Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03377:Fgfr2'

420524

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fgfr2

Ensembl Gene

ENSMUSG00000030849

Gene Name

fibroblast growth factor receptor 2

Synonyms

KGFRTr, svs, Bek, Fgfr-2, Fgfr2b, Fgfr-7, Fgfr7

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL03377

Quality Score

Status

Chromosome

Chromosomal Location

129764181-129868538 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 129800247 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 329 (I329N)

Ref Sequence

ENSEMBL: ENSMUSP00000113010 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000117073] [ENSMUST00000117089] [ENSMUST00000117357] [ENSMUST00000117691] [ENSMUST00000117754] [ENSMUST00000117858] [ENSMUST00000117872] [ENSMUST00000119260] [ENSMUST00000122054] [ENSMUST00000124096] [ENSMUST00000121064] [ENSMUST00000120141] [ENSMUST00000120715] [ENSMUST00000118296] [ENSMUST00000120187] [ENSMUST00000122448] [ENSMUST00000121080] [ENSMUST00000153166]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000117073
AA Change: I214N

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000112672
Gene: ENSMUSG00000030849
AA Change: I214N

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	55	123	4.66e-13	SMART
IGc2	154	234	7.41e-7	SMART
transmembrane domain	260	282	N/A	INTRINSIC
low complexity region	314	323	N/A	INTRINSIC
TyrKc	364	640	4.38e-152	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000117089

SMART Domains

Protein: ENSMUSP00000112992
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
IGc2	269	347	1.9e-4	SMART
transmembrane domain	376	398	N/A	INTRINSIC
low complexity region	430	439	N/A	INTRINSIC
TyrKc	480	756	4.38e-152	SMART
low complexity region	784	798	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117357

SMART Domains

Protein: ENSMUSP00000112580
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	55	123	4.66e-13	SMART
IGc2	154	232	1.9e-4	SMART
transmembrane domain	261	283	N/A	INTRINSIC
low complexity region	315	324	N/A	INTRINSIC
TyrKc	365	641	4.38e-152	SMART
low complexity region	669	683	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117691

SMART Domains

Protein: ENSMUSP00000113180
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
IGc2	269	347	1.9e-4	SMART
transmembrane domain	376	398	N/A	INTRINSIC
low complexity region	432	441	N/A	INTRINSIC
TyrKc	482	758	4.38e-152	SMART
low complexity region	786	800	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000117754
AA Change: I116N

PolyPhen 2 Score 0.921 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000113187
Gene: ENSMUSG00000030849
AA Change: I116N

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	56	136	7.41e-7	SMART
transmembrane domain	162	184	N/A	INTRINSIC
low complexity region	218	227	N/A	INTRINSIC
TyrKc	268	544	4.38e-152	SMART
low complexity region	572	586	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117858

SMART Domains

Protein: ENSMUSP00000112623
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
IGc2	269	347	1.9e-4	SMART
transmembrane domain	376	398	N/A	INTRINSIC
low complexity region	432	441	N/A	INTRINSIC
TyrKc	482	758	4.38e-152	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000117872
AA Change: I233N

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000113994
Gene: ENSMUSG00000030849
AA Change: I233N

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
IGc2	74	142	4.66e-13	SMART
IGc2	173	253	7.41e-7	SMART
transmembrane domain	279	301	N/A	INTRINSIC
low complexity region	333	342	N/A	INTRINSIC
TyrKc	383	659	4.38e-152	SMART
low complexity region	687	701	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000119260
AA Change: I329N

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000113010
Gene: ENSMUSG00000030849
AA Change: I329N

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
IGc2	269	349	7.41e-7	SMART
transmembrane domain	375	397	N/A	INTRINSIC
low complexity region	429	438	N/A	INTRINSIC
TyrKc	479	755	4.38e-152	SMART
low complexity region	783	797	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000122054
AA Change: I348N

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000112430
Gene: ENSMUSG00000030849
AA Change: I348N

