Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03394:Oog2'

421163

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oog2

Ensembl Gene

ENSMUSG00000066030

Gene Name

oogenesin 2

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03394

Quality Score

Status

Chromosome

Chromosomal Location

144190719-144196934 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 144194006 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 3 (F3S)

Ref Sequence

ENSEMBL: ENSMUSP00000079267 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080405] [ENSMUST00000143978]

AlphaFold

Q7TPX8

Predicted Effect

probably benign
Transcript: ENSMUST00000080405
AA Change: F3S

PolyPhen 2 Score 0.165 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000079267
Gene: ENSMUSG00000066030
AA Change: F3S

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	204	391	2e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129781

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141847

Predicted Effect

probably benign
Transcript: ENSMUST00000143978
AA Change: F21S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc10	A	G	17: 46,324,351	L242P	probably damaging	Het
Adam22	T	C	5: 8,167,379	I139V	probably benign	Het
Ahr	G	T	12: 35,503,752	Y789*	probably null	Het
Ankrd27	C	A	7: 35,607,098		probably null	Het
Ano1	T	C	7: 144,595,439		probably null	Het
Ap4e1	T	A	2: 127,063,397	M996K	probably benign	Het
Bglap	T	C	3: 88,384,005	K42E	probably benign	Het
Ccdc30	A	T	4: 119,359,582	S220R	probably damaging	Het
Clic5	A	G	17: 44,237,218	N50S	probably benign	Het
Cyp20a1	T	G	1: 60,366,681	D211E	probably damaging	Het
Dctn1	G	A	6: 83,191,284	V408I	possibly damaging	Het
Exoc6	T	C	19: 37,599,572	I551T	probably benign	Het
Fat4	C	T	3: 38,892,019	T1687M	probably damaging	Het
Fat4	T	A	3: 39,009,364	C4490S	probably damaging	Het
Fras1	T	A	5: 96,667,477	I1351N	probably damaging	Het
Gm10031	A	T	1: 156,525,222	Q331L	probably benign	Het
Igkv2-116	T	C	6: 68,152,343		noncoding transcript	Het
Iws1	T	G	18: 32,088,248		probably benign	Het
Mlh1	A	T	9: 111,268,243	I61N	probably damaging	Het
Mtmr7	C	T	8: 40,608,929	V38M	probably damaging	Het
Myh7	G	T	14: 54,975,361	A1409D	probably damaging	Het
Myt1	A	T	2: 181,797,845	I387F	probably damaging	Het
Nars2	A	G	7: 97,040,013	N381D	possibly damaging	Het
Nsd3	T	C	8: 25,675,749		probably benign	Het
Nup107	A	G	10: 117,782,028	S162P	probably damaging	Het
Olfr904	A	G	9: 38,464,221	Y60C	probably damaging	Het
Oxgr1	T	C	14: 120,022,610	M62V	possibly damaging	Het
Pcgf1	A	G	6: 83,079,140	Y75C	probably damaging	Het
Ppp3cc	C	A	14: 70,225,028	E396*	probably null	Het
Ptx4	T	A	17: 25,124,675	C300S	probably damaging	Het
Rassf4	C	T	6: 116,641,747	V192I	probably damaging	Het
Rundc3b	T	C	5: 8,548,261	T203A	possibly damaging	Het
Serpinb3c	T	C	1: 107,271,873	D306G	probably benign	Het
Sipa1l2	T	C	8: 125,491,659	E313G	possibly damaging	Het
Snx5	G	A	2: 144,253,754	A329V	probably damaging	Het
Stx1b	T	C	7: 127,807,884	D213G	probably damaging	Het
Tpd52l2	G	A	2: 181,515,086	V172I	probably benign	Het
Trim50	A	T	5: 135,363,953	I241F	probably damaging	Het
Ttn	G	A	2: 76,750,416	H23378Y	probably benign	Het
Vmn1r193	T	A	13: 22,219,769	M18L	probably benign	Het
Vmn1r226	A	G	17: 20,688,184	N226S	probably benign	Het
Vmn2r14	T	A	5: 109,219,836	Q430L	probably null	Het
Xirp2	T	A	2: 67,515,194	V2593D	probably damaging	Het
Zfp169	A	T	13: 48,489,924	F576I	possibly damaging	Het
Zfp667	T	C	7: 6,289,439		probably null	Het
Zzef1	A	G	11: 72,886,775		probably null	Het

Other mutations in Oog2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00843:Oog2	APN	4	144195172	missense	probably damaging	1.00
IGL01317:Oog2	APN	4	144195267	missense	probably benign	0.16
IGL01697:Oog2	APN	4	144195184	missense	possibly damaging	0.90
IGL02237:Oog2	APN	4	144196446	missense	possibly damaging	0.95
IGL02411:Oog2	APN	4	144195048	missense	probably damaging	0.99
IGL02476:Oog2	APN	4	144195229	missense	probably benign	0.02
IGL03284:Oog2	APN	4	144196607	unclassified	probably benign
R0538:Oog2	UTSW	4	144196084	nonsense	probably null
R0892:Oog2	UTSW	4	144196499	missense	probably benign	0.00
R1024:Oog2	UTSW	4	144196286	missense	probably damaging	1.00
R4156:Oog2	UTSW	4	144193953	intron	probably benign
R4157:Oog2	UTSW	4	144193953	intron	probably benign
R4166:Oog2	UTSW	4	144194841	missense	probably damaging	1.00
R4167:Oog2	UTSW	4	144196212	missense	probably benign	0.18
R4732:Oog2	UTSW	4	144193941	intron	probably benign
R4734:Oog2	UTSW	4	144196451	missense	probably benign	0.00
R4741:Oog2	UTSW	4	144195145	missense	possibly damaging	0.94
R4909:Oog2	UTSW	4	144195099	missense	possibly damaging	0.78
R4954:Oog2	UTSW	4	144190732	start gained	probably benign
R6437:Oog2	UTSW	4	144195108	splice site	probably null
R6487:Oog2	UTSW	4	144196485	missense	possibly damaging	0.48
R6946:Oog2	UTSW	4	144196464	missense	possibly damaging	0.95
R7000:Oog2	UTSW	4	144195327	missense	probably damaging	1.00
R7167:Oog2	UTSW	4	144195175	missense	probably benign	0.04
R7303:Oog2	UTSW	4	144195342	missense	probably benign	0.04
R7399:Oog2	UTSW	4	144195281	missense	probably benign	0.01
R8004:Oog2	UTSW	4	144194251	missense	probably benign	0.00
R8141:Oog2	UTSW	4	144194207	missense	probably damaging	0.97
R8411:Oog2	UTSW	4	144194173	missense	probably damaging	1.00
R8932:Oog2	UTSW	4	144194115	missense	probably benign	0.00
R9290:Oog2	UTSW	4	144196445	missense	probably benign	0.02
R9348:Oog2	UTSW	4	144195219	missense	probably damaging	1.00
R9614:Oog2	UTSW	4	144196137	missense	probably damaging	1.00
RF009:Oog2	UTSW	4	144195285	missense	probably benign	0.36
Z1177:Oog2	UTSW	4	144194015	missense	probably damaging	0.99

Posted On

2016-08-02