C 19: 55,233,080 R330G possibly damaging Het
Hist1h1e C T 13: 23,622,077 probably benign Het
Kif1a T C 1: 93,060,235 H549R probably damaging Het
Klhl14 T A 18: 21,651,728 D214V probably damaging Het
Lipo2 A G 19: 33,730,870 F248S probably benign Het
Mctp2 C T 7: 72,161,244 V661I probably benign Het
Myh15 A T 16: 49,172,010 M1616L probably benign Het
Nlrp4b A T 7: 10,714,538 I223F probably damaging Het
Olfr1133 T C 2: 87,645,595 N176S probably damaging Het
Olfr1367 T C 13: 21,347,516 V196A possibly damaging Het
Olfr1368 T C 13: 21,142,484 Y191C probably damaging Het
Olfr347 A T 2: 36,734,512 S64C possibly damaging Het
Olfr347 G T 2: 36,734,513 S64I possibly damaging Het
Olfr508 T A 7: 108,630,528 C179S possibly damaging Het
Olfr706 A G 7: 106,886,100 V239A probably benign Het
Pcsk4 T C 10: 80,326,059 D116G probably damaging Het
Pibf1 A G 14: 99,150,738 D440G probably benign Het
Plekho2 T C 9: 65,559,421 E129G probably null Het
Ptgds T C 2: 25,469,610 T22A probably benign Het
Rars A G 11: 35,824,475 L248P probably damaging Het
Ruvbl1 C A 6: 88,479,215 Y90* probably null Het
Schip1 A G 3: 68,494,965 D125G possibly damaging Het
Smarca2 T C 19: 26,619,903 S62P probably benign Het
Sort1 T C 3: 108,348,706 V656A probably benign Het
Tlr12 A G 4: 128,615,937 L840P probably damaging Het
Trpm3 T A 19: 22,856,718 I438N probably damaging Het
Ttc37 T C 13: 76,182,822 V1457A possibly damaging Het
Wdr11 C A 7: 129,625,302 F829L probably benign Het
Zdhhc11 A T 13: 73,979,145 I214F possibly damaging Het
Other mutations in Olfr140
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02220:Olfr140 APN 2 90051694 missense probably damaging 1.00
IGL02631:Olfr140 APN 2 90051442 missense probably damaging 0.97
3-1:Olfr140 UTSW 2 90052152 missense possibly damaging 0.48
R0673:Olfr140 UTSW 2 90052252 missense probably benign 0.04
R1355:Olfr140 UTSW 2 90051613 missense probably benign 0.29
R1452:Olfr140 UTSW 2 90051671 missense possibly damaging 0.68
R1719:Olfr140 UTSW 2 90051784 missense probably damaging 1.00
R2230:Olfr140 UTSW 2 90052225 missense probably benign
R2231:Olfr140 UTSW 2 90052225 missense probably benign
R2232:Olfr140 UTSW 2 90052225 missense probably benign
R4540:Olfr140 UTSW 2 90052150 missense probably damaging 1.00
R4710:Olfr140 UTSW 2 90052150 missense probably damaging 1.00
R5304:Olfr140 UTSW 2 90051913 missense probably benign 0.29
R5599:Olfr140 UTSW 2 90052219 missense probably benign 0.00
R7309:Olfr140 UTSW 2 90051457 missense probably damaging 1.00
R7361:Olfr140 UTSW 2 90051745 missense probably benign 0.01
R8314:Olfr140 UTSW 2 90052097 missense probably benign 0.00
Z1176:Olfr140 UTSW 2 90052265 missense probably benign
Posted On2016-08-02