Incidental Mutation 'IGL03382:Zfp942'
ID420749
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp942
Ensembl Gene ENSMUSG00000071267
Gene Namezinc finger protein 942
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.069) question?
Stock #IGL03382
Quality Score
Status
Chromosome17
Chromosomal Location21926960-21962464 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 21929102 bp
ZygosityHeterozygous
Amino Acid Change Proline to Leucine at position 182 (P182L)
Ref Sequence ENSEMBL: ENSMUSP00000089494 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074295] [ENSMUST00000091879]
Predicted Effect probably benign
Transcript: ENSMUST00000074295
AA Change: P182L

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000073907
Gene: ENSMUSG00000071267
AA Change: P182L

DomainStartEndE-ValueType
KRAB 13 69 6.55e-19 SMART
ZnF_C2H2 183 205 1.16e-1 SMART
ZnF_C2H2 211 233 8.22e-2 SMART
ZnF_C2H2 239 261 5.14e-3 SMART
ZnF_C2H2 267 289 8.02e-5 SMART
ZnF_C2H2 295 317 2.32e-1 SMART
ZnF_C2H2 323 345 1.6e-4 SMART
ZnF_C2H2 351 373 8.94e-3 SMART
ZnF_C2H2 379 401 1.95e-3 SMART
ZnF_C2H2 407 429 2.24e-3 SMART
ZnF_C2H2 435 457 7.49e-5 SMART
ZnF_C2H2 463 485 2.99e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000091879
AA Change: P182L

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000089494
Gene: ENSMUSG00000071267
AA Change: P182L

DomainStartEndE-ValueType
KRAB 13 69 6.55e-19 SMART
ZnF_C2H2 183 205 1.16e-1 SMART
ZnF_C2H2 211 233 8.22e-2 SMART
ZnF_C2H2 239 261 5.14e-3 SMART
ZnF_C2H2 267 289 8.02e-5 SMART
ZnF_C2H2 295 317 2.32e-1 SMART
ZnF_C2H2 323 345 1.6e-4 SMART
ZnF_C2H2 351 373 8.94e-3 SMART
ZnF_C2H2 379 401 1.95e-3 SMART
ZnF_C2H2 407 429 2.24e-3 SMART
ZnF_C2H2 435 457 7.49e-5 SMART
ZnF_C2H2 463 485 2.99e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930021J03Rik C T 19: 29,717,276 G1606R probably damaging Het
Aff1 A G 5: 103,841,060 D831G possibly damaging Het
Amer2 A G 14: 60,379,882 K509E possibly damaging Het
Ankrd6 T C 4: 32,808,771 K449E probably damaging Het
Atp8b2 G A 3: 89,948,521 P459L probably benign Het
Atr C T 9: 95,920,822 R1846* probably null Het
Ccdc159 C A 9: 21,931,696 probably null Het
Ccna1 A C 3: 55,047,277 Y338D probably damaging Het
Cpq A T 15: 33,212,943 E36V probably damaging Het
Cyp2c23 A G 19: 44,014,932 I268T probably damaging Het
Dctn2 G T 10: 127,278,188 Q332H probably damaging Het
Dnah17 T A 11: 118,081,943 I2055F probably damaging Het
Dnmt3b A G 2: 153,686,359 H764R probably damaging Het
Gphn T A 12: 78,481,313 I135K probably damaging Het
Hnrnpul1 A G 7: 25,750,984 M1T probably null Het
Htra4 T C 8: 25,029,698 D406G probably benign Het
Klk10 G T 7: 43,784,459 probably benign Het
Lilrb4a T A 10: 51,491,520 W53R probably benign Het
Magel2 T C 7: 62,378,713 V455A probably benign Het
Mrgprb5 T C 7: 48,168,694 T98A probably benign Het
Mrps35 T A 6: 147,049,875 C76* probably null Het
Myh7b C T 2: 155,623,479 R701C probably damaging Het
Nbeal1 G A 1: 60,261,586 probably null Het
Neb T A 2: 52,325,708 M196L probably benign Het
Nmd3 A G 3: 69,735,088 K207R probably damaging Het
Plxna4 C T 6: 32,202,194 R962Q probably benign Het
Pom121 T C 5: 135,392,407 K230E unknown Het
Psme4 A G 11: 30,807,788 D307G possibly damaging Het
Rnf41 T G 10: 128,438,280 M267R possibly damaging Het
Sis T C 3: 72,928,719 N846D probably benign Het
Slc22a19 T A 19: 7,681,862 I463L probably benign Het
Slc25a39 A T 11: 102,406,204 probably null Het
Slc35b2 C T 17: 45,566,645 R233C probably damaging Het
Slc4a4 T C 5: 89,228,836 L983P probably damaging Het
Sp110 A C 1: 85,577,329 F434C probably benign Het
Tbc1d10a A G 11: 4,209,984 Y123C probably damaging Het
Thbs4 A C 13: 92,769,548 I395S probably benign Het
Triml2 A G 8: 43,193,739 T422A probably benign Het
Ubn2 T C 6: 38,440,447 probably benign Het
Vmn1r15 T A 6: 57,258,570 M141K probably benign Het
Vmn2r80 A G 10: 79,169,528 E333G probably damaging Het
Zfp169 T C 13: 48,491,163 probably benign Het
Other mutations in Zfp942
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Zfp942 APN 17 21929061 missense probably benign
IGL00586:Zfp942 APN 17 21928624 missense probably damaging 1.00
IGL02973:Zfp942 APN 17 21932991 critical splice donor site probably null
IGL03212:Zfp942 APN 17 21929464 nonsense probably null
R0008:Zfp942 UTSW 17 21928338 missense probably damaging 1.00
R0113:Zfp942 UTSW 17 21929085 missense probably benign 0.18
R0244:Zfp942 UTSW 17 21928572 missense probably benign 0.02
R0369:Zfp942 UTSW 17 21929036 missense probably benign 0.41
R1664:Zfp942 UTSW 17 21928439 missense possibly damaging 0.83
R1824:Zfp942 UTSW 17 21928541 missense probably damaging 1.00
R4545:Zfp942 UTSW 17 21928304 missense probably benign 0.00
R4785:Zfp942 UTSW 17 21929419 missense probably damaging 1.00
R5493:Zfp942 UTSW 17 21933004 missense probably null 0.66
R6568:Zfp942 UTSW 17 21929062 missense probably benign 0.14
R6733:Zfp942 UTSW 17 21928752 nonsense probably null
R7650:Zfp942 UTSW 17 21928837 missense probably benign 0.07
R7935:Zfp942 UTSW 17 21929227 nonsense probably null
R8065:Zfp942 UTSW 17 21930410 missense probably damaging 0.96
R8067:Zfp942 UTSW 17 21930410 missense probably damaging 0.96
R8237:Zfp942 UTSW 17 21928245 missense possibly damaging 0.92
R8513:Zfp942 UTSW 17 21928301 missense probably benign
X0025:Zfp942 UTSW 17 21929307 missense probably damaging 1.00
Posted On2016-08-02