Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03394:Zfp169'

421192

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp169

Ensembl Gene

ENSMUSG00000050954

Gene Name

zinc finger protein 169

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL03394

Quality Score

Status

Chromosome

Chromosomal Location

48487647-48513451 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 48489924 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 576 (F576I)

Ref Sequence

ENSEMBL: ENSMUSP00000135414 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110110] [ENSMUST00000167682] [ENSMUST00000176176] [ENSMUST00000176949] [ENSMUST00000176996] [ENSMUST00000177530]

AlphaFold

E9Q3R6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000110110
AA Change: F576I

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000105737
Gene: ENSMUSG00000050954
AA Change: F576I

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART
ZnF_C2H2	257	279	9.08e-4	SMART
ZnF_C2H2	285	308	2.2e-2	SMART
ZnF_C2H2	314	336	9.73e-4	SMART
ZnF_C2H2	342	364	2.86e-1	SMART
ZnF_C2H2	370	392	4.72e-2	SMART
ZnF_C2H2	398	420	4.24e-4	SMART
ZnF_C2H2	426	448	1.13e-4	SMART
ZnF_C2H2	454	476	2.2e-2	SMART
ZnF_C2H2	482	504	2.99e-4	SMART
ZnF_C2H2	510	532	2.57e-3	SMART
ZnF_C2H2	539	561	3.44e-4	SMART
ZnF_C2H2	567	589	3.69e-4	SMART
ZnF_C2H2	595	617	8.02e-5	SMART
ZnF_C2H2	623	645	1.26e-2	SMART
ZnF_C2H2	651	673	4.79e-3	SMART
ZnF_C2H2	679	701	1.3e-4	SMART
ZnF_C2H2	707	729	5.5e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000167682

SMART Domains

Protein: ENSMUSP00000127591
Gene: ENSMUSG00000050954

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176176

SMART Domains

Protein: ENSMUSP00000134793
Gene: ENSMUSG00000050954

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176949

SMART Domains

Protein: ENSMUSP00000135695
Gene: ENSMUSG00000050954

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000176996

SMART Domains

Protein: ENSMUSP00000135520
Gene: ENSMUSG00000050954

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177474

Predicted Effect

possibly damaging
Transcript: ENSMUST00000177530
AA Change: F576I

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000135414
Gene: ENSMUSG00000050954
AA Change: F576I

Domain	Start	End	E-Value	Type
KRAB	14	74	9.74e-36	SMART
ZnF_C2H2	257	279	9.08e-4	SMART
ZnF_C2H2	285	308	2.2e-2	SMART
ZnF_C2H2	314	336	9.73e-4	SMART
ZnF_C2H2	342	364	2.86e-1	SMART
ZnF_C2H2	370	392	4.72e-2	SMART
ZnF_C2H2	398	420	4.24e-4	SMART
ZnF_C2H2	426	448	1.13e-4	SMART
ZnF_C2H2	454	476	2.2e-2	SMART
ZnF_C2H2	482	504	2.99e-4	SMART
ZnF_C2H2	510	532	2.57e-3	SMART
ZnF_C2H2	539	561	3.44e-4	SMART
ZnF_C2H2	567	589	3.69e-4	SMART
ZnF_C2H2	595	617	8.02e-5	SMART
ZnF_C2H2	623	645	1.26e-2	SMART
ZnF_C2H2	651	673	4.79e-3	SMART
ZnF_C2H2	679	701	1.3e-4	SMART
ZnF_C2H2	707	729	5.5e-3	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous disruption of this locus does not result in an overt phenotype early in life. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc10	A	G	17: 46,324,351	L242P	probably damaging	Het
Adam22	T	C	5: 8,167,379	I139V	probably benign	Het
Ahr	G	T	12: 35,503,752	Y789*	probably null	Het
Ankrd27	C	A	7: 35,607,098		probably null	Het
Ano1	T	C	7: 144,595,439		probably null	Het
Ap4e1	T	A	2: 127,063,397	M996K	probably benign	Het
Bglap	T	C	3: 88,384,005	K42E	probably benign	Het
Ccdc30	A	T	4: 119,359,582	S220R	probably damaging	Het
Clic5	A	G	17: 44,237,218	N50S	probably benign	Het
Cyp20a1	T	G	1: 60,366,681	D211E	probably damaging	Het
Dctn1	G	A	6: 83,191,284	V408I	possibly damaging	Het
Exoc6	T	C	19: 37,599,572	I551T	probably benign	Het
Fat4	C	T	3: 38,892,019	T1687M	probably damaging	Het
Fat4	T	A	3: 39,009,364	C4490S	probably damaging	Het
Fras1	T	A	5: 96,667,477	I1351N	probably damaging	Het
Gm10031	A	T	1: 156,525,222	Q331L	probably benign	Het
Igkv2-116	T	C	6: 68,152,343		noncoding transcript	Het
Iws1	T	G	18: 32,088,248		probably benign	Het
Mlh1	A	T	9: 111,268,243	I61N	probably damaging	Het
Mtmr7	C	T	8: 40,608,929	V38M	probably damaging	Het
Myh7	G	T	14: 54,975,361	A1409D	probably damaging	Het
Myt1	A	T	2: 181,797,845	I387F	probably damaging	Het
Nars2	A	G	7: 97,040,013	N381D	possibly damaging	Het
Nsd3	T	C	8: 25,675,749		probably benign	Het
Nup107	A	G	10: 117,782,028	S162P	probably damaging	Het
Olfr904	A	G	9: 38,464,221	Y60C	probably damaging	Het
Oog2	T	C	4: 144,194,006	F3S	probably benign	Het
Oxgr1	T	C	14: 120,022,610	M62V	possibly damaging	Het
Pcgf1	A	G	6: 83,079,140	Y75C	probably damaging	Het
Ppp3cc	C	A	14: 70,225,028	E396*	probably null	Het
Ptx4	T	A	17: 25,124,675	C300S	probably damaging	Het
Rassf4	C	T	6: 116,641,747	V192I	probably damaging	Het
Rundc3b	T	C	5: 8,548,261	T203A	possibly damaging	Het
Serpinb3c	T	C	1: 107,271,873	D306G	probably benign	Het
Sipa1l2	T	C	8: 125,491,659	E313G	possibly damaging	Het
Snx5	G	A	2: 144,253,754	A329V	probably damaging	Het
Stx1b	T	C	7: 127,807,884	D213G	probably damaging	Het
Tpd52l2	G	A	2: 181,515,086	V172I	probably benign	Het
Trim50	A	T	5: 135,363,953	I241F	probably damaging	Het
Ttn	G	A	2: 76,750,416	H23378Y	probably benign	Het
Vmn1r193	T	A	13: 22,219,769	M18L	probably benign	Het
Vmn1r226	A	G	17: 20,688,184	N226S	probably benign	Het
Vmn2r14	T	A	5: 109,219,836	Q430L	probably null	Het
Xirp2	T	A	2: 67,515,194	V2593D	probably damaging	Het
Zfp667	T	C	7: 6,289,439		probably null	Het
Zzef1	A	G	11: 72,886,775		probably null	Het

