Incidental Mutation 'IGL03392:Prss45'
ID421101
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss45
Ensembl Gene ENSMUSG00000047257
Gene Nameprotease, serine 45
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL03392
Quality Score
Status
Chromosome9
Chromosomal Location110834588-110841313 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 110840550 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 231 (Y231*)
Ref Sequence ENSEMBL: ENSMUSP00000120471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000011391] [ENSMUST00000146794] [ENSMUST00000176403]
Predicted Effect probably null
Transcript: ENSMUST00000011391
AA Change: Y240*
SMART Domains Protein: ENSMUSP00000011391
Gene: ENSMUSG00000047257
AA Change: Y240*

DomainStartEndE-ValueType
signal peptide 1 36 N/A INTRINSIC
Tryp_SPc 44 286 6.39e-50 SMART
low complexity region 302 317 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000146794
AA Change: Y231*
SMART Domains Protein: ENSMUSP00000120471
Gene: ENSMUSG00000047257
AA Change: Y231*

DomainStartEndE-ValueType
Tryp_SPc 35 277 3.19e-50 SMART
low complexity region 293 308 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176403
SMART Domains Protein: ENSMUSP00000135787
Gene: ENSMUSG00000049719

DomainStartEndE-ValueType
Tryp_SPc 43 276 1.62e-60 SMART
transmembrane domain 291 313 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 T A 2: 155,562,011 D692E probably damaging Het
Adgrb3 T A 1: 25,504,448 R366S probably damaging Het
Afg3l2 C A 18: 67,414,069 probably benign Het
Cd5 T C 19: 10,726,289 probably benign Het
Cnbd1 A G 4: 18,862,111 S360P probably damaging Het
Col13a1 A T 10: 61,885,711 L305I possibly damaging Het
Commd7 A T 2: 153,622,764 probably benign Het
Cpsf6 A T 10: 117,367,979 Y23N probably damaging Het
Cry1 A G 10: 85,157,129 V75A possibly damaging Het
Cyp2c39 A G 19: 39,513,323 N107D probably benign Het
Dcaf11 T A 14: 55,561,421 V45E probably damaging Het
Dnm2 A G 9: 21,474,611 E310G probably damaging Het
Fat3 T A 9: 16,003,862 I1597L probably benign Het
Fcamr A G 1: 130,800,948 probably benign Het
Fer A G 17: 63,991,642 I529V probably damaging Het
Fhdc1 T C 3: 84,444,519 K1133R possibly damaging Het
Foxd3 A G 4: 99,657,195 K191E probably damaging Het
Fut2 C T 7: 45,650,769 G193E possibly damaging Het
Gbp8 A G 5: 105,016,544 probably null Het
Glb1 T G 9: 114,430,321 N106K probably damaging Het
Hpx A G 7: 105,592,402 I295T probably damaging Het
Ipo5 T A 14: 120,942,687 D844E probably damaging Het
Krt17 T C 11: 100,259,735 I159V possibly damaging Het
Lgi4 G A 7: 31,063,180 probably null Het
Lrrc49 T C 9: 60,666,280 probably benign Het
Ltn1 T C 16: 87,425,611 K178R probably damaging Het
Myh8 T A 11: 67,294,418 W832R probably damaging Het
Nbn A G 4: 15,962,362 N30S probably damaging Het
Olfr1245 A T 2: 89,575,249 V159D probably damaging Het
Olfr1312 T A 2: 112,042,976 N19Y probably benign Het
Olfr137 A G 17: 38,304,895 S189P probably benign Het
Olfr632 T C 7: 103,938,025 V215A probably benign Het
Pcdh15 A T 10: 74,624,272 I1314F probably damaging Het
Phf14 G A 6: 11,962,659 S435N probably damaging Het
Pus7l T C 15: 94,536,568 D339G probably damaging Het
Sbk2 A G 7: 4,957,409 F254S probably damaging Het
Serpina1b T G 12: 103,732,070 K173N possibly damaging Het
Slc13a5 G A 11: 72,245,178 T469I probably damaging Het
Spon1 A G 7: 114,034,287 E655G probably damaging Het
Sv2b T C 7: 75,156,760 probably null Het
Treh A G 9: 44,685,931 D514G probably damaging Het
Umodl1 T A 17: 30,996,355 L1051Q probably damaging Het
Usp5 A G 6: 124,826,387 F4S probably damaging Het
Vmn1r16 A G 6: 57,322,894 S248P probably damaging Het
Other mutations in Prss45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00160:Prss45 APN 9 110841005 missense probably damaging 1.00
IGL00561:Prss45 APN 9 110840510 missense probably damaging 1.00
BB002:Prss45 UTSW 9 110841035 missense unknown
BB012:Prss45 UTSW 9 110841035 missense unknown
PIT4260001:Prss45 UTSW 9 110838445 missense probably benign 0.00
R0025:Prss45 UTSW 9 110840894 missense probably damaging 0.99
R0576:Prss45 UTSW 9 110838429 missense probably benign
R1464:Prss45 UTSW 9 110840951 missense possibly damaging 0.56
R1464:Prss45 UTSW 9 110840951 missense possibly damaging 0.56
R1572:Prss45 UTSW 9 110838429 missense probably benign 0.00
R2420:Prss45 UTSW 9 110839092 missense possibly damaging 0.48
R4289:Prss45 UTSW 9 110840929 missense probably benign 0.01
R5049:Prss45 UTSW 9 110840470 missense probably damaging 0.98
R6761:Prss45 UTSW 9 110840419 missense probably damaging 1.00
R7379:Prss45 UTSW 9 110839193 missense possibly damaging 0.89
R7925:Prss45 UTSW 9 110841035 missense unknown
Z1177:Prss45 UTSW 9 110839046 missense probably damaging 1.00
Posted On2016-08-02