Incidental Mutation 'IGL03370:Fbxw26'
ID420246
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw26
Ensembl Gene ENSMUSG00000059547
Gene NameF-box and WD-40 domain protein 26
SynonymsGm5163
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03370
Quality Score
Status
Chromosome9
Chromosomal Location109717566-109746089 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 109746019 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Leucine at position 13 (I13L)
Ref Sequence ENSEMBL: ENSMUSP00000071811 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071917]
Predicted Effect probably damaging
Transcript: ENSMUST00000071917
AA Change: I13L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: I13L

DomainStartEndE-ValueType
FBOX 5 45 2.54e-6 SMART
SCOP:d1tbga_ 128 249 1e-5 SMART
Blast:WD40 137 176 4e-7 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl7b A G 4: 56,741,173 Y62H probably damaging Het
Cfap52 A G 11: 67,939,055 I296T probably damaging Het
Col14a1 A G 15: 55,488,541 probably null Het
Daam2 G T 17: 49,486,501 D329E probably benign Het
Defb26 A G 2: 152,507,982 V126A probably benign Het
Fasn A T 11: 120,812,795 I1535N possibly damaging Het
Fbxw15 A T 9: 109,555,151 Y431N probably benign Het
Fggy A T 4: 95,822,064 H300L probably damaging Het
Fndc3c1 G A X: 106,420,701 T1277I probably benign Het
Gigyf1 G T 5: 137,525,690 V1041L possibly damaging Het
Kif26b G A 1: 178,915,381 R567H probably benign Het
Kpna6 G A 4: 129,655,521 T156M probably damaging Het
Lrrc37a C T 11: 103,497,673 E2309K unknown Het
Lyn T C 4: 3,780,931 Y357H possibly damaging Het
Mki67 A G 7: 135,695,490 V2605A probably benign Het
Mtmr3 T C 11: 4,487,385 D1023G probably damaging Het
Muc5b G T 7: 141,864,777 R3820L probably benign Het
Mus81 A G 19: 5,484,963 probably benign Het
Nup188 A G 2: 30,340,641 Y1397C possibly damaging Het
Pgd A T 4: 149,165,228 V29D probably damaging Het
Plch2 T C 4: 154,986,914 S244G probably benign Het
Rapgef5 C A 12: 117,730,559 T372K probably damaging Het
Rb1 A G 14: 73,282,866 probably null Het
Ryr3 A T 2: 112,756,599 V2680E possibly damaging Het
Sgsm3 A C 15: 81,011,654 probably null Het
Slc38a1 C T 15: 96,579,347 V362I possibly damaging Het
Sun1 T A 5: 139,231,131 D308E probably damaging Het
Tns1 C T 1: 73,985,894 V387M probably damaging Het
Ttn C A 2: 76,751,739 G22937C probably damaging Het
Ubr1 C A 2: 120,895,160 A1258S probably benign Het
Vmn2r74 A G 7: 85,958,057 F153L probably benign Het
Other mutations in Fbxw26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00589:Fbxw26 APN 9 109717948 utr 3 prime probably benign
IGL01072:Fbxw26 APN 9 109723837 missense probably damaging 1.00
IGL01151:Fbxw26 APN 9 109721780 missense possibly damaging 0.50
IGL01394:Fbxw26 APN 9 109717989 missense probably benign 0.00
IGL01432:Fbxw26 APN 9 109717975 missense probably benign 0.32
IGL02559:Fbxw26 APN 9 109722164 missense probably benign 0.34
IGL02981:Fbxw26 APN 9 109744794 missense probably benign 0.09
R0023:Fbxw26 UTSW 9 109718011 missense probably benign 0.01
R0087:Fbxw26 UTSW 9 109724938 missense probably benign
R0369:Fbxw26 UTSW 9 109723712 critical splice donor site probably null
R0446:Fbxw26 UTSW 9 109743720 missense probably benign 0.03
R1844:Fbxw26 UTSW 9 109724878 missense probably benign 0.42
R1891:Fbxw26 UTSW 9 109722164 missense probably benign 0.34
R2042:Fbxw26 UTSW 9 109732704 missense probably damaging 1.00
R3615:Fbxw26 UTSW 9 109743760 nonsense probably null
R3616:Fbxw26 UTSW 9 109743760 nonsense probably null
R4659:Fbxw26 UTSW 9 109744871 missense probably damaging 0.97
R4785:Fbxw26 UTSW 9 109724800 missense possibly damaging 0.50
R4898:Fbxw26 UTSW 9 109717969 missense possibly damaging 0.95
R5791:Fbxw26 UTSW 9 109745153 missense probably damaging 1.00
R5818:Fbxw26 UTSW 9 109732566 missense probably benign
R5921:Fbxw26 UTSW 9 109746018 missense probably damaging 1.00
R5983:Fbxw26 UTSW 9 109717965 missense possibly damaging 0.49
R6145:Fbxw26 UTSW 9 109732623 missense probably benign 0.09
R6209:Fbxw26 UTSW 9 109717965 missense possibly damaging 0.49
R6412:Fbxw26 UTSW 9 109732647 missense probably damaging 0.97
R6842:Fbxw26 UTSW 9 109724920 missense probably damaging 1.00
R7228:Fbxw26 UTSW 9 109724944 missense possibly damaging 0.93
R7451:Fbxw26 UTSW 9 109732623 missense probably benign 0.03
R7467:Fbxw26 UTSW 9 109732697 missense probably benign 0.00
R8397:Fbxw26 UTSW 9 109732647 missense probably damaging 0.99
X0020:Fbxw26 UTSW 9 109732632 missense probably damaging 1.00
Posted On2016-08-02