Incidental Mutation 'IGL03368:Scaper'
ID 420163
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Scaper
Ensembl Gene ENSMUSG00000034007
Gene Name S phase cyclin A-associated protein in the ER
Synonyms Zfp291, D530014O03Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.629) question?
Stock # IGL03368
Quality Score
Status
Chromosome 9
Chromosomal Location 55457163-55845403 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 55563311 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 492 (S492T)
Ref Sequence ENSEMBL: ENSMUSP00000149836 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037408] [ENSMUST00000214747] [ENSMUST00000216595] [ENSMUST00000217647]
AlphaFold F8VQ70
Predicted Effect probably benign
Transcript: ENSMUST00000037408
AA Change: S985T

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000043411
Gene: ENSMUSG00000034007
AA Change: S985T

DomainStartEndE-ValueType
Pfam:SCAPER_N 88 185 3.4e-47 PFAM
low complexity region 323 338 N/A INTRINSIC
coiled coil region 415 466 N/A INTRINSIC
coiled coil region 535 597 N/A INTRINSIC
SCOP:d1eq1a_ 605 769 3e-6 SMART
ZnF_C2H2 791 815 1.16e1 SMART
low complexity region 866 883 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000214747
AA Change: S979T

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216595
AA Change: S492T

PolyPhen 2 Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000217647
AA Change: S985T

