Incidental Mutation 'IGL03394:Olfr904'
ID421161
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr904
Ensembl Gene ENSMUSG00000094380
Gene Nameolfactory receptor 904
SynonymsGA_x6K02T2PVTD-32156773-32157705, MOR167-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.109) question?
Stock #IGL03394
Quality Score
Status
Chromosome9
Chromosomal Location38463144-38468995 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 38464221 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 60 (Y60C)
Ref Sequence ENSEMBL: ENSMUSP00000150057 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058153] [ENSMUST00000216724]
Predicted Effect probably damaging
Transcript: ENSMUST00000058153
AA Change: Y60C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000057148
Gene: ENSMUSG00000094380
AA Change: Y60C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.7e-51 PFAM
Pfam:7tm_1 41 291 1.5e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216724
AA Change: Y60C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 A G 17: 46,324,351 L242P probably damaging Het
Adam22 T C 5: 8,167,379 I139V probably benign Het
Ahr G T 12: 35,503,752 Y789* probably null Het
Ankrd27 C A 7: 35,607,098 probably null Het
Ano1 T C 7: 144,595,439 probably null Het
Ap4e1 T A 2: 127,063,397 M996K probably benign Het
Bglap T C 3: 88,384,005 K42E probably benign Het
Ccdc30 A T 4: 119,359,582 S220R probably damaging Het
Clic5 A G 17: 44,237,218 N50S probably benign Het
Cyp20a1 T G 1: 60,366,681 D211E probably damaging Het
Dctn1 G A 6: 83,191,284 V408I possibly damaging Het
Exoc6 T C 19: 37,599,572 I551T probably benign Het
Fat4 C T 3: 38,892,019 T1687M probably damaging Het
Fat4 T A 3: 39,009,364 C4490S probably damaging Het
Fras1 T A 5: 96,667,477 I1351N probably damaging Het
Gm10031 A T 1: 156,525,222 Q331L probably benign Het
Igkv2-116 T C 6: 68,152,343 noncoding transcript Het
Iws1 T G 18: 32,088,248 probably benign Het
Mlh1 A T 9: 111,268,243 I61N probably damaging Het
Mtmr7 C T 8: 40,608,929 V38M probably damaging Het
Myh7 G T 14: 54,975,361 A1409D probably damaging Het
Myt1 A T 2: 181,797,845 I387F probably damaging Het
Nars2 A G 7: 97,040,013 N381D possibly damaging Het
Nsd3 T C 8: 25,675,749 probably benign Het
Nup107 A G 10: 117,782,028 S162P probably damaging Het
Oog2 T C 4: 144,194,006 F3S probably benign Het
Oxgr1 T C 14: 120,022,610 M62V possibly damaging Het
Pcgf1 A G 6: 83,079,140 Y75C probably damaging Het
Ppp3cc C A 14: 70,225,028 E396* probably null Het
Ptx4 T A 17: 25,124,675 C300S probably damaging Het
Rassf4 C T 6: 116,641,747 V192I probably damaging Het
Rundc3b T C 5: 8,548,261 T203A possibly damaging Het
Serpinb3c T C 1: 107,271,873 D306G probably benign Het
Sipa1l2 T C 8: 125,491,659 E313G possibly damaging Het
Snx5 G A 2: 144,253,754 A329V probably damaging Het
Stx1b T C 7: 127,807,884 D213G probably damaging Het
Tpd52l2 G A 2: 181,515,086 V172I probably benign Het
Trim50 A T 5: 135,363,953 I241F probably damaging Het
Ttn G A 2: 76,750,416 H23378Y probably benign Het
Vmn1r193 T A 13: 22,219,769 M18L probably benign Het
Vmn1r226 A G 17: 20,688,184 N226S probably benign Het
Vmn2r14 T A 5: 109,219,836 Q430L probably null Het
Xirp2 T A 2: 67,515,194 V2593D probably damaging Het
Zfp169 A T 13: 48,489,924 F576I possibly damaging Het
Zfp667 T C 7: 6,289,439 probably null Het
Zzef1 A G 11: 72,886,775 probably null Het
Other mutations in Olfr904
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01352:Olfr904 APN 9 38464734 missense probably benign
IGL01966:Olfr904 APN 9 38464929 missense possibly damaging 0.82
IGL02328:Olfr904 APN 9 38464676 missense probably benign
R0085:Olfr904 UTSW 9 38464662 missense probably benign 0.37
R0125:Olfr904 UTSW 9 38464461 nonsense probably null
R1506:Olfr904 UTSW 9 38464143 missense probably benign 0.02
R1545:Olfr904 UTSW 9 38464519 missense probably benign 0.37
R1610:Olfr904 UTSW 9 38464631 missense probably damaging 0.97
R2008:Olfr904 UTSW 9 38464241 missense probably damaging 1.00
R2424:Olfr904 UTSW 9 38464832 missense probably damaging 0.99
R3824:Olfr904 UTSW 9 38464526 missense probably benign 0.13
R3964:Olfr904 UTSW 9 38464683 missense probably benign 0.25
R4093:Olfr904 UTSW 9 38464083 missense probably null 1.00
R4454:Olfr904 UTSW 9 38464642 missense probably benign 0.03
R5650:Olfr904 UTSW 9 38464727 nonsense probably null
R6921:Olfr904 UTSW 9 38464247 missense probably benign 0.01
R7406:Olfr904 UTSW 9 38464143 missense possibly damaging 0.88
R7597:Olfr904 UTSW 9 38464506 missense probably benign 0.01
Posted On2016-08-02