Incidental Mutation 'IGL03401:Mgst2'
ID 421432
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mgst2
Ensembl Gene ENSMUSG00000074604
Gene Name microsomal glutathione S-transferase 2
Synonyms GST2, MGST-II
Accession Numbers
Essential gene? Probably non essential (E-score: 0.224) question?
Stock # IGL03401
Quality Score
Status
Chromosome 3
Chromosomal Location 51567781-51590098 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 51571933 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 20 (S20R)
Ref Sequence ENSEMBL: ENSMUSP00000141745 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099106] [ENSMUST00000159554] [ENSMUST00000161590]
AlphaFold A2RST1
Predicted Effect possibly damaging
Transcript: ENSMUST00000099106
AA Change: S20R

PolyPhen 2 Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000096705
Gene: ENSMUSG00000074604
AA Change: S20R

DomainStartEndE-ValueType
Pfam:MAPEG 8 124 8.8e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000159554
AA Change: S20R

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000141745
Gene: ENSMUSG00000074604
AA Change: S20R

DomainStartEndE-ValueType
Pfam:MAPEG 8 80 3.8e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160753
Predicted Effect possibly damaging
Transcript: ENSMUST00000161590
AA Change: S20R

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000125670
Gene: ENSMUSG00000074604
AA Change: S20R

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161627
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trap allele display resistance to induced ER stress related cell death and mortality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,384,223 (GRCm39) R581* probably null Het
Actn1 A T 12: 80,215,741 (GRCm39) L799* probably null Het
Adam12 A T 7: 133,518,192 (GRCm39) N327K probably damaging Het
Adamts9 A G 6: 92,763,849 (GRCm39) V1314A probably damaging Het
Agbl4 G T 4: 110,976,216 (GRCm39) R191L probably damaging Het
Ano6 T C 15: 95,847,786 (GRCm39) I611T probably damaging Het
Arhgef26 T A 3: 62,330,953 (GRCm39) S556T possibly damaging Het
AW209491 A G 13: 14,812,041 (GRCm39) D298G probably benign Het
Cc2d1a A G 8: 84,861,258 (GRCm39) M763T probably benign Het
Cep290 A G 10: 100,336,127 (GRCm39) D388G probably benign Het
Cept1 T C 3: 106,440,706 (GRCm39) E151G probably damaging Het
Chat T C 14: 32,174,526 (GRCm39) K139E probably damaging Het
Edc4 T A 8: 106,614,146 (GRCm39) Y7* probably null Het
Enpep T A 3: 129,106,269 (GRCm39) Q319L probably benign Het
F13a1 A G 13: 37,082,054 (GRCm39) I550T probably benign Het
Fbxw19 A G 9: 109,324,038 (GRCm39) probably null Het
Frem3 T G 8: 81,341,170 (GRCm39) D1154E probably damaging Het
Frmpd1 G T 4: 45,284,383 (GRCm39) C1068F probably benign Het
Fsip2 C A 2: 82,820,814 (GRCm39) P5516T probably benign Het
Hyou1 G A 9: 44,296,206 (GRCm39) A429T probably damaging Het
Lrp1b C T 2: 41,000,790 (GRCm39) E2145K probably benign Het
Map1b A T 13: 99,563,776 (GRCm39) V2397D unknown Het
Mcm3ap T C 10: 76,320,483 (GRCm39) probably benign Het
Nr4a3 T A 4: 48,070,987 (GRCm39) probably null Het
Nup93 T A 8: 95,036,339 (GRCm39) probably null Het
Or1e1f T C 11: 73,856,388 (GRCm39) probably benign Het
Papola A T 12: 105,795,381 (GRCm39) T611S probably benign Het
Pik3ca C A 3: 32,491,963 (GRCm39) probably null Het
Pklr T C 3: 89,050,036 (GRCm39) V337A probably benign Het
Prl7b1 A G 13: 27,785,964 (GRCm39) Y235H probably benign Het
Proc T C 18: 32,256,326 (GRCm39) Y447C possibly damaging Het
Pum1 T C 4: 130,470,992 (GRCm39) probably benign Het
Rimklb A T 6: 122,441,077 (GRCm39) I32N probably damaging Het
Rrm1 T A 7: 102,114,951 (GRCm39) D644E possibly damaging Het
Scgb2b7 A T 7: 31,404,506 (GRCm39) C65S probably damaging Het
Shbg A G 11: 69,505,925 (GRCm39) S361P probably damaging Het
Trmt9b A C 8: 36,972,823 (GRCm39) D91A probably damaging Het
Zfp647 T A 15: 76,795,568 (GRCm39) H364L probably damaging Het
Zfp715 A T 7: 42,949,160 (GRCm39) S267T probably benign Het
Other mutations in Mgst2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00824:Mgst2 APN 3 51,589,999 (GRCm39) missense probably benign 0.00
IGL01712:Mgst2 APN 3 51,571,992 (GRCm39) missense probably damaging 1.00
R0294:Mgst2 UTSW 3 51,589,251 (GRCm39) missense probably damaging 1.00
R2867:Mgst2 UTSW 3 51,571,954 (GRCm39) synonymous silent
R4394:Mgst2 UTSW 3 51,571,949 (GRCm39) missense probably damaging 1.00
R5149:Mgst2 UTSW 3 51,589,958 (GRCm39) missense probably benign 0.02
R5878:Mgst2 UTSW 3 51,568,651 (GRCm39) utr 5 prime probably benign
R6703:Mgst2 UTSW 3 51,572,033 (GRCm39) critical splice donor site probably null
R7946:Mgst2 UTSW 3 51,584,991 (GRCm39) missense probably damaging 1.00
R9108:Mgst2 UTSW 3 51,589,233 (GRCm39) missense probably damaging 1.00
Z1177:Mgst2 UTSW 3 51,568,691 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02