Incidental Mutation 'IGL03366:Tmem266'
ID420115
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem266
Ensembl Gene ENSMUSG00000032313
Gene Nametransmembrane protein 266
SynonymsAI118078
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.096) question?
Stock #IGL03366
Quality Score
Status
Chromosome9
Chromosomal Location55326913-55438345 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 55437233 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Phenylalanine at position 383 (C383F)
Ref Sequence ENSEMBL: ENSMUSP00000034862 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034862] [ENSMUST00000085754]
Predicted Effect probably benign
Transcript: ENSMUST00000034862
AA Change: C383F

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000034862
Gene: ENSMUSG00000032313
AA Change: C383F

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
transmembrane domain 95 117 N/A INTRINSIC
transmembrane domain 137 159 N/A INTRINSIC
transmembrane domain 172 191 N/A INTRINSIC
low complexity region 260 283 N/A INTRINSIC
low complexity region 298 309 N/A INTRINSIC
low complexity region 381 396 N/A INTRINSIC
low complexity region 423 439 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000085754
SMART Domains Protein: ENSMUSP00000082906
Gene: ENSMUSG00000032313

DomainStartEndE-ValueType
transmembrane domain 30 52 N/A INTRINSIC
transmembrane domain 72 94 N/A INTRINSIC
low complexity region 195 218 N/A INTRINSIC
low complexity region 233 244 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130465
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap2a2 T A 7: 141,629,273 S793T probably benign Het
Btnl6 T C 17: 34,508,179 D459G probably damaging Het
Cacna1g C A 11: 94,457,151 D704Y probably damaging Het
Cry2 A G 2: 92,413,715 I371T probably damaging Het
Dock3 A T 9: 107,005,433 F384I probably benign Het
Dpp4 T C 2: 62,356,957 probably null Het
Hecw1 G T 13: 14,377,797 D72E probably damaging Het
Htt T A 5: 34,907,580 W3046R probably damaging Het
Hydin A T 8: 110,267,363 N10Y unknown Het
Ighv8-8 T A 12: 115,294,140 T94S probably benign Het
Igkv4-58 A G 6: 69,500,554 S20P probably damaging Het
Il4i1 T C 7: 44,837,495 probably benign Het
Kif13a A T 13: 46,764,623 S403T probably benign Het
Klhl40 T C 9: 121,783,380 L616P probably damaging Het
Krt7 T C 15: 101,427,610 L440P possibly damaging Het
Lpin1 A G 12: 16,544,677 L755P probably damaging Het
Magee2 C A X: 104,855,528 E506* probably null Het
Mast3 G A 8: 70,781,563 R143* probably null Het
Med12 T A X: 101,278,089 H459Q probably benign Het
Mmp3 T C 9: 7,450,149 S294P probably benign Het
Muc6 T C 7: 141,648,082 Y714C probably damaging Het
Myh2 T C 11: 67,183,523 L662S probably damaging Het
Notch4 G T 17: 34,572,568 C567F probably damaging Het
Nprl3 A G 11: 32,250,256 I20T probably damaging Het
Olfr1123 A T 2: 87,418,243 D65V possibly damaging Het
Pcdhb19 A G 18: 37,498,612 T487A possibly damaging Het
Phlpp2 A G 8: 109,940,835 E1332G probably benign Het
Pick1 T C 15: 79,241,281 S113P probably damaging Het
Ptpru T C 4: 131,779,867 E1023G probably damaging Het
Rspry1 A C 8: 94,650,334 I382L probably benign Het
Sf3b3 A C 8: 110,839,954 V248G probably damaging Het
Smg5 T A 3: 88,346,452 Y126* probably null Het
Spert A G 14: 75,583,389 S299P probably benign Het
Spin1 T C 13: 51,127,937 V22A probably benign Het
Stab1 C T 14: 31,150,263 R1189Q possibly damaging Het
Sytl5 A G X: 9,963,700 D538G probably damaging Het
Taar7e T A 10: 24,037,915 M101K probably damaging Het
Taf4 A G 2: 179,935,054 V578A probably damaging Het
Trim34a T C 7: 104,260,933 probably null Het
Vmn2r104 T C 17: 20,029,604 T802A probably damaging Het
Vmn2r32 A C 7: 7,464,030 I833S probably damaging Het
Vmn2r85 T C 10: 130,426,459 D137G probably benign Het
Vps13c C T 9: 67,946,026 S2467L probably benign Het
Other mutations in Tmem266
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01726:Tmem266 APN 9 55435202 missense probably benign 0.12
R0088:Tmem266 UTSW 9 55437329 missense probably damaging 1.00
R0418:Tmem266 UTSW 9 55437413 missense probably benign 0.06
R0497:Tmem266 UTSW 9 55380884 splice site probably null
R0763:Tmem266 UTSW 9 55414955 missense probably damaging 1.00
R1657:Tmem266 UTSW 9 55418008 missense probably damaging 1.00
R3617:Tmem266 UTSW 9 55400634 missense probably damaging 0.99
R4235:Tmem266 UTSW 9 55418107 missense probably damaging 0.99
R4767:Tmem266 UTSW 9 55380741 missense probably damaging 1.00
R5587:Tmem266 UTSW 9 55437566 missense probably damaging 1.00
R5732:Tmem266 UTSW 9 55380836 missense probably damaging 1.00
R5783:Tmem266 UTSW 9 55397803 missense probably damaging 1.00
R6193:Tmem266 UTSW 9 55437209 missense probably benign 0.01
R6943:Tmem266 UTSW 9 55377567 start gained probably benign
R7459:Tmem266 UTSW 9 55396599 missense unknown
X0063:Tmem266 UTSW 9 55380749 missense probably benign 0.00
Z1177:Tmem266 UTSW 9 55397767 missense probably damaging 1.00
Z1177:Tmem266 UTSW 9 55437470 missense possibly damaging 0.70
Posted On2016-08-02