Incidental Mutation 'IGL03390:Cdnf'
ID421025
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdnf
Ensembl Gene ENSMUSG00000039496
Gene Namecerebral dopamine neurotrophic factor
SynonymsArmetl1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.039) question?
Stock #IGL03390
Quality Score
Status
Chromosome2
Chromosomal Location3513030-3526376 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 3523826 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Stop codon at position 134 (L134*)
Ref Sequence ENSEMBL: ENSMUSP00000046297 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036350]
Predicted Effect probably null
Transcript: ENSMUST00000036350
AA Change: L134*
SMART Domains Protein: ENSMUSP00000046297
Gene: ENSMUSG00000039496
AA Change: L134*

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Armet 36 181 2.6e-70 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132566
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140610
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810004N23Rik A G 8: 124,839,825 probably benign Het
Ccdc18 A G 5: 108,212,131 Y1127C probably damaging Het
Col11a1 A G 3: 114,090,253 D257G unknown Het
Cthrc1 T A 15: 39,077,134 I44N probably benign Het
Dlec1 T C 9: 119,123,220 Y545H probably benign Het
Drosha T G 15: 12,884,983 probably null Het
Ebf2 A G 14: 67,424,109 N562S probably benign Het
Fem1b G A 9: 62,796,964 A338V probably benign Het
Gga3 A T 11: 115,586,994 probably null Het
Gm7247 A T 14: 51,523,457 H161L probably benign Het
Gm7367 A G 7: 60,155,769 noncoding transcript Het
Inpp5a T G 7: 139,525,748 V213G probably benign Het
Kcns3 T C 12: 11,091,232 T489A probably benign Het
Kifc3 G A 8: 95,108,613 A211V probably damaging Het
Krt71 T C 15: 101,734,552 D507G possibly damaging Het
Lama5 T C 2: 180,207,218 Y224C probably damaging Het
Lrrc37a A G 11: 103,496,031 L2421P unknown Het
Mtch2 C T 2: 90,859,550 T205I probably benign Het
Olfr108 T C 17: 37,446,364 V281A probably benign Het
Prkdc T A 16: 15,670,626 C537* probably null Het
Prl2a1 T C 13: 27,801,716 V5A probably benign Het
Prob1 T C 18: 35,654,139 Y354C probably benign Het
Rimklb C T 6: 122,456,321 S347N possibly damaging Het
Rnase2a T C 14: 51,255,488 D140G probably damaging Het
Ryr2 G A 13: 11,772,416 P1017S probably benign Het
Slc3a1 A G 17: 85,032,777 D209G probably damaging Het
Sntn T A 14: 13,682,205 probably benign Het
Tal2 G T 4: 53,785,994 L58F probably damaging Het
Trim39 T C 17: 36,260,571 K432E probably damaging Het
Trmt5 A T 12: 73,282,727 M219K probably benign Het
Vmn2r3 T A 3: 64,275,346 I311L possibly damaging Het
Wfdc17 A T 11: 83,704,785 probably benign Het
Zbtb6 T G 2: 37,429,572 I115L probably damaging Het
Zfp750 A T 11: 121,511,944 C659* probably null Het
Other mutations in Cdnf
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00773:Cdnf APN 2 3519355 missense possibly damaging 0.73
IGL02552:Cdnf APN 2 3523975 nonsense probably null
R1528:Cdnf UTSW 2 3521041 missense probably damaging 1.00
R2846:Cdnf UTSW 2 3513128 start codon destroyed probably null 0.99
R4077:Cdnf UTSW 2 3521023 missense probably damaging 1.00
Z1177:Cdnf UTSW 2 3521083 missense possibly damaging 0.50
Posted On2016-08-02