Incidental Mutation 'IGL03358:Ube2u'
ID420027
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ube2u
Ensembl Gene ENSMUSG00000069733
Gene Nameubiquitin-conjugating enzyme E2U (putative)
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03358
Quality Score
Status
Chromosome4
Chromosomal Location100478849-100550147 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 100547275 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137472 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092730] [ENSMUST00000133493]
Predicted Effect probably benign
Transcript: ENSMUST00000092730
SMART Domains Protein: ENSMUSP00000090406
Gene: ENSMUSG00000069733

DomainStartEndE-ValueType
Blast:UBCc 1 40 4e-17 BLAST
coiled coil region 147 189 N/A INTRINSIC
low complexity region 196 207 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000133493
SMART Domains Protein: ENSMUSP00000137472
Gene: ENSMUSG00000069733

DomainStartEndE-ValueType
UBCc 7 153 1.58e-25 SMART
coiled coil region 260 302 N/A INTRINSIC
low complexity region 309 320 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930453N24Rik T C 16: 64,766,546 I272V possibly damaging Het
4930590J08Rik A G 6: 91,928,735 N496D probably damaging Het
Adcy2 C T 13: 68,729,277 G448E probably damaging Het
Alad G A 4: 62,510,607 probably benign Het
Ank2 C A 3: 126,955,870 E503D probably damaging Het
Appbp2 A T 11: 85,210,034 M193K probably benign Het
Cd300a G A 11: 114,897,797 M204I possibly damaging Het
Cep350 T A 1: 155,928,539 M933L probably benign Het
Cyp2s1 T A 7: 25,808,148 N292I probably damaging Het
Ddx58 T C 4: 40,206,069 E841G possibly damaging Het
Gnl2 T C 4: 125,052,594 I536T probably damaging Het
Ift140 C T 17: 25,087,984 R898C probably damaging Het
Oosp2 A T 19: 11,651,569 L56* probably null Het
Pars2 A T 4: 106,653,042 H7L probably benign Het
Pbx4 T C 8: 69,859,111 S59P probably benign Het
Psg20 G T 7: 18,680,966 H332N probably benign Het
Slc6a13 G A 6: 121,334,536 V384I probably benign Het
Spg21 G A 9: 65,480,416 V164I probably benign Het
Tnc A T 4: 64,017,615 C361* probably null Het
Tsr1 T C 11: 74,903,998 V493A probably benign Het
Vav3 G A 3: 109,647,673 G79E probably damaging Het
Vmn1r81 T G 7: 12,260,305 R125S possibly damaging Het
Vmn2r45 A C 7: 8,471,716 L771R probably damaging Het
Vps54 T A 11: 21,268,799 H119Q probably damaging Het
Other mutations in Ube2u
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01324:Ube2u APN 4 100479225 missense possibly damaging 0.77
IGL01641:Ube2u APN 4 100481657 missense probably benign 0.02
IGL02633:Ube2u APN 4 100482774 splice site probably benign
IGL03126:Ube2u APN 4 100550002 makesense probably null
R0043:Ube2u UTSW 4 100482829 missense possibly damaging 0.93
R0102:Ube2u UTSW 4 100549925 missense possibly damaging 0.66
R0102:Ube2u UTSW 4 100549925 missense possibly damaging 0.66
R0110:Ube2u UTSW 4 100486673 missense probably benign 0.01
R0113:Ube2u UTSW 4 100481655 missense possibly damaging 0.93
R0357:Ube2u UTSW 4 100481654 nonsense probably null
R0395:Ube2u UTSW 4 100481648 missense probably benign 0.02
R0465:Ube2u UTSW 4 100532096 splice site probably benign
R0469:Ube2u UTSW 4 100486673 missense probably benign 0.01
R0788:Ube2u UTSW 4 100514740 splice site probably benign
R1958:Ube2u UTSW 4 100481636 missense probably benign
R2216:Ube2u UTSW 4 100532168 missense probably benign 0.00
R2937:Ube2u UTSW 4 100524298 missense possibly damaging 0.93
R4086:Ube2u UTSW 4 100549842 missense probably benign 0.18
R4471:Ube2u UTSW 4 100481646 nonsense probably null
R4781:Ube2u UTSW 4 100486658 missense probably benign 0.08
R6385:Ube2u UTSW 4 100532144 missense possibly damaging 0.91
R6912:Ube2u UTSW 4 100532155 missense probably damaging 0.99
R7382:Ube2u UTSW 4 100532182 nonsense probably null
Z1176:Ube2u UTSW 4 100482840 missense probably benign 0.00
Posted On2016-08-02