Incidental Mutation 'IGL03388:Rnf115'
ID420955
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnf115
Ensembl Gene ENSMUSG00000028098
Gene Namering finger protein 115
Synonyms2610028E05Rik, Rabring7, Zfp364
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03388
Quality Score
Status
Chromosome3
Chromosomal Location96727664-96791638 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 96788668 bp
ZygosityHeterozygous
Amino Acid Change Valine to Methionine at position 257 (V257M)
Ref Sequence ENSEMBL: ENSMUSP00000029740 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029740] [ENSMUST00000199051]
Predicted Effect probably damaging
Transcript: ENSMUST00000029740
AA Change: V257M

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000029740
Gene: ENSMUSG00000028098
AA Change: V257M

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
RING 229 269 1.14e-8 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197286
Predicted Effect probably benign
Transcript: ENSMUST00000199051
SMART Domains Protein: ENSMUSP00000143321
Gene: ENSMUSG00000028098

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
Pfam:zf-RING_3 18 49 4.5e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199974
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030468B19Rik T C 11: 117,802,770 probably benign Het
B3gnt5 A G 16: 19,770,051 K340R possibly damaging Het
Ccr3 A G 9: 124,028,621 probably benign Het
Cdan1 A G 2: 120,730,511 probably benign Het
Clasp1 T A 1: 118,505,503 D237E possibly damaging Het
Ddx18 T C 1: 121,565,923 K111E possibly damaging Het
Defa21 T C 8: 21,025,748 L54P probably damaging Het
Dennd3 T C 15: 73,544,359 V486A probably damaging Het
Dnah9 T A 11: 65,947,542 D3143V probably damaging Het
Dnm1l A G 16: 16,314,052 probably benign Het
Epb41 T C 4: 131,974,794 Y510C probably damaging Het
Fat4 T C 3: 38,957,227 Y2159H probably damaging Het
Fmo1 A G 1: 162,836,147 V271A probably benign Het
Gm11492 T A 11: 87,568,216 L472* probably null Het
Gm12185 A G 11: 48,908,286 V460A probably benign Het
Hspa8 T C 9: 40,804,928 probably benign Het
Hspb7 A G 4: 141,424,045 E166G probably damaging Het
Il31ra C A 13: 112,546,212 S120I probably damaging Het
Kdm5b A G 1: 134,627,322 T1323A probably benign Het
Lgals9 T A 11: 78,963,421 I346F probably damaging Het
Lgi2 T C 5: 52,538,477 D372G probably damaging Het
Magi3 A C 3: 104,015,841 S1187A probably benign Het
Nr1d2 A G 14: 18,215,403 F203S probably benign Het
Nup210l G A 3: 90,170,044 V896I probably damaging Het
Nxf7 T C X: 135,584,740 K440E probably damaging Het
Olfr1505 T A 19: 13,919,620 V200D probably damaging Het
Olfr776 A T 10: 129,261,443 I161F probably benign Het
Pcdhb6 T C 18: 37,336,137 S20P probably damaging Het
Per2 G T 1: 91,444,789 probably benign Het
Pi15 G A 1: 17,602,777 A67T probably benign Het
Pnp2 A T 14: 50,963,538 N160I probably damaging Het
Ppp1r12c A G 7: 4,482,070 probably benign Het
Rabgap1l A T 1: 160,733,523 probably null Het
Rtkn T A 6: 83,150,090 V346D probably benign Het
Rubcn A T 16: 32,841,568 N427K probably benign Het
Scgb2b7 A T 7: 31,705,081 C65S probably damaging Het
Sel1l2 A C 2: 140,263,364 probably benign Het
Slc5a5 A G 8: 70,890,328 V196A probably benign Het
Sox13 A T 1: 133,388,948 L207H probably damaging Het
Tmtc2 A G 10: 105,321,483 probably benign Het
Trip12 T C 1: 84,743,186 K1409R probably damaging Het
Ttn C T 2: 76,967,137 A528T probably benign Het
Ubr4 T C 4: 139,415,032 I1310T probably damaging Het
Ypel5 T C 17: 72,846,405 F35L probably damaging Het
Zfp13 G T 17: 23,576,914 R228S probably benign Het
Other mutations in Rnf115
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0051:Rnf115 UTSW 3 96785022 missense probably damaging 1.00
R0051:Rnf115 UTSW 3 96785022 missense probably damaging 1.00
R1864:Rnf115 UTSW 3 96727837 unclassified probably benign
R3015:Rnf115 UTSW 3 96754359 missense probably damaging 1.00
R4030:Rnf115 UTSW 3 96785983 missense probably damaging 1.00
R4590:Rnf115 UTSW 3 96788573 missense probably benign 0.00
R5370:Rnf115 UTSW 3 96758020 missense probably benign 0.05
R5820:Rnf115 UTSW 3 96727848 unclassified probably benign
R5978:Rnf115 UTSW 3 96788666 missense probably damaging 1.00
Posted On2016-08-02