Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03382:Vmn2r80'

420717

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r80

Ensembl Gene

ENSMUSG00000091888

Gene Name

vomeronasal 2, receptor 80

Synonyms

EG624765

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

IGL03382

Quality Score

Status

Chromosome

Chromosomal Location

78984650-79030767 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 79005362 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 333 (E333G)

Ref Sequence

ENSEMBL: ENSMUSP00000132299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165834]

AlphaFold

E9Q1L0

Predicted Effect

probably damaging
Transcript: ENSMUST00000165834
AA Change: E333G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000132299
Gene: ENSMUSG00000091888
AA Change: E333G

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	79	474	1.5e-36	PFAM
Pfam:NCD3G	517	570	7.9e-22	PFAM
Pfam:7tm_3	603	838	6.2e-49	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aff1	A	G	5: 103,988,926 (GRCm39)	D831G	possibly damaging	Het
Amer2	A	G	14: 60,617,331 (GRCm39)	K509E	possibly damaging	Het
Ankrd6	T	C	4: 32,808,771 (GRCm39)	K449E	probably damaging	Het
Atp8b2	G	A	3: 89,855,828 (GRCm39)	P459L	probably benign	Het
Atr	C	T	9: 95,802,875 (GRCm39)	R1846*	probably null	Het
Brd10	C	T	19: 29,694,676 (GRCm39)	G1606R	probably damaging	Het
Ccdc159	C	A	9: 21,842,992 (GRCm39)		probably null	Het
Ccna1	A	C	3: 54,954,698 (GRCm39)	Y338D	probably damaging	Het
Cpq	A	T	15: 33,213,089 (GRCm39)	E36V	probably damaging	Het
Cyp2c23	A	G	19: 44,003,371 (GRCm39)	I268T	probably damaging	Het
Dctn2	G	T	10: 127,114,057 (GRCm39)	Q332H	probably damaging	Het
Dnah17	T	A	11: 117,972,769 (GRCm39)	I2055F	probably damaging	Het
Dnmt3b	A	G	2: 153,528,279 (GRCm39)	H764R	probably damaging	Het
Gphn	T	A	12: 78,528,087 (GRCm39)	I135K	probably damaging	Het
Hnrnpul1	A	G	7: 25,450,409 (GRCm39)	M1T	probably null	Het
Htra4	T	C	8: 25,519,714 (GRCm39)	D406G	probably benign	Het
Klk10	G	T	7: 43,433,883 (GRCm39)		probably benign	Het
Lilrb4a	T	A	10: 51,367,616 (GRCm39)	W53R	probably benign	Het
Magel2	T	C	7: 62,028,461 (GRCm39)	V455A	probably benign	Het
Mrgprb5	T	C	7: 47,818,442 (GRCm39)	T98A	probably benign	Het
Mrps35	T	A	6: 146,951,373 (GRCm39)	C76*	probably null	Het
Myh7b	C	T	2: 155,465,399 (GRCm39)	R701C	probably damaging	Het
Nbeal1	G	A	1: 60,300,745 (GRCm39)		probably null	Het
Neb	T	A	2: 52,215,720 (GRCm39)	M196L	probably benign	Het
Nmd3	A	G	3: 69,642,421 (GRCm39)	K207R	probably damaging	Het
Plxna4	C	T	6: 32,179,129 (GRCm39)	R962Q	probably benign	Het
Pom121	T	C	5: 135,421,261 (GRCm39)	K230E	unknown	Het
Psme4	A	G	11: 30,757,788 (GRCm39)	D307G	possibly damaging	Het
Rnf41	T	G	10: 128,274,149 (GRCm39)	M267R	possibly damaging	Het
Sis	T	C	3: 72,836,052 (GRCm39)	N846D	probably benign	Het
Slc22a19	T	A	19: 7,659,227 (GRCm39)	I463L	probably benign	Het
Slc25a39	A	T	11: 102,297,030 (GRCm39)		probably null	Het
Slc35b2	C	T	17: 45,877,571 (GRCm39)	R233C	probably damaging	Het
Slc4a4	T	C	5: 89,376,695 (GRCm39)	L983P	probably damaging	Het
Sp110	A	C	1: 85,505,050 (GRCm39)	F434C	probably benign	Het
Tbc1d10a	A	G	11: 4,159,984 (GRCm39)	Y123C	probably damaging	Het
Thbs4	A	C	13: 92,906,056 (GRCm39)	I395S	probably benign	Het
Triml2	A	G	8: 43,646,776 (GRCm39)	T422A	probably benign	Het
Ubn2	T	C	6: 38,417,382 (GRCm39)		probably benign	Het
Vmn1r15	T	A	6: 57,235,555 (GRCm39)	M141K	probably benign	Het
Zfp169	T	C	13: 48,644,639 (GRCm39)		probably benign	Het
Zfp942	G	A	17: 22,148,083 (GRCm39)	P182L	probably benign	Het

