Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03392:Prss45'

421101

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss45

Ensembl Gene

ENSMUSG00000047257

Gene Name

serine protease 45

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL03392

Quality Score

Status

Chromosome

Chromosomal Location

110663656-110670378 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 110669618 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 231 (Y231*)

Ref Sequence

ENSEMBL: ENSMUSP00000120471 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000011391] [ENSMUST00000146794] [ENSMUST00000176403]

AlphaFold

Q8K4I7

Predicted Effect

probably null
Transcript: ENSMUST00000011391
AA Change: Y240*

SMART Domains

Protein: ENSMUSP00000011391
Gene: ENSMUSG00000047257
AA Change: Y240*

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
Tryp_SPc	44	286	6.39e-50	SMART
low complexity region	302	317	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000146794
AA Change: Y231*

SMART Domains

Protein: ENSMUSP00000120471
Gene: ENSMUSG00000047257
AA Change: Y231*

Domain	Start	End	E-Value	Type
Tryp_SPc	35	277	3.19e-50	SMART
low complexity region	293	308	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000176403

SMART Domains

Protein: ENSMUSP00000135787
Gene: ENSMUSG00000049719

Domain	Start	End	E-Value	Type
Tryp_SPc	43	276	1.62e-60	SMART
transmembrane domain	291	313	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss2	T	A	2: 155,403,931 (GRCm39)	D692E	probably damaging	Het
Adgrb3	T	A	1: 25,543,529 (GRCm39)	R366S	probably damaging	Het
Afg3l2	C	A	18: 67,547,139 (GRCm39)		probably benign	Het
Cd5	T	C	19: 10,703,653 (GRCm39)		probably benign	Het
Cnbd1	A	G	4: 18,862,111 (GRCm39)	S360P	probably damaging	Het
Col13a1	A	T	10: 61,721,490 (GRCm39)	L305I	possibly damaging	Het
Commd7	A	T	2: 153,464,684 (GRCm39)		probably benign	Het
Cpsf6	A	T	10: 117,203,884 (GRCm39)	Y23N	probably damaging	Het
Cry1	A	G	10: 84,992,993 (GRCm39)	V75A	possibly damaging	Het
Cyp2c39	A	G	19: 39,501,767 (GRCm39)	N107D	probably benign	Het
Dcaf11	T	A	14: 55,798,878 (GRCm39)	V45E	probably damaging	Het
Dnm2	A	G	9: 21,385,907 (GRCm39)	E310G	probably damaging	Het
Fat3	T	A	9: 15,915,158 (GRCm39)	I1597L	probably benign	Het
Fcamr	A	G	1: 130,728,685 (GRCm39)		probably benign	Het
Fer	A	G	17: 64,298,637 (GRCm39)	I529V	probably damaging	Het
Fhdc1	T	C	3: 84,351,826 (GRCm39)	K1133R	possibly damaging	Het
Foxd3	A	G	4: 99,545,432 (GRCm39)	K191E	probably damaging	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
Gbp8	A	G	5: 105,164,410 (GRCm39)		probably null	Het
Glb1	T	G	9: 114,259,389 (GRCm39)	N106K	probably damaging	Het
Hpx	A	G	7: 105,241,609 (GRCm39)	I295T	probably damaging	Het
Ipo5	T	A	14: 121,180,099 (GRCm39)	D844E	probably damaging	Het
Krt17	T	C	11: 100,150,561 (GRCm39)	I159V	possibly damaging	Het
Lgi4	G	A	7: 30,762,605 (GRCm39)		probably null	Het
Lrrc49	T	C	9: 60,573,563 (GRCm39)		probably benign	Het
Ltn1	T	C	16: 87,222,499 (GRCm39)	K178R	probably damaging	Het
Myh8	T	A	11: 67,185,244 (GRCm39)	W832R	probably damaging	Het
Nbn	A	G	4: 15,962,362 (GRCm39)	N30S	probably damaging	Het
Or2j3	A	G	17: 38,615,786 (GRCm39)	S189P	probably benign	Het
Or4a72	A	T	2: 89,405,593 (GRCm39)	V159D	probably damaging	Het
Or4f59	T	A	2: 111,873,321 (GRCm39)	N19Y	probably benign	Het
Or51ai2	T	C	7: 103,587,232 (GRCm39)	V215A	probably benign	Het
Pcdh15	A	T	10: 74,460,104 (GRCm39)	I1314F	probably damaging	Het
Phf14	G	A	6: 11,962,658 (GRCm39)	S435N	probably damaging	Het
Pus7l	T	C	15: 94,434,449 (GRCm39)	D339G	probably damaging	Het
Sbk2	A	G	7: 4,960,408 (GRCm39)	F254S	probably damaging	Het
Serpina1b	T	G	12: 103,698,329 (GRCm39)	K173N	possibly damaging	Het
Slc13a5	G	A	11: 72,136,004 (GRCm39)	T469I	probably damaging	Het
Spon1	A	G	7: 113,633,522 (GRCm39)	E655G	probably damaging	Het
Sv2b	T	C	7: 74,806,508 (GRCm39)		probably null	Het
Treh	A	G	9: 44,597,228 (GRCm39)	D514G	probably damaging	Het
Umodl1	T	A	17: 31,215,329 (GRCm39)	L1051Q	probably damaging	Het
Usp5	A	G	6: 124,803,350 (GRCm39)	F4S	probably damaging	Het
Vmn1r16	A	G	6: 57,299,879 (GRCm39)	S248P	probably damaging	Het

Other mutations in Prss45

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00160:Prss45	APN	9	110,670,073 (GRCm39)	missense	probably damaging	1.00
IGL00561:Prss45	APN	9	110,669,578 (GRCm39)	missense	probably damaging	1.00
BB002:Prss45	UTSW	9	110,670,103 (GRCm39)	missense	unknown
BB012:Prss45	UTSW	9	110,670,103 (GRCm39)	missense	unknown
PIT4260001:Prss45	UTSW	9	110,667,513 (GRCm39)	missense	probably benign	0.00
R0025:Prss45	UTSW	9	110,669,962 (GRCm39)	missense	probably damaging	0.99
R0576:Prss45	UTSW	9	110,667,497 (GRCm39)	missense	probably benign
R1464:Prss45	UTSW	9	110,670,019 (GRCm39)	missense	possibly damaging	0.56
R1464:Prss45	UTSW	9	110,670,019 (GRCm39)	missense	possibly damaging	0.56
R1572:Prss45	UTSW	9	110,667,497 (GRCm39)	missense	probably benign	0.00
R2420:Prss45	UTSW	9	110,668,160 (GRCm39)	missense	possibly damaging	0.48
R4289:Prss45	UTSW	9	110,669,997 (GRCm39)	missense	probably benign	0.01
R5049:Prss45	UTSW	9	110,669,538 (GRCm39)	missense	probably damaging	0.98
R6761:Prss45	UTSW	9	110,669,487 (GRCm39)	missense	probably damaging	1.00
R7379:Prss45	UTSW	9	110,668,261 (GRCm39)	missense	possibly damaging	0.89
R7925:Prss45	UTSW	9	110,670,103 (GRCm39)	missense	unknown
R9348:Prss45	UTSW	9	110,668,278 (GRCm39)	missense	probably damaging	1.00
Z1177:Prss45	UTSW	9	110,668,114 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02