Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03394:Zfp667'

421205

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp667

Ensembl Gene

ENSMUSG00000054893

Gene Name

zinc finger protein 667

Synonyms

A830025F02Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL03394

Quality Score

Status

Chromosome

Chromosomal Location

6289578-6310882 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to C at 6292438 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000128658 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086327] [ENSMUST00000108562] [ENSMUST00000153840] [ENSMUST00000170776]

AlphaFold

Q2TL60

Predicted Effect

probably null
Transcript: ENSMUST00000086327

SMART Domains

Protein: ENSMUSP00000083507
Gene: ENSMUSG00000054893

Domain	Start	End	E-Value	Type
KRAB	14	74	4.77e-30	SMART
ZnF_C2H2	144	166	5.42e-2	SMART
ZnF_C2H2	172	194	3.11e-2	SMART
ZnF_C2H2	200	222	1.67e-2	SMART
ZnF_C2H2	253	275	2.57e-3	SMART
ZnF_C2H2	329	351	2.4e-3	SMART
ZnF_C2H2	357	379	3.16e-3	SMART
ZnF_C2H2	385	407	8.94e-3	SMART
ZnF_C2H2	414	436	5.06e-2	SMART
ZnF_C2H2	442	464	2.4e-3	SMART
ZnF_C2H2	470	492	5.29e-5	SMART
ZnF_C2H2	498	520	7.37e-4	SMART
ZnF_C2H2	526	548	1.38e-3	SMART
ZnF_C2H2	554	576	1.13e-4	SMART
ZnF_C2H2	582	604	1.38e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000108562

SMART Domains

Protein: ENSMUSP00000104202
Gene: ENSMUSG00000054893

Domain	Start	End	E-Value	Type
KRAB	14	74	4.77e-30	SMART
ZnF_C2H2	144	166	5.42e-2	SMART
ZnF_C2H2	172	194	3.11e-2	SMART
ZnF_C2H2	200	222	1.67e-2	SMART
ZnF_C2H2	253	275	2.57e-3	SMART
ZnF_C2H2	329	351	2.4e-3	SMART
ZnF_C2H2	357	379	3.16e-3	SMART
ZnF_C2H2	385	407	8.94e-3	SMART
ZnF_C2H2	414	436	5.06e-2	SMART
ZnF_C2H2	442	464	2.4e-3	SMART
ZnF_C2H2	470	492	5.29e-5	SMART
ZnF_C2H2	498	520	7.37e-4	SMART
ZnF_C2H2	526	548	1.38e-3	SMART
ZnF_C2H2	554	576	1.13e-4	SMART
ZnF_C2H2	582	604	1.38e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147784

Predicted Effect

probably null
Transcript: ENSMUST00000153840

Predicted Effect

probably null
Transcript: ENSMUST00000170776

SMART Domains

Protein: ENSMUSP00000128658
Gene: ENSMUSG00000054893

Domain	Start	End	E-Value	Type
KRAB	14	74	4.77e-30	SMART
ZnF_C2H2	144	166	5.42e-2	SMART
ZnF_C2H2	172	194	3.11e-2	SMART
ZnF_C2H2	200	222	1.67e-2	SMART
ZnF_C2H2	253	275	2.57e-3	SMART
ZnF_C2H2	329	351	2.4e-3	SMART
ZnF_C2H2	357	379	3.16e-3	SMART
ZnF_C2H2	385	407	8.94e-3	SMART
ZnF_C2H2	414	436	5.06e-2	SMART
ZnF_C2H2	442	464	2.4e-3	SMART
ZnF_C2H2	470	492	5.29e-5	SMART
ZnF_C2H2	498	520	7.37e-4	SMART
ZnF_C2H2	526	548	1.38e-3	SMART
ZnF_C2H2	554	576	1.13e-4	SMART
ZnF_C2H2	582	604	1.38e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(4) : Targeted, other(2) Gene trapped(2)

