Incidental Mutation 'IGL03377:Klhl31'
ID420535
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klhl31
Ensembl Gene ENSMUSG00000044938
Gene Namekelch-like 31
SynonymsD930047P17Rik, 9830147P19Rik, Kbtbd1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03377
Quality Score
Status
Chromosome9
Chromosomal Location77636500-77660127 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 77651063 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 354 (K354*)
Ref Sequence ENSEMBL: ENSMUSP00000059643 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057781]
Predicted Effect probably null
Transcript: ENSMUST00000057781
AA Change: K354*
SMART Domains Protein: ENSMUSP00000059643
Gene: ENSMUSG00000044938
AA Change: K354*

DomainStartEndE-ValueType
low complexity region 4 12 N/A INTRINSIC
low complexity region 30 44 N/A INTRINSIC
BTB 73 167 3.39e-18 SMART
BACK 172 273 1.91e-25 SMART
Kelch 317 365 5.58e-1 SMART
Kelch 366 419 4.98e-4 SMART
Kelch 420 466 1.05e-11 SMART
Kelch 467 513 4.01e-8 SMART
Kelch 514 565 1.41e-3 SMART
Kelch 566 614 1.1e0 SMART
low complexity region 617 633 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 T A 5: 104,948,390 I489L probably benign Het
Acox3 T C 5: 35,594,332 L237P probably damaging Het
Ahi1 T G 10: 21,018,004 I878S possibly damaging Het
Alox15 T A 11: 70,349,662 Y231F probably damaging Het
Asxl1 A T 2: 153,396,780 K342M probably damaging Het
Atl2 T C 17: 79,865,090 I150M probably damaging Het
Bag6 T C 17: 35,144,982 Y822H probably damaging Het
Ccdc171 T C 4: 83,663,517 Y628H probably damaging Het
Ceacam5 T A 7: 17,715,131 Y141N probably benign Het
Ces1a A G 8: 93,039,488 V166A probably damaging Het
Chrdl2 G A 7: 100,022,052 A126T probably benign Het
Cyp2d26 T C 15: 82,790,554 E409G possibly damaging Het
Dicer1 T C 12: 104,712,197 I621V probably damaging Het
Enpp1 T A 10: 24,660,283 probably null Het
Epha2 T A 4: 141,322,412 S776R probably benign Het
Fam107b A T 2: 3,778,444 E52V probably damaging Het
Fam169a A G 13: 97,091,873 N18S probably benign Het
Fbxw21 A T 9: 109,139,529 F460I probably benign Het
Fgfr2 A T 7: 130,198,517 I329N probably damaging Het
Fndc7 T C 3: 108,876,532 S254G probably benign Het
Glis1 T G 4: 107,632,281 H688Q probably damaging Het
Grip1 A G 10: 120,055,032 E898G probably damaging Het
Gtf2a1l T A 17: 88,711,593 D368E probably benign Het
Gucy1a1 T A 3: 82,106,015 H440L probably damaging Het
H2-M10.5 A T 17: 36,773,485 D113V probably benign Het
Hook2 G T 8: 85,001,335 E554* probably null Het
Itpr2 A C 6: 146,329,715 V1182G probably damaging Het
Itpr2 T A 6: 146,329,758 T1135S probably benign Het
Kdm4c T C 4: 74,271,255 I69T possibly damaging Het
Krt222 T A 11: 99,236,513 K159* probably null Het
Loxhd1 A G 18: 77,441,673 E2004G possibly damaging Het
Man2a2 A T 7: 80,359,052 probably null Het
Med24 A G 11: 98,705,136 F963L possibly damaging Het
Mphosph8 A G 14: 56,693,486 E744G probably damaging Het
Mypn A G 10: 63,192,865 S140P probably benign Het
Npc1 A G 18: 12,211,821 F331L probably benign Het
Obscn C A 11: 58,999,873 G1798W probably damaging Het
Olfr73 A T 2: 88,034,245 V298D probably damaging Het
Patj C T 4: 98,465,104 P110L probably damaging Het
Pkhd1l1 T G 15: 44,484,351 probably null Het
Prdm5 A G 6: 65,859,473 H256R possibly damaging Het
Ralgps1 A G 2: 33,172,461 Y267H probably damaging Het
Rfpl4 T G 7: 5,110,465 Y239S probably damaging Het
Rnpepl1 A T 1: 92,919,231 M592L probably benign Het
Serpinc1 A T 1: 160,993,442 H32L probably damaging Het
Skint5 T A 4: 113,763,538 T660S unknown Het
Slc26a2 T C 18: 61,198,586 N591S probably damaging Het
Slc9b2 C T 3: 135,336,358 A466V probably damaging Het
Slco1a5 T A 6: 142,234,766 T637S probably benign Het
Snx25 A G 8: 46,080,301 probably benign Het
Szt2 T C 4: 118,402,397 probably benign Het
Vmn1r183 A G 7: 24,055,392 M207V possibly damaging Het
Wdcp T G 12: 4,850,691 Y182* probably null Het
Zc3h13 A G 14: 75,293,976 T105A possibly damaging Het
Zfp933 T C 4: 147,828,711 K30R possibly damaging Het
Other mutations in Klhl31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01377:Klhl31 APN 9 77650731 missense probably benign 0.00
IGL01443:Klhl31 APN 9 77650260 missense possibly damaging 0.88
IGL01939:Klhl31 APN 9 77655206 missense probably benign 0.01
IGL02806:Klhl31 APN 9 77655774 missense probably damaging 0.97
itty UTSW 9 77650809 missense probably damaging 1.00
R0399:Klhl31 UTSW 9 77650653 missense probably benign 0.05
R1596:Klhl31 UTSW 9 77650074 missense probably damaging 0.97
R1598:Klhl31 UTSW 9 77651016 missense possibly damaging 0.92
R2199:Klhl31 UTSW 9 77650101 missense probably damaging 1.00
R2265:Klhl31 UTSW 9 77650158 missense possibly damaging 0.82
R2269:Klhl31 UTSW 9 77650158 missense possibly damaging 0.82
R3619:Klhl31 UTSW 9 77655476 missense probably benign 0.00
R4197:Klhl31 UTSW 9 77650809 missense probably damaging 1.00
R4279:Klhl31 UTSW 9 77655839 missense unknown
R5195:Klhl31 UTSW 9 77650290 missense possibly damaging 0.56
R5912:Klhl31 UTSW 9 77655730 missense probably damaging 1.00
R7516:Klhl31 UTSW 9 77651147 missense probably damaging 1.00
Posted On2016-08-02