Incidental Mutation 'IGL03357:Igsf10'
ID 419986
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igsf10
Ensembl Gene ENSMUSG00000036334
Gene Name immunoglobulin superfamily, member 10
Synonyms 6530405F15Rik, CMF608, Adlican2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # IGL03357
Quality Score
Status
Chromosome 3
Chromosomal Location 59224156-59251815 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 59243632 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 234 (M234K)
Ref Sequence ENSEMBL: ENSMUSP00000141391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039419] [ENSMUST00000193455] [ENSMUST00000194546] [ENSMUST00000195983]
AlphaFold Q3V1M1
Predicted Effect probably benign
Transcript: ENSMUST00000039419
AA Change: M234K

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000037246
Gene: ENSMUSG00000036334
AA Change: M234K

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 3.24e-4 SMART
LRR 57 79 9.24e1 SMART
LRR 80 103 2.02e-1 SMART
LRR 104 127 7.16e0 SMART
LRR_TYP 128 151 1.2e-3 SMART
LRR 152 175 1.25e-1 SMART
LRR 188 207 2.33e2 SMART
LRRCT 219 280 4.19e-4 SMART
IGc2 488 558 2.34e-4 SMART
IGc2 586 652 7.88e-11 SMART
low complexity region 917 930 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
low complexity region 1245 1263 N/A INTRINSIC
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1449 1465 N/A INTRINSIC
IGc2 1632 1701 7.69e-14 SMART
IGc2 1729 1798 5.07e-14 SMART
IGc2 1826 1895 2.19e-9 SMART
IGc2 1925 1994 4.59e-12 SMART
IGc2 2022 2097 1.33e-8 SMART
IGc2 2125 2191 2.96e-15 SMART
IGc2 2223 2291 2.03e-4 SMART
IGc2 2321 2389 9.99e-13 SMART
IGc2 2416 2484 3.03e-12 SMART
IGc2 2512 2583 7.76e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000193455
AA Change: M234K

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000141971
Gene: ENSMUSG00000036334
AA Change: M234K

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 3.24e-4 SMART
LRR 57 79 9.24e1 SMART
LRR 80 103 2.02e-1 SMART
LRR 104 127 7.16e0 SMART
LRR_TYP 128 151 1.2e-3 SMART
LRR 152 175 1.25e-1 SMART
LRR 188 207 2.33e2 SMART
LRRCT 219 280 4.19e-4 SMART
IGc2 488 558 2.34e-4 SMART
IGc2 586 652 7.88e-11 SMART
low complexity region 917 930 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
low complexity region 1245 1263 N/A INTRINSIC
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1449 1465 N/A INTRINSIC
IGc2 1632 1701 7.69e-14 SMART
IGc2 1729 1798 5.07e-14 SMART
IGc2 1826 1895 2.19e-9 SMART
IGc2 1925 1994 4.59e-12 SMART
IGc2 2022 2097 1.33e-8 SMART
IGc2 2125 2191 2.96e-15 SMART
IGc2 2223 2291 2.03e-4 SMART
IGc2 2321 2389 9.99e-13 SMART
IGc2 2416 2484 3.03e-12 SMART
IGc2 2512 2583 7.76e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000194546
AA Change: M234K

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000141391
Gene: ENSMUSG00000036334
AA Change: M234K

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 3.24e-4 SMART
LRR 57 79 9.24e1 SMART
LRR 80 103 2.02e-1 SMART
LRR 104 127 7.16e0 SMART
LRR_TYP 128 151 1.2e-3 SMART
LRR 152 175 1.25e-1 SMART
LRR 188 207 2.33e2 SMART
LRRCT 219 280 4.19e-4 SMART
IGc2 488 558 2.34e-4 SMART
IGc2 586 652 7.88e-11 SMART
low complexity region 917 930 N/A INTRINSIC
low complexity region 1175 1185 N/A INTRINSIC
low complexity region 1245 1263 N/A INTRINSIC