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	50	59	N/A	INTRINSIC
IGc2	72	133	6.59e-13	SMART
low complexity region	148	165	N/A	INTRINSIC
IGc2	189	257	4.66e-13	SMART
IGc2	288	368	7.41e-7	SMART
transmembrane domain	394	416	N/A	INTRINSIC
low complexity region	450	459	N/A	INTRINSIC
TyrKc	500	776	4.38e-152	SMART
low complexity region	804	818	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148675

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133806

Predicted Effect

probably benign
Transcript: ENSMUST00000124096

SMART Domains

Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
Pfam:Pkinase	1	118	4.8e-19	PFAM
Pfam:Pkinase_Tyr	1	118	1.7e-50	PFAM
low complexity region	146	160	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000121064

SMART Domains

Protein: ENSMUSP00000113452
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	56	134	1.9e-4	SMART
transmembrane domain	163	185	N/A	INTRINSIC
low complexity region	219	228	N/A	INTRINSIC
TyrKc	269	545	4.38e-152	SMART
low complexity region	573	587	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000120141

SMART Domains

Protein: ENSMUSP00000113415
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	36	57	N/A	INTRINSIC
IGc2	81	149	4.66e-13	SMART
IGc2	180	258	1.9e-4	SMART
transmembrane domain	287	309	N/A	INTRINSIC
low complexity region	341	350	N/A	INTRINSIC
TyrKc	391	667	4.38e-152	SMART
low complexity region	695	709	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000120715

SMART Domains

Protein: ENSMUSP00000113474
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
transmembrane domain	263	285	N/A	INTRINSIC
low complexity region	319	328	N/A	INTRINSIC
TyrKc	369	645	4.38e-152	SMART
low complexity region	673	687	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000118296

SMART Domains

Protein: ENSMUSP00000112471
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	36	57	N/A	INTRINSIC
IGc2	81	149	4.66e-13	SMART
IGc2	180	258	1.9e-4	SMART
transmembrane domain	287	309	N/A	INTRINSIC
low complexity region	343	352	N/A	INTRINSIC
TyrKc	393	669	4.38e-152	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000120187

SMART Domains

Protein: ENSMUSP00000113248
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
IGc2	74	142	4.66e-13	SMART
IGc2	173	251	1.9e-4	SMART
transmembrane domain	280	302	N/A	INTRINSIC
low complexity region	336	345	N/A	INTRINSIC
TyrKc	386	662	4.38e-152	SMART
low complexity region	690	704	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000122448

SMART Domains

Protein: ENSMUSP00000113993
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	55	123	4.66e-13	SMART
IGc2	154	232	1.9e-4	SMART
transmembrane domain	261	283	N/A	INTRINSIC
low complexity region	315	324	N/A	INTRINSIC
TyrKc	365	641	4.38e-152	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000121080

SMART Domains

Protein: ENSMUSP00000112585
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	55	123	4.66e-13	SMART
IGc2	154	232	1.9e-4	SMART
transmembrane domain	261	283	N/A	INTRINSIC
low complexity region	317	326	N/A	INTRINSIC
TyrKc	367	643	4.38e-152	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000153166

SMART Domains

Protein: ENSMUSP00000120100
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
transmembrane domain	21	40	N/A	INTRINSIC
low complexity region	50	59	N/A	INTRINSIC
IGc2	72	133	6.59e-13	SMART
low complexity region	148	165	N/A	INTRINSIC
IGc2	189	257	4.66e-13	SMART
SCOP:d1ev2e1	269	311	1e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000127091

