Incidental Mutation 'IGL03354:Olfr1367'
ID419846
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1367
Ensembl Gene ENSMUSG00000045508
Gene Nameolfactory receptor 1367
SynonymsMOR256-16, MOR256-65, GA_x6K02T2QHY8-11899770-11898820
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL03354
Quality Score
Status
Chromosome13
Chromosomal Location21346910-21347964 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 21347516 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 196 (V196A)
Ref Sequence ENSEMBL: ENSMUSP00000055870 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059216]
Predicted Effect possibly damaging
Transcript: ENSMUST00000059216
AA Change: V196A

PolyPhen 2 Score 0.649 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000055870
Gene: ENSMUSG00000045508
AA Change: V196A

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.6e-54 PFAM
Pfam:7TM_GPCR_Srsx 37 153 9.3e-7 PFAM
Pfam:7tm_1 43 292 4.5e-25 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik G A 5: 138,646,779 A309T possibly damaging Het
Abca15 C A 7: 120,394,488 Y1310* probably null Het
Adad1 G T 3: 37,106,173 C552F probably damaging Het
Adam22 A G 5: 8,158,890 S180P possibly damaging Het
Anxa10 A T 8: 62,096,744 D22E probably damaging Het
Astn1 T C 1: 158,688,604 S1255P probably damaging Het
Bhlhe41 T C 6: 145,864,203 T92A probably damaging Het
Bicc1 G A 10: 70,946,602 P603S probably benign Het
Camk2d T C 3: 126,796,966 probably null Het
Ccdc136 T A 6: 29,419,103 I808N probably damaging Het
Cd200r3 C T 16: 44,953,597 A124V possibly damaging Het
Cfap70 T C 14: 20,431,982 E310G probably damaging Het
Cyp2d12 A T 15: 82,558,961 D357V probably damaging Het
Dnah7b G A 1: 46,085,689 V173I probably damaging Het
Dnajb4 T A 3: 152,186,478 E239D probably benign Het
Dzip1 G A 14: 118,912,569 probably benign Het
Emp2 A G 16: 10,285,565 I74T probably damaging Het
Ermn T G 2: 58,052,622 E32A probably benign Het
F10 C A 8: 13,045,089 T82N probably benign Het
Fam227a T C 15: 79,636,750 D295G possibly damaging Het
Gm527 T A 12: 64,922,380 F194I probably damaging Het
Gmcl1 G A 6: 86,726,158 T98M probably damaging Het
Gucy2g T C 19: 55,233,080 R330G possibly damaging Het
Hist1h1e C T 13: 23,622,077 probably benign Het
Kif1a T C 1: 93,060,235 H549R probably damaging Het
Klhl14 T A 18: 21,651,728 D214V probably damaging Het
Lipo2 A G 19: 33,730,870 F248S probably benign Het
Mctp2 C T 7: 72,161,244 V661I probably benign Het
Myh15 A T 16: 49,172,010 M1616L probably benign Het
Nlrp4b A T 7: 10,714,538 I223F probably damaging Het
Olfr1133 T C 2: 87,645,595 N176S probably damaging Het
Olfr1368 T C 13: 21,142,484 Y191C probably damaging Het
Olfr140 A C 2: 90,051,567 C252W probably damaging Het
Olfr347 A T 2: 36,734,512 S64C possibly damaging Het
Olfr347 G T 2: 36,734,513 S64I possibly damaging Het
Olfr508 T A 7: 108,630,528 C179S possibly damaging Het
Olfr706 A G 7: 106,886,100 V239A probably benign Het
Pcsk4 T C 10: 80,326,059 D116G probably damaging Het
Pibf1 A G 14: 99,150,738 D440G probably benign Het
Plekho2 T C 9: 65,559,421 E129G probably null Het
Ptgds T C 2: 25,469,610 T22A probably benign Het
Rars A G 11: 35,824,475 L248P probably damaging Het
Ruvbl1 C A 6: 88,479,215 Y90* probably null Het
Schip1 A G 3: 68,494,965 D125G possibly damaging Het
Smarca2 T C 19: 26,619,903 S62P probably benign Het
Sort1 T C 3: 108,348,706 V656A probably benign Het
Tlr12 A G 4: 128,615,937 L840P probably damaging Het
Trpm3 T A 19: 22,856,718 I438N probably damaging Het
Ttc37 T C 13: 76,182,822 V1457A possibly damaging Het
Wdr11 C A 7: 129,625,302 F829L probably benign Het
Zdhhc11 A T 13: 73,979,145 I214F possibly damaging Het
Other mutations in Olfr1367
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Olfr1367 APN 13 21347015 missense probably damaging 0.99
IGL01327:Olfr1367 APN 13 21347207 missense probably benign 0.00
IGL02624:Olfr1367 APN 13 21347512 missense probably benign 0.11
IGL02718:Olfr1367 APN 13 21347384 missense probably damaging 1.00
IGL02744:Olfr1367 APN 13 21346994 missense probably damaging 0.99
R1433:Olfr1367 UTSW 13 21347024 missense probably benign 0.00
R1567:Olfr1367 UTSW 13 21347425 missense probably benign 0.00
R1857:Olfr1367 UTSW 13 21347176 missense possibly damaging 0.63
R1858:Olfr1367 UTSW 13 21347176 missense possibly damaging 0.63
R1927:Olfr1367 UTSW 13 21346946 missense probably benign 0.04
R4627:Olfr1367 UTSW 13 21347464 missense probably damaging 1.00
R6146:Olfr1367 UTSW 13 21346994 missense possibly damaging 0.49
R7903:Olfr1367 UTSW 13 21347876 missense probably benign 0.09
Posted On2016-08-02