Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03366:Tmem266'

420115

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem266

Ensembl Gene

ENSMUSG00000032313

Gene Name

transmembrane protein 266

Synonyms

AI118078

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

IGL03366

Quality Score

Status

Chromosome

Chromosomal Location

55326913-55438345 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 55437233 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 383 (C383F)

Ref Sequence

ENSEMBL: ENSMUSP00000034862 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034862] [ENSMUST00000085754]

AlphaFold

Q8BZB3

Predicted Effect

probably benign
Transcript: ENSMUST00000034862
AA Change: C383F

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000034862
Gene: ENSMUSG00000032313
AA Change: C383F

Domain	Start	End	E-Value	Type
low complexity region	16	27	N/A	INTRINSIC
transmembrane domain	95	117	N/A	INTRINSIC
transmembrane domain	137	159	N/A	INTRINSIC
transmembrane domain	172	191	N/A	INTRINSIC
low complexity region	260	283	N/A	INTRINSIC
low complexity region	298	309	N/A	INTRINSIC
low complexity region	381	396	N/A	INTRINSIC
low complexity region	423	439	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000085754

SMART Domains

Protein: ENSMUSP00000082906
Gene: ENSMUSG00000032313

Domain	Start	End	E-Value	Type
transmembrane domain	30	52	N/A	INTRINSIC
transmembrane domain	72	94	N/A	INTRINSIC
low complexity region	195	218	N/A	INTRINSIC
low complexity region	233	244	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130465

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap2a2	T	A	7: 141,629,273 (GRCm38)	S793T	probably benign	Het
Btnl6	T	C	17: 34,508,179 (GRCm38)	D459G	probably damaging	Het
Cacna1g	C	A	11: 94,457,151 (GRCm38)	D704Y	probably damaging	Het
Cby2	A	G	14: 75,583,389 (GRCm38)	S299P	probably benign	Het
Cry2	A	G	2: 92,413,715 (GRCm38)	I371T	probably damaging	Het
Dock3	A	T	9: 107,005,433 (GRCm38)	F384I	probably benign	Het
Dpp4	T	C	2: 62,356,957 (GRCm38)		probably null	Het
Hecw1	G	T	13: 14,377,797 (GRCm38)	D72E	probably damaging	Het
Htt	T	A	5: 34,907,580 (GRCm38)	W3046R	probably damaging	Het
Hydin	A	T	8: 110,267,363 (GRCm38)	N10Y	unknown	Het
Ighv8-8	T	A	12: 115,294,140 (GRCm38)	T94S	probably benign	Het
Igkv4-58	A	G	6: 69,500,554 (GRCm38)	S20P	probably damaging	Het
Il4i1	T	C	7: 44,837,495 (GRCm38)		probably benign	Het
Kif13a	A	T	13: 46,764,623 (GRCm38)	S403T	probably benign	Het
Klhl40	T	C	9: 121,783,380 (GRCm38)	L616P	probably damaging	Het
Krt7	T	C	15: 101,427,610 (GRCm38)	L440P	possibly damaging	Het
Lpin1	A	G	12: 16,544,677 (GRCm38)	L755P	probably damaging	Het
Magee2	C	A	X: 104,855,528 (GRCm38)	E506*	probably null	Het
Mast3	G	A	8: 70,781,563 (GRCm38)	R143*	probably null	Het
Med12	T	A	X: 101,278,089 (GRCm38)	H459Q	probably benign	Het
Mmp3	T	C	9: 7,450,149 (GRCm38)	S294P	probably benign	Het
Muc6	T	C	7: 141,648,082 (GRCm38)	Y714C	probably damaging	Het
Myh2	T	C	11: 67,183,523 (GRCm38)	L662S	probably damaging	Het
Notch4	G	T	17: 34,572,568 (GRCm38)	C567F	probably damaging	Het
Nprl3	A	G	11: 32,250,256 (GRCm38)	I20T	probably damaging	Het
Or10ag2	A	T	2: 87,418,243 (GRCm38)	D65V	possibly damaging	Het
Pcdhb19	A	G	18: 37,498,612 (GRCm38)	T487A	possibly damaging	Het
Phlpp2	A	G	8: 109,940,835 (GRCm38)	E1332G	probably benign	Het
Pick1	T	C	15: 79,241,281 (GRCm38)	S113P	probably damaging	Het
Ptpru	T	C	4: 131,779,867 (GRCm38)	E1023G	probably damaging	Het
Rspry1	A	C	8: 94,650,334 (GRCm38)	I382L	probably benign	Het
Sf3b3	A	C	8: 110,839,954 (GRCm38)	V248G	probably damaging	Het
Smg5	T	A	3: 88,346,452 (GRCm38)	Y126*	probably null	Het
Spin1	T	C	13: 51,127,937 (GRCm38)	V22A	probably benign	Het
Stab1	C	T	14: 31,150,263 (GRCm38)	R1189Q	possibly damaging	Het
Sytl5	A	G	X: 9,963,700 (GRCm38)	D538G	probably damaging	Het
Taar7e	T	A	10: 24,037,915 (GRCm38)	M101K	probably damaging	Het
Taf4	A	G	2: 179,935,054 (GRCm38)	V578A	probably damaging	Het
Trim34a	T	C	7: 104,260,933 (GRCm38)		probably null	Het
Vmn2r104	T	C	17: 20,029,604 (GRCm38)	T802A	probably damaging	Het
Vmn2r32	A	C	7: 7,464,030 (GRCm38)	I833S	probably damaging	Het
Vmn2r85	T	C	10: 130,426,459 (GRCm38)	D137G	probably benign	Het
Vps13c	C	T	9: 67,946,026 (GRCm38)	S2467L	probably benign	Het

