Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03377:Cyp2d26'

420523

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2d26

Ensembl Gene

ENSMUSG00000022445

Gene Name

cytochrome P450, family 2, subfamily d, polypeptide 26

Synonyms

1300006E06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.090) question?

Stock #

IGL03377

Quality Score

Status

Chromosome

Chromosomal Location

82674302-82678495 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 82674755 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 409 (E409G)

Ref Sequence

ENSEMBL: ENSMUSP00000006094 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006094] [ENSMUST00000229387] [ENSMUST00000229512]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000006094
AA Change: E409G

PolyPhen 2 Score 0.467 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000006094
Gene: ENSMUSG00000022445
AA Change: E409G

Domain	Start	End	E-Value	Type
transmembrane domain	10	27	N/A	INTRINSIC
Pfam:p450	37	497	3.5e-141	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000229387

Predicted Effect

probably benign
Transcript: ENSMUST00000229512

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230125

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	T	A	5: 105,096,256 (GRCm39)	I489L	probably benign	Het
Acox3	T	C	5: 35,751,676 (GRCm39)	L237P	probably damaging	Het
Ahi1	T	G	10: 20,893,903 (GRCm39)	I878S	possibly damaging	Het
Alox15	T	A	11: 70,240,488 (GRCm39)	Y231F	probably damaging	Het
Asxl1	A	T	2: 153,238,700 (GRCm39)	K342M	probably damaging	Het
Atl2	T	C	17: 80,172,519 (GRCm39)	I150M	probably damaging	Het
Bag6	T	C	17: 35,363,958 (GRCm39)	Y822H	probably damaging	Het
Ccdc171	T	C	4: 83,581,754 (GRCm39)	Y628H	probably damaging	Het
Ceacam5	T	A	7: 17,449,056 (GRCm39)	Y141N	probably benign	Het
Ces1a	A	G	8: 93,766,116 (GRCm39)	V166A	probably damaging	Het
Chrdl2	G	A	7: 99,671,259 (GRCm39)	A126T	probably benign	Het
Dicer1	T	C	12: 104,678,456 (GRCm39)	I621V	probably damaging	Het
Enpp1	T	A	10: 24,536,181 (GRCm39)		probably null	Het
Epha2	T	A	4: 141,049,723 (GRCm39)	S776R	probably benign	Het
Fam107b	A	T	2: 3,779,481 (GRCm39)	E52V	probably damaging	Het
Fam169a	A	G	13: 97,228,381 (GRCm39)	N18S	probably benign	Het
Fbxw21	A	T	9: 108,968,597 (GRCm39)	F460I	probably benign	Het
Fgfr2	A	T	7: 129,800,247 (GRCm39)	I329N	probably damaging	Het
Fndc7	T	C	3: 108,783,848 (GRCm39)	S254G	probably benign	Het
Glis1	T	G	4: 107,489,478 (GRCm39)	H688Q	probably damaging	Het
Grip1	A	G	10: 119,890,937 (GRCm39)	E898G	probably damaging	Het
Gtf2a1l	T	A	17: 89,019,021 (GRCm39)	D368E	probably benign	Het
Gucy1a1	T	A	3: 82,013,322 (GRCm39)	H440L	probably damaging	Het
H2-M10.5	A	T	17: 37,084,377 (GRCm39)	D113V	probably benign	Het
Hook2	G	T	8: 85,727,964 (GRCm39)	E554*	probably null	Het
Itpr2	A	C	6: 146,231,213 (GRCm39)	V1182G	probably damaging	Het
Itpr2	T	A	6: 146,231,256 (GRCm39)	T1135S	probably benign	Het
Kdm4c	T	C	4: 74,189,492 (GRCm39)	I69T	possibly damaging	Het
Klhl31	A	T	9: 77,558,345 (GRCm39)	K354*	probably null	Het
Krt222	T	A	11: 99,127,339 (GRCm39)	K159*	probably null	Het
Loxhd1	A	G	18: 77,529,369 (GRCm39)	E2004G	possibly damaging	Het
Man2a2	A	T	7: 80,008,800 (GRCm39)		probably null	Het
Med24	A	G	11: 98,595,962 (GRCm39)	F963L	possibly damaging	Het
Mphosph8	A	G	14: 56,930,943 (GRCm39)	E744G	probably damaging	Het
Mypn	A	G	10: 63,028,644 (GRCm39)	S140P	probably benign	Het
Npc1	A	G	18: 12,344,878 (GRCm39)	F331L	probably benign	Het
Obscn	C	A	11: 58,890,699 (GRCm39)	G1798W	probably damaging	Het
Or5d18	A	T	2: 87,864,589 (GRCm39)	V298D	probably damaging	Het
Patj	C	T	4: 98,353,341 (GRCm39)	P110L	probably damaging	Het
Pkhd1l1	T	G	15: 44,347,747 (GRCm39)		probably null	Het
Prdm5	A	G	6: 65,836,457 (GRCm39)	H256R	possibly damaging	Het
Ralgps1	A	G	2: 33,062,473 (GRCm39)	Y267H	probably damaging	Het
Rfpl4	T	G	7: 5,113,464 (GRCm39)	Y239S	probably damaging	Het
Rnpepl1	A	T	1: 92,846,953 (GRCm39)	M592L	probably benign	Het
Serpinc1	A	T	1: 160,821,012 (GRCm39)	H32L	probably damaging	Het
Skint5	T	A	4: 113,620,735 (GRCm39)	T660S	unknown	Het
Slc26a2	T	C	18: 61,331,658 (GRCm39)	N591S	probably damaging	Het
Slc9b2	C	T	3: 135,042,119 (GRCm39)	A466V	probably damaging	Het
Slco1a5	T	A	6: 142,180,492 (GRCm39)	T637S	probably benign	Het
Snx25	A	G	8: 46,533,338 (GRCm39)		probably benign	Het
Szt2	T	C	4: 118,259,594 (GRCm39)		probably benign	Het
Vmn1r183	A	G	7: 23,754,817 (GRCm39)	M207V	possibly damaging	Het
Wdcp	T	G	12: 4,900,691 (GRCm39)	Y182*	probably null	Het
Zc3h13	A	G	14: 75,531,416 (GRCm39)	T105A	possibly damaging	Het
Zfp933	T	C	4: 147,913,168 (GRCm39)	K30R	possibly damaging	Het

