Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03392:Fcamr'

421121

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fcamr

Ensembl Gene

ENSMUSG00000026415

Gene Name

Fc receptor, IgA, IgM, high affinity

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL03392

Quality Score

Status

Chromosome

Chromosomal Location

130728639-130742477 bp(+) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

A to G at 130728685 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000108096 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027670] [ENSMUST00000112477]

AlphaFold

Q2TB54

Predicted Effect

probably benign
Transcript: ENSMUST00000027670

SMART Domains

Protein: ENSMUSP00000027670
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
IG	87	191	1.19e-5	SMART
low complexity region	208	220	N/A	INTRINSIC
low complexity region	241	253	N/A	INTRINSIC
transmembrane domain	456	475	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000112477

SMART Domains

Protein: ENSMUSP00000108096
Gene: ENSMUSG00000026415

Domain	Start	End	E-Value	Type
low complexity region	80	87	N/A	INTRINSIC
IG	143	247	1.19e-5	SMART
low complexity region	264	276	N/A	INTRINSIC
low complexity region	297	309	N/A	INTRINSIC
transmembrane domain	512	531	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice have enhanced germinal center formation, affinity maturation and memory induction of IgG3 producing B cells after immunization with T cell-independent antigens. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss2	T	A	2: 155,403,931 (GRCm39)	D692E	probably damaging	Het
Adgrb3	T	A	1: 25,543,529 (GRCm39)	R366S	probably damaging	Het
Afg3l2	C	A	18: 67,547,139 (GRCm39)		probably benign	Het
Cd5	T	C	19: 10,703,653 (GRCm39)		probably benign	Het
Cnbd1	A	G	4: 18,862,111 (GRCm39)	S360P	probably damaging	Het
Col13a1	A	T	10: 61,721,490 (GRCm39)	L305I	possibly damaging	Het
Commd7	A	T	2: 153,464,684 (GRCm39)		probably benign	Het
Cpsf6	A	T	10: 117,203,884 (GRCm39)	Y23N	probably damaging	Het
Cry1	A	G	10: 84,992,993 (GRCm39)	V75A	possibly damaging	Het
Cyp2c39	A	G	19: 39,501,767 (GRCm39)	N107D	probably benign	Het
Dcaf11	T	A	14: 55,798,878 (GRCm39)	V45E	probably damaging	Het
Dnm2	A	G	9: 21,385,907 (GRCm39)	E310G	probably damaging	Het
Fat3	T	A	9: 15,915,158 (GRCm39)	I1597L	probably benign	Het
Fer	A	G	17: 64,298,637 (GRCm39)	I529V	probably damaging	Het
Fhdc1	T	C	3: 84,351,826 (GRCm39)	K1133R	possibly damaging	Het
Foxd3	A	G	4: 99,545,432 (GRCm39)	K191E	probably damaging	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
Gbp8	A	G	5: 105,164,410 (GRCm39)		probably null	Het
Glb1	T	G	9: 114,259,389 (GRCm39)	N106K	probably damaging	Het
Hpx	A	G	7: 105,241,609 (GRCm39)	I295T	probably damaging	Het
Ipo5	T	A	14: 121,180,099 (GRCm39)	D844E	probably damaging	Het
Krt17	T	C	11: 100,150,561 (GRCm39)	I159V	possibly damaging	Het
Lgi4	G	A	7: 30,762,605 (GRCm39)		probably null	Het
Lrrc49	T	C	9: 60,573,563 (GRCm39)		probably benign	Het
Ltn1	T	C	16: 87,222,499 (GRCm39)	K178R	probably damaging	Het
Myh8	T	A	11: 67,185,244 (GRCm39)	W832R	probably damaging	Het
Nbn	A	G	4: 15,962,362 (GRCm39)	N30S	probably damaging	Het
Or2j3	A	G	17: 38,615,786 (GRCm39)	S189P	probably benign	Het
Or4a72	A	T	2: 89,405,593 (GRCm39)	V159D	probably damaging	Het
Or4f59	T	A	2: 111,873,321 (GRCm39)	N19Y	probably benign	Het
Or51ai2	T	C	7: 103,587,232 (GRCm39)	V215A	probably benign	Het
Pcdh15	A	T	10: 74,460,104 (GRCm39)	I1314F	probably damaging	Het
Phf14	G	A	6: 11,962,658 (GRCm39)	S435N	probably damaging	Het
Prss45	T	A	9: 110,669,618 (GRCm39)	Y231*	probably null	Het
Pus7l	T	C	15: 94,434,449 (GRCm39)	D339G	probably damaging	Het
Sbk2	A	G	7: 4,960,408 (GRCm39)	F254S	probably damaging	Het
Serpina1b	T	G	12: 103,698,329 (GRCm39)	K173N	possibly damaging	Het
Slc13a5	G	A	11: 72,136,004 (GRCm39)	T469I	probably damaging	Het
Spon1	A	G	7: 113,633,522 (GRCm39)	E655G	probably damaging	Het
Sv2b	T	C	7: 74,806,508 (GRCm39)		probably null	Het
Treh	A	G	9: 44,597,228 (GRCm39)	D514G	probably damaging	Het
Umodl1	T	A	17: 31,215,329 (GRCm39)	L1051Q	probably damaging	Het
Usp5	A	G	6: 124,803,350 (GRCm39)	F4S	probably damaging	Het
Vmn1r16	A	G	6: 57,299,879 (GRCm39)	S248P	probably damaging	Het

