Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03372:Vmn1r75'

420320

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r75

Ensembl Gene

ENSMUSG00000043308

Gene Name

vomeronasal 1 receptor 75

Synonyms

V1rg6

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL03372

Quality Score

Status

Chromosome

Chromosomal Location

11874630-11884307 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 11880569 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 76 (D76G)

Ref Sequence

ENSEMBL: ENSMUSP00000154577 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057229] [ENSMUST00000226622] [ENSMUST00000226855] [ENSMUST00000227611] [ENSMUST00000228268] [ENSMUST00000228463] [ENSMUST00000228646]

AlphaFold

Q8R289

Predicted Effect

probably benign
Transcript: ENSMUST00000057229
AA Change: D76G

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000051510
Gene: ENSMUSG00000043308
AA Change: D76G

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	294	2.9e-10	PFAM
Pfam:V1R	35	293	1e-29	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226622
AA Change: D76G

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000226855
AA Change: D76G

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000227611
AA Change: D34G

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000228268
AA Change: D34G

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000228463
AA Change: D76G

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000228646
AA Change: D34G

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb2	C	T	4: 130,017,569	A1161V	probably benign	Het
Alpi	A	G	1: 87,100,628		probably benign	Het
Asxl1	A	T	2: 153,400,413	N961I	probably damaging	Het
Bcl2l10	A	G	9: 75,348,047	I49V	probably benign	Het
Bod1l	T	C	5: 41,805,235		probably benign	Het
Ccl20	A	G	1: 83,117,876	M54V	probably benign	Het
Cep72	A	C	13: 74,043,518	L200V	possibly damaging	Het
Clic4	T	C	4: 135,218,614	D164G	probably damaging	Het
Col5a3	G	A	9: 20,775,328	P1334S	unknown	Het
Dab2	T	C	15: 6,429,549	L293P	probably damaging	Het
Ddx50	A	T	10: 62,643,330	S140T	probably benign	Het
Dnah6	A	T	6: 73,075,850	M2897K	probably benign	Het
Dnmt3a	A	G	12: 3,902,666	E721G	probably damaging	Het
Esyt3	A	T	9: 99,336,056		probably benign	Het
Fat4	G	T	3: 38,889,134	K725N	possibly damaging	Het
Fezf1	T	C	6: 23,246,910	I308V	probably damaging	Het
Fut2	C	T	7: 45,650,769	G193E	possibly damaging	Het
Gapdhs	T	C	7: 30,733,249		probably benign	Het
Gm10109	A	T	7: 44,221,702		probably benign	Het
Gpd2	G	A	2: 57,355,507	V405I	probably damaging	Het
Gtf2e1	T	C	16: 37,535,715		probably benign	Het
Iqca	A	G	1: 90,144,969	I63T	possibly damaging	Het
Kcmf1	A	C	6: 72,849,563	L161R	probably damaging	Het
Kif19a	G	T	11: 114,779,218	V80L	probably damaging	Het
Kif21a	A	T	15: 90,956,376	M1179K	probably benign	Het
Krtap19-2	A	G	16: 88,873,886		probably benign	Het
Ksr2	T	A	5: 117,702,718	I575N	possibly damaging	Het
L3mbtl1	A	T	2: 162,971,157		probably benign	Het
Larp1b	A	T	3: 41,024,527	H6L	possibly damaging	Het
Map4k2	T	A	19: 6,342,249		probably benign	Het
Mdh1b	T	C	1: 63,719,995	H146R	possibly damaging	Het
Morc2a	T	C	11: 3,681,813		probably benign	Het
Mvd	A	G	8: 122,443,374		probably benign	Het
Myo7b	C	T	18: 31,998,601	S514N	probably damaging	Het
Nav1	A	T	1: 135,450,903	I1610K	probably damaging	Het
Nbas	T	C	12: 13,534,472	L2095P	probably damaging	Het
Nrros	T	C	16: 32,144,770	N115S	probably damaging	Het
Olfr472	T	C	7: 107,903,370	Y218H	probably damaging	Het
Otud6b	A	C	4: 14,812,519	I276R	possibly damaging	Het
P2rx6	G	A	16: 17,567,492	E150K	probably damaging	Het
Pan2	T	A	10: 128,315,127	L771Q	probably benign	Het
Pbrm1	T	A	14: 31,085,019	N1087K	probably benign	Het
Pcdhb5	G	T	18: 37,320,660	R31L	probably benign	Het
Proser3	A	C	7: 30,543,568	S195A	probably damaging	Het
Rad50	T	C	11: 53,695,294	K292E	probably benign	Het
Rbm27	G	A	18: 42,305,716	R394H	probably damaging	Het
Samd9l	A	G	6: 3,375,314	I649T	probably damaging	Het
Skint3	G	A	4: 112,255,906		probably benign	Het
Slc4a4	T	A	5: 89,156,426	L576Q	probably damaging	Het
Snx2	A	G	18: 53,216,391	D408G	probably damaging	Het
Taar2	T	C	10: 23,941,171	V203A	probably benign	Het
Tdrd6	C	T	17: 43,625,568	V1530M	probably damaging	Het
Tsc2	A	C	17: 24,619,470	L515R	probably damaging	Het
Unc13a	A	T	8: 71,655,709	M500K	probably damaging	Het
Whrn	T	C	4: 63,418,618	D127G	probably damaging	Het

Other mutations in Vmn1r75

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01901:Vmn1r75	APN	7	11880812	missense	probably damaging	1.00
IGL02175:Vmn1r75	APN	7	11880847	missense	probably damaging	1.00
IGL02399:Vmn1r75	APN	7	11881166	missense	possibly damaging	0.82
IGL02648:Vmn1r75	APN	7	11881164	missense	probably benign	0.04
R0538:Vmn1r75	UTSW	7	11880870	missense	probably damaging	0.97
R0599:Vmn1r75	UTSW	7	11881262	splice site	probably null
R3910:Vmn1r75	UTSW	7	11880830	missense	possibly damaging	0.92
R4491:Vmn1r75	UTSW	7	11880982	missense	probably damaging	0.97
R5566:Vmn1r75	UTSW	7	11880480	missense	probably damaging	1.00
R6051:Vmn1r75	UTSW	7	11881051	missense	probably damaging	1.00
R6230:Vmn1r75	UTSW	7	11881039	missense	probably damaging	0.98
R6490:Vmn1r75	UTSW	7	11881076	missense	probably damaging	1.00
R6570:Vmn1r75	UTSW	7	11880956	missense	probably damaging	0.98
R7184:Vmn1r75	UTSW	7	11880988	nonsense	probably null
R7189:Vmn1r75	UTSW	7	11880548	missense	possibly damaging	0.93
R7501:Vmn1r75	UTSW	7	11881070	missense	possibly damaging	0.67
R7973:Vmn1r75	UTSW	7	11881034	missense	probably benign	0.04
R7997:Vmn1r75	UTSW	7	11880673	missense	probably damaging	1.00
R8372:Vmn1r75	UTSW	7	11880730	missense	probably benign	0.10
R8812:Vmn1r75	UTSW	7	11880703	missense	possibly damaging	0.54
R8932:Vmn1r75	UTSW	7	11880911	missense	probably damaging	1.00
R9089:Vmn1r75	UTSW	7	11880526	missense	probably damaging	1.00
R9129:Vmn1r75	UTSW	7	11880586	missense	probably benign	0.15

Posted On

2016-08-02