Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03382:Mrgprb5'

420728

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgprb5

Ensembl Gene

ENSMUSG00000070551

Gene Name

MAS-related GPR, member B5

Synonyms

MrgB5

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL03382

Quality Score

Status

Chromosome

Chromosomal Location

47817765-47818733 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 47818442 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 98 (T98A)

Ref Sequence

ENSEMBL: ENSMUSP00000091953 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094389]

AlphaFold

Q91ZB9

Predicted Effect

probably benign
Transcript: ENSMUST00000094389
AA Change: T98A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000091953
Gene: ENSMUSG00000070551
AA Change: T98A

Domain	Start	End	E-Value	Type
low complexity region	9	21	N/A	INTRINSIC
Pfam:7TM_GPCR_Srx	38	217	1.4e-8	PFAM
Pfam:7tm_1	47	210	1.7e-7	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aff1	A	G	5: 103,988,926 (GRCm39)	D831G	possibly damaging	Het
Amer2	A	G	14: 60,617,331 (GRCm39)	K509E	possibly damaging	Het
Ankrd6	T	C	4: 32,808,771 (GRCm39)	K449E	probably damaging	Het
Atp8b2	G	A	3: 89,855,828 (GRCm39)	P459L	probably benign	Het
Atr	C	T	9: 95,802,875 (GRCm39)	R1846*	probably null	Het
Brd10	C	T	19: 29,694,676 (GRCm39)	G1606R	probably damaging	Het
Ccdc159	C	A	9: 21,842,992 (GRCm39)		probably null	Het
Ccna1	A	C	3: 54,954,698 (GRCm39)	Y338D	probably damaging	Het
Cpq	A	T	15: 33,213,089 (GRCm39)	E36V	probably damaging	Het
Cyp2c23	A	G	19: 44,003,371 (GRCm39)	I268T	probably damaging	Het
Dctn2	G	T	10: 127,114,057 (GRCm39)	Q332H	probably damaging	Het
Dnah17	T	A	11: 117,972,769 (GRCm39)	I2055F	probably damaging	Het
Dnmt3b	A	G	2: 153,528,279 (GRCm39)	H764R	probably damaging	Het
Gphn	T	A	12: 78,528,087 (GRCm39)	I135K	probably damaging	Het
Hnrnpul1	A	G	7: 25,450,409 (GRCm39)	M1T	probably null	Het
Htra4	T	C	8: 25,519,714 (GRCm39)	D406G	probably benign	Het
Klk10	G	T	7: 43,433,883 (GRCm39)		probably benign	Het
Lilrb4a	T	A	10: 51,367,616 (GRCm39)	W53R	probably benign	Het
Magel2	T	C	7: 62,028,461 (GRCm39)	V455A	probably benign	Het
Mrps35	T	A	6: 146,951,373 (GRCm39)	C76*	probably null	Het
Myh7b	C	T	2: 155,465,399 (GRCm39)	R701C	probably damaging	Het
Nbeal1	G	A	1: 60,300,745 (GRCm39)		probably null	Het
Neb	T	A	2: 52,215,720 (GRCm39)	M196L	probably benign	Het
Nmd3	A	G	3: 69,642,421 (GRCm39)	K207R	probably damaging	Het
Plxna4	C	T	6: 32,179,129 (GRCm39)	R962Q	probably benign	Het
Pom121	T	C	5: 135,421,261 (GRCm39)	K230E	unknown	Het
Psme4	A	G	11: 30,757,788 (GRCm39)	D307G	possibly damaging	Het
Rnf41	T	G	10: 128,274,149 (GRCm39)	M267R	possibly damaging	Het
Sis	T	C	3: 72,836,052 (GRCm39)	N846D	probably benign	Het
Slc22a19	T	A	19: 7,659,227 (GRCm39)	I463L	probably benign	Het
Slc25a39	A	T	11: 102,297,030 (GRCm39)		probably null	Het
Slc35b2	C	T	17: 45,877,571 (GRCm39)	R233C	probably damaging	Het
Slc4a4	T	C	5: 89,376,695 (GRCm39)	L983P	probably damaging	Het
Sp110	A	C	1: 85,505,050 (GRCm39)	F434C	probably benign	Het
Tbc1d10a	A	G	11: 4,159,984 (GRCm39)	Y123C	probably damaging	Het
Thbs4	A	C	13: 92,906,056 (GRCm39)	I395S	probably benign	Het
Triml2	A	G	8: 43,646,776 (GRCm39)	T422A	probably benign	Het
Ubn2	T	C	6: 38,417,382 (GRCm39)		probably benign	Het
Vmn1r15	T	A	6: 57,235,555 (GRCm39)	M141K	probably benign	Het
Vmn2r80	A	G	10: 79,005,362 (GRCm39)	E333G	probably damaging	Het
Zfp169	T	C	13: 48,644,639 (GRCm39)		probably benign	Het
Zfp942	G	A	17: 22,148,083 (GRCm39)	P182L	probably benign	Het