Other mutations in Cyp2d26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00559:Cyp2d26	APN	15	82,675,244 (GRCm39)	missense	probably benign	0.31
IGL00670:Cyp2d26	APN	15	82,675,942 (GRCm39)	missense	probably benign
IGL01646:Cyp2d26	APN	15	82,675,619 (GRCm39)	missense	probably benign	0.00
IGL01915:Cyp2d26	APN	15	82,674,450 (GRCm39)	missense	probably benign	0.06
IGL01940:Cyp2d26	APN	15	82,676,758 (GRCm39)	missense	probably benign	0.00
IGL02127:Cyp2d26	APN	15	82,675,307 (GRCm39)	missense	probably benign	0.09
IGL02452:Cyp2d26	APN	15	82,676,827 (GRCm39)	missense	probably benign	0.00
IGL03216:Cyp2d26	APN	15	82,677,462 (GRCm39)	missense	probably benign
R0149:Cyp2d26	UTSW	15	82,676,968 (GRCm39)	missense	probably damaging	1.00
R0848:Cyp2d26	UTSW	15	82,674,434 (GRCm39)	missense	probably benign	0.00
R1165:Cyp2d26	UTSW	15	82,678,242 (GRCm39)	missense	probably damaging	1.00
R1217:Cyp2d26	UTSW	15	82,677,068 (GRCm39)	splice site	probably benign
R1780:Cyp2d26	UTSW	15	82,678,208 (GRCm39)	missense	probably damaging	1.00
R2048:Cyp2d26	UTSW	15	82,676,928 (GRCm39)	utr 3 prime	probably benign
R2152:Cyp2d26	UTSW	15	82,676,907 (GRCm39)	critical splice donor site	probably null
R2397:Cyp2d26	UTSW	15	82,678,236 (GRCm39)	missense	probably damaging	1.00
R4702:Cyp2d26	UTSW	15	82,676,648 (GRCm39)	intron	probably benign
R5157:Cyp2d26	UTSW	15	82,675,190 (GRCm39)	missense	probably benign	0.01
R5444:Cyp2d26	UTSW	15	82,676,739 (GRCm39)	missense	probably benign	0.18
R6017:Cyp2d26	UTSW	15	82,674,774 (GRCm39)	missense	possibly damaging	0.68
R6223:Cyp2d26	UTSW	15	82,675,918 (GRCm39)	missense	probably benign	0.04
R6390:Cyp2d26	UTSW	15	82,676,825 (GRCm39)	missense	possibly damaging	0.68
R6473:Cyp2d26	UTSW	15	82,675,968 (GRCm39)	missense	probably benign	0.02
R6858:Cyp2d26	UTSW	15	82,678,284 (GRCm39)	missense	probably damaging	1.00
R6912:Cyp2d26	UTSW	15	82,675,320 (GRCm39)	missense	probably benign	0.16
R6936:Cyp2d26	UTSW	15	82,676,741 (GRCm39)	missense	probably benign	0.14
R6960:Cyp2d26	UTSW	15	82,674,446 (GRCm39)	missense	probably damaging	0.98
R7053:Cyp2d26	UTSW	15	82,676,801 (GRCm39)	missense	probably benign	0.00
R7113:Cyp2d26	UTSW	15	82,674,403 (GRCm39)	missense	probably benign	0.02
R7126:Cyp2d26	UTSW	15	82,678,209 (GRCm39)	missense	probably benign	0.00
R7272:Cyp2d26	UTSW	15	82,676,764 (GRCm39)	missense	probably benign
R7771:Cyp2d26	UTSW	15	82,675,947 (GRCm39)	missense	probably benign
R8695:Cyp2d26	UTSW	15	82,676,907 (GRCm39)	critical splice donor site	probably benign
R9466:Cyp2d26	UTSW	15	82,674,424 (GRCm39)	missense	probably benign	0.01
R9489:Cyp2d26	UTSW	15	82,674,672 (GRCm39)	missense	probably benign	0.00
R9605:Cyp2d26	UTSW	15	82,674,672 (GRCm39)	missense	probably benign	0.00
R9656:Cyp2d26	UTSW	15	82,677,059 (GRCm39)	missense	probably benign	0.03
X0021:Cyp2d26	UTSW	15	82,674,718 (GRCm39)	missense	probably benign	0.04

Posted On

2016-08-02