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1449 1465 N/A INTRINSIC
IGc2 1632 1701 7.69e-14 SMART
IGc2 1729 1798 5.07e-14 SMART
IGc2 1826 1895 2.19e-9 SMART
IGc2 1925 1994 4.59e-12 SMART
IGc2 2022 2097 1.33e-8 SMART
IGc2 2125 2191 2.96e-15 SMART
IGc2 2223 2291 2.03e-4 SMART
IGc2 2321 2389 9.99e-13 SMART
IGc2 2416 2484 3.03e-12 SMART
IGc2 2512 2583 7.76e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000195983
SMART Domains Protein: ENSMUSP00000143071
Gene: ENSMUSG00000036334

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 28 61 1.5e-6 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak C T 19: 8,986,689 (GRCm39) probably benign Het
Asah1 A G 8: 41,799,233 (GRCm39) probably benign Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Chd6 T C 2: 160,859,936 (GRCm39) probably benign Het
Chn2 G A 6: 54,171,062 (GRCm39) R47Q probably benign Het
Clmp A G 9: 40,597,623 (GRCm39) probably benign Het
Col11a1 G A 3: 113,987,740 (GRCm39) G245R probably damaging Het
Cyp4a32 T A 4: 115,468,798 (GRCm39) S395T probably benign Het
Dcc A T 18: 71,460,625 (GRCm39) I1155K probably damaging Het
Dpy19l4 G A 4: 11,267,615 (GRCm39) H442Y probably damaging Het
Dpys T C 15: 39,687,612 (GRCm39) I395M probably damaging Het
Dpysl2 T C 14: 67,050,736 (GRCm39) K374E probably damaging Het
Fryl A T 5: 73,211,402 (GRCm39) D660E probably damaging Het
Gabrb2 T C 11: 42,482,771 (GRCm39) F210L probably damaging Het
Gm4831 C T 17: 37,422,879 (GRCm39) probably benign Het
Ints11 T C 4: 155,956,581 (GRCm39) probably benign Het
Mex3a T A 3: 88,443,553 (GRCm39) S210T probably benign Het
Or4k42 C T 2: 111,320,289 (GRCm39) M71I probably benign Het
Or4k52 G A 2: 111,610,871 (GRCm39) V69I probably benign Het
Pde1c A G 6: 56,157,078 (GRCm39) V106A probably damaging Het
Pitpnm3 G A 11: 71,961,716 (GRCm39) Q284* probably null Het
Pkd1l2 A G 8: 117,722,548 (GRCm39) L2420P probably damaging Het
Prpf39 A G 12: 65,108,211 (GRCm39) probably benign Het
Prss28 C T 17: 25,528,669 (GRCm39) T37I probably benign Het
Serpinb6c A T 13: 34,079,369 (GRCm39) S108T probably benign Het
Snx7 T C 3: 117,632,524 (GRCm39) H131R probably damaging Het
Tex101 A T 7: 24,367,758 (GRCm39) I198K probably damaging Het
Thoc2l T G 5: 104,668,334 (GRCm39) V952G probably damaging Het
Thumpd2 T C 17: 81,351,519 (GRCm39) probably benign Het
Ubqln3 A C 7: 103,791,763 (GRCm39) I109S probably benign Het
Zfp212 A T 6: 47,907,771 (GRCm39) N250I probably benign Het
Other mutations in Igsf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00773:Igsf10 APN 3 59,238,960 (GRCm39) missense probably benign 0.03
IGL00790:Igsf10 APN 3 59,226,938 (GRCm39) missense probably damaging 1.00
IGL00916:Igsf10 APN 3 59,238,548 (GRCm39) missense probably damaging 0.97
IGL00928:Igsf10 APN 3 59,238,018 (GRCm39) missense probably benign 0.00
IGL01066:Igsf10 APN 3 59,235,203 (GRCm39) critical splice donor site probably null
IGL01107:Igsf10 APN 3 59,238,945 (GRCm39) missense probably damaging 1.00
IGL01420:Igsf10 APN 3 59,227,071 (GRCm39) missense probably benign 0.02
IGL01533:Igsf10 APN 3 59,226,651 (GRCm39) missense probably damaging 0.98
IGL01537:Igsf10 APN 3 59,237,452 (GRCm39) missense probably benign 0.00
IGL01676:Igsf10 APN 3 59,236,756 (GRCm39) missense probably benign 0.17
