Incidental Mutation 'IGL03357:Cyp4a32'
ID 419976
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp4a32
Ensembl Gene ENSMUSG00000063929
Gene Name cytochrome P450, family 4, subfamily a, polypeptide 32
Synonyms OTTMUSG00000008689
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # IGL03357
Quality Score
Status
Chromosome 4
Chromosomal Location 115458166-115478799 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 115468798 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 395 (S395T)
Ref Sequence ENSEMBL: ENSMUSP00000081369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084342]
AlphaFold A2A8T1
Predicted Effect probably benign
Transcript: ENSMUST00000084342
AA Change: S395T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000081369
Gene: ENSMUSG00000063929
AA Change: S395T

DomainStartEndE-ValueType
transmembrane domain 15 32 N/A INTRINSIC
Pfam:p450 51 504 1.3e-133 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129918
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak C T 19: 8,986,689 (GRCm39) probably benign Het
Asah1 A G 8: 41,799,233 (GRCm39) probably benign Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Chd6 T C 2: 160,859,936 (GRCm39) probably benign Het
Chn2 G A 6: 54,171,062 (GRCm39) R47Q probably benign Het
Clmp A G 9: 40,597,623 (GRCm39) probably benign Het
Col11a1 G A 3: 113,987,740 (GRCm39) G245R probably damaging Het
Dcc A T 18: 71,460,625 (GRCm39) I1155K probably damaging Het
Dpy19l4 G A 4: 11,267,615 (GRCm39) H442Y probably damaging Het
Dpys T C 15: 39,687,612 (GRCm39) I395M probably damaging Het
Dpysl2 T C 14: 67,050,736 (GRCm39) K374E probably damaging Het
Fryl A T 5: 73,211,402 (GRCm39) D660E probably damaging Het
Gabrb2 T C 11: 42,482,771 (GRCm39) F210L probably damaging Het
Gm4831 C T 17: 37,422,879 (GRCm39) probably benign Het
Igsf10 A T 3: 59,243,632 (GRCm39) M234K probably benign Het
Ints11 T C 4: 155,956,581 (GRCm39) probably benign Het
Mex3a T A 3: 88,443,553 (GRCm39) S210T probably benign Het
Or4k42 C T 2: 111,320,289 (GRCm39) M71I probably benign Het
Or4k52 G A 2: 111,610,871 (GRCm39) V69I probably benign Het
Pde1c A G 6: 56,157,078 (GRCm39) V106A probably damaging Het
Pitpnm3 G A 11: 71,961,716 (GRCm39) Q284* probably null Het
Pkd1l2 A G 8: 117,722,548 (GRCm39) L2420P probably damaging Het
Prpf39 A G 12: 65,108,211 (GRCm39) probably benign Het
Prss28 C T 17: 25,528,669 (GRCm39) T37I probably benign Het
Serpinb6c A T 13: 34,079,369 (GRCm39) S108T probably benign Het
Snx7 T C 3: 117,632,524 (GRCm39) H131R probably damaging Het
Tex101 A T 7: 24,367,758 (GRCm39) I198K probably damaging Het
Thoc2l T G 5: 104,668,334 (GRCm39) V952G probably damaging Het
Thumpd2 T C 17: 81,351,519 (GRCm39) probably benign Het
Ubqln3 A C 7: 103,791,763 (GRCm39) I109S probably benign Het
Zfp212 A T 6: 47,907,771 (GRCm39) N250I probably benign Het
Other mutations in Cyp4a32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02225:Cyp4a32 APN 4 115,467,700 (GRCm39) missense probably benign
IGL02546:Cyp4a32 APN 4 115,468,520 (GRCm39) missense probably damaging 0.98
IGL02578:Cyp4a32 APN 4 115,466,939 (GRCm39) missense possibly damaging 0.79
IGL02663:Cyp4a32 APN 4 115,467,787 (GRCm39) missense probably damaging 1.00
IGL02832:Cyp4a32 APN 4 115,471,818 (GRCm39) missense probably damaging 0.99
IGL03283:Cyp4a32 APN 4 115,468,280 (GRCm39) missense possibly damaging 0.79
IGL03406:Cyp4a32 APN 4 115,459,500 (GRCm39) missense probably benign 0.00
R0379:Cyp4a32 UTSW 4 115,478,671 (GRCm39) missense probably damaging 1.00
R1339:Cyp4a32 UTSW 4 115,468,760 (GRCm39) missense probably damaging 0.98
R1435:Cyp4a32 UTSW 4 115,463,863 (GRCm39) missense probably damaging 0.97
R1445:Cyp4a32 UTSW 4 115,460,147 (GRCm39) nonsense probably null
R1520:Cyp4a32 UTSW 4 115,471,849 (GRCm39) missense probably damaging 0.97
R1587:Cyp4a32 UTSW 4 115,467,731 (GRCm39) missense probably benign 0.06
R1719:Cyp4a32 UTSW 4 115,468,505 (GRCm39) missense possibly damaging 0.61
R1932:Cyp4a32 UTSW 4 115,468,474 (GRCm39) missense possibly damaging 0.78
R4184:Cyp4a32 UTSW 4 115,478,720 (GRCm39) missense possibly damaging 0.94
R4580:Cyp4a32 UTSW 4 115,460,126 (GRCm39) splice site silent
R5004:Cyp4a32 UTSW 4 115,458,238 (GRCm39) missense probably damaging 0.98
R6345:Cyp4a32 UTSW 4 115,459,560 (GRCm39) missense possibly damaging 0.81
R7231:Cyp4a32 UTSW 4 115,466,894 (GRCm39) missense probably damaging 1.00
R7241:Cyp4a32 UTSW 4 115,459,499 (GRCm39) missense probably benign
R7419:Cyp4a32 UTSW 4 115,468,234 (GRCm39) missense probably benign
R7716:Cyp4a32 UTSW 4 115,458,283 (GRCm39) missense probably damaging 1.00
R8921:Cyp4a32 UTSW 4 115,468,460 (GRCm39) missense probably damaging 0.99
R9009:Cyp4a32 UTSW 4 115,467,802 (GRCm39) missense probably null 1.00
R9266:Cyp4a32 UTSW 4 115,468,307 (GRCm39) missense probably damaging 1.00
R9330:Cyp4a32 UTSW 4 115,478,635 (GRCm39) missense probably damaging 1.00
R9345:Cyp4a32 UTSW 4 115,467,699 (GRCm39) missense probably benign
R9442:Cyp4a32 UTSW 4 115,468,422 (GRCm39) missense probably benign 0.21
Z1177:Cyp4a32 UTSW 4 115,468,542 (GRCm39) missense probably benign 0.03
Posted On 2016-08-02