SMART Domains

Protein: ENSMUSP00000122856
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
Pfam:I-set	3	56	1.8e-7	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
PHENOTYPE: Mice homozygous for null mutations die as embryos. Isoform IIIb deficient mutants die at birth with defects in multiple organs and tissues. Isoform IIIc deficient mutants have defects in osteoblast and chondrocyte lineages, producing dwarfism. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	T	A	5: 105,096,256 (GRCm39)	I489L	probably benign	Het
Acox3	T	C	5: 35,751,676 (GRCm39)	L237P	probably damaging	Het
Ahi1	T	G	10: 20,893,903 (GRCm39)	I878S	possibly damaging	Het
Alox15	T	A	11: 70,240,488 (GRCm39)	Y231F	probably damaging	Het
Asxl1	A	T	2: 153,238,700 (GRCm39)	K342M	probably damaging	Het
Atl2	T	C	17: 80,172,519 (GRCm39)	I150M	probably damaging	Het
Bag6	T	C	17: 35,363,958 (GRCm39)	Y822H	probably damaging	Het
Ccdc171	T	C	4: 83,581,754 (GRCm39)	Y628H	probably damaging	Het
Ceacam5	T	A	7: 17,449,056 (GRCm39)	Y141N	probably benign	Het
Ces1a	A	G	8: 93,766,116 (GRCm39)	V166A	probably damaging	Het
Chrdl2	G	A	7: 99,671,259 (GRCm39)	A126T	probably benign	Het
Cyp2d26	T	C	15: 82,674,755 (GRCm39)	E409G	possibly damaging	Het
Dicer1	T	C	12: 104,678,456 (GRCm39)	I621V	probably damaging	Het
Enpp1	T	A	10: 24,536,181 (GRCm39)		probably null	Het
Epha2	T	A	4: 141,049,723 (GRCm39)	S776R	probably benign	Het
Fam107b	A	T	2: 3,779,481 (GRCm39)	E52V	probably damaging	Het
Fam169a	A	G	13: 97,228,381 (GRCm39)	N18S	probably benign	Het
Fbxw21	A	T	9: 108,968,597 (GRCm39)	F460I	probably benign	Het
Fndc7	T	C	3: 108,783,848 (GRCm39)	S254G	probably benign	Het
Glis1	T	G	4: 107,489,478 (GRCm39)	H688Q	probably damaging	Het
Grip1	A	G	10: 119,890,937 (GRCm39)	E898G	probably damaging	Het
Gtf2a1l	T	A	17: 89,019,021 (GRCm39)	D368E	probably benign	Het
Gucy1a1	T	A	3: 82,013,322 (GRCm39)	H440L	probably damaging	Het
H2-M10.5	A	T	17: 37,084,377 (GRCm39)	D113V	probably benign	Het
Hook2	G	T	8: 85,727,964 (GRCm39)	E554*	probably null	Het
Itpr2	A	C	6: 146,231,213 (GRCm39)	V1182G	probably damaging	Het
Itpr2	T	A	6: 146,231,256 (GRCm39)	T1135S	probably benign	Het
Kdm4c	T	C	4: 74,189,492 (GRCm39)	I69T	possibly damaging	Het
Klhl31	A	T	9: 77,558,345 (GRCm39)	K354*	probably null	Het
Krt222	T	A	11: 99,127,339 (GRCm39)	K159*	probably null	Het
Loxhd1	A	G	18: 77,529,369 (GRCm39)	E2004G	possibly damaging	Het
Man2a2	A	T	7: 80,008,800 (GRCm39)		probably null	Het
Med24	A	G	11: 98,595,962 (GRCm39)	F963L	possibly damaging	Het
Mphosph8	A	G	14: 56,930,943 (GRCm39)	E744G	probably damaging	Het
Mypn	A	G	10: 63,028,644 (GRCm39)	S140P	probably benign	Het
Npc1	A	G	18: 12,344,878 (GRCm39)	F331L	probably benign	Het
Obscn	C	A	11: 58,890,699 (GRCm39)	G1798W	probably damaging	Het
Or5d18	A	T	2: 87,864,589 (GRCm39)	V298D	probably damaging	Het
Patj	C	T	4: 98,353,341 (GRCm39)	P110L	probably damaging	Het
Pkhd1l1	T	G	15: 44,347,747 (GRCm39)		probably null	Het
Prdm5	A	G	6: 65,836,457 (GRCm39)	H256R	possibly damaging	Het
Ralgps1	A	G	2: 33,062,473 (GRCm39)	Y267H	probably damaging	Het
Rfpl4	T	G	7: 5,113,464 (GRCm39)	Y239S	probably damaging	Het
Rnpepl1	A	T	1: 92,846,953 (GRCm39)	M592L	probably benign	Het
Serpinc1	A	T	1: 160,821,012 (GRCm39)	H32L	probably damaging	Het
Skint5	T	A	4: 113,620,735 (GRCm39)	T660S	unknown	Het
Slc26a2	T	C	18: 61,331,658 (GRCm39)	N591S	probably damaging	Het
Slc9b2	C	T	3: 135,042,119 (GRCm39)	A466V	probably damaging	Het
Slco1a5	T	A	6: 142,180,492 (GRCm39)	T637S	probably benign	Het
Snx25	A	G	8: 46,533,338 (GRCm39)		probably benign	Het
Szt2	T	C	4: 118,259,594 (GRCm39)		probably benign	Het
Vmn1r183	A	G	7: 23,754,817 (GRCm39)	M207V	possibly damaging	Het
Wdcp	T	G	12: 4,900,691 (GRCm39)	Y182*	probably null	Het
Zc3h13	A	G	14: 75,531,416 (GRCm39)	T105A	possibly damaging	Het
Zfp933	T	C	4: 147,913,168 (GRCm39)	K30R	possibly damaging	Het