IGL01676:Igsf10 APN 3 59,233,432 (GRCm39) missense probably benign 0.06
IGL01960:Igsf10 APN 3 59,226,158 (GRCm39) missense probably benign 0.00
IGL02123:Igsf10 APN 3 59,226,081 (GRCm39) missense probably damaging 0.97
IGL02198:Igsf10 APN 3 59,233,399 (GRCm39) missense possibly damaging 0.95
IGL02268:Igsf10 APN 3 59,238,573 (GRCm39) nonsense probably null
IGL02313:Igsf10 APN 3 59,238,111 (GRCm39) missense probably benign 0.01
IGL02368:Igsf10 APN 3 59,235,652 (GRCm39) missense probably benign
IGL02494:Igsf10 APN 3 59,235,427 (GRCm39) missense probably damaging 0.98
IGL02549:Igsf10 APN 3 59,236,662 (GRCm39) missense probably benign 0.03
IGL02616:Igsf10 APN 3 59,226,027 (GRCm39) missense probably benign 0.06
IGL02957:Igsf10 APN 3 59,238,285 (GRCm39) missense probably damaging 1.00
IGL03067:Igsf10 APN 3 59,226,339 (GRCm39) missense probably benign 0.25
IGL03104:Igsf10 APN 3 59,226,905 (GRCm39) missense probably damaging 1.00
IGL03124:Igsf10 APN 3 59,227,086 (GRCm39) missense probably benign 0.01
IGL03212:Igsf10 APN 3 59,235,586 (GRCm39) missense probably benign 0.09
IGL03347:Igsf10 APN 3 59,239,321 (GRCm39) missense possibly damaging 0.94
F6893:Igsf10 UTSW 3 59,238,481 (GRCm39) missense probably damaging 1.00
FR4449:Igsf10 UTSW 3 59,226,531 (GRCm39) missense probably damaging 1.00
PIT1430001:Igsf10 UTSW 3 59,235,579 (GRCm39) missense probably benign 0.06
PIT4402001:Igsf10 UTSW 3 59,233,000 (GRCm39) missense probably benign 0.00
PIT4810001:Igsf10 UTSW 3 59,225,903 (GRCm39) missense probably damaging 1.00
R0068:Igsf10 UTSW 3 59,238,045 (GRCm39) missense probably damaging 0.98
R0095:Igsf10 UTSW 3 59,238,617 (GRCm39) nonsense probably null
R0095:Igsf10 UTSW 3 59,238,617 (GRCm39) nonsense probably null
R0112:Igsf10 UTSW 3 59,233,429 (GRCm39) missense probably benign 0.00
R0141:Igsf10 UTSW 3 59,238,253 (GRCm39) missense probably damaging 1.00
R0538:Igsf10 UTSW 3 59,227,527 (GRCm39) missense probably damaging 0.99
R0551:Igsf10 UTSW 3 59,236,089 (GRCm39) missense probably benign 0.01
R0556:Igsf10 UTSW 3 59,236,296 (GRCm39) missense probably benign 0.02
R0582:Igsf10 UTSW 3 59,227,188 (GRCm39) missense probably benign 0.00
R0630:Igsf10 UTSW 3 59,233,483 (GRCm39) missense probably damaging 1.00
R0675:Igsf10 UTSW 3 59,236,015 (GRCm39) missense probably benign 0.14
R0948:Igsf10 UTSW 3 59,238,525 (GRCm39) missense probably damaging 1.00
R1252:Igsf10 UTSW 3 59,239,269 (GRCm39) missense probably benign 0.03
R1412:Igsf10 UTSW 3 59,235,196 (GRCm39) splice site probably benign
R1473:Igsf10 UTSW 3 59,226,188 (GRCm39) missense probably damaging 1.00
R1585:Igsf10 UTSW 3 59,237,838 (GRCm39) missense probably damaging 1.00
R1650:Igsf10 UTSW 3 59,233,583 (GRCm39) missense probably damaging 1.00
R1660:Igsf10 UTSW 3 59,238,706 (GRCm39) missense probably damaging 1.00
R1671:Igsf10 UTSW 3 59,235,921 (GRCm39) nonsense probably null
R1748:Igsf10 UTSW 3 59,226,514 (GRCm39) missense probably damaging 1.00
R1758:Igsf10 UTSW 3 59,236,617 (GRCm39) missense probably benign 0.09
R1856:Igsf10 UTSW 3 59,238,693 (GRCm39) missense possibly damaging 0.63
R1912:Igsf10 UTSW 3 59,236,993 (GRCm39) missense probably benign 0.40
R2148:Igsf10 UTSW 3 59,243,998 (GRCm39) missense possibly damaging 0.77
R2155:Igsf10 UTSW 3 59,239,101 (GRCm39) missense probably damaging 1.00