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530053G22Rik T C 6: 60,380,530 (GRCm39) noncoding transcript Het
Abca5 A G 11: 110,204,348 (GRCm39) probably benign Het
Agxt2 T A 15: 10,388,256 (GRCm39) C278* probably null Het
Ankar A G 1: 72,714,972 (GRCm39) L384P probably damaging Het
Ankrd55 T C 13: 112,455,090 (GRCm39) probably benign Het
Ap5m1 A G 14: 49,318,593 (GRCm39) probably benign Het
Arhgap18 C T 10: 26,648,689 (GRCm39) S37F possibly damaging Het
Btnl10 G A 11: 58,810,212 (GRCm39) V118I possibly damaging Het
Chst11 C A 10: 82,927,980 (GRCm39) P66T probably benign Het
Cited2 C A 10: 17,599,944 (GRCm39) P84Q possibly damaging Het
Cplane1 T C 15: 8,251,857 (GRCm39) V1914A probably benign Het
Dpy19l4 T A 4: 11,290,253 (GRCm39) I302F possibly damaging Het
Ece2 A G 16: 20,462,908 (GRCm39) E640G possibly damaging Het
Fam184b T C 5: 45,689,166 (GRCm39) D890G possibly damaging Het
Fam227b A T 2: 125,960,983 (GRCm39) D215E probably damaging Het
Foxp2 A G 6: 15,394,717 (GRCm39) K139R probably damaging Het
Gle1 T C 2: 29,833,805 (GRCm39) C401R probably damaging Het
Gp2 A T 7: 119,052,097 (GRCm39) C206S probably damaging Het
Hdgfl2 G T 17: 56,386,746 (GRCm39) probably benign Het
Hmcn1 T C 1: 150,539,623 (GRCm39) N2956S probably damaging Het
Ifi209 A G 1: 173,470,057 (GRCm39) Q215R possibly damaging Het
Il20rb C T 9: 100,341,174 (GRCm39) probably benign Het
Katnip T C 7: 125,468,030 (GRCm39) probably benign Het
Kif26b A C 1: 178,743,773 (GRCm39) S1290R probably damaging Het
Mical1 A G 10: 41,355,625 (GRCm39) I156M probably damaging Het
Nbas C T 12: 13,378,452 (GRCm39) A613V probably benign Het
Nbea C T 3: 55,987,351 (GRCm39) V380M probably damaging Het
Nutf2 T C 8: 106,602,232 (GRCm39) F14S probably damaging Het
Or4c35 A T 2: 89,808,133 (GRCm39) I4L probably benign Het
Or52r1b T A 7: 102,690,972 (GRCm39) H95Q possibly damaging Het
Parp1 A G 1: 180,408,187 (GRCm39) E236G probably benign Het
Podnl1 G A 8: 84,858,818 (GRCm39) V548I probably benign Het
Ptcd2 T A 13: 99,466,577 (GRCm39) probably benign Het
Pygl T C 12: 70,237,926 (GRCm39) Q704R probably benign Het
Sephs1 G A 2: 4,894,080 (GRCm39) D94N possibly damaging Het
Slc22a29 A C 19: 8,184,626 (GRCm39) probably null Het
Slc22a8 G T 19: 8,586,483 (GRCm39) probably benign Het
Slfn5 A G 11: 82,847,211 (GRCm39) D32G possibly damaging Het
Sphkap T A 1: 83,253,397 (GRCm39) T1451S probably benign Het
Srp54a A C 12: 55,138,051 (GRCm39) E63A probably null Het
Stap1 T A 5: 86,238,827 (GRCm39) I165N probably damaging Het
Terf2 T C 8: 107,797,181 (GRCm39) E494G probably damaging Het
Trak1 C A 9: 121,196,188 (GRCm39) L7I possibly damaging Het
Twnk T C 19: 44,998,931 (GRCm39) V557A probably damaging Het
U2af2 T A 7: 5,070,263 (GRCm39) probably benign Het
Ube2j1 T A 4: 33,038,317 (GRCm39) I75N probably damaging Het
Ubr5 A G 15: 37,998,560 (GRCm39) V1643A probably damaging Het
Vsx2 A G 12: 84,617,074 (GRCm39) T120A probably benign Het
Other mutations in Scaper
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00653:Scaper APN 9 55,767,143 (GRCm39) missense probably damaging 0.99
IGL00912:Scaper APN 9 55,593,239 (GRCm39) missense probably damaging 1.00
IGL01469:Scaper APN 9 55,767,051 (GRCm39) missense probably damaging 1.00
IGL01626:Scaper APN 9 55,819,335 (GRCm39) missense possibly damaging 0.61
IGL01779:Scaper APN 9 55,799,524 (GRCm39) missense probably benign 0.20
IGL02011:Scaper APN 9 55,487,606 (GRCm39) missense probably damaging 1.00
IGL02997:Scaper APN 9 55,722,783 (GRCm39) missense probably damaging 1.00
IGL03107:Scaper APN 9 55,765,686 (GRCm39) splice site probably benign
IGL03167:Scaper APN 9 55,767,108 (GRCm39) missense probably damaging 1.00
IGL03293:Scaper APN 9 55,782,107 (GRCm39) missense probably benign
IGL03340:Scaper APN 9 55,510,116 (GRCm39) missense possibly damaging 0.88
R0111:Scaper UTSW 9 55,510,074 (GRCm39) missense probably benign 0.01
R0510:Scaper UTSW 9 55,665,346 (GRCm39) splice site probably benign
R0531:Scaper UTSW 9 55,517,158 (GRCm39) missense possibly damaging 0.91
R0558:Scaper UTSW 9 55,593,207 (GRCm39) missense probably benign 0.08
R0605:Scaper UTSW 9 55,722,802 (GRCm39) splice site probably benign