Other mutations in Fcamr

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00840:Fcamr	APN	1	130,740,951 (GRCm39)	missense	probably benign	0.01
IGL02880:Fcamr	APN	1	130,741,071 (GRCm39)	missense	probably benign	0.00
IGL03199:Fcamr	APN	1	130,740,655 (GRCm39)	missense	probably damaging	1.00
IGL03398:Fcamr	APN	1	130,730,985 (GRCm39)	missense	probably damaging	0.97
R1101:Fcamr	UTSW	1	130,742,223 (GRCm39)	splice site	probably null
R1312:Fcamr	UTSW	1	130,739,224 (GRCm39)	missense	probably damaging	1.00
R1351:Fcamr	UTSW	1	130,740,757 (GRCm39)	missense	possibly damaging	0.83
R1387:Fcamr	UTSW	1	130,732,379 (GRCm39)	missense	possibly damaging	0.85
R1475:Fcamr	UTSW	1	130,742,221 (GRCm39)	splice site	probably null
R1728:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1728:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1728:Fcamr	UTSW	1	130,732,306 (GRCm39)	missense	probably benign	0.06
R1728:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1728:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1728:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1728:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1728:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1728:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1729:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1729:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1729:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1729:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1729:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1729:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1729:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1729:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1730:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1730:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1730:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1730:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1730:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1730:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1730:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1739:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1739:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1739:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1739:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1739:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1739:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1739:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1739:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1762:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1762:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1762:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1762:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1762:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1762:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1762:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1762:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1783:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1783:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1783:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1783:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1783:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1784:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1784:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1784:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1784:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1784:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1784:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1784:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1784:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130,740,546 (GRCm39)	missense	probably benign	0.02
R1785:Fcamr	UTSW	1	130,740,475 (GRCm39)	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130,740,429 (GRCm39)	missense	probably benign
R1785:Fcamr	UTSW	1	130,740,366 (GRCm39)	missense	probably benign	0.38
R1785:Fcamr	UTSW	1	130,739,317 (GRCm39)	missense	probably benign
R1785:Fcamr	UTSW	1	130,732,364 (GRCm39)	missense	probably benign	0.00
R1785:Fcamr	UTSW	1	130,732,306 (GRCm39)	missense	probably benign	0.06
R1785:Fcamr	UTSW	1	130,742,334 (GRCm39)	missense	probably benign
R1785:Fcamr	UTSW	1	130,740,553 (GRCm39)	missense	probably benign	0.41
R1793:Fcamr	UTSW	1	130,739,284 (GRCm39)	missense	probably benign	0.03
R2085:Fcamr	UTSW	1	130,739,335 (GRCm39)	missense	probably damaging	1.00
R3937:Fcamr	UTSW	1	130,732,313 (GRCm39)	missense	probably damaging	0.97
R4529:Fcamr	UTSW	1	130,732,313 (GRCm39)	missense	probably damaging	0.99
R4624:Fcamr	UTSW	1	130,730,999 (GRCm39)	missense	probably damaging	0.99
R4822:Fcamr	UTSW	1	130,740,423 (GRCm39)	missense	possibly damaging	0.82
R5055:Fcamr	UTSW	1	130,739,174 (GRCm39)	missense	probably damaging	1.00
R5514:Fcamr	UTSW	1	130,741,793 (GRCm39)	missense	probably damaging	1.00
R5807:Fcamr	UTSW	1	130,739,263 (GRCm39)	missense	probably damaging	1.00
R6077:Fcamr	UTSW	1	130,740,663 (GRCm39)	missense	probably damaging	1.00
R6200:Fcamr	UTSW	1	130,730,927 (GRCm39)	missense	probably benign	0.16
R6653:Fcamr	UTSW	1	130,740,939 (GRCm39)	missense	possibly damaging	0.89
R7081:Fcamr	UTSW	1	130,740,949 (GRCm39)	missense	probably damaging	1.00
R7362:Fcamr	UTSW	1	130,741,760 (GRCm39)	missense	possibly damaging	0.52
R7828:Fcamr	UTSW	1	130,739,443 (GRCm39)	missense	probably damaging	1.00
R7861:Fcamr	UTSW	1	130,742,375 (GRCm39)	missense	probably benign
R8188:Fcamr	UTSW	1	130,730,665 (GRCm39)	splice site	probably null
R8869:Fcamr	UTSW	1	130,739,335 (GRCm39)	missense	probably damaging	1.00
R8907:Fcamr	UTSW	1	130,740,328 (GRCm39)	missense	probably damaging	1.00
R9568:Fcamr	UTSW	1	130,732,356 (GRCm39)	missense	probably damaging	0.99
X0012:Fcamr	UTSW	1	130,740,471 (GRCm39)	missense	probably benign	0.09

Posted On

2016-08-02