Incidental Mutation 'IGL03376:Tns4'
ID 420500
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tns4
Ensembl Gene ENSMUSG00000017607
Gene Name tensin 4
Synonyms 9930017A07Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.392) question?
Stock # IGL03376
Quality Score
Status
Chromosome 11
Chromosomal Location 99065678-99089306 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99078556 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 360 (S360G)
Ref Sequence ENSEMBL: ENSMUSP00000017751 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017751]
AlphaFold Q8BZ33
Predicted Effect probably benign
Transcript: ENSMUST00000017751
AA Change: S360G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000017751
Gene: ENSMUSG00000017607
AA Change: S360G

DomainStartEndE-ValueType
low complexity region 63 72 N/A INTRINSIC
low complexity region 271 304 N/A INTRINSIC
SH2 427 527 6.95e-18 SMART
Pfam:PTB 562 695 1.6e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000107465
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153351
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp6v1b2 T C 8: 69,102,159 probably benign Het
Ccdc122 A G 14: 77,068,912 E41G probably damaging Het
Cdh3 C T 8: 106,541,404 T357I probably benign Het
Cfap57 T A 4: 118,584,720 Q717L probably damaging Het
Cfap58 A T 19: 48,034,725 T859S possibly damaging Het
Cmtr1 C T 17: 29,691,411 R497C probably benign Het
Csmd2 T C 4: 128,517,671 I2494T probably benign Het
Dmkn C T 7: 30,771,242 T385I possibly damaging Het
Eml3 A G 19: 8,933,790 D260G probably damaging Het
Gbf1 T C 19: 46,262,521 F493L possibly damaging Het
Gjb5 C T 4: 127,356,255 R32H probably damaging Het
Hpx C T 7: 105,592,251 probably benign Het
Ikzf3 T A 11: 98,488,953 H163L probably damaging Het
Irak3 G A 10: 120,146,636 probably benign Het
Itih5 G A 2: 10,206,773 V275I probably benign Het
Klc1 G T 12: 111,775,953 E174D probably damaging Het
Ly6g6e A G 17: 35,078,232 *108W probably null Het
Mcph1 T C 8: 18,596,973 S31P probably damaging Het
Mettl4 A T 17: 94,735,371 S346T probably damaging Het
Myo3a A T 2: 22,600,074 probably benign Het
Olfr703 T A 7: 106,845,470 N286K probably damaging Het
Otol1 A G 3: 70,027,512 E279G probably damaging Het
Pappa T A 4: 65,196,834 N722K probably benign Het
Pramel7 A G 2: 87,489,603 S449P probably damaging Het
Rassf9 A G 10: 102,545,198 N145S probably damaging Het
Robo2 T C 16: 73,956,492 I158M probably damaging Het
Sbf1 A G 15: 89,289,016 probably benign Het
Slc30a8 C T 15: 52,306,457 R27* probably null Het
Tmco2 T A 4: 121,109,052 T36S probably benign Het
Vwa8 A G 14: 79,183,134 probably null Het
Wwc1 C T 11: 35,852,294 R900Q possibly damaging Het
Zzef1 T C 11: 72,876,551 probably benign Het
Other mutations in Tns4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00783:Tns4 APN 11 99070395 splice site probably benign
IGL01940:Tns4 APN 11 99068221 missense probably benign 0.43
IGL03130:Tns4 APN 11 99068269 missense probably damaging 1.00
PIT4486001:Tns4 UTSW 11 99071335 missense probably damaging 1.00
R0089:Tns4 UTSW 11 99075198 missense probably damaging 1.00
R1598:Tns4 UTSW 11 99070417 missense probably damaging 1.00
R1872:Tns4 UTSW 11 99080100 missense probably damaging 1.00
R1903:Tns4 UTSW 11 99075575 missense probably damaging 1.00
R1998:Tns4 UTSW 11 99085703 missense probably benign
R2126:Tns4 UTSW 11 99080078 critical splice donor site probably null
R4468:Tns4 UTSW 11 99070415 missense probably benign 0.41
R4973:Tns4 UTSW 11 99075213 missense probably damaging 1.00
R5048:Tns4 UTSW 11 99078779 missense possibly damaging 0.95
R5918:Tns4 UTSW 11 99073671 critical splice donor site probably null
R6088:Tns4 UTSW 11 99073720 missense probably damaging 1.00
R6151:Tns4 UTSW 11 99075550 missense probably benign 0.11
R6586:Tns4 UTSW 11 99080267 missense probably benign 0.00
R7543:Tns4 UTSW 11 99072253 missense probably benign 0.38
R7667:Tns4 UTSW 11 99071470 missense probably damaging 1.00
R7909:Tns4 UTSW 11 99086023 missense probably damaging 0.99
R8206:Tns4 UTSW 11 99085801 missense probably damaging 1.00
Posted On 2016-08-02