Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03382:Zfp169'

420731

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp169

Ensembl Gene

ENSMUSG00000050954

Gene Name

zinc finger protein 169

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL03382

Quality Score

Status

Chromosome

Chromosomal Location

48487647-48513451 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 48491163 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000135520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110110] [ENSMUST00000167682] [ENSMUST00000176176] [ENSMUST00000176949] [ENSMUST00000176996] [ENSMUST00000177530]

AlphaFold

E9Q3R6

Predicted Effect

unknown
Transcript: ENSMUST00000110110
AA Change: T163A

SMART Domains

Protein: ENSMUSP00000105737
Gene: ENSMUSG00000050954
AA Change: T163A

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART
ZnF_C2H2	257	279	9.08e-4	SMART
ZnF_C2H2	285	308	2.2e-2	SMART
ZnF_C2H2	314	336	9.73e-4	SMART
ZnF_C2H2	342	364	2.86e-1	SMART
ZnF_C2H2	370	392	4.72e-2	SMART
ZnF_C2H2	398	420	4.24e-4	SMART
ZnF_C2H2	426	448	1.13e-4	SMART
ZnF_C2H2	454	476	2.2e-2	SMART
ZnF_C2H2	482	504	2.99e-4	SMART
ZnF_C2H2	510	532	2.57e-3	SMART
ZnF_C2H2	539	561	3.44e-4	SMART
ZnF_C2H2	567	589	3.69e-4	SMART
ZnF_C2H2	595	617	8.02e-5	SMART
ZnF_C2H2	623	645	1.26e-2	SMART
ZnF_C2H2	651	673	4.79e-3	SMART
ZnF_C2H2	679	701	1.3e-4	SMART
ZnF_C2H2	707	729	5.5e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000167682