R0646:Scaper UTSW 9 55,665,340 (GRCm39) missense probably damaging 1.00
R0837:Scaper UTSW 9 55,766,326 (GRCm39) nonsense probably null
R1440:Scaper UTSW 9 55,510,202 (GRCm39) nonsense probably null
R1548:Scaper UTSW 9 55,723,954 (GRCm39) missense probably damaging 1.00
R1777:Scaper UTSW 9 55,771,830 (GRCm39) missense probably benign 0.33
R1822:Scaper UTSW 9 55,767,184 (GRCm39) missense probably damaging 0.99
R1834:Scaper UTSW 9 55,724,018 (GRCm39) missense possibly damaging 0.90
R1870:Scaper UTSW 9 55,593,222 (GRCm39) missense probably damaging 1.00
R2102:Scaper UTSW 9 55,819,334 (GRCm39) missense probably benign 0.43
R2168:Scaper UTSW 9 55,650,923 (GRCm39) missense probably damaging 1.00
R2174:Scaper UTSW 9 55,766,321 (GRCm39) missense probably null 0.01
R3690:Scaper UTSW 9 55,791,205 (GRCm39) missense probably benign 0.00
R4392:Scaper UTSW 9 55,765,399 (GRCm39) missense probably damaging 0.99
R4418:Scaper UTSW 9 55,745,464 (GRCm39) missense probably damaging 1.00
R4606:Scaper UTSW 9 55,563,187 (GRCm39) critical splice donor site probably null
R4643:Scaper UTSW 9 55,745,463 (GRCm39) missense probably damaging 0.99
R4665:Scaper UTSW 9 55,819,339 (GRCm39) missense probably damaging 1.00
R4739:Scaper UTSW 9 55,650,932 (GRCm39) missense probably damaging 1.00
R4921:Scaper UTSW 9 55,799,519 (GRCm39) missense probably benign 0.02
R4934:Scaper UTSW 9 55,716,459 (GRCm39) missense probably damaging 1.00
R4956:Scaper UTSW 9 55,745,426 (GRCm39) missense probably damaging 1.00
R5055:Scaper UTSW 9 55,767,003 (GRCm39) splice site probably null
R5107:Scaper UTSW 9 55,487,616 (GRCm39) missense probably damaging 1.00
R5155:Scaper UTSW 9 55,463,370 (GRCm39) missense probably null 1.00
R5265:Scaper UTSW 9 55,771,830 (GRCm39) missense probably benign
R5408:Scaper UTSW 9 55,493,508 (GRCm39) missense probably damaging 0.99
R5623:Scaper UTSW 9 55,771,791 (GRCm39) missense probably benign 0.02
R5665:Scaper UTSW 9 55,714,916 (GRCm39) missense probably damaging 1.00
R5748:Scaper UTSW 9 55,766,360 (GRCm39) critical splice acceptor site probably null
R5771:Scaper UTSW 9 55,724,075 (GRCm39) missense probably damaging 1.00
R6534:Scaper UTSW 9 55,791,260 (GRCm39) missense probably benign 0.00
R6557:Scaper UTSW 9 55,458,134 (GRCm39) missense probably benign 0.02
R6651:Scaper UTSW 9 55,765,788 (GRCm39) missense probably benign 0.05
R6796:Scaper UTSW 9 55,771,711 (GRCm39) missense probably benign 0.00
R6962:Scaper UTSW 9 55,767,055 (GRCm39) missense probably benign 0.01
R7145:Scaper UTSW 9 55,819,395 (GRCm39) missense unknown
R7199:Scaper UTSW 9 55,745,460 (GRCm39) nonsense probably null
R7356:Scaper UTSW 9 55,799,495 (GRCm39) missense unknown
R7426:Scaper UTSW 9 55,669,561 (GRCm39) nonsense probably null
R7503:Scaper UTSW 9 55,715,038 (GRCm39) missense probably damaging 0.98
R7844:Scaper UTSW 9 55,722,732 (GRCm39) missense probably benign 0.04
R7966:Scaper UTSW 9 55,669,611 (GRCm39) missense probably damaging 0.98
R7992:Scaper UTSW 9 55,765,438 (GRCm39) missense probably benign 0.02
R8081:Scaper UTSW 9 55,823,330 (GRCm39) missense unknown
R8189:Scaper UTSW 9 55,819,404 (GRCm39) missense probably damaging 1.00
R8294:Scaper UTSW 9 55,517,280 (GRCm39) missense possibly damaging 0.62
R8351:Scaper UTSW 9 55,724,088 (GRCm39) missense possibly damaging 0.92
R8451:Scaper UTSW 9 55,724,088 (GRCm39) missense possibly damaging 0.92
R8473:Scaper UTSW 9 55,458,131 (GRCm39) missense probably damaging 1.00
R8476:Scaper UTSW 9 55,669,575 (GRCm39) missense probably damaging 1.00
R8504:Scaper UTSW 9 55,771,722 (GRCm39) missense probably benign
R9058:Scaper UTSW 9 55,722,762 (GRCm39) missense probably damaging 1.00
R9071:Scaper UTSW 9 55,771,803 (GRCm39) missense probably benign
R9099:Scaper UTSW 9 55,669,616 (GRCm39) missense probably damaging 0.98
R9104:Scaper UTSW 9 55,819,400 (GRCm39) missense unknown
R9516:Scaper UTSW 9 55,593,275 (GRCm39) missense probably benign 0.05
R9685:Scaper UTSW 9 55,771,835 (GRCm39) missense probably benign 0.10
X0012:Scaper UTSW 9 55,563,214 (GRCm39) missense probably damaging 0.98
X0052:Scaper UTSW 9 55,723,948 (GRCm39) missense probably damaging 1.00
Z1176:Scaper UTSW 9 55,463,532 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02