Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03373:Vmn1r78'

420380

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r78

Ensembl Gene

ENSMUSG00000061602

Gene Name

vomeronasal 1 receptor 78

Synonyms

V1rg7

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL03373

Quality Score

Status

Chromosome

Chromosomal Location

12150257-12159959 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 12153343 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 294 (S294P)

Ref Sequence

ENSEMBL: ENSMUSP00000154797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000078039
AA Change: S294P

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: S294P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	5.7e-8	PFAM
Pfam:V1R	12	301	1.5e-29	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209489

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228244
AA Change: S294P

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228664
AA Change: S294P

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam6a	A	T	12: 113,545,552	Y515F	possibly damaging	Het
Adgrv1	A	G	13: 81,563,632	V1075A	probably damaging	Het
Alox8	T	C	11: 69,186,617	T436A	probably benign	Het
Cdc7	T	A	5: 106,972,919		probably benign	Het
Cdhr1	T	A	14: 37,096,300	D65V	possibly damaging	Het
Dnase1	A	G	16: 4,039,843	E278G	probably damaging	Het
Eif3g	A	T	9: 20,894,426		probably benign	Het
Flnb	G	A	14: 7,890,867		probably null	Het
Hars2	G	T	18: 36,785,945	R86L	probably damaging	Het
Lmod1	C	T	1: 135,364,526	A373V	possibly damaging	Het
Mdga2	A	G	12: 66,716,722	I200T	probably damaging	Het
Mup1	T	G	4: 60,501,850		probably benign	Het
Nat8f5	A	C	6: 85,817,547	S144A	probably benign	Het
Ndnf	A	C	6: 65,704,288	Y517S	possibly damaging	Het
Nedd4l	G	A	18: 65,181,320		probably benign	Het
Nlrp4g	A	T	9: 124,349,853		noncoding transcript	Het
Nob1	C	T	8: 107,418,046		probably benign	Het
Nploc4	G	A	11: 120,409,629	R326*	probably null	Het
Obox3	A	T	7: 15,625,790	V318D	probably benign	Het
Olfr1122	T	C	2: 87,388,233	F176S	probably damaging	Het
Olfr512	G	A	7: 108,714,132	V248I	probably damaging	Het
Pgm2	T	C	4: 99,961,544	I130T	probably damaging	Het
Ptprk	A	T	10: 28,566,537	D845V	probably damaging	Het
Ptx4	T	A	17: 25,120,899	S17T	probably benign	Het
Rasgrf1	T	C	9: 90,017,031		probably benign	Het
Rfx6	A	G	10: 51,720,000	T426A	probably damaging	Het
Sfpq	C	A	4: 127,026,785	R564S	possibly damaging	Het
Spint2	A	G	7: 29,258,209		probably benign	Het
Vmn1r27	A	G	6: 58,215,704	I105T	probably damaging	Het
Vmn2r40	T	C	7: 8,920,093	D423G	probably benign	Het

Other mutations in Vmn1r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01129:Vmn1r78	APN	7	12153238	missense	probably benign	0.10
IGL02019:Vmn1r78	APN	7	12152707	missense	probably damaging	0.99
IGL02143:Vmn1r78	APN	7	12152480	missense	probably benign
IGL02154:Vmn1r78	APN	7	12152545	missense	probably benign	0.22
IGL02290:Vmn1r78	APN	7	12153155	missense	probably damaging	1.00
IGL03012:Vmn1r78	APN	7	12153364	missense	probably benign	0.32
IGL03256:Vmn1r78	APN	7	12152798	missense	probably damaging	1.00
IGL03384:Vmn1r78	APN	7	12153209	missense	possibly damaging	0.94
R0016:Vmn1r78	UTSW	7	12153352	missense	probably benign	0.02
R1445:Vmn1r78	UTSW	7	12152581	missense	possibly damaging	0.64
R1748:Vmn1r78	UTSW	7	12153323	missense	probably damaging	1.00
R2017:Vmn1r78	UTSW	7	12153343	missense	possibly damaging	0.86
R2032:Vmn1r78	UTSW	7	12153283	missense	probably benign	0.00
R2198:Vmn1r78	UTSW	7	12152560	missense	probably benign	0.06
R4330:Vmn1r78	UTSW	7	12152459	splice site	probably null
R4564:Vmn1r78	UTSW	7	12152558	missense	probably damaging	1.00
R4769:Vmn1r78	UTSW	7	12152798	missense	probably damaging	1.00
R4801:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4802:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R5648:Vmn1r78	UTSW	7	12152766	missense	possibly damaging	0.92
R6561:Vmn1r78	UTSW	7	12152899	missense	probably damaging	1.00
R6869:Vmn1r78	UTSW	7	12152749	missense	probably benign	0.01
R6945:Vmn1r78	UTSW	7	12152905	missense	probably benign	0.01
R7793:Vmn1r78	UTSW	7	12153314	missense	probably benign	0.01
R7954:Vmn1r78	UTSW	7	12153300	nonsense	probably null
Z1088:Vmn1r78	UTSW	7	12152714	missense	probably damaging	1.00

Posted On

2016-08-02