Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03380:Fpr-rs6'

420643

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fpr-rs6

Ensembl Gene

ENSMUSG00000071275

Gene Name

formyl peptide receptor, related sequence 6

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

IGL03380

Quality Score

Status

Chromosome

Chromosomal Location

20182078-20183097 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20182983 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 39 (L39F)

Ref Sequence

ENSEMBL: ENSMUSP00000093296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095636]

AlphaFold

Q3SXG2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000095636
AA Change: L39F

PolyPhen 2 Score 0.664 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000093296
Gene: ENSMUSG00000071275
AA Change: L39F

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	5.7e-38	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,298,574	N2774D	probably benign	Het
Aldh1a2	T	G	9: 71,255,117	Y149*	probably null	Het
Ank2	C	A	3: 126,955,870	E503D	probably damaging	Het
Arhgap23	A	G	11: 97,452,518	D542G	probably damaging	Het
Atp8a1	T	C	5: 67,732,186	E582G	probably benign	Het
C4b	A	T	17: 34,740,286	V438D	probably benign	Het
Caps2	A	G	10: 112,200,696	E345G	probably benign	Het
Cdk19	C	T	10: 40,476,912	P308L	probably benign	Het
Drc3	A	G	11: 60,377,905	E307G	probably benign	Het
Dst	G	A	1: 34,257,800	A1041T	probably damaging	Het
Elp2	T	C	18: 24,622,480	V428A	probably benign	Het
Eml5	G	T	12: 98,874,647		probably benign	Het
Fam120b	G	A	17: 15,403,134		probably benign	Het
Fsd1	T	C	17: 55,995,456	I300T	probably benign	Het
Hsd17b6	T	C	10: 127,994,338		probably null	Het
Hspa1a	T	C	17: 34,970,277	K550R	probably benign	Het
Krba1	A	G	6: 48,403,453	H37R	possibly damaging	Het
Lama2	T	C	10: 27,050,265	D2117G	probably damaging	Het
Map4k2	T	C	19: 6,344,590	F332S	possibly damaging	Het
Mindy1	T	C	3: 95,291,018		probably benign	Het
Nhsl1	T	G	10: 18,523,879	Y284*	probably null	Het
Olfr1463	T	A	19: 13,235,001	F250L	probably benign	Het
Pkhd1	T	A	1: 20,200,670	T3220S	probably damaging	Het
Pramel7	A	T	2: 87,491,372	D106E	probably benign	Het
Psme3	T	C	11: 101,320,026		probably null	Het
Rsph1	T	C	17: 31,277,236	E7G	unknown	Het
Slc13a2	T	C	11: 78,399,082	T469A	probably benign	Het
Slc30a9	C	T	5: 67,315,711	T46I	probably benign	Het
Slc37a4	T	G	9: 44,400,023	S204A	probably benign	Het
Slc8b1	T	C	5: 120,519,735	F88L	probably damaging	Het
Smpd3	C	T	8: 106,259,659	V504I	probably benign	Het
Tbx4	A	G	11: 85,914,639	N418S	probably benign	Het
Tmem132c	A	G	5: 127,536,442	T470A	probably benign	Het
Tmem207	A	T	16: 26,526,657	C20S	probably damaging	Het
Usp43	G	A	11: 67,875,316	A761V	possibly damaging	Het
Vmn1r191	C	T	13: 22,178,885	S233N	probably damaging	Het
Vmn2r58	T	A	7: 41,864,450	E256D	probably benign	Het
Zc3hav1	T	C	6: 38,336,558	Y184C	probably damaging	Het

Other mutations in Fpr-rs6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02836:Fpr-rs6	APN	17	20183045	missense	probably benign	0.30
R0149:Fpr-rs6	UTSW	17	20182213	missense	probably benign	0.29
R0190:Fpr-rs6	UTSW	17	20182479	missense	probably benign	0.07
R1347:Fpr-rs6	UTSW	17	20182749	missense	probably benign	0.23
R1347:Fpr-rs6	UTSW	17	20182749	missense	probably benign	0.23
R1934:Fpr-rs6	UTSW	17	20182890	missense	probably benign	0.36
R1965:Fpr-rs6	UTSW	17	20182656	missense	probably damaging	0.98
R3690:Fpr-rs6	UTSW	17	20182875	missense	probably benign	0.02
R3963:Fpr-rs6	UTSW	17	20182217	missense	probably damaging	1.00
R4564:Fpr-rs6	UTSW	17	20182906	nonsense	probably null
R4574:Fpr-rs6	UTSW	17	20183097	start codon destroyed	probably damaging	1.00
R5015:Fpr-rs6	UTSW	17	20182346	missense	probably damaging	1.00
R5599:Fpr-rs6	UTSW	17	20182113	missense	probably benign	0.05
R6737:Fpr-rs6	UTSW	17	20183077	missense	probably benign	0.08
R6786:Fpr-rs6	UTSW	17	20182838	missense	possibly damaging	0.95
R6908:Fpr-rs6	UTSW	17	20182439	missense	probably damaging	1.00
R7040:Fpr-rs6	UTSW	17	20182934	missense	probably damaging	1.00
R7462:Fpr-rs6	UTSW	17	20182223	missense	probably damaging	1.00
R7673:Fpr-rs6	UTSW	17	20182737	missense	probably benign	0.03
R7958:Fpr-rs6	UTSW	17	20182443	missense	probably damaging	0.98
R8103:Fpr-rs6	UTSW	17	20182577	missense	possibly damaging	0.69
R8772:Fpr-rs6	UTSW	17	20182233	missense	probably damaging	1.00

Posted On

2016-08-02