Other mutations in Fgfr2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00514:Fgfr2	APN	7	129,769,441 (GRCm39)	missense	probably benign	0.45
IGL00594:Fgfr2	APN	7	129,830,453 (GRCm39)	missense	probably damaging	1.00
IGL00963:Fgfr2	APN	7	129,830,491 (GRCm39)	missense	probably damaging	0.99
IGL01968:Fgfr2	APN	7	129,786,978 (GRCm39)	missense	probably damaging	1.00
IGL02003:Fgfr2	APN	7	129,820,802 (GRCm39)	missense	probably damaging	1.00
IGL02063:Fgfr2	APN	7	129,769,485 (GRCm39)	missense	probably damaging	1.00
IGL02239:Fgfr2	APN	7	129,779,416 (GRCm39)	missense	probably damaging	1.00
IGL02349:Fgfr2	APN	7	129,844,336 (GRCm39)	missense	probably damaging	1.00
IGL02630:Fgfr2	APN	7	129,830,525 (GRCm39)	splice site	probably null
IGL02639:Fgfr2	APN	7	129,830,532 (GRCm39)	splice site	probably benign
IGL03058:Fgfr2	APN	7	129,784,422 (GRCm39)	missense	probably damaging	1.00
IGL03263:Fgfr2	APN	7	129,782,149 (GRCm39)	missense	probably benign	0.12
R0048:Fgfr2	UTSW	7	129,782,218 (GRCm39)	splice site	probably benign
R0048:Fgfr2	UTSW	7	129,782,218 (GRCm39)	splice site	probably benign
R0078:Fgfr2	UTSW	7	129,802,805 (GRCm39)	missense	possibly damaging	0.95
R0085:Fgfr2	UTSW	7	129,797,993 (GRCm39)	missense	probably damaging	0.99
R0278:Fgfr2	UTSW	7	129,863,592 (GRCm39)	splice site	probably null
R0335:Fgfr2	UTSW	7	129,797,979 (GRCm39)	missense	probably benign	0.00
R0557:Fgfr2	UTSW	7	129,820,811 (GRCm39)	missense	probably damaging	1.00
R0631:Fgfr2	UTSW	7	129,828,969 (GRCm39)	intron	probably benign
R0637:Fgfr2	UTSW	7	129,773,354 (GRCm39)	missense	possibly damaging	0.89
R0841:Fgfr2	UTSW	7	130,373,737 (GRCm39)	unclassified	probably benign
R0841:Fgfr2	UTSW	7	129,863,635 (GRCm39)	missense	probably benign	0.03
R1646:Fgfr2	UTSW	7	129,844,374 (GRCm39)	missense	probably damaging	1.00
R1670:Fgfr2	UTSW	7	129,782,187 (GRCm39)	missense	probably damaging	1.00
R1678:Fgfr2	UTSW	7	129,830,350 (GRCm39)	splice site	probably null
R1950:Fgfr2	UTSW	7	129,800,211 (GRCm39)	missense	probably damaging	0.96
R2393:Fgfr2	UTSW	7	129,828,968 (GRCm39)	splice site	probably null
R3706:Fgfr2	UTSW	7	129,800,161 (GRCm39)	missense	probably benign	0.31
R3717:Fgfr2	UTSW	7	129,784,487 (GRCm39)	missense	probably damaging	1.00
R3808:Fgfr2	UTSW	7	129,801,578 (GRCm39)	missense	probably benign	0.01
R3945:Fgfr2	UTSW	7	129,779,485 (GRCm39)	missense	possibly damaging	0.71
R4438:Fgfr2	UTSW	7	129,774,660 (GRCm39)	nonsense	probably null