Other mutations in Mrgprb5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01516:Mrgprb5	APN	7	47,818,132 (GRCm39)	missense	probably damaging	1.00
IGL01662:Mrgprb5	APN	7	47,818,172 (GRCm39)	missense	probably benign	0.02
IGL01752:Mrgprb5	APN	7	47,818,415 (GRCm39)	missense	probably benign	0.22
IGL02117:Mrgprb5	APN	7	47,818,742 (GRCm39)	utr 5 prime	probably benign
IGL02866:Mrgprb5	APN	7	47,817,914 (GRCm39)	missense	probably damaging	0.99
R0545:Mrgprb5	UTSW	7	47,818,633 (GRCm39)	missense	probably benign	0.08
R1389:Mrgprb5	UTSW	7	47,818,078 (GRCm39)	missense	probably damaging	1.00
R1939:Mrgprb5	UTSW	7	47,818,686 (GRCm39)	missense	probably benign	0.00
R2277:Mrgprb5	UTSW	7	47,818,579 (GRCm39)	missense	probably damaging	1.00
R2367:Mrgprb5	UTSW	7	47,818,347 (GRCm39)	nonsense	probably null
R2912:Mrgprb5	UTSW	7	47,817,815 (GRCm39)	missense	probably benign
R2968:Mrgprb5	UTSW	7	47,818,317 (GRCm39)	missense	probably damaging	0.98
R2969:Mrgprb5	UTSW	7	47,818,317 (GRCm39)	missense	probably damaging	0.98
R2970:Mrgprb5	UTSW	7	47,818,317 (GRCm39)	missense	probably damaging	0.98
R3499:Mrgprb5	UTSW	7	47,818,661 (GRCm39)	missense	probably benign	0.04
R3828:Mrgprb5	UTSW	7	47,817,839 (GRCm39)	missense	probably benign	0.01
R4590:Mrgprb5	UTSW	7	47,817,809 (GRCm39)	missense	probably benign	0.16
R4719:Mrgprb5	UTSW	7	47,818,526 (GRCm39)	missense	probably damaging	1.00
R5263:Mrgprb5	UTSW	7	47,817,937 (GRCm39)	missense	probably damaging	0.99
R5264:Mrgprb5	UTSW	7	47,817,796 (GRCm39)	missense	probably benign	0.10
R5644:Mrgprb5	UTSW	7	47,817,955 (GRCm39)	missense	probably benign	0.00
R6485:Mrgprb5	UTSW	7	47,818,525 (GRCm39)	missense	probably damaging	0.99
R6713:Mrgprb5	UTSW	7	47,818,537 (GRCm39)	missense	probably damaging	0.98
R7112:Mrgprb5	UTSW	7	47,818,655 (GRCm39)	missense	probably benign
R7176:Mrgprb5	UTSW	7	47,818,059 (GRCm39)	missense	possibly damaging	0.68
R7446:Mrgprb5	UTSW	7	47,818,252 (GRCm39)	missense	possibly damaging	0.65
R7640:Mrgprb5	UTSW	7	47,818,007 (GRCm39)	missense	probably benign	0.00
R7831:Mrgprb5	UTSW	7	47,817,997 (GRCm39)	missense	probably benign	0.05
R9041:Mrgprb5	UTSW	7	47,818,509 (GRCm39)	missense	probably damaging	1.00
R9314:Mrgprb5	UTSW	7	47,818,174 (GRCm39)	missense	probably benign	0.09

Posted On

2016-08-02