Incidental Mutation 'IGL03375:Gstt2'
ID420474
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gstt2
Ensembl Gene ENSMUSG00000033318
Gene Nameglutathione S-transferase, theta 2
SynonymsYrs, mGSTT2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03375
Quality Score
Status
Chromosome10
Chromosomal Location75831114-75837424 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 75832821 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038257] [ENSMUST00000218500] [ENSMUST00000220195] [ENSMUST00000220440]
Predicted Effect probably null
Transcript: ENSMUST00000038257
SMART Domains Protein: ENSMUSP00000046324
Gene: ENSMUSG00000033318

DomainStartEndE-ValueType
Pfam:GST_N 1 76 4.6e-12 PFAM
Pfam:GST_N_3 5 84 1.4e-11 PFAM
Pfam:GST_N_2 11 77 3.5e-10 PFAM
Pfam:GST_C 73 199 1.5e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218034
Predicted Effect probably null
Transcript: ENSMUST00000218500
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218646
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218745
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219343
Predicted Effect probably benign
Transcript: ENSMUST00000220195
AA Change: M71K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably null
Transcript: ENSMUST00000220440
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a disruption in this gene display a normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap31 A G 16: 38,602,828 S959P probably damaging Het
Arrb2 G A 11: 70,436,179 G24D probably damaging Het
Catsper4 A G 4: 134,218,208 I180T probably damaging Het
Chst15 G A 7: 132,270,457 Q32* probably null Het
Cntnap5c A T 17: 58,162,205 Y594F possibly damaging Het
Cse1l T A 2: 166,943,057 probably benign Het
Dab1 A T 4: 104,681,601 I201F possibly damaging Het
Eif2ak4 T C 2: 118,422,318 V457A probably benign Het
Fkbp1b T C 12: 4,838,220 probably benign Het
Fryl C A 5: 73,088,449 V1122F possibly damaging Het
Gas2l2 A G 11: 83,426,210 probably benign Het
Gm960 T C 19: 4,698,178 E164G probably benign Het
Hcst T G 7: 30,418,611 probably benign Het
Hectd4 A G 5: 121,328,382 E2420G possibly damaging Het
Hist2h4 T C 3: 96,263,142 T55A possibly damaging Het
Ifi206 A T 1: 173,480,778 S551T probably benign Het
Itgb3bp A G 4: 99,769,487 probably benign Het
Krtap6-2 A G 16: 89,419,756 Y108H unknown Het
Krtap6-5 T G 16: 89,047,852 probably benign Het
Muc5b A G 7: 141,861,962 T2882A possibly damaging Het
Nup214 C T 2: 32,010,221 T854M probably damaging Het
Olfml2b A G 1: 170,649,832 K179E probably benign Het
Olfr1281 A T 2: 111,328,884 H155L probably damaging Het
Olfr149 A G 9: 39,702,575 S65P probably damaging Het
Per2 A T 1: 91,424,228 I852K possibly damaging Het
Pkhd1 A T 1: 20,117,023 I3687N probably damaging Het
Slc7a2 A T 8: 40,916,373 S622C probably damaging Het
Smarcc2 G A 10: 128,482,912 V719I probably damaging Het
Syne2 T C 12: 75,925,435 I1033T possibly damaging Het
Tmod1 T C 4: 46,096,999 I264T probably damaging Het
Tmtc3 G A 10: 100,447,719 A658V possibly damaging Het
Tpm3 A G 3: 90,073,772 E56G possibly damaging Het
Tra2b T C 16: 22,247,243 probably benign Het
Trmu T A 15: 85,894,937 Y262N possibly damaging Het
Uox C T 3: 146,625,835 T213I probably damaging Het
Vps13d A G 4: 145,091,947 W2R probably damaging Het
Other mutations in Gstt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01571:Gstt2 APN 10 75834171 splice site probably benign
IGL01710:Gstt2 APN 10 75833745 splice site probably benign
IGL02642:Gstt2 APN 10 75832818 missense probably benign 0.17
R0389:Gstt2 UTSW 10 75832432 missense probably damaging 1.00
R1751:Gstt2 UTSW 10 75834264 missense probably damaging 1.00
R1767:Gstt2 UTSW 10 75834264 missense probably damaging 1.00
R1971:Gstt2 UTSW 10 75832665 missense probably benign 0.10
R2367:Gstt2 UTSW 10 75832690 missense probably benign 0.44
R5027:Gstt2 UTSW 10 75831892 missense probably damaging 0.99
R7457:Gstt2 UTSW 10 75832520 missense probably damaging 1.00
R7579:Gstt2 UTSW 10 75834185 missense probably benign 0.00
R7910:Gstt2 UTSW 10 75831902 missense probably benign 0.25
R7912:Gstt2 UTSW 10 75832584 missense probably benign 0.27
R7991:Gstt2 UTSW 10 75831902 missense probably benign 0.25
R7993:Gstt2 UTSW 10 75832584 missense probably benign 0.27
Posted On2016-08-02