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc10	A	G	17: 46,635,277 (GRCm39)	L242P	probably damaging	Het
Adam22	T	C	5: 8,217,379 (GRCm39)	I139V	probably benign	Het
Ahr	G	T	12: 35,553,751 (GRCm39)	Y789*	probably null	Het
Ankrd27	C	A	7: 35,306,523 (GRCm39)		probably null	Het
Ano1	T	C	7: 144,149,176 (GRCm39)		probably null	Het
Ap4e1	T	A	2: 126,905,317 (GRCm39)	M996K	probably benign	Het
Bglap	T	C	3: 88,291,312 (GRCm39)	K42E	probably benign	Het
Ccdc30	A	T	4: 119,216,779 (GRCm39)	S220R	probably damaging	Het
Clic5	A	G	17: 44,548,105 (GRCm39)	N50S	probably benign	Het
Csnk2a1-ps3	A	T	1: 156,352,792 (GRCm39)	Q331L	probably benign	Het
Cyp20a1	T	G	1: 60,405,840 (GRCm39)	D211E	probably damaging	Het
Dctn1	G	A	6: 83,168,266 (GRCm39)	V408I	possibly damaging	Het
Exoc6	T	C	19: 37,588,020 (GRCm39)	I551T	probably benign	Het
Fat4	C	T	3: 38,946,168 (GRCm39)	T1687M	probably damaging	Het
Fat4	T	A	3: 39,063,513 (GRCm39)	C4490S	probably damaging	Het
Fras1	T	A	5: 96,815,336 (GRCm39)	I1351N	probably damaging	Het
Igkv2-116	T	C	6: 68,129,327 (GRCm39)		noncoding transcript	Het
Iws1	T	G	18: 32,221,301 (GRCm39)		probably benign	Het
Mlh1	A	T	9: 111,097,311 (GRCm39)	I61N	probably damaging	Het
Mtmr7	C	T	8: 41,061,972 (GRCm39)	V38M	probably damaging	Het
Myh7	G	T	14: 55,212,818 (GRCm39)	A1409D	probably damaging	Het
Myt1	A	T	2: 181,439,638 (GRCm39)	I387F	probably damaging	Het
Nars2	A	G	7: 96,689,220 (GRCm39)	N381D	possibly damaging	Het
Nsd3	T	C	8: 26,165,765 (GRCm39)		probably benign	Het
Nup107	A	G	10: 117,617,933 (GRCm39)	S162P	probably damaging	Het
Oog2	T	C	4: 143,920,576 (GRCm39)	F3S	probably benign	Het
Or8b1b	A	G	9: 38,375,517 (GRCm39)	Y60C	probably damaging	Het
Oxgr1	T	C	14: 120,260,022 (GRCm39)	M62V	possibly damaging	Het
Pcgf1	A	G	6: 83,056,121 (GRCm39)	Y75C	probably damaging	Het
Ppp3cc	C	A	14: 70,462,477 (GRCm39)	E396*	probably null	Het
Ptx4	T	A	17: 25,343,649 (GRCm39)	C300S	probably damaging	Het
Rassf4	C	T	6: 116,618,708 (GRCm39)	V192I	probably damaging	Het
Rundc3b	T	C	5: 8,598,261 (GRCm39)	T203A	possibly damaging	Het
Serpinb3c	T	C	1: 107,199,603 (GRCm39)	D306G	probably benign	Het
Sipa1l2	T	C	8: 126,218,398 (GRCm39)	E313G	possibly damaging	Het
Snx5	G	A	2: 144,095,674 (GRCm39)	A329V	probably damaging	Het
Stx1b	T	C	7: 127,407,056 (GRCm39)	D213G	probably damaging	Het
Tpd52l2	G	A	2: 181,156,879 (GRCm39)	V172I	probably benign	Het
Trim50	A	T	5: 135,392,807 (GRCm39)	I241F	probably damaging	Het
Ttn	G	A	2: 76,580,760 (GRCm39)	H23378Y	probably benign	Het
Vmn1r193	T	A	13: 22,403,939 (GRCm39)	M18L	probably benign	Het
Vmn1r226	A	G	17: 20,908,446 (GRCm39)	N226S	probably benign	Het
Vmn2r14	T	A	5: 109,367,702 (GRCm39)	Q430L	probably null	Het
Xirp2	T	A	2: 67,345,538 (GRCm39)	V2593D	probably damaging	Het
Zfp169	A	T	13: 48,643,400 (GRCm39)	F576I	possibly damaging	Het
Zzef1	A	G	11: 72,777,601 (GRCm39)		probably null	Het

Other mutations in Zfp667

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00821:Zfp667	APN	7	6,308,396 (GRCm39)	missense	possibly damaging	0.53
IGL01325:Zfp667	APN	7	6,293,545 (GRCm39)	missense	probably damaging	1.00
IGL01386:Zfp667	APN	7	6,307,869 (GRCm39)	missense	probably benign	0.00
IGL01960:Zfp667	APN	7	6,308,336 (GRCm39)	missense	probably benign	0.00
B5639:Zfp667	UTSW	7	6,293,544 (GRCm39)	missense	probably damaging	1.00
R0458:Zfp667	UTSW	7	6,307,844 (GRCm39)	missense	probably benign	0.40
R0845:Zfp667	UTSW	7	6,309,091 (GRCm39)	missense	possibly damaging	0.85
R1768:Zfp667	UTSW	7	6,308,066 (GRCm39)	missense	possibly damaging	0.53
R1953:Zfp667	UTSW	7	6,308,087 (GRCm39)	missense	probably benign	0.04
R2023:Zfp667	UTSW	7	6,308,416 (GRCm39)	missense	possibly damaging	0.85
R3159:Zfp667	UTSW	7	6,308,999 (GRCm39)	missense	probably damaging	1.00
R4080:Zfp667	UTSW	7	6,308,105 (GRCm39)	missense	possibly damaging	0.71
R4476:Zfp667	UTSW	7	6,307,598 (GRCm39)	missense	possibly damaging	0.53
R4584:Zfp667	UTSW	7	6,293,624 (GRCm39)	missense	possibly damaging	0.84
R4783:Zfp667	UTSW	7	6,308,684 (GRCm39)	missense	possibly damaging	0.83
R5037:Zfp667	UTSW	7	6,308,949 (GRCm39)	missense	possibly damaging	0.71
R5300:Zfp667	UTSW	7	6,307,635 (GRCm39)	missense	probably benign
R5311:Zfp667	UTSW	7	6,308,715 (GRCm39)	missense	probably benign	0.10
R5312:Zfp667	UTSW	7	6,308,466 (GRCm39)	missense	probably benign
R5340:Zfp667	UTSW	7	6,308,252 (GRCm39)	missense	possibly damaging	0.53
R6262:Zfp667	UTSW	7	6,307,973 (GRCm39)	missense	probably benign	0.03
R7386:Zfp667	UTSW	7	6,308,949 (GRCm39)	missense	possibly damaging	0.86
R8383:Zfp667	UTSW	7	6,308,370 (GRCm39)	missense	probably damaging	0.98
R8919:Zfp667	UTSW	7	6,308,256 (GRCm39)	missense	possibly damaging	0.53
R9099:Zfp667	UTSW	7	6,308,322 (GRCm39)	missense	probably benign	0.00
R9422:Zfp667	UTSW	7	6,308,321 (GRCm39)	missense	probably benign	0.00
Z1177:Zfp667	UTSW	7	6,307,856 (GRCm39)	missense	possibly damaging	0.91

Posted On

2016-08-02