Incidental Mutation 'IGL03354:Ptgds'
ID 419863
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ptgds
Ensembl Gene ENSMUSG00000015090
Gene Name prostaglandin D2 synthase (brain)
Synonyms L-PGDS, PGD2, Ptgs3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # IGL03354
Quality Score
Status
Chromosome 2
Chromosomal Location 25356721-25360058 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25359622 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 22 (T22A)
Ref Sequence ENSEMBL: ENSMUSP00000109897 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015234] [ENSMUST00000114251] [ENSMUST00000114259]
AlphaFold O09114
Predicted Effect probably benign
Transcript: ENSMUST00000015234
AA Change: T22A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000015234
Gene: ENSMUSG00000015090
AA Change: T22A

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
Pfam:Lipocalin 40 184 4.2e-35 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114251
AA Change: T22A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000109889
Gene: ENSMUSG00000015090
AA Change: T22A

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
Pfam:Lipocalin 40 184 4.2e-35 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114259
AA Change: T22A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000109897
Gene: ENSMUSG00000015090
AA Change: T22A

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
Pfam:Lipocalin 40 184 4.2e-35 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137417
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144016
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for one knock-out allele fail to exhibit PGE2- and bicuculline-induced allodynia and exhibit decreased susceptibility to IgE-induced PCA. Mice homozygous for another knock-out allele show normal induction of muscle injury after reperfusion of ischemic skeletal muscle. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik G A 5: 138,645,041 (GRCm39) A309T possibly damaging Het
Abca15 C A 7: 119,993,711 (GRCm39) Y1310* probably null Het
Adad1 G T 3: 37,160,322 (GRCm39) C552F probably damaging Het
Adam22 A G 5: 8,208,890 (GRCm39) S180P possibly damaging Het
Anxa10 A T 8: 62,549,778 (GRCm39) D22E probably damaging Het
Astn1 T C 1: 158,516,174 (GRCm39) S1255P probably damaging Het
Bhlhe41 T C 6: 145,809,929 (GRCm39) T92A probably damaging Het
Bicc1 G A 10: 70,782,432 (GRCm39) P603S probably benign Het
Camk2d T C 3: 126,590,615 (GRCm39) probably null Het
Ccdc136 T A 6: 29,419,102 (GRCm39) I808N probably damaging Het
Cd200r3 C T 16: 44,773,960 (GRCm39) A124V possibly damaging Het
Cfap70 T C 14: 20,482,050 (GRCm39) E310G probably damaging Het
Cyp2d12 A T 15: 82,443,162 (GRCm39) D357V probably damaging Het
Dnah7b G A 1: 46,124,849 (GRCm39) V173I probably damaging Het
Dnajb4 T A 3: 151,892,115 (GRCm39) E239D probably benign Het
Dzip1 G A 14: 119,149,981 (GRCm39) probably benign Het
Emp2 A G 16: 10,103,429 (GRCm39) I74T probably damaging Het
Ermn T G 2: 57,942,634 (GRCm39) E32A probably benign Het
F10 C A 8: 13,095,089 (GRCm39) T82N probably benign Het
Fam227a T C 15: 79,520,951 (GRCm39) D295G possibly damaging Het
Gm527 T A 12: 64,969,154 (GRCm39) F194I probably damaging Het
Gmcl1 G A 6: 86,703,140 (GRCm39) T98M probably damaging Het
Gucy2g T C 19: 55,221,512 (GRCm39) R330G possibly damaging Het
H1f4 C T 13: 23,806,060 (GRCm39) probably benign Het
Kif1a T C 1: 92,987,957 (GRCm39) H549R probably damaging Het
Klhl14 T A 18: 21,784,785 (GRCm39) D214V probably damaging Het
Lipo2 A G 19: 33,708,270 (GRCm39) F248S probably benign Het
Mctp2 C T 7: 71,810,992 (GRCm39) V661I probably benign Het
Myh15 A T 16: 48,992,373 (GRCm39) M1616L probably benign Het
Nlrp4b A T 7: 10,448,465 (GRCm39) I223F probably damaging Het
Or1j18 A T 2: 36,624,524 (GRCm39) S64C possibly damaging Het
Or1j18 G T 2: 36,624,525 (GRCm39) S64I possibly damaging Het
Or2ad1 T C 13: 21,326,654 (GRCm39) Y191C probably damaging Het
Or2ag2 A G 7: 106,485,307 (GRCm39) V239A probably benign Het
Or2b28 T C 13: 21,531,686 (GRCm39) V196A possibly damaging Het
Or4c3d A C 2: 89,881,911 (GRCm39) C252W probably damaging Het
Or5p80 T A 7: 108,229,735 (GRCm39) C179S possibly damaging Het
Or5w1b T C 2: 87,475,939 (GRCm39) N176S probably damaging Het
Pcsk4 T C 10: 80,161,893 (GRCm39) D116G probably damaging Het
Pibf1 A G 14: 99,388,174 (GRCm39) D440G probably benign Het
Plekho2 T C 9: 65,466,703 (GRCm39) E129G probably null Het
Rars1 A G 11: 35,715,302 (GRCm39) L248P probably damaging Het
Ruvbl1 C A 6: 88,456,197 (GRCm39) Y90* probably null Het
Schip1 A G 3: 68,402,298 (GRCm39) D125G possibly damaging Het
Skic3 T C 13: 76,330,941 (GRCm39) V1457A possibly damaging Het
Smarca2 T C 19: 26,597,303 (GRCm39) S62P probably benign Het
Sort1 T C 3: 108,256,022 (GRCm39) V656A probably benign Het
Tlr12 A G 4: 128,509,730 (GRCm39) L840P probably damaging Het
Trpm3 T A 19: 22,834,082 (GRCm39) I438N probably damaging Het
Wdr11 C A 7: 129,227,026 (GRCm39) F829L probably benign Het
Zdhhc11 A T 13: 74,127,264 (GRCm39) I214F possibly damaging Het
Other mutations in Ptgds
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02164:Ptgds APN 2 25,359,124 (GRCm39) missense probably damaging 0.99
IGL03035:Ptgds APN 2 25,359,622 (GRCm39) missense probably benign 0.06
IGL03036:Ptgds APN 2 25,359,622 (GRCm39) missense probably benign 0.06
IGL03117:Ptgds APN 2 25,359,622 (GRCm39) missense probably benign 0.06
IGL03352:Ptgds APN 2 25,359,622 (GRCm39) missense probably benign 0.06
R0780:Ptgds UTSW 2 25,358,104 (GRCm39) missense possibly damaging 0.90
R0885:Ptgds UTSW 2 25,357,357 (GRCm39) missense possibly damaging 0.80
R4820:Ptgds UTSW 2 25,359,058 (GRCm39) missense probably benign 0.02
R7000:Ptgds UTSW 2 25,357,828 (GRCm39) critical splice donor site probably null
R7522:Ptgds UTSW 2 25,357,920 (GRCm39) missense probably benign 0.38
R8401:Ptgds UTSW 2 25,359,669 (GRCm39) missense unknown
R9794:Ptgds UTSW 2 25,359,129 (GRCm39) missense probably benign 0.05
Posted On 2016-08-02