R4718:Fgfr2	UTSW	7	129,863,518 (GRCm39)	missense	probably damaging	1.00
R4779:Fgfr2	UTSW	7	129,786,923 (GRCm39)	intron	probably benign
R4925:Fgfr2	UTSW	7	129,787,002 (GRCm39)	missense	probably damaging	1.00
R4932:Fgfr2	UTSW	7	129,843,007 (GRCm39)	missense	probably damaging	1.00
R4941:Fgfr2	UTSW	7	129,800,175 (GRCm39)	missense	probably benign	0.21
R4980:Fgfr2	UTSW	7	129,802,810 (GRCm39)	missense	probably damaging	1.00
R5304:Fgfr2	UTSW	7	129,769,504 (GRCm39)	missense	probably damaging	1.00
R5313:Fgfr2	UTSW	7	129,842,970 (GRCm39)	missense	probably benign	0.01
R5375:Fgfr2	UTSW	7	129,842,945 (GRCm39)	missense	possibly damaging	0.65
R5652:Fgfr2	UTSW	7	129,863,593 (GRCm39)	missense	probably damaging	1.00
R6120:Fgfr2	UTSW	7	129,830,420 (GRCm39)	missense	probably benign	0.24
R6347:Fgfr2	UTSW	7	129,863,487 (GRCm39)	missense	probably damaging	1.00
R6375:Fgfr2	UTSW	7	129,769,475 (GRCm39)	missense	probably damaging	1.00
R6475:Fgfr2	UTSW	7	129,802,850 (GRCm39)	missense	probably benign	0.03
R6481:Fgfr2	UTSW	7	129,787,008 (GRCm39)	missense	possibly damaging	0.85
R6494:Fgfr2	UTSW	7	129,800,280 (GRCm39)	missense	probably damaging	1.00
R6542:Fgfr2	UTSW	7	129,802,853 (GRCm39)	missense	probably benign	0.02
R7246:Fgfr2	UTSW	7	129,844,136 (GRCm39)
R7937:Fgfr2	UTSW	7	129,820,823 (GRCm39)	missense	probably damaging	1.00
R7976:Fgfr2	UTSW	7	129,787,074 (GRCm39)	missense	probably damaging	0.99
R8007:Fgfr2	UTSW	7	129,765,719 (GRCm39)	nonsense	probably null
R8189:Fgfr2	UTSW	7	129,774,629 (GRCm39)	missense	probably damaging	1.00
R8430:Fgfr2	UTSW	7	129,765,708 (GRCm39)	missense	probably damaging	1.00
R8486:Fgfr2	UTSW	7	129,765,745 (GRCm39)	missense	possibly damaging	0.93
R8489:Fgfr2	UTSW	7	129,769,534 (GRCm39)	missense	probably benign	0.01
R8776:Fgfr2	UTSW	7	129,798,002 (GRCm39)	missense	possibly damaging	0.64
R8776-TAIL:Fgfr2	UTSW	7	129,798,002 (GRCm39)	missense	possibly damaging	0.64
R9338:Fgfr2	UTSW	7	129,863,561 (GRCm39)	nonsense	probably null
R9340:Fgfr2	UTSW	7	129,782,136 (GRCm39)	missense	probably damaging	1.00
R9497:Fgfr2	UTSW	7	129,765,763 (GRCm39)	missense	probably damaging	1.00
RF016:Fgfr2	UTSW	7	129,779,410 (GRCm39)	missense	probably benign	0.03
X0024:Fgfr2	UTSW	7	129,787,059 (GRCm39)	missense	probably damaging	0.99
Z1088:Fgfr2	UTSW	7	129,771,529 (GRCm39)	missense	probably damaging	1.00
Z1177:Fgfr2	UTSW	7	129,800,187 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02