R2509:Igsf10 UTSW 3 59,239,287 (GRCm39) missense probably damaging 1.00
R2511:Igsf10 UTSW 3 59,239,287 (GRCm39) missense probably damaging 1.00
R2680:Igsf10 UTSW 3 59,232,875 (GRCm39) missense probably benign 0.14
R2913:Igsf10 UTSW 3 59,239,157 (GRCm39) missense possibly damaging 0.70
R2927:Igsf10 UTSW 3 59,236,848 (GRCm39) missense probably benign
R3547:Igsf10 UTSW 3 59,243,935 (GRCm39) missense probably damaging 1.00
R3547:Igsf10 UTSW 3 59,237,962 (GRCm39) missense probably benign 0.02
R3548:Igsf10 UTSW 3 59,243,935 (GRCm39) missense probably damaging 1.00
R3620:Igsf10 UTSW 3 59,243,752 (GRCm39) missense probably damaging 1.00
R3732:Igsf10 UTSW 3 59,233,135 (GRCm39) missense probably benign 0.29
R3743:Igsf10 UTSW 3 59,233,546 (GRCm39) missense possibly damaging 0.69
R3973:Igsf10 UTSW 3 59,239,345 (GRCm39) missense probably damaging 1.00
R4005:Igsf10 UTSW 3 59,235,981 (GRCm39) missense probably benign 0.00
R4184:Igsf10 UTSW 3 59,227,152 (GRCm39) missense probably damaging 1.00
R4302:Igsf10 UTSW 3 59,226,171 (GRCm39) missense probably damaging 1.00
R4404:Igsf10 UTSW 3 59,236,972 (GRCm39) missense probably benign 0.04
R4575:Igsf10 UTSW 3 59,237,521 (GRCm39) missense probably benign
R4676:Igsf10 UTSW 3 59,233,370 (GRCm39) missense probably benign 0.23
R4700:Igsf10 UTSW 3 59,227,751 (GRCm39) missense probably damaging 0.99
R4765:Igsf10 UTSW 3 59,237,126 (GRCm39) missense probably benign 0.01
R4986:Igsf10 UTSW 3 59,236,027 (GRCm39) missense probably benign 0.24
R5012:Igsf10 UTSW 3 59,226,143 (GRCm39) missense probably damaging 1.00
R5070:Igsf10 UTSW 3 59,235,714 (GRCm39) missense probably benign 0.02
R5083:Igsf10 UTSW 3 59,233,694 (GRCm39) missense probably damaging 1.00
R5336:Igsf10 UTSW 3 59,227,553 (GRCm39) missense probably damaging 1.00
R5462:Igsf10 UTSW 3 59,233,175 (GRCm39) missense probably damaging 1.00
R5648:Igsf10 UTSW 3 59,235,574 (GRCm39) missense probably benign 0.01
R5810:Igsf10 UTSW 3 59,226,492 (GRCm39) missense probably damaging 1.00
R5871:Igsf10 UTSW 3 59,237,832 (GRCm39) missense possibly damaging 0.83
R5880:Igsf10 UTSW 3 59,238,252 (GRCm39) missense probably damaging 1.00
R5935:Igsf10 UTSW 3 59,235,578 (GRCm39) missense probably benign 0.12
R5979:Igsf10 UTSW 3 59,243,894 (GRCm39) missense probably damaging 1.00
R6145:Igsf10 UTSW 3 59,239,077 (GRCm39) missense possibly damaging 0.83
R6222:Igsf10 UTSW 3 59,226,336 (GRCm39) missense possibly damaging 0.90
R6224:Igsf10 UTSW 3 59,232,931 (GRCm39) missense probably damaging 1.00
R6264:Igsf10 UTSW 3 59,235,928 (GRCm39) missense possibly damaging 0.88
R6283:Igsf10 UTSW 3 59,226,870 (GRCm39) missense probably damaging 1.00
R6336:Igsf10 UTSW 3 59,237,760 (GRCm39) missense probably benign 0.00
R6490:Igsf10 UTSW 3 59,236,992 (GRCm39) missense probably benign 0.06
R6785:Igsf10 UTSW 3 59,226,665 (GRCm39) missense probably damaging 1.00
R6873:Igsf10 UTSW 3 59,235,865 (GRCm39) missense probably benign
R6889:Igsf10 UTSW 3 59,239,354 (GRCm39) missense probably benign
R7024:Igsf10 UTSW 3 59,239,122 (GRCm39) missense probably benign 0.00
R7056:Igsf10 UTSW 3 59,238,501 (GRCm39) missense probably damaging 1.00
R7128:Igsf10 UTSW 3 59,236,326 (GRCm39) missense probably benign
R7251:Igsf10 UTSW 3 59,226,875 (GRCm39) missense probably damaging 1.00