Other mutations in Tmem266

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01726:Tmem266	APN	9	55,435,202 (GRCm38)	missense	probably benign	0.12
R0088:Tmem266	UTSW	9	55,437,329 (GRCm38)	missense	probably damaging	1.00
R0418:Tmem266	UTSW	9	55,437,413 (GRCm38)	missense	probably benign	0.06
R0497:Tmem266	UTSW	9	55,380,884 (GRCm38)	splice site	probably null
R0763:Tmem266	UTSW	9	55,414,955 (GRCm38)	missense	probably damaging	1.00
R1657:Tmem266	UTSW	9	55,418,008 (GRCm38)	missense	probably damaging	1.00
R3617:Tmem266	UTSW	9	55,400,634 (GRCm38)	missense	probably damaging	0.99
R4235:Tmem266	UTSW	9	55,418,107 (GRCm38)	missense	probably damaging	0.99
R4767:Tmem266	UTSW	9	55,380,741 (GRCm38)	missense	probably damaging	1.00
R5587:Tmem266	UTSW	9	55,437,566 (GRCm38)	missense	probably damaging	1.00
R5732:Tmem266	UTSW	9	55,380,836 (GRCm38)	missense	probably damaging	1.00
R5783:Tmem266	UTSW	9	55,397,803 (GRCm38)	missense	probably damaging	1.00
R6193:Tmem266	UTSW	9	55,437,209 (GRCm38)	missense	probably benign	0.01
R6943:Tmem266	UTSW	9	55,377,567 (GRCm38)	start gained	probably benign
R7459:Tmem266	UTSW	9	55,396,599 (GRCm38)	missense	unknown
R9167:Tmem266	UTSW	9	55,414,947 (GRCm38)	missense	probably damaging	1.00
R9502:Tmem266	UTSW	9	55,437,689 (GRCm38)	missense	probably damaging	0.96
X0063:Tmem266	UTSW	9	55,380,749 (GRCm38)	missense	probably benign	0.00
Z1177:Tmem266	UTSW	9	55,437,470 (GRCm38)	missense	possibly damaging	0.70
Z1177:Tmem266	UTSW	9	55,397,767 (GRCm38)	missense	probably damaging	1.00

Posted On

2016-08-02