Incidental Mutation 'IGL03358:Oosp2'
| ID |
420010 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Oosp2
|
| Ensembl Gene |
ENSMUSG00000055895 |
| Gene Name |
oocyte secreted protein 2 |
| Synonyms |
Plac1l, Tmem122, LOC225922 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.058)
|
| Stock # |
IGL03358
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
19 |
| Chromosomal Location |
11624648-11637923 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 11628933 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 56
(L56*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113931
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000121793]
[ENSMUST00000135994]
|
| AlphaFold |
Q4FZG8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000121793
AA Change: L56*
|
| SMART Domains |
Protein: ENSMUSP00000113931
Gene: ENSMUSG00000055895
AA Change: L56*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135994
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930453N24Rik |
T |
C |
16: 64,586,909 (GRCm39) |
I272V |
possibly damaging |
Het |
| 4930590J08Rik |
A |
G |
6: 91,905,716 (GRCm39) |
N496D |
probably damaging |
Het |
| Adcy2 |
C |
T |
13: 68,877,396 (GRCm39) |
G448E |
probably damaging |
Het |
| Alad |
G |
A |
4: 62,428,844 (GRCm39) |
|
probably benign |
Het |
| Ank2 |
C |
A |
3: 126,749,519 (GRCm39) |
E503D |
probably damaging |
Het |
| Appbp2 |
A |
T |
11: 85,100,860 (GRCm39) |
M193K |
probably benign |
Het |
| Cd300a |
G |
A |
11: 114,788,623 (GRCm39) |
M204I |
possibly damaging |
Het |
| Cep350 |
T |
A |
1: 155,804,285 (GRCm39) |
M933L |
probably benign |
Het |
| Cyp2s1 |
T |
A |
7: 25,507,573 (GRCm39) |
N292I |
probably damaging |
Het |
| Gnl2 |
T |
C |
4: 124,946,387 (GRCm39) |
I536T |
probably damaging |
Het |
| Ift140 |
C |
T |
17: 25,306,958 (GRCm39) |
R898C |
probably damaging |
Het |
| Pars2 |
A |
T |
4: 106,510,239 (GRCm39) |
H7L |
probably benign |
Het |
| Pbx4 |
T |
C |
8: 70,311,761 (GRCm39) |
S59P |
probably benign |
Het |
| Psg20 |
G |
T |
7: 18,414,891 (GRCm39) |
H332N |
probably benign |
Het |
| Rigi |
T |
C |
4: 40,206,069 (GRCm39) |
E841G |
possibly damaging |
Het |
| Slc6a13 |
G |
A |
6: 121,311,495 (GRCm39) |
V384I |
probably benign |
Het |
| Spg21 |
G |
A |
9: 65,387,698 (GRCm39) |
V164I |
probably benign |
Het |
| Tnc |
A |
T |
4: 63,935,852 (GRCm39) |
C361* |
probably null |
Het |
| Tsr1 |
T |
C |
11: 74,794,824 (GRCm39) |
V493A |
probably benign |
Het |
| Ube2u |
A |
G |
4: 100,404,472 (GRCm39) |
|
probably benign |
Het |
| Vav3 |
G |
A |
3: 109,554,989 (GRCm39) |
G79E |
probably damaging |
Het |
| Vmn1r81 |
T |
G |
7: 11,994,232 (GRCm39) |
R125S |
possibly damaging |
Het |
| Vmn2r45 |
A |
C |
7: 8,474,715 (GRCm39) |
L771R |
probably damaging |
Het |
| Vps54 |
T |
A |
11: 21,218,799 (GRCm39) |
H119Q |
probably damaging |
Het |
|
| Other mutations in Oosp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01323:Oosp2
|
APN |
19 |
11,624,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01813:Oosp2
|
APN |
19 |
11,628,847 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01818:Oosp2
|
APN |
19 |
11,627,053 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02484:Oosp2
|
APN |
19 |
11,628,847 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0938:Oosp2
|
UTSW |
19 |
11,628,904 (GRCm39) |
nonsense |
probably null |
|
|
R1867:Oosp2
|
UTSW |
19 |
11,626,959 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1944:Oosp2
|
UTSW |
19 |
11,626,959 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1945:Oosp2
|
UTSW |
19 |
11,626,959 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2149:Oosp2
|
UTSW |
19 |
11,626,978 (GRCm39) |
nonsense |
probably null |
|
|
R4604:Oosp2
|
UTSW |
19 |
11,627,047 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4684:Oosp2
|
UTSW |
19 |
11,627,017 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5034:Oosp2
|
UTSW |
19 |
11,628,899 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6034:Oosp2
|
UTSW |
19 |
11,628,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6034:Oosp2
|
UTSW |
19 |
11,628,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9695:Oosp2
|
UTSW |
19 |
11,628,994 (GRCm39) |
missense |
|
|
|
| Posted On |
2016-08-02 |
Incidental Mutation