Incidental Mutation 'IGL03391:Olfr1134'
ID421051
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1134
Ensembl Gene ENSMUSG00000111747
Gene Name
SynonymsGA_x6K02T2Q125-49162076-49161138, MOR176-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.157) question?
Stock #IGL03391
Quality Score
Status
Chromosome2
Chromosomal Location87655673-87658460 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 87656688 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 78 (S78P)
Ref Sequence ENSEMBL: ENSMUSP00000150358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099857] [ENSMUST00000135875] [ENSMUST00000213939]
Predicted Effect possibly damaging
Transcript: ENSMUST00000099854
AA Change: S78P

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097440
Gene: ENSMUSG00000075154
AA Change: S78P

DomainStartEndE-ValueType
GHB 123 190 1.21e0 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000099857
AA Change: S78P

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097443
Gene: ENSMUSG00000111747
AA Change: S78P

DomainStartEndE-ValueType
GHB 123 190 1.21e0 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000135875
AA Change: S78P

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213939
AA Change: S78P

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 120,246,884 D586G probably damaging Het
Acadvl A C 11: 70,010,716 M557R probably damaging Het
Ano2 T A 6: 125,807,839 N327K probably damaging Het
Cdh11 A T 8: 102,674,023 D104E possibly damaging Het
Chrnb2 A G 3: 89,760,877 F377S probably damaging Het
Cngb1 T C 8: 95,303,705 probably benign Het
Dnaaf1 C T 8: 119,582,616 R148C probably damaging Het
Esrrg A T 1: 188,150,223 I226F possibly damaging Het
Evl C A 12: 108,676,099 probably null Het
Gpam T C 19: 55,081,696 E376G probably damaging Het
Gzf1 C A 2: 148,683,683 R25S probably damaging Het
Ighv5-2 A T 12: 113,578,518 Y113* probably null Het
Izumo4 A G 10: 80,705,113 T216A probably damaging Het
Lrp1b T G 2: 41,295,641 Y1354S possibly damaging Het
Mark1 A G 1: 184,919,435 probably benign Het
Mylpf A G 7: 127,213,177 I17V probably benign Het
Myo18b C A 5: 112,874,479 probably benign Het
Nbas C T 12: 13,483,749 A1795V probably benign Het
Olfr1484 A G 19: 13,586,119 M272V probably benign Het
Olfr697 A T 7: 106,741,755 Y60N probably damaging Het
Oprm1 A C 10: 7,014,077 probably benign Het
Parp14 T C 16: 35,858,270 M443V probably benign Het
Psca T C 15: 74,714,868 F5S probably benign Het
Ptbp2 A T 3: 119,720,382 Y514* probably null Het
Scg3 A G 9: 75,661,251 probably null Het
Scn2a T C 2: 65,764,213 V1802A probably damaging Het
Serpinb3a A G 1: 107,046,342 S280P possibly damaging Het
Slc39a14 T C 14: 70,309,842 I352V probably damaging Het
Slc6a2 G T 8: 92,961,452 V69L probably damaging Het
Slc8a1 A G 17: 81,432,638 probably benign Het
Tjp1 T C 7: 65,314,969 D818G probably damaging Het
Tnfaip8 T C 18: 50,090,485 V120A probably damaging Het
Trmt5 G A 12: 73,281,452 H326Y probably benign Het
Vmn1r222 T C 13: 23,232,462 M194V possibly damaging Het
Zbtb17 A G 4: 141,466,758 E699G probably damaging Het
Other mutations in Olfr1134
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Olfr1134 APN 2 87656238 missense probably benign 0.01
IGL01397:Olfr1134 APN 2 87656905 missense probably damaging 0.99
IGL01583:Olfr1134 APN 2 87656413 nonsense probably null
IGL01655:Olfr1134 APN 2 87656429 missense probably damaging 1.00
IGL02184:Olfr1134 APN 2 87656792 missense probably damaging 0.99
IGL02263:Olfr1134 APN 2 87656199 missense probably damaging 1.00
IGL02964:Olfr1134 APN 2 87656714 missense probably damaging 1.00
R5171:Olfr1134 UTSW 2 87656544 missense possibly damaging 0.95
R6434:Olfr1134 UTSW 2 87656214 nonsense probably null
R7466:Olfr1134 UTSW 2 87656396 missense possibly damaging 0.73
R7770:Olfr1134 UTSW 2 87656469 missense not run
Posted On2016-08-02