Other mutations in Zfp169

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01925:Zfp169	APN	13	48490763	unclassified	probably benign
IGL03329:Zfp169	APN	13	48490794	unclassified	probably benign
IGL03382:Zfp169	APN	13	48491163	unclassified	probably benign
BB010:Zfp169	UTSW	13	48490481	missense	unknown
BB020:Zfp169	UTSW	13	48490481	missense	unknown
R0571:Zfp169	UTSW	13	48489690	missense	possibly damaging	0.71
R1714:Zfp169	UTSW	13	48498854	missense	probably benign	0.35
R1784:Zfp169	UTSW	13	48489819	missense	possibly damaging	0.61
R3108:Zfp169	UTSW	13	48489996	missense	possibly damaging	0.86
R3689:Zfp169	UTSW	13	48506901	splice site	probably benign
R4444:Zfp169	UTSW	13	48490337	missense	possibly damaging	0.94
R4665:Zfp169	UTSW	13	48490863	unclassified	probably benign
R4719:Zfp169	UTSW	13	48490158	missense	probably benign	0.06
R4745:Zfp169	UTSW	13	48490232	missense	possibly damaging	0.71
R5288:Zfp169	UTSW	13	48490275	missense	possibly damaging	0.61
R5384:Zfp169	UTSW	13	48490275	missense	possibly damaging	0.61
R5979:Zfp169	UTSW	13	48491040	unclassified	probably benign
R6053:Zfp169	UTSW	13	48498858	missense	probably damaging	1.00
R6823:Zfp169	UTSW	13	48490996	unclassified	probably benign
R7084:Zfp169	UTSW	13	48498863	missense	probably benign	0.10
R7679:Zfp169	UTSW	13	48498383	missense	probably damaging	0.99
R7933:Zfp169	UTSW	13	48490481	missense	unknown
R8298:Zfp169	UTSW	13	48498377	nonsense	probably null
R8322:Zfp169	UTSW	13	48491099	missense	unknown
R9047:Zfp169	UTSW	13	48498816	missense	probably damaging	1.00
R9124:Zfp169	UTSW	13	48491081	missense	unknown
R9126:Zfp169	UTSW	13	48491081	missense	unknown
R9131:Zfp169	UTSW	13	48491081	missense	unknown
R9132:Zfp169	UTSW	13	48491081	missense	unknown

Posted On

2016-08-02