Other mutations in Vmn2r80

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01084:Vmn2r80	APN	10	79,030,433 (GRCm39)	missense	probably damaging	1.00
IGL01325:Vmn2r80	APN	10	79,030,081 (GRCm39)	missense	possibly damaging	0.62
IGL01611:Vmn2r80	APN	10	79,007,488 (GRCm39)	missense	probably damaging	1.00
IGL01799:Vmn2r80	APN	10	79,007,385 (GRCm39)	missense	possibly damaging	0.95
IGL01877:Vmn2r80	APN	10	79,007,334 (GRCm39)	splice site	probably null
IGL02673:Vmn2r80	APN	10	79,005,318 (GRCm39)	missense	probably benign	0.02
IGL02756:Vmn2r80	APN	10	79,030,145 (GRCm39)	missense	probably damaging	1.00
IGL02820:Vmn2r80	APN	10	79,007,439 (GRCm39)	missense	probably benign	0.04
R0071:Vmn2r80	UTSW	10	79,007,566 (GRCm39)	missense	possibly damaging	0.83
R0071:Vmn2r80	UTSW	10	79,007,566 (GRCm39)	missense	possibly damaging	0.83
R0129:Vmn2r80	UTSW	10	79,005,330 (GRCm39)	missense	probably damaging	1.00
R0325:Vmn2r80	UTSW	10	78,984,773 (GRCm39)	missense	possibly damaging	0.89
R0567:Vmn2r80	UTSW	10	79,030,665 (GRCm39)	missense	possibly damaging	0.89
R1510:Vmn2r80	UTSW	10	79,005,553 (GRCm39)	missense	possibly damaging	0.69
R1519:Vmn2r80	UTSW	10	79,030,053 (GRCm39)	missense	probably damaging	1.00
R1520:Vmn2r80	UTSW	10	79,030,594 (GRCm39)	missense	probably damaging	1.00
R1627:Vmn2r80	UTSW	10	79,030,249 (GRCm39)	missense	probably damaging	1.00
R1709:Vmn2r80	UTSW	10	79,030,223 (GRCm39)	missense	probably benign	0.04
R2116:Vmn2r80	UTSW	10	79,030,558 (GRCm39)	missense	probably benign	0.09
R2237:Vmn2r80	UTSW	10	79,004,104 (GRCm39)	missense	probably damaging	1.00
R2308:Vmn2r80	UTSW	10	79,007,455 (GRCm39)	missense	probably damaging	1.00
R2893:Vmn2r80	UTSW	10	78,984,699 (GRCm39)	missense	possibly damaging	0.63
R3408:Vmn2r80	UTSW	10	79,004,227 (GRCm39)	missense	possibly damaging	0.95
R4502:Vmn2r80	UTSW	10	78,984,764 (GRCm39)	missense	probably benign	0.00
R4685:Vmn2r80	UTSW	10	79,030,162 (GRCm39)	missense	possibly damaging	0.95
R4851:Vmn2r80	UTSW	10	79,030,156 (GRCm39)	missense	possibly damaging	0.68
R4947:Vmn2r80	UTSW	10	79,030,532 (GRCm39)	missense	probably damaging	1.00
R5112:Vmn2r80	UTSW	10	79,030,292 (GRCm39)	missense	possibly damaging	0.61
R5217:Vmn2r80	UTSW	10	79,004,980 (GRCm39)	missense	possibly damaging	0.62
R5226:Vmn2r80	UTSW	10	79,029,874 (GRCm39)	missense	probably benign	0.36
R5512:Vmn2r80	UTSW	10	79,004,066 (GRCm39)	missense	probably benign	0.00
R5618:Vmn2r80	UTSW	10	78,984,755 (GRCm39)	missense	probably benign
