Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03373:Eif3g'

420402

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Eif3g

Ensembl Gene

ENSMUSG00000070319

Gene Name

eukaryotic translation initiation factor 3, subunit G

Synonyms

44kDa, D0Jmb4, Eif3s4, p44, TU-189B2

Accession Numbers

Essential gene?

Probably essential (E-score: 0.963) question?

Stock #

IGL03373

Quality Score

Status

Chromosome

Chromosomal Location

20805645-20809886 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to T at 20805722 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149658 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000004203] [ENSMUST00000004206] [ENSMUST00000214331]

AlphaFold

Q9Z1D1

Predicted Effect

probably benign
Transcript: ENSMUST00000004203

SMART Domains

Protein: ENSMUSP00000004203
Gene: ENSMUSG00000004100

Domain	Start	End	E-Value	Type
Brix	32	286	1.13e-77	SMART
Blast:Brix	321	429	6e-9	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000004206

SMART Domains

Protein: ENSMUSP00000004206
Gene: ENSMUSG00000070319

Domain	Start	End	E-Value	Type
Pfam:eIF3g	56	175	5.5e-45	PFAM
RRM	240	313	1.49e-22	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000104514

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135608

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145231

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147780

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153227

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158946

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000157047

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213454

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213882

Predicted Effect

probably benign
Transcript: ENSMUST00000214331

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216133

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam6a	A	T	12: 113,509,172 (GRCm39)	Y515F	possibly damaging	Het
Adgrv1	A	G	13: 81,711,751 (GRCm39)	V1075A	probably damaging	Het
Alox8	T	C	11: 69,077,443 (GRCm39)	T436A	probably benign	Het
Cdc7	T	A	5: 107,120,785 (GRCm39)		probably benign	Het
Cdhr1	T	A	14: 36,818,257 (GRCm39)	D65V	possibly damaging	Het
Dnase1	A	G	16: 3,857,707 (GRCm39)	E278G	probably damaging	Het
Flnb	G	A	14: 7,890,867 (GRCm38)		probably null	Het
Hars2	G	T	18: 36,918,998 (GRCm39)	R86L	probably damaging	Het
Lmod1	C	T	1: 135,292,264 (GRCm39)	A373V	possibly damaging	Het
Mdga2	A	G	12: 66,763,496 (GRCm39)	I200T	probably damaging	Het
Mup1	T	G	4: 60,457,849 (GRCm39)		probably benign	Het
Nat8f5	A	C	6: 85,794,529 (GRCm39)	S144A	probably benign	Het
Ndnf	A	C	6: 65,681,272 (GRCm39)	Y517S	possibly damaging	Het
Nedd4l	G	A	18: 65,314,391 (GRCm39)		probably benign	Het
Nlrp4g	A	T	9: 124,349,853 (GRCm38)		noncoding transcript	Het
Nob1	C	T	8: 108,144,678 (GRCm39)		probably benign	Het
Nploc4	G	A	11: 120,300,455 (GRCm39)	R326*	probably null	Het
Obox3	A	T	7: 15,359,715 (GRCm39)	V318D	probably benign	Het
Or10a3m	G	A	7: 108,313,339 (GRCm39)	V248I	probably damaging	Het
Or10ag57	T	C	2: 87,218,577 (GRCm39)	F176S	probably damaging	Het
Pgm1	T	C	4: 99,818,741 (GRCm39)	I130T	probably damaging	Het
Ptprk	A	T	10: 28,442,533 (GRCm39)	D845V	probably damaging	Het
Ptx4	T	A	17: 25,339,873 (GRCm39)	S17T	probably benign	Het
Rasgrf1	T	C	9: 89,899,084 (GRCm39)		probably benign	Het
Rfx6	A	G	10: 51,596,096 (GRCm39)	T426A	probably damaging	Het
Sfpq	C	A	4: 126,920,578 (GRCm39)	R564S	possibly damaging	Het
Spint2	A	G	7: 28,957,634 (GRCm39)		probably benign	Het
Vmn1r27	A	G	6: 58,192,689 (GRCm39)	I105T	probably damaging	Het
Vmn1r78	T	C	7: 11,887,270 (GRCm39)	S294P	possibly damaging	Het
Vmn2r40	T	C	7: 8,923,092 (GRCm39)	D423G	probably benign	Het

Other mutations in Eif3g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0076:Eif3g	UTSW	9	20,809,049 (GRCm39)	missense	probably damaging	0.98
R0076:Eif3g	UTSW	9	20,809,049 (GRCm39)	missense	probably damaging	0.98
R0332:Eif3g	UTSW	9	20,809,280 (GRCm39)	splice site	probably benign
R2343:Eif3g	UTSW	9	20,806,450 (GRCm39)	missense	probably damaging	1.00
R3746:Eif3g	UTSW	9	20,805,993 (GRCm39)	missense	probably benign	0.04
R4087:Eif3g	UTSW	9	20,809,248 (GRCm39)	missense	possibly damaging	0.56
R4151:Eif3g	UTSW	9	20,806,429 (GRCm39)	missense	probably benign	0.03
R8175:Eif3g	UTSW	9	20,809,026 (GRCm39)	missense	probably damaging	0.98
R8530:Eif3g	UTSW	9	20,809,026 (GRCm39)	missense	possibly damaging	0.71
R9025:Eif3g	UTSW	9	20,807,426 (GRCm39)	missense	probably benign	0.12
R9522:Eif3g	UTSW	9	20,809,452 (GRCm39)	missense	probably benign
R9522:Eif3g	UTSW	9	20,809,451 (GRCm39)	missense	probably benign

Posted On

2016-08-02