Incidental Mutation 'IGL03386:Qrsl1'
ID420880
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Qrsl1
Ensembl Gene ENSMUSG00000019863
Gene Nameglutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
SynonymsGatA, 2700038P16Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.963) question?
Stock #IGL03386
Quality Score
Status
Chromosome10
Chromosomal Location43874188-43901745 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 43876550 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 426 (Y426H)
Ref Sequence ENSEMBL: ENSMUSP00000020012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020012]
Predicted Effect possibly damaging
Transcript: ENSMUST00000020012
AA Change: Y426H

PolyPhen 2 Score 0.628 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000020012
Gene: ENSMUSG00000019863
AA Change: Y426H

DomainStartEndE-ValueType
Pfam:Amidase 22 484 6e-129 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146937
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154405
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI481877 T C 4: 59,069,315 K704E possibly damaging Het
Arid2 T C 15: 96,361,574 F236L probably damaging Het
AU018091 T C 7: 3,161,267 Y274C probably damaging Het
BC024139 A G 15: 76,121,745 F419L probably benign Het
Cd300ld T G 11: 114,984,172 D212A probably benign Het
Ces1g T C 8: 93,325,812 H283R probably benign Het
Chac2 T A 11: 30,977,720 K66N probably benign Het
Emc1 T C 4: 139,363,781 probably null Het
Eml6 G A 11: 29,749,934 A1734V probably benign Het
Erich3 G A 3: 154,739,239 E548K possibly damaging Het
Gm3604 T A 13: 62,370,167 E105D possibly damaging Het
Gpr158 A G 2: 21,826,246 K719R probably damaging Het
Heatr6 T C 11: 83,759,377 S220P probably damaging Het
Kcnip4 T C 5: 48,482,547 Y74C probably damaging Het
Kmt2b T C 7: 30,573,971 H2380R possibly damaging Het
Lars2 A T 9: 123,453,390 K680* probably null Het
Macc1 T A 12: 119,445,863 M122K probably benign Het
Pbrm1 A G 14: 31,050,092 D381G probably damaging Het
Phf11d A G 14: 59,361,860 probably benign Het
Riok1 T A 13: 38,057,237 L456* probably null Het
Rps6kc1 A G 1: 190,799,570 L745P probably damaging Het
Sh3tc2 A T 18: 61,973,311 H137L probably benign Het
Shroom3 T A 5: 92,948,483 probably benign Het
Stac2 T A 11: 98,041,140 Q103L possibly damaging Het
Thnsl1 G A 2: 21,211,548 A38T probably benign Het
Traf3ip2 A G 10: 39,645,708 I421V probably benign Het
Vmn2r14 T C 5: 109,220,484 D214G possibly damaging Het
Other mutations in Qrsl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00477:Qrsl1 APN 10 43876492 missense probably damaging 1.00
IGL01724:Qrsl1 APN 10 43874608 missense probably benign 0.01
IGL01896:Qrsl1 APN 10 43876504 missense probably benign 0.02
IGL02192:Qrsl1 APN 10 43885014 missense probably damaging 1.00
IGL02239:Qrsl1 APN 10 43894600 missense possibly damaging 0.96
IGL02478:Qrsl1 APN 10 43882162 missense probably damaging 0.97
IGL02756:Qrsl1 APN 10 43882114 missense probably benign 0.00
R0277:Qrsl1 UTSW 10 43896007 critical splice donor site probably null
R0323:Qrsl1 UTSW 10 43896007 critical splice donor site probably null
R0674:Qrsl1 UTSW 10 43896001 splice site probably benign
R1054:Qrsl1 UTSW 10 43882081 missense probably damaging 1.00
R1719:Qrsl1 UTSW 10 43896030 missense probably damaging 0.97
R1743:Qrsl1 UTSW 10 43881515 missense probably damaging 1.00
R1854:Qrsl1 UTSW 10 43894545 missense probably damaging 1.00
R2233:Qrsl1 UTSW 10 43896096 missense probably benign 0.00
R4176:Qrsl1 UTSW 10 43884832 missense probably damaging 1.00
R4452:Qrsl1 UTSW 10 43882162 missense probably damaging 1.00
R4732:Qrsl1 UTSW 10 43876663 missense probably damaging 1.00
R4733:Qrsl1 UTSW 10 43876663 missense probably damaging 1.00
R5626:Qrsl1 UTSW 10 43881520 missense probably benign 0.00
R6159:Qrsl1 UTSW 10 43882193 missense probably benign 0.00
R7563:Qrsl1 UTSW 10 43876517 missense probably damaging 1.00
R8050:Qrsl1 UTSW 10 43874635 missense not run
Z1176:Qrsl1 UTSW 10 43884948 missense not run
Posted On2016-08-02