Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03396:Cdcp2'

421268

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdcp2

Ensembl Gene

ENSMUSG00000047636

Gene Name

CUB domain containing protein 2

Synonyms

D030010E02Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL03396

Quality Score

Status

Chromosome

Chromosomal Location

106954088-106970322 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 106964369 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 406 (Y406*)

Ref Sequence

ENSEMBL: ENSMUSP00000061401 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062495] [ENSMUST00000221740]

AlphaFold

Q8BQH6

Predicted Effect

probably null
Transcript: ENSMUST00000062495
AA Change: Y406*

SMART Domains

Protein: ENSMUSP00000061401
Gene: ENSMUSG00000047636
AA Change: Y406*

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
CUB	30	143	1.74e-42	SMART
CUB	145	255	2.37e-35	SMART
CUB	257	373	9.57e-31	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000221740

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadvl	G	A	11: 69,902,239 (GRCm39)	R457*	probably null	Het
Arl5b	C	A	2: 15,079,915 (GRCm39)	T153K	probably damaging	Het
Arsb	A	T	13: 94,075,825 (GRCm39)	Y436F	probably benign	Het
Azgp1	C	T	5: 137,983,445 (GRCm39)	P40L	possibly damaging	Het
B020004C17Rik	A	G	14: 57,253,993 (GRCm39)	T39A	possibly damaging	Het
Cacna2d3	G	A	14: 29,442,834 (GRCm39)	Q67*	probably null	Het
Cep89	T	A	7: 35,128,603 (GRCm39)	D585E	probably benign	Het
Cfap65	A	G	1: 74,943,801 (GRCm39)	F1570S	probably damaging	Het
Cnfn	A	G	7: 25,067,783 (GRCm39)		probably benign	Het
Fgd6	G	A	10: 93,880,318 (GRCm39)	V391I	probably benign	Het
Fra10ac1	C	T	19: 38,189,994 (GRCm39)		probably null	Het
Gjd3	T	C	11: 102,691,353 (GRCm39)	K217E	probably benign	Het
Il20rb	T	C	9: 100,341,251 (GRCm39)	E285G	probably damaging	Het
Ints2	T	C	11: 86,103,888 (GRCm39)	T1086A	probably damaging	Het
Itih4	A	T	14: 30,609,906 (GRCm39)	I79F	probably damaging	Het
Jmjd6	A	T	11: 116,732,077 (GRCm39)	L208H	probably damaging	Het
Lilrb4b	A	G	10: 51,357,253 (GRCm39)	I30V	possibly damaging	Het
Limch1	A	G	5: 67,111,016 (GRCm39)	N81S	probably damaging	Het
Mettl21e	A	T	1: 44,245,759 (GRCm39)	N162K	possibly damaging	Het
Ninl	A	G	2: 150,808,132 (GRCm39)	S299P	possibly damaging	Het
Obscn	A	G	11: 58,964,404 (GRCm39)	L3046P	probably benign	Het
Or1j14	C	A	2: 36,417,692 (GRCm39)	S89R	probably benign	Het
Or5b98	T	A	19: 12,931,184 (GRCm39)	V77E	probably damaging	Het
Or6c68	A	G	10: 129,157,916 (GRCm39)	I141M	probably benign	Het
Pnpla8	G	A	12: 44,330,309 (GRCm39)	R287H	probably benign	Het
Pot1a	A	C	6: 25,745,913 (GRCm39)	I596R	possibly damaging	Het
Prkaa1	A	G	15: 5,206,131 (GRCm39)	D329G	probably damaging	Het
Ptprr	T	G	10: 116,024,235 (GRCm39)	V182G	probably damaging	Het
Rrp1b	T	A	17: 32,276,237 (GRCm39)		probably benign	Het
Sec24a	A	G	11: 51,599,794 (GRCm39)	V837A	probably benign	Het
Slc17a6	A	G	7: 51,318,840 (GRCm39)	Y494C	probably damaging	Het
Slc38a10	A	T	11: 120,019,301 (GRCm39)	I360N	probably damaging	Het
Snrpb2	T	C	2: 142,913,377 (GRCm39)	F194L	possibly damaging	Het
Tcam1	A	G	11: 106,176,212 (GRCm39)	I313V	probably benign	Het
Trpv1	A	G	11: 73,143,882 (GRCm39)	N238S	probably benign	Het
Usp20	T	C	2: 30,901,729 (GRCm39)	V498A	probably benign	Het
Vmn2r23	T	C	6: 123,706,585 (GRCm39)	S472P	probably damaging	Het
Vmn2r98	A	T	17: 19,290,107 (GRCm39)	T548S	possibly damaging	Het
Zfp429	A	T	13: 67,544,159 (GRCm39)		probably benign	Het

Other mutations in Cdcp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01149:Cdcp2	APN	4	106,964,308 (GRCm39)	missense	probably benign
IGL02041:Cdcp2	APN	4	106,964,386 (GRCm39)	intron	probably benign
R0128:Cdcp2	UTSW	4	106,963,904 (GRCm39)	splice site	probably benign
R0130:Cdcp2	UTSW	4	106,963,904 (GRCm39)	splice site	probably benign
R0519:Cdcp2	UTSW	4	106,964,389 (GRCm39)	intron	probably benign
R0543:Cdcp2	UTSW	4	106,954,873 (GRCm39)	splice site	probably null
R1376:Cdcp2	UTSW	4	106,959,956 (GRCm39)	missense	possibly damaging	0.93
R1376:Cdcp2	UTSW	4	106,959,956 (GRCm39)	missense	possibly damaging	0.93
R1606:Cdcp2	UTSW	4	106,959,710 (GRCm39)	missense	probably damaging	1.00
R1866:Cdcp2	UTSW	4	106,964,197 (GRCm39)	missense	probably damaging	0.99
R1887:Cdcp2	UTSW	4	106,959,899 (GRCm39)	missense	probably damaging	1.00
R2944:Cdcp2	UTSW	4	106,959,755 (GRCm39)	missense	possibly damaging	0.88
R4620:Cdcp2	UTSW	4	106,963,927 (GRCm39)	missense	probably damaging	0.99
R4816:Cdcp2	UTSW	4	106,963,969 (GRCm39)	missense	probably damaging	1.00
R5298:Cdcp2	UTSW	4	106,964,182 (GRCm39)	missense	probably benign	0.01
R5646:Cdcp2	UTSW	4	106,962,339 (GRCm39)	missense	probably damaging	1.00
R5979:Cdcp2	UTSW	4	106,962,478 (GRCm39)	missense	probably damaging	1.00
R6062:Cdcp2	UTSW	4	106,959,689 (GRCm39)	missense	probably damaging	1.00
R6702:Cdcp2	UTSW	4	106,964,283 (GRCm39)	missense	probably benign
R8114:Cdcp2	UTSW	4	106,962,555 (GRCm39)	missense	probably damaging	0.99
R8472:Cdcp2	UTSW	4	106,959,981 (GRCm39)	missense	probably damaging	0.99
R9291:Cdcp2	UTSW	4	106,964,053 (GRCm39)	missense	probably damaging	1.00
R9726:Cdcp2	UTSW	4	106,959,936 (GRCm39)	missense	probably damaging	1.00
R9801:Cdcp2	UTSW	4	106,964,262 (GRCm39)	missense	possibly damaging	0.63

Posted On

2016-08-02