Incidental Mutation 'IGL03380:Tmem132c'
ID 420667
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem132c
Ensembl Gene ENSMUSG00000034324
Gene Name transmembrane protein 132C
Synonyms 2810482M11Rik, 4632425D07Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # IGL03380
Quality Score
Status
Chromosome 5
Chromosomal Location 127318890-127642854 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 127613506 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 470 (T470A)
Ref Sequence ENSEMBL: ENSMUSP00000113090 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119026]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000119026
AA Change: T470A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000113090
Gene: ENSMUSG00000034324
AA Change: T470A

DomainStartEndE-ValueType
low complexity region 14 21 N/A INTRINSIC
Pfam:TMEM132D_N 58 187 1.2e-54 PFAM
Pfam:TMEM132 444 787 4.5e-143 PFAM
Pfam:TMEM132D_C 892 980 2.4e-39 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128068
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,248,574 (GRCm39) N2774D probably benign Het
Aldh1a2 T G 9: 71,162,399 (GRCm39) Y149* probably null Het
Ank2 C A 3: 126,749,519 (GRCm39) E503D probably damaging Het
Arhgap23 A G 11: 97,343,344 (GRCm39) D542G probably damaging Het
Atp8a1 T C 5: 67,889,529 (GRCm39) E582G probably benign Het
C4b A T 17: 34,959,260 (GRCm39) V438D probably benign Het
Caps2 A G 10: 112,036,601 (GRCm39) E345G probably benign Het
Cdk19 C T 10: 40,352,908 (GRCm39) P308L probably benign Het
Drc3 A G 11: 60,268,731 (GRCm39) E307G probably benign Het
Dst G A 1: 34,296,881 (GRCm39) A1041T probably damaging Het
Elp2 T C 18: 24,755,537 (GRCm39) V428A probably benign Het
Eml5 G T 12: 98,840,906 (GRCm39) probably benign Het
Fam120b G A 17: 15,623,396 (GRCm39) probably benign Het
Fpr-rs6 G A 17: 20,403,245 (GRCm39) L39F possibly damaging Het
Fsd1 T C 17: 56,302,456 (GRCm39) I300T probably benign Het
Hsd17b6 T C 10: 127,830,207 (GRCm39) probably null Het
Hspa1a T C 17: 35,189,253 (GRCm39) K550R probably benign Het
Krba1 A G 6: 48,380,387 (GRCm39) H37R possibly damaging Het
Lama2 T C 10: 26,926,261 (GRCm39) D2117G probably damaging Het
Map4k2 T C 19: 6,394,620 (GRCm39) F332S possibly damaging Het
Mindy1 T C 3: 95,198,329 (GRCm39) probably benign Het
Nhsl1 T G 10: 18,399,627 (GRCm39) Y284* probably null Het
Or5b109 T A 19: 13,212,365 (GRCm39) F250L probably benign Het
Pkhd1 T A 1: 20,270,894 (GRCm39) T3220S probably damaging Het
Pramel7 A T 2: 87,321,716 (GRCm39) D106E probably benign Het
Psme3 T C 11: 101,210,852 (GRCm39) probably null Het
Rsph1 T C 17: 31,496,210 (GRCm39) E7G unknown Het
Slc13a2 T C 11: 78,289,908 (GRCm39) T469A probably benign Het
Slc30a9 C T 5: 67,473,054 (GRCm39) T46I probably benign Het
Slc37a4 T G 9: 44,311,320 (GRCm39) S204A probably benign Het
Slc8b1 T C 5: 120,657,800 (GRCm39) F88L probably damaging Het
Smpd3 C T 8: 106,986,291 (GRCm39) V504I probably benign Het
Tbx4 A G 11: 85,805,465 (GRCm39) N418S probably benign Het
Tmem207 A T 16: 26,345,407 (GRCm39) C20S probably damaging Het
Usp43 G A 11: 67,766,142 (GRCm39) A761V possibly damaging Het
Vmn1r191 C T 13: 22,363,055 (GRCm39) S233N probably damaging Het
Vmn2r58 T A 7: 41,513,874 (GRCm39) E256D probably benign Het
Zc3hav1 T C 6: 38,313,493 (GRCm39) Y184C probably damaging Het
Other mutations in Tmem132c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00869:Tmem132c APN 5 127,640,306 (GRCm39) missense possibly damaging 0.95
IGL00985:Tmem132c APN 5 127,581,930 (GRCm39) missense probably damaging 0.99
IGL01599:Tmem132c APN 5 127,436,616 (GRCm39) splice site probably benign
IGL01750:Tmem132c APN 5 127,540,023 (GRCm39) missense possibly damaging 0.91
