Incidental Mutation 'IGL03392:Olfr632'
ID421102
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr632
Ensembl Gene ENSMUSG00000073938
Gene Nameolfactory receptor 632
SynonymsGA_x6K02T2PBJ9-6671256-6672209, MOR2-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL03392
Quality Score
Status
Chromosome7
Chromosomal Location103934347-103940579 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 103938025 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 215 (V215A)
Ref Sequence ENSEMBL: ENSMUSP00000149598 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098189] [ENSMUST00000214711]
Predicted Effect probably benign
Transcript: ENSMUST00000098189
AA Change: V215A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000095791
Gene: ENSMUSG00000073938
AA Change: V215A

DomainStartEndE-ValueType
Pfam:7tm_4 35 313 2.5e-109 PFAM
Pfam:7TM_GPCR_Srsx 39 232 7.5e-11 PFAM
Pfam:7tm_1 45 296 1.4e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211625
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214509
Predicted Effect probably benign
Transcript: ENSMUST00000214711
AA Change: V215A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 T A 2: 155,562,011 D692E probably damaging Het
Adgrb3 T A 1: 25,504,448 R366S probably damaging Het
Afg3l2 C A 18: 67,414,069 probably benign Het
Cd5 T C 19: 10,726,289 probably benign Het
Cnbd1 A G 4: 18,862,111 S360P probably damaging Het
Col13a1 A T 10: 61,885,711 L305I possibly damaging Het
Commd7 A T 2: 153,622,764 probably benign Het
Cpsf6 A T 10: 117,367,979 Y23N probably damaging Het
Cry1 A G 10: 85,157,129 V75A possibly damaging Het
Cyp2c39 A G 19: 39,513,323 N107D probably benign Het
Dcaf11 T A 14: 55,561,421 V45E probably damaging Het
Dnm2 A G 9: 21,474,611 E310G probably damaging Het
Fat3 T A 9: 16,003,862 I1597L probably benign Het
Fcamr A G 1: 130,800,948 probably benign Het
Fer A G 17: 63,991,642 I529V probably damaging Het
Fhdc1 T C 3: 84,444,519 K1133R possibly damaging Het
Foxd3 A G 4: 99,657,195 K191E probably damaging Het
Fut2 C T 7: 45,650,769 G193E possibly damaging Het
Gbp8 A G 5: 105,016,544 probably null Het
Glb1 T G 9: 114,430,321 N106K probably damaging Het
Hpx A G 7: 105,592,402 I295T probably damaging Het
Ipo5 T A 14: 120,942,687 D844E probably damaging Het
Krt17 T C 11: 100,259,735 I159V possibly damaging Het
Lgi4 G A 7: 31,063,180 probably null Het
Lrrc49 T C 9: 60,666,280 probably benign Het
Ltn1 T C 16: 87,425,611 K178R probably damaging Het
Myh8 T A 11: 67,294,418 W832R probably damaging Het
Nbn A G 4: 15,962,362 N30S probably damaging Het
Olfr1245 A T 2: 89,575,249 V159D probably damaging Het
Olfr1312 T A 2: 112,042,976 N19Y probably benign Het
Olfr137 A G 17: 38,304,895 S189P probably benign Het
Pcdh15 A T 10: 74,624,272 I1314F probably damaging Het
Phf14 G A 6: 11,962,659 S435N probably damaging Het
Prss45 T A 9: 110,840,550 Y231* probably null Het
Pus7l T C 15: 94,536,568 D339G probably damaging Het
Sbk2 A G 7: 4,957,409 F254S probably damaging Het
Serpina1b T G 12: 103,732,070 K173N possibly damaging Het
Slc13a5 G A 11: 72,245,178 T469I probably damaging Het
Spon1 A G 7: 114,034,287 E655G probably damaging Het
Sv2b T C 7: 75,156,760 probably null Het
Treh A G 9: 44,685,931 D514G probably damaging Het
Umodl1 T A 17: 30,996,355 L1051Q probably damaging Het
Usp5 A G 6: 124,826,387 F4S probably damaging Het
Vmn1r16 A G 6: 57,322,894 S248P probably damaging Het
Other mutations in Olfr632
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01331:Olfr632 APN 7 103937575 missense possibly damaging 0.88
IGL01817:Olfr632 APN 7 103937823 missense probably benign 0.01
IGL02303:Olfr632 APN 7 103937563 missense possibly damaging 0.62
R0092:Olfr632 UTSW 7 103937727 missense probably damaging 1.00
R0492:Olfr632 UTSW 7 103937764 missense probably benign 0.05
R0711:Olfr632 UTSW 7 103937817 missense probably benign 0.29
R2893:Olfr632 UTSW 7 103938182 missense probably damaging 1.00
R3911:Olfr632 UTSW 7 103937409 missense possibly damaging 0.94
R4825:Olfr632 UTSW 7 103937503 missense probably benign 0.02
R6106:Olfr632 UTSW 7 103938193 missense probably benign 0.05
R6254:Olfr632 UTSW 7 103937534 missense probably benign 0.07
R6383:Olfr632 UTSW 7 103937823 missense probably benign 0.01
R6821:Olfr632 UTSW 7 103937586 missense probably benign 0.07
R6890:Olfr632 UTSW 7 103937859 missense possibly damaging 0.71
R7646:Olfr632 UTSW 7 103938297 missense probably damaging 0.98
R8041:Olfr632 UTSW 7 103937581 missense probably damaging 1.00
R8232:Olfr632 UTSW 7 103937773 missense possibly damaging 0.65
R8266:Olfr632 UTSW 7 103937539 missense probably damaging 0.96
R8326:Olfr632 UTSW 7 103937602 missense probably damaging 1.00
Z1177:Olfr632 UTSW 7 103937758 missense possibly damaging 0.93
Posted On2016-08-02