SMART Domains

Protein: ENSMUSP00000127591
Gene: ENSMUSG00000050954

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176176

SMART Domains

Protein: ENSMUSP00000134793
Gene: ENSMUSG00000050954

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176949

SMART Domains

Protein: ENSMUSP00000135695
Gene: ENSMUSG00000050954

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176996

SMART Domains

Protein: ENSMUSP00000135520
Gene: ENSMUSG00000050954

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177474

Predicted Effect

unknown
Transcript: ENSMUST00000177530
AA Change: T163A

SMART Domains

Protein: ENSMUSP00000135414
Gene: ENSMUSG00000050954
AA Change: T163A

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART
ZnF_C2H2	257	279	9.08e-4	SMART
ZnF_C2H2	285	308	2.2e-2	SMART
ZnF_C2H2	314	336	9.73e-4	SMART
ZnF_C2H2	342	364	2.86e-1	SMART
ZnF_C2H2	370	392	4.72e-2	SMART
ZnF_C2H2	398	420	4.24e-4	SMART
ZnF_C2H2	426	448	1.13e-4	SMART
ZnF_C2H2	454	476	2.2e-2	SMART
ZnF_C2H2	482	504	2.99e-4	SMART
ZnF_C2H2	510	532	2.57e-3	SMART
ZnF_C2H2	539	561	3.44e-4	SMART
ZnF_C2H2	567	589	3.69e-4	SMART
ZnF_C2H2	595	617	8.02e-5	SMART
ZnF_C2H2	623	645	1.26e-2	SMART
ZnF_C2H2	651	673	4.79e-3	SMART
ZnF_C2H2	679	701	1.3e-4	SMART
ZnF_C2H2	707	729	5.5e-3	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous disruption of this locus does not result in an overt phenotype early in life. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930021J03Rik	C	T	19: 29,717,276	G1606R	probably damaging	Het
Aff1	A	G	5: 103,841,060	D831G	possibly damaging	Het
Amer2	A	G	14: 60,379,882	K509E	possibly damaging	Het
Ankrd6	T	C	4: 32,808,771	K449E	probably damaging	Het
Atp8b2	G	A	3: 89,948,521	P459L	probably benign	Het
Atr	C	T	9: 95,920,822	R1846*	probably null	Het
Ccdc159	C	A	9: 21,931,696		probably null	Het
Ccna1	A	C	3: 55,047,277	Y338D	probably damaging	Het
Cpq	A	T	15: 33,212,943	E36V	probably damaging	Het
Cyp2c23	A	G	19: 44,014,932	I268T	probably damaging	Het
Dctn2	G	T	10: 127,278,188	Q332H	probably damaging	Het
Dnah17	T	A	11: 118,081,943	I2055F	probably damaging	Het
Dnmt3b	A	G	2: 153,686,359	H764R	probably damaging	Het
Gphn	T	A	12: 78,481,313	I135K	probably damaging	Het
Hnrnpul1	A	G	7: 25,750,984	M1T	probably null	Het
Htra4	T	C	8: 25,029,698	D406G	probably benign	Het
Klk10	G	T	7: 43,784,459		probably benign	Het
Lilrb4a	T	A	10: 51,491,520	W53R	probably benign	Het
Magel2	T	C	7: 62,378,713	V455A	probably benign	Het
Mrgprb5	T	C	7: 48,168,694	T98A	probably benign	Het
Mrps35	T	A	6: 147,049,875	C76*	probably null	Het
Myh7b	C	T	2: 155,623,479	R701C	probably damaging	Het
Nbeal1	G	A	1: 60,261,586		probably null	Het
Neb	T	A	2: 52,325,708	M196L	probably benign	Het
Nmd3	A	G	3: 69,735,088	K207R	probably damaging	Het
Plxna4	C	T	6: 32,202,194	R962Q	probably benign	Het
Pom121	T	C	5: 135,392,407	K230E	unknown	Het
Psme4	A	G	11: 30,807,788	D307G	possibly damaging	Het
Rnf41	T	G	10: 128,438,280	M267R	possibly damaging	Het
Sis	T	C	3: 72,928,719	N846D	probably benign	Het
Slc22a19	T	A	19: 7,681,862	I463L	probably benign	Het
Slc25a39	A	T	11: 102,406,204		probably null	Het
Slc35b2	C	T	17: 45,566,645	R233C	probably damaging	Het
Slc4a4	T	C	5: 89,228,836	L983P	probably damaging	Het
Sp110	A	C	1: 85,577,329	F434C	probably benign	Het
Tbc1d10a	A	G	11: 4,209,984	Y123C	probably damaging	Het
Thbs4	A	C	13: 92,769,548	I395S	probably benign	Het
Triml2	A	G	8: 43,193,739	T422A	probably benign	Het
Ubn2	T	C	6: 38,440,447		probably benign	Het
Vmn1r15	T	A	6: 57,258,570	M141K	probably benign	Het
Vmn2r80	A	G	10: 79,169,528	E333G	probably damaging	Het
Zfp942	G	A	17: 21,929,102	P182L	probably benign	Het

Other mutations in Zfp169

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01925:Zfp169	APN	13	48490763	unclassified	probably benign
IGL03329:Zfp169	APN	13	48490794	unclassified	probably benign
IGL03394:Zfp169	APN	13	48489924	missense	possibly damaging	0.93
BB010:Zfp169	UTSW	13	48490481	missense	unknown
BB020:Zfp169	UTSW	13	48490481	missense	unknown
R0571:Zfp169	UTSW	13	48489690	missense	possibly damaging	0.71
R1714:Zfp169	UTSW	13	48498854	missense	probably benign	0.35
R1784:Zfp169	UTSW	13	48489819	missense	possibly damaging	0.61
R3108:Zfp169	UTSW	13	48489996	missense	possibly damaging	0.86
R3689:Zfp169	UTSW	13	48506901	splice site	probably benign
R4444:Zfp169	UTSW	13	48490337	missense	possibly damaging	0.94
R4665:Zfp169	UTSW	13	48490863	unclassified	probably benign
R4719:Zfp169	UTSW	13	48490158	missense	probably benign	0.06
R4745:Zfp169	UTSW	13	48490232	missense	possibly damaging	0.71
R5288:Zfp169	UTSW	13	48490275	missense	possibly damaging	0.61
R5384:Zfp169	UTSW	13	48490275	missense	possibly damaging	0.61
R5979:Zfp169	UTSW	13	48491040	unclassified	probably benign
R6053:Zfp169	UTSW	13	48498858	missense	probably damaging	1.00
R6823:Zfp169	UTSW	13	48490996	unclassified	probably benign
R7084:Zfp169	UTSW	13	48498863	missense	probably benign	0.10
R7679:Zfp169	UTSW	13	48498383	missense	probably damaging	0.99
R7933:Zfp169	UTSW	13	48490481	missense	unknown
R8298:Zfp169	UTSW	13	48498377	nonsense	probably null
R8322:Zfp169	UTSW	13	48491099	missense	unknown
R9047:Zfp169	UTSW	13	48498816	missense	probably damaging	1.00
R9124:Zfp169	UTSW	13	48491081	missense	unknown
R9126:Zfp169	UTSW	13	48491081	missense	unknown
R9131:Zfp169	UTSW	13	48491081	missense	unknown
R9132:Zfp169	UTSW	13	48491081	missense	unknown

Posted On

2016-08-02