R7313:Igsf10 UTSW 3 59,236,837 (GRCm39) missense probably benign 0.05
R7340:Igsf10 UTSW 3 59,233,189 (GRCm39) missense probably damaging 1.00
R7447:Igsf10 UTSW 3 59,239,222 (GRCm39) missense probably benign 0.39
R7506:Igsf10 UTSW 3 59,226,775 (GRCm39) missense probably damaging 1.00
R7678:Igsf10 UTSW 3 59,226,761 (GRCm39) missense possibly damaging 0.81
R7695:Igsf10 UTSW 3 59,233,612 (GRCm39) missense probably damaging 1.00
R7709:Igsf10 UTSW 3 59,238,964 (GRCm39) missense probably damaging 0.96
R7749:Igsf10 UTSW 3 59,236,549 (GRCm39) missense possibly damaging 0.88
R7808:Igsf10 UTSW 3 59,235,489 (GRCm39) missense probably benign 0.00
R7850:Igsf10 UTSW 3 59,227,053 (GRCm39) missense probably benign 0.33
R7879:Igsf10 UTSW 3 59,238,145 (GRCm39) missense probably damaging 1.00
R7886:Igsf10 UTSW 3 59,235,748 (GRCm39) missense probably benign 0.01
R7891:Igsf10 UTSW 3 59,235,832 (GRCm39) nonsense probably null
R7946:Igsf10 UTSW 3 59,227,125 (GRCm39) missense possibly damaging 0.69
R7948:Igsf10 UTSW 3 59,239,279 (GRCm39) missense probably benign 0.02
R8004:Igsf10 UTSW 3 59,237,130 (GRCm39) missense probably benign 0.01
R8096:Igsf10 UTSW 3 59,236,380 (GRCm39) missense probably damaging 0.98
R8141:Igsf10 UTSW 3 59,237,949 (GRCm39) missense probably damaging 0.96
R8183:Igsf10 UTSW 3 59,238,036 (GRCm39) missense probably benign 0.04
R8203:Igsf10 UTSW 3 59,236,254 (GRCm39) missense probably benign 0.11
R8325:Igsf10 UTSW 3 59,225,954 (GRCm39) missense probably damaging 0.96
R8350:Igsf10 UTSW 3 59,238,949 (GRCm39) missense probably damaging 1.00
R8387:Igsf10 UTSW 3 59,236,564 (GRCm39) missense probably damaging 1.00
R8488:Igsf10 UTSW 3 59,227,431 (GRCm39) missense probably damaging 1.00
R8697:Igsf10 UTSW 3 59,226,308 (GRCm39) missense probably benign 0.02
R8786:Igsf10 UTSW 3 59,238,063 (GRCm39) missense probably benign 0.25
R8804:Igsf10 UTSW 3 59,243,876 (GRCm39) missense probably damaging 1.00
R8886:Igsf10 UTSW 3 59,237,410 (GRCm39) missense probably benign 0.00
R8902:Igsf10 UTSW 3 59,243,633 (GRCm39) missense probably benign 0.00
R8906:Igsf10 UTSW 3 59,233,739 (GRCm39) missense probably benign 0.01
R8917:Igsf10 UTSW 3 59,226,888 (GRCm39) missense possibly damaging 0.69
R9051:Igsf10 UTSW 3 59,236,668 (GRCm39) missense probably benign 0.00
R9178:Igsf10 UTSW 3 59,233,480 (GRCm39) missense possibly damaging 0.69
R9228:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9230:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9231:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9232:Igsf10 UTSW 3 59,243,843 (GRCm39) missense probably damaging 1.00
R9417:Igsf10 UTSW 3 59,236,526 (GRCm39) missense possibly damaging 0.94
R9609:Igsf10 UTSW 3 59,226,869 (GRCm39) missense probably damaging 1.00
R9631:Igsf10 UTSW 3 59,237,904 (GRCm39) missense probably damaging 1.00
R9689:Igsf10 UTSW 3 59,233,624 (GRCm39) missense probably damaging 1.00
R9762:Igsf10 UTSW 3 59,237,106 (GRCm39) missense probably damaging 1.00
R9770:Igsf10 UTSW 3 59,227,199 (GRCm39) missense probably benign 0.07
R9798:Igsf10 UTSW 3 59,239,126 (GRCm39) missense probably damaging 1.00
Z1088:Igsf10 UTSW 3 59,237,359 (GRCm39) missense possibly damaging 0.59
Z1177:Igsf10 UTSW 3 59,237,026 (GRCm39) nonsense probably null
Posted On 2016-08-02