R5959:Vmn2r80	UTSW	10	79,005,313 (GRCm39)	missense	probably benign	0.00
R6104:Vmn2r80	UTSW	10	78,984,854 (GRCm39)	missense	probably benign	0.00
R6110:Vmn2r80	UTSW	10	79,017,837 (GRCm39)	missense	probably damaging	1.00
R6270:Vmn2r80	UTSW	10	79,030,159 (GRCm39)	missense	probably benign	0.00
R6508:Vmn2r80	UTSW	10	79,030,290 (GRCm39)	missense	probably benign	0.03
R6843:Vmn2r80	UTSW	10	79,005,502 (GRCm39)	missense	probably benign	0.08
R6894:Vmn2r80	UTSW	10	79,005,438 (GRCm39)	missense	probably benign	0.06
R7048:Vmn2r80	UTSW	10	79,030,153 (GRCm39)	missense	probably damaging	1.00
R7149:Vmn2r80	UTSW	10	79,030,654 (GRCm39)	missense	probably benign	0.00
R7262:Vmn2r80	UTSW	10	79,005,579 (GRCm39)	missense	probably damaging	0.98
R7559:Vmn2r80	UTSW	10	79,030,459 (GRCm39)	missense	probably benign	0.00
R7622:Vmn2r80	UTSW	10	79,030,097 (GRCm39)	missense	probably damaging	1.00
R8003:Vmn2r80	UTSW	10	78,984,711 (GRCm39)	missense	probably benign	0.16
R8207:Vmn2r80	UTSW	10	79,030,150 (GRCm39)	nonsense	probably null
R8330:Vmn2r80	UTSW	10	79,007,550 (GRCm39)	missense	probably damaging	1.00
R8337:Vmn2r80	UTSW	10	78,984,707 (GRCm39)	missense	probably benign	0.00
R8354:Vmn2r80	UTSW	10	78,984,710 (GRCm39)	missense	probably benign
R8688:Vmn2r80	UTSW	10	79,004,069 (GRCm39)	missense	probably damaging	1.00
R8903:Vmn2r80	UTSW	10	79,017,928 (GRCm39)	missense	probably damaging	1.00
R9088:Vmn2r80	UTSW	10	79,005,378 (GRCm39)	missense	probably benign	0.05
R9125:Vmn2r80	UTSW	10	78,984,760 (GRCm39)	missense	probably benign	0.12
R9147:Vmn2r80	UTSW	10	79,030,687 (GRCm39)	missense	probably damaging	0.98
R9148:Vmn2r80	UTSW	10	79,030,687 (GRCm39)	missense	probably damaging	0.98
R9187:Vmn2r80	UTSW	10	79,030,438 (GRCm39)	missense	probably benign	0.20
R9218:Vmn2r80	UTSW	10	79,030,270 (GRCm39)	missense	possibly damaging	0.61
R9553:Vmn2r80	UTSW	10	78,984,743 (GRCm39)	missense	probably benign
R9612:Vmn2r80	UTSW	10	79,030,712 (GRCm39)	missense	probably damaging	1.00
R9677:Vmn2r80	UTSW	10	78,984,672 (GRCm39)	missense	probably benign	0.15
R9769:Vmn2r80	UTSW	10	79,005,443 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r80	UTSW	10	79,030,441 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r80	UTSW	10	79,030,232 (GRCm39)	missense	possibly damaging	0.65
Z1176:Vmn2r80	UTSW	10	79,005,311 (GRCm39)	missense	not run
Z1176:Vmn2r80	UTSW	10	79,030,605 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn2r80	UTSW	10	79,005,311 (GRCm39)	missense	not run

Posted On

2016-08-02