Incidental Mutation 'IGL03365:Morf4l2'
ID 420056
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Morf4l2
Ensembl Gene ENSMUSG00000031422
Gene Name mortality factor 4 like 2
Synonyms Sid393p, 2410017O14Rik
Accession Numbers
Essential gene? Not available question?
Stock # IGL03365
Quality Score
Status
Chromosome X
Chromosomal Location 135633691-135644435 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 135634464 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 255 (Y255H)
Ref Sequence ENSEMBL: ENSMUSP00000132643 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033797] [ENSMUST00000080411] [ENSMUST00000113095] [ENSMUST00000113097] [ENSMUST00000131923] [ENSMUST00000135731] [ENSMUST00000136650] [ENSMUST00000166478] [ENSMUST00000169418] [ENSMUST00000164609] [ENSMUST00000166930] [ENSMUST00000137605] [ENSMUST00000152150] [ENSMUST00000155207]
AlphaFold Q9R0Q4
Predicted Effect probably benign
Transcript: ENSMUST00000033797
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000033797
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080411
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000108722
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113095
SMART Domains Protein: ENSMUSP00000108718
Gene: ENSMUSG00000031422

DomainStartEndE-ValueType
Pfam:MRG 94 174 2.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113097
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000108720
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131923
Predicted Effect probably benign
Transcript: ENSMUST00000135731
Predicted Effect probably benign
Transcript: ENSMUST00000136650
Predicted Effect probably benign
Transcript: ENSMUST00000166478
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000131909
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169418
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000132643
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164609
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000129774
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166930
AA Change: Y255H

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000126363
Gene: ENSMUSG00000031422
AA Change: Y255H

DomainStartEndE-ValueType
Pfam:MRG 94 276 1.5e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137979
Predicted Effect probably benign
Transcript: ENSMUST00000137605
SMART Domains Protein: ENSMUSP00000115303
Gene: ENSMUSG00000031422

DomainStartEndE-ValueType
Pfam:MRG 94 205 4.7e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000152150
Predicted Effect probably benign
Transcript: ENSMUST00000155207
SMART Domains Protein: ENSMUSP00000121632
Gene: ENSMUSG00000031422

DomainStartEndE-ValueType
Pfam:MRG 94 214 4.1e-35 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null females and hemizygous null males are healthy and fertile with no obvious abnormalities and null MEFs have normal growth rates. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1500035N22Rik T G 5: 25,202,809 (GRCm39) probably benign Het
Adam6a T A 12: 113,507,765 (GRCm39) I46N possibly damaging Het
Adipor1 A G 1: 134,359,380 (GRCm39) D371G possibly damaging Het
Akr1c21 C T 13: 4,633,851 (GRCm39) P307S probably benign Het
Aoc1l3 A G 6: 48,965,531 (GRCm39) D513G probably damaging Het
Asxl1 T A 2: 153,243,674 (GRCm39) I1408N probably damaging Het
Avil T C 10: 126,846,852 (GRCm39) V472A probably damaging Het
Bpifa6 C A 2: 153,831,204 (GRCm39) Q257K possibly damaging Het
Cacna2d4 G T 6: 119,248,225 (GRCm39) V380L probably benign Het
Clip1 A C 5: 123,721,649 (GRCm39) S1111A probably damaging Het
Dennd4c A G 4: 86,725,663 (GRCm39) probably null Het
Dock8 C T 19: 25,077,048 (GRCm39) P506L possibly damaging Het
Ecsit A C 9: 21,987,822 (GRCm39) H72Q probably damaging Het
Eif1b T A 9: 120,323,186 (GRCm39) D15E probably benign Het
Enpp1 A G 10: 24,544,923 (GRCm39) Y319H probably damaging Het
Fat3 T C 9: 15,907,765 (GRCm39) N2746D probably damaging Het
Fgf20 G T 8: 40,732,932 (GRCm39) L115I possibly damaging Het
Hip1r C T 5: 124,138,230 (GRCm39) R775W probably damaging Het
Hycc1 A T 5: 24,188,158 (GRCm39) Y245N probably benign Het
Lrp12 A T 15: 39,735,917 (GRCm39) S672T probably benign Het
Mri1 A G 8: 84,978,262 (GRCm39) V343A possibly damaging Het
Mybphl T A 3: 108,272,314 (GRCm39) M1K probably null Het
Nelfcd G A 2: 174,268,625 (GRCm39) A559T possibly damaging Het
Ofd1 C A X: 165,175,512 (GRCm39) V951F probably damaging Het
Or4k51 G T 2: 111,584,772 (GRCm39) M59I possibly damaging Het
Or51r1 G T 7: 102,227,836 (GRCm39) V45F probably benign Het
Or6c208 T A 10: 129,224,108 (GRCm39) V202D possibly damaging Het
Parp12 G A 6: 39,079,581 (GRCm39) R310W probably damaging Het
Pcdh11x T A X: 119,425,935 (GRCm39) D1019E probably benign Het
Ppp1r9a T A 6: 5,110,993 (GRCm39) probably benign Het
Ptprz1 T A 6: 23,030,581 (GRCm39) probably benign Het
Qser1 T A 2: 104,617,344 (GRCm39) N1156I probably damaging Het
Rgs3 T A 4: 62,607,912 (GRCm39) D59E probably benign Het
Rims2 T C 15: 39,339,937 (GRCm39) F917S probably damaging Het
Sap30bp G A 11: 115,855,078 (GRCm39) V263M possibly damaging Het
Scart2 T A 7: 139,876,682 (GRCm39) V691E probably damaging Het
Scfd2 G T 5: 74,691,596 (GRCm39) H229N possibly damaging Het
Sspo T C 6: 48,436,349 (GRCm39) V1233A possibly damaging Het
Stam T A 2: 14,151,201 (GRCm39) Y519* probably null Het
Synj2 A G 17: 6,069,679 (GRCm39) T602A probably damaging Het
Tas2r126 C T 6: 42,412,391 (GRCm39) A308V probably benign Het
Tm4sf20 T C 1: 82,745,948 (GRCm39) probably benign Het
Ttc23 G A 7: 67,312,085 (GRCm39) probably benign Het
Vmn1r90 T C 7: 14,295,229 (GRCm39) I290V probably damaging Het
Xirp1 A C 9: 119,847,605 (GRCm39) L426W probably damaging Het
Zgrf1 T G 3: 127,392,423 (GRCm39) F430L possibly damaging Het
Other mutations in Morf4l2
AlleleSourceChrCoordTypePredicted EffectPPH Score
FR4976:Morf4l2 UTSW X 135,634,371 (GRCm39) missense probably benign 0.29
Posted On 2016-08-02