IGL01893:Tmem132c APN 5 127,540,093 (GRCm39) missense possibly damaging 0.51
IGL02143:Tmem132c APN 5 127,640,466 (GRCm39) missense probably benign 0.03
IGL02164:Tmem132c APN 5 127,613,441 (GRCm39) missense probably damaging 1.00
IGL02252:Tmem132c APN 5 127,539,991 (GRCm39) missense possibly damaging 0.91
IGL02527:Tmem132c APN 5 127,436,675 (GRCm39) missense possibly damaging 0.95
IGL02584:Tmem132c APN 5 127,582,063 (GRCm39) missense probably damaging 1.00
IGL02878:Tmem132c APN 5 127,640,154 (GRCm39) missense probably damaging 0.99
IGL03065:Tmem132c APN 5 127,640,688 (GRCm39) missense probably damaging 1.00
IGL03120:Tmem132c APN 5 127,640,448 (GRCm39) missense probably benign 0.06
IGL03387:Tmem132c APN 5 127,640,784 (GRCm39) missense probably benign 0.00
R0106:Tmem132c UTSW 5 127,631,733 (GRCm39) missense possibly damaging 0.94
R0106:Tmem132c UTSW 5 127,631,733 (GRCm39) missense possibly damaging 0.94
R0415:Tmem132c UTSW 5 127,640,769 (GRCm39) missense probably damaging 1.00
R0607:Tmem132c UTSW 5 127,640,617 (GRCm39) nonsense probably null
R1413:Tmem132c UTSW 5 127,640,631 (GRCm39) missense probably damaging 1.00
R1531:Tmem132c UTSW 5 127,436,955 (GRCm39) missense probably damaging 1.00
R1648:Tmem132c UTSW 5 127,540,120 (GRCm39) splice site probably benign
R2148:Tmem132c UTSW 5 127,540,026 (GRCm39) missense probably damaging 1.00
R2149:Tmem132c UTSW 5 127,540,026 (GRCm39) missense probably damaging 1.00
R2259:Tmem132c UTSW 5 127,581,988 (GRCm39) missense probably benign 0.01
R3853:Tmem132c UTSW 5 127,436,933 (GRCm39) missense probably benign 0.00
R4204:Tmem132c UTSW 5 127,640,829 (GRCm39) missense possibly damaging 0.73
R4543:Tmem132c UTSW 5 127,582,041 (GRCm39) missense probably benign 0.00
R4701:Tmem132c UTSW 5 127,641,560 (GRCm39) unclassified probably benign
R5017:Tmem132c UTSW 5 127,640,414 (GRCm39) missense probably benign 0.13
R5037:Tmem132c UTSW 5 127,630,199 (GRCm39) missense probably benign 0.42
R5327:Tmem132c UTSW 5 127,640,816 (GRCm39) missense possibly damaging 0.50
R5423:Tmem132c UTSW 5 127,640,907 (GRCm39) missense probably benign 0.02
R5548:Tmem132c UTSW 5 127,628,587 (GRCm39) nonsense probably null
R6425:Tmem132c UTSW 5 127,630,329 (GRCm39) missense possibly damaging 0.95
R6717:Tmem132c UTSW 5 127,641,093 (GRCm39) missense possibly damaging 0.93
R6899:Tmem132c UTSW 5 127,628,744 (GRCm39) missense probably damaging 1.00
R7007:Tmem132c UTSW 5 127,436,679 (GRCm39) missense probably damaging 1.00
R7297:Tmem132c UTSW 5 127,437,281 (GRCm39) missense probably benign 0.06
R7326:Tmem132c UTSW 5 127,641,123 (GRCm39) missense possibly damaging 0.51
R7386:Tmem132c UTSW 5 127,640,990 (GRCm39) missense probably benign 0.16
R7504:Tmem132c UTSW 5 127,631,696 (GRCm39) missense probably damaging 1.00
R7640:Tmem132c UTSW 5 127,640,070 (GRCm39) missense probably damaging 1.00
R7718:Tmem132c UTSW 5 127,640,504 (GRCm39) missense probably benign 0.06
R7762:Tmem132c UTSW 5 127,631,760 (GRCm39) missense possibly damaging 0.90
R7818:Tmem132c UTSW 5 127,641,152 (GRCm39) makesense probably null
R8117:Tmem132c UTSW 5 127,437,176 (GRCm39) missense probably benign 0.22
R8425:Tmem132c UTSW 5 127,641,421 (GRCm39) missense
R8749:Tmem132c UTSW 5 127,437,003 (GRCm39) missense possibly damaging 0.75
R8771:Tmem132c UTSW 5 127,437,192 (GRCm39) missense probably benign 0.00
R8798:Tmem132c UTSW 5 127,437,217 (GRCm39) nonsense probably null
R9372:Tmem132c UTSW 5 127,640,145 (GRCm39) missense probably damaging 1.00
X0067:Tmem132c UTSW 5 127,613,471 (GRCm39) missense possibly damaging 0.79
Z1088:Tmem132c UTSW 5 127,581,985 (GRCm39) missense probably benign 0.14
Posted On 2016-08-02