Incidental Mutation 'IGL03375:Gm960'
ID420460
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm960
Ensembl Gene ENSMUSG00000071691
Gene Namepredicted gene 960
SynonymsLOC381196
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.082) question?
Stock #IGL03375
Quality Score
Status
Chromosome19
Chromosomal Location4625734-4698668 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 4698178 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 164 (E164G)
Ref Sequence ENSEMBL: ENSMUSP00000136515 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096325] [ENSMUST00000177696] [ENSMUST00000225896]
Predicted Effect unknown
Transcript: ENSMUST00000096325
AA Change: E10G
SMART Domains Protein: ENSMUSP00000094049
Gene: ENSMUSG00000071691
AA Change: E10G

DomainStartEndE-ValueType
Pfam:DUF4554 120 162 1.6e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177696
AA Change: E164G

PolyPhen 2 Score 0.258 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000136515
Gene: ENSMUSG00000071691
AA Change: E164G

DomainStartEndE-ValueType
low complexity region 65 79 N/A INTRINSIC
low complexity region 106 122 N/A INTRINSIC
low complexity region 128 140 N/A INTRINSIC
Pfam:DUF4554 274 719 5.3e-206 PFAM
low complexity region 720 731 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000225896
AA Change: E10G
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired double-strand break formation that imapires female and male meiosis and results in no spermatids and reduced primary and primordial follicle numbers. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap31 A G 16: 38,602,828 S959P probably damaging Het
Arrb2 G A 11: 70,436,179 G24D probably damaging Het
Catsper4 A G 4: 134,218,208 I180T probably damaging Het
Chst15 G A 7: 132,270,457 Q32* probably null Het
Cntnap5c A T 17: 58,162,205 Y594F possibly damaging Het
Cse1l T A 2: 166,943,057 probably benign Het
Dab1 A T 4: 104,681,601 I201F possibly damaging Het
Eif2ak4 T C 2: 118,422,318 V457A probably benign Het
Fkbp1b T C 12: 4,838,220 probably benign Het
Fryl C A 5: 73,088,449 V1122F possibly damaging Het
Gas2l2 A G 11: 83,426,210 probably benign Het
Gstt2 A T 10: 75,832,821 probably null Het
Hcst T G 7: 30,418,611 probably benign Het
Hectd4 A G 5: 121,328,382 E2420G possibly damaging Het
Hist2h4 T C 3: 96,263,142 T55A possibly damaging Het
Ifi206 A T 1: 173,480,778 S551T probably benign Het
Itgb3bp A G 4: 99,769,487 probably benign Het
Krtap6-2 A G 16: 89,419,756 Y108H unknown Het
Krtap6-5 T G 16: 89,047,852 probably benign Het
Muc5b A G 7: 141,861,962 T2882A possibly damaging Het
Nup214 C T 2: 32,010,221 T854M probably damaging Het
Olfml2b A G 1: 170,649,832 K179E probably benign Het
Olfr1281 A T 2: 111,328,884 H155L probably damaging Het
Olfr149 A G 9: 39,702,575 S65P probably damaging Het
Per2 A T 1: 91,424,228 I852K possibly damaging Het
Pkhd1 A T 1: 20,117,023 I3687N probably damaging Het
Slc7a2 A T 8: 40,916,373 S622C probably damaging Het
Smarcc2 G A 10: 128,482,912 V719I probably damaging Het
Syne2 T C 12: 75,925,435 I1033T possibly damaging Het
Tmod1 T C 4: 46,096,999 I264T probably damaging Het
Tmtc3 G A 10: 100,447,719 A658V possibly damaging Het
Tpm3 A G 3: 90,073,772 E56G possibly damaging Het
Tra2b T C 16: 22,247,243 probably benign Het
Trmu T A 15: 85,894,937 Y262N possibly damaging Het
Uox C T 3: 146,625,835 T213I probably damaging Het
Vps13d A G 4: 145,091,947 W2R probably damaging Het
Other mutations in Gm960
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01303:Gm960 APN 19 4659482 missense possibly damaging 0.93
IGL01678:Gm960 APN 19 4672165 missense possibly damaging 0.94
IGL02160:Gm960 APN 19 4663584 missense probably damaging 1.00
IGL02308:Gm960 APN 19 4663555 missense probably damaging 1.00
R0485:Gm960 UTSW 19 4658414 missense probably damaging 1.00
R0671:Gm960 UTSW 19 4626188 missense probably damaging 0.97
R1583:Gm960 UTSW 19 4652171 missense probably damaging 1.00
R2049:Gm960 UTSW 19 4698605 utr 5 prime probably benign
R3956:Gm960 UTSW 19 4692497 missense probably benign 0.13
R4554:Gm960 UTSW 19 4649819 missense possibly damaging 0.95
R4635:Gm960 UTSW 19 4698496 utr 5 prime probably benign
R4717:Gm960 UTSW 19 4625873 unclassified probably benign
R4996:Gm960 UTSW 19 4626084 missense probably benign 0.09
R5133:Gm960 UTSW 19 4658421 missense probably damaging 1.00
R5752:Gm960 UTSW 19 4626020 missense probably benign 0.28
R6277:Gm960 UTSW 19 4627222 nonsense probably null
R6348:Gm960 UTSW 19 4672078 missense probably damaging 0.96
R7386:Gm960 UTSW 19 4663558 nonsense probably null
R7673:Gm960 UTSW 19 4645633 missense probably damaging 1.